Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice

Circulation

Volumn 131, Issue 21, 2015, Pages 1861-1871

  Lin, Zhuofeng ^a   Pan, Xuebo ^a   Wu, Fan ^b   Ye, Dewei ^c,d   Zhang, Yi ^a   Wang, Yu ^c,d   Jin, Leigang ^a   Lian, Qizhou ^c,d   Huang, Yu ^e   Ding, Hong ^f   Triggle, Chris ^f   Wang, Kai ^g   Li, Xiaokun ^a,b   Xu, Aimin ^a,c,d  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF HONG KONG   (Hong Kong)

^e CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^f WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^g ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Adipokines; Atherosclerosis; Fibroblast growth factor 21; Hormones

Indexed keywords

ADIPONECTIN; APOLIPOPROTEIN E; BILE ACID; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; GERANYLTRANSFERASE; HIGH DENSITY LIPOPROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; KLOTHO PROTEIN; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RECOMBINANT FIBROBLAST GROWTH FACTOR; RECOMBINANT FIBROBLAST GROWTH FACTOR 21; SQUALENE SYNTHASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR ADHESION PROTEIN 1; VERY LOW DENSITY LIPOPROTEIN; ADIPOQ PROTEIN, MOUSE; CHOLESTEROL; FGFR2 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; KLB PROTEIN, MOUSE; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; SREBF2 PROTEIN, MOUSE;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BILE ACID METABOLISM; BILE SECRETION; BLOOD VESSEL; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DEATH; DISEASE EXACERBATION; DISEASE SEVERITY; FOOD INTAKE; HEART PROTECTION; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; HYPOADIPONECTINEMIA; INFLAMMATION; INTESTINE ABSORPTION; LIPID ABSORPTION; LIVER; LONG TERM CARE; LONGEVITY; MACROPHAGE; MOUSE; NEOINTIMA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRIACYLGLYCEROL BLOOD LEVEL; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPLICATION; DEFICIENCY; DRUG EFFECTS; FAMILIAL HYPERCHOLESTEROLEMIA; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ADIPOCYTES; ADIPONECTIN; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CHOLESTEROL; ENDOTHELIUM, VASCULAR; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HYPERLIPOPROTEINEMIA TYPE II; LIVER; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECOMBINANT PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 84933548383     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.115.015308     Document Type: Article

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