-
1
-
-
79960110157
-
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
-
doi: nm.2347 10.1038/nm.2347
-
Lee, J. H. et al. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat. Med. 17, 812-815, doi: nm.2347 10.1038/nm.2347 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 812-815
-
-
Lee, J.H.1
-
2
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
doi: S0092-8674(06)00004-3 10.1016/j.cell.2005. 11.040
-
Zhang, K. et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell 124, 587-599, doi: S0092-8674(06)00004-3 10.1016/j.cell.2005.11.040 (2006).
-
(2006)
Cell
, vol.124
, pp. 587-599
-
-
Zhang, K.1
-
3
-
-
73449099559
-
The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha
-
doi: S0006-291X(09)02419-X 10.1016/j.bbrc.2009.12.046
-
Danno, H. et al. The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. Biochem Biophys Res Commun 391, 1222-1227, doi: S0006-291X(09)02419-X 10.1016/j.bbrc.2009.12.046 (2010).
-
(2010)
Biochem Biophys Res Commun
, vol.391
, pp. 1222-1227
-
-
Danno, H.1
-
4
-
-
84896838463
-
Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor alpha to regulate metabolic hormone FGF21
-
Kim, H. et al. Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor alpha to regulate metabolic hormone FGF21. Endocrinology 155, 769-782, doi: 10.1210/en.2013-1490 (2014).
-
(2014)
Endocrinology
, vol.155
, pp. 769-782
-
-
Kim, H.1
-
5
-
-
84914141378
-
Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes
-
Nakagawa, Y. et al. Hepatic CREB3L3 Controls Whole-Body Energy Homeostasis and Improves Obesity and Diabetes. Endocrinology 155, 4706-4719, doi: 10.1210/en.2014-1113 (2014).
-
(2014)
Endocrinology
, vol.155
, pp. 4706-4719
-
-
Nakagawa, Y.1
-
6
-
-
84863012022
-
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis
-
Fisher, F. M. et al. FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 26, 271-281, doi: 10.1101/gad.177857.111 (2012).
-
(2012)
Genes Dev.
, vol.26
, pp. 271-281
-
-
Fisher, F.M.1
-
7
-
-
78149261827
-
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
-
Garneau, J. E. et al. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature 468, 67-71, doi: 10.1038/nature09523 (2010).
-
(2010)
Nature
, vol.468
, pp. 67-71
-
-
Garneau, J.E.1
-
8
-
-
79956157571
-
Evolution and classification of the CRISPR-Cas systems
-
Makarova, K. S. et al. Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol. 9, 467-477, doi: 10.1038/nrmicro2577 (2011).
-
(2011)
Nat Rev Microbiol.
, vol.9
, pp. 467-477
-
-
Makarova, K.S.1
-
9
-
-
84884856342
-
Cas9 as a versatile tool for engineering biology
-
Mali, P., Esvelt, K. M. & Church, G. M. Cas9 as a versatile tool for engineering biology. Nat. methods 10, 957-963, doi: 10.1038/nmeth.2649 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 957-963
-
-
Mali, P.1
Esvelt, K.M.2
Church, G.M.3
-
10
-
-
84884289608
-
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
-
Yang, H. et al. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell 154, 1370-1379, doi: 10.1016/j.cell.2013.08.022 (2013).
-
(2013)
Cell
, vol.154
, pp. 1370-1379
-
-
Yang, H.1
-
11
-
-
84891745242
-
Generating rats with conditional alleles using CRISPR/Cas9
-
Ma, Y. et al. Generating rats with conditional alleles using CRISPR/Cas9. Cell Res. 24, 122-125, doi: 10.1038/cr.2013.157 (2014).
-
(2014)
Cell Res.
, vol.24
, pp. 122-125
-
-
Ma, Y.1
-
12
-
-
84904737686
-
Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice
-
Lee, A. Y. & Lloyd, K. C. Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice. FEBS Open Bio 4, 637-642, doi: 10.1016/j.fob.2014.06.007 (2014).
-
(2014)
FEBS Open Bio
, vol.4
, pp. 637-642
-
-
Lee, A.Y.1
Lloyd, K.C.2
-
13
-
-
54449091729
-
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H
-
Luebke-Wheeler, J. et al. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology 48, 1242-1250, doi: 10.1002/hep.22439 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 1242-1250
-
-
Luebke-Wheeler, J.1
-
14
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823, doi: 10.1126/science.1231143 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
15
-
-
84889589440
-
Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA
-
Mashiko, D. et al. Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA. Sci Rep. 3, 3355, doi: 10.1038/srep03355 (2013).
-
(2013)
Sci Rep.
, vol.3
, pp. 3355
-
-
Mashiko, D.1
-
16
-
-
84862828272
-
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, lipolysis upon metabolic stress in mice
-
Zhang, C. et al. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, lipolysis upon metabolic stress in mice. Hepatology 55, 1070-1082, doi: 10.1002/hep.24783 (2012).
-
(2012)
Hepatology
, vol.55
, pp. 1070-1082
-
-
Zhang, C.1
-
17
-
-
84908291960
-
Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets
-
e1076
-
Fisher, F. M. et al. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology 147, 1073-1083 e1076, doi: 10.1053/j.gastro.2014.07.044 (2014).
-
(2014)
Gastroenterology
, vol.147
, pp. 1073-1083
-
-
Fisher, F.M.1
-
18
-
-
84933548383
-
Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice
-
Lin, Z. et al. Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation 131, 1861-1871, doi: 10.1161/circulationaha.115.015308 (2015).
-
(2015)
Circulation
, vol.131
, pp. 1861-1871
-
-
Lin, Z.1
-
19
-
-
84928969190
-
Hepatic injury in nonalcoholic steatohepatitis contributes to altered intestinal permeability
-
Luther, J. et al. Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability. Cell Mol Gastroenterol Hepatol. 1, 222-232, doi: 10.1016/j.jcmgh.2015.01.001 (2015).
-
(2015)
Cell Mol Gastroenterol Hepatol.
, vol.1
, pp. 222-232
-
-
Luther, J.1
-
20
-
-
85027918012
-
Leaky guts: Intestinal permeability and NASH Nature reviews
-
Ray, K. N. A. F. L. D. Leaky guts: intestinal permeability and NASH. Nature reviews. Gastroenterology & hepatology 12, 123, doi: 10.1038/nrgastro.2015.15 (2015).
-
(2015)
Gastroenterology & Hepatology
, vol.12
, pp. 123
-
-
Ray, K.N.A.F.L.D.1
-
21
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
-
Postic, C. et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 274, 305-315 (1999).
-
(1999)
J Biol Chem.
, vol.274
, pp. 305-315
-
-
Postic, C.1
-
22
-
-
30044437308
-
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
-
doi: nm1334 10.1038/nm1334
-
Nakagawa, Y. et al. TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nat. Med. 12, 107-113, doi: nm1334 10.1038/nm1334 (2006).
-
(2006)
Nat. Med.
, vol.12
, pp. 107-113
-
-
Nakagawa, Y.1
-
23
-
-
80051552229
-
Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice
-
Karasawa, T. et al. Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 31, 1788-1795, doi: 10.1161/ATVBAHA.110.219659 (2011).
-
(2011)
Arterioscler. Thromb. Vasc. Biol.
, vol.31
, pp. 1788-1795
-
-
Karasawa, T.1
-
24
-
-
84884686048
-
TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis
-
Fujimoto, Y. et al. TFE3 controls lipid metabolism in adipose tissue of male mice by suppressing lipolysis and thermogenesis. Endocrinology 154, 3577-3588, doi: 10.1210/en.2013-1203 (2013).
-
(2013)
Endocrinology
, vol.154
, pp. 3577-3588
-
-
Fujimoto, Y.1
|