-
1
-
-
57649214103
-
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
-
Musso G, Gambino R, Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res. 2009;48(1):1-26.
-
(2009)
Prog Lipid Res
, vol.48
, Issue.1
, pp. 1-26
-
-
Musso, G.1
Gambino, R.2
Cassader, M.3
-
2
-
-
32044453080
-
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response
-
DOI 10.1016/j.cell.2005.11.040, PII S0092867406000043
-
Zhang K, Shen X, Wu J, et al. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell. 2006;124(3):587-599. (Pubitemid 43199443)
-
(2006)
Cell
, vol.124
, Issue.3
, pp. 587-599
-
-
Zhang, K.1
Shen, X.2
Wu, J.3
Sakaki, K.4
Saunders, T.5
Rutkowski, D.T.6
Back, S.H.7
Kaufman, R.J.8
-
3
-
-
84862828272
-
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice
-
Zhang C, Wang G, Zheng Z, et al Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology. 2012; 55(4):1070-1082.
-
(2012)
Hepatology
, vol.55
, Issue.4
, pp. 1070-1082
-
-
Zhang, C.1
Wang, G.2
Zheng, Z.3
-
4
-
-
0034681260
-
Regulated intramem-brane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown MS, Ye J, Rawson RB, Goldstein JL. Regulated intramem-brane proteolysis: a control mechanism conserved from bacteria to humans. Cell. 2000;100(4):391-398.
-
(2000)
Cell
, vol.100
, Issue.4
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
5
-
-
79960110157
-
The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism
-
Lee JH, Giannikopoulos P, Duncan SA, et al. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med. 2011;17(7):812-815.
-
(2011)
Nat Med
, vol.17
, Issue.7
, pp. 812-815
-
-
Lee, J.H.1
Giannikopoulos, P.2
Duncan, S.A.3
-
6
-
-
77950285163
-
Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH
-
Lee MW, Chanda D, Yang J, et al. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metab. 2010;11(4):331-339.
-
(2010)
Cell Metab
, vol.11
, Issue.4
, pp. 331-339
-
-
Lee, M.W.1
Chanda, D.2
Yang, J.3
-
7
-
-
0034697846
-
Identification of a novel FGF, FGF-21, preferentially expressed in the liver
-
DOI 10.1016/S0167-4781(00)00067-1, PII S0167478100000671
-
Nishimura T, Nakatake Y, Konishi M, Itoh N. Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta. 2000;1492(1):203-206. (Pubitemid 30349198)
-
(2000)
Biochimica et Biophysica Acta - Gene Structure and Expression
, vol.1492
, Issue.1
, pp. 203-206
-
-
Nishimura, T.1
Nakatake, Y.2
Konishi, M.3
Itoh, N.4
-
8
-
-
20444435873
-
FGF-21 as a novel metabolic regulator
-
DOI 10.1172/JCI23606
-
Kharitonenkov A, Shiyanova TL, Koester A, et al. FGF-21 as a novel metabolic regulator. J Clin Invest. 2005;115(6):1627-1635. (Pubitemid 40814671)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.6
, pp. 1627-1635
-
-
Kharitonenkov, A.1
Shiyanova, T.L.2
Koester, A.3
Ford, A.M.4
Micanovic, R.5
Galbreath, E.J.6
Sandusky, G.E.7
Hammond, L.J.8
Moyers, J.S.9
Owens, R.A.10
Gromada, J.11
Brozinick, J.T.12
Hawkins, E.D.13
Wroblewski, V.J.14
Li, D.-S.15
Mehrbod, F.16
Jaskunas, S.R.17
Shanafelt, A.B.18
-
9
-
-
34249711964
-
Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARalpha and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
-
DOI 10.1016/j.cmet.2007.05.002, PII S1550413107001295
-
Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARα and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007;5(6):426-437. (Pubitemid 46825495)
-
(2007)
Cell Metabolism
, vol.5
, Issue.6
, pp. 426-437
-
-
Badman, M.K.1
Pissios, P.2
Kennedy, A.R.3
Koukos, G.4
Flier, J.S.5
Maratos-Flier, E.6
-
10
-
-
34249686631
-
Endocrine Regulation of the Fasting Response by PPARalpha-Mediated Induction of Fibroblast Growth Factor 21
-
DOI 10.1016/j.cmet.2007.05.003, PII S1550413107001301
-
Inagaki T, Dutchak P, Zhao G, et al. Endocrine regulation of the fasting response byPPARα-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5(6):415-425. (Pubitemid 46825496)
-
(2007)
Cell Metabolism
, vol.5
, Issue.6
, pp. 415-425
-
-
Inagaki, T.1
Dutchak, P.2
Zhao, G.3
Ding, X.4
Gautron, L.5
Parameswara, V.6
Li, Y.7
Goetz, R.8
Mohammadi, M.9
Esser, V.10
Elmquist, J.K.11
Gerard, R.D.12
Burgess, S.C.13
Hammer, R.E.14
Mangelsdorf, D.J.15
Kliewer, S.A.16
-
11
-
-
84863012022
-
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
-
Fisher FM, Kleiner S, Douris N, et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012;26(3):271-281.
-
(2012)
Genes Dev
, vol.26
, Issue.3
, pp. 271-281
-
-
Fisher, F.M.1
Kleiner, S.2
Douris, N.3
-
12
-
-
77955474305
-
Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
-
Dushay J, Chui PC, Gopalakrishnan GS, et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology. 2010;139(2):456-463.
-
(2010)
Gastroenterology
, vol.139
, Issue.2
, pp. 456-463
-
-
Dushay, J.1
Chui, P.C.2
Gopalakrishnan, G.S.3
-
13
-
-
68149091653
-
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
-
Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. Diabetes Care. 2009;32(8):1542-1546.
-
(2009)
Diabetes Care
, vol.32
, Issue.8
, pp. 1542-1546
-
-
Chavez, A.O.1
Molina-Carrion, M.2
Abdul-Ghani, M.A.3
Folli, F.4
Defronzo, R.A.5
Tripathy, D.6
-
14
-
-
84874117479
-
High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China
-
Li H, Dong K, Fang Q, et al. High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: A 3-year prospective study in China. J Hepatol. 2013;58: 557-563.
-
(2013)
J Hepatol
, vol.58
, pp. 557-563
-
-
Li, H.1
Dong, K.2
Fang, Q.3
-
15
-
-
33846418834
-
The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21
-
DOI 10.1210/en.2006-1168
-
Kharitonenkov A, Wroblewski VJ, Koester A, et al. The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology. 2007;148(2):774-781. (Pubitemid 46143178)
-
(2007)
Endocrinology
, vol.148
, Issue.2
, pp. 774-781
-
-
Kharitonenkov, A.1
Wroblewski, V.J.2
Koester, A.3
Chen, Y.-F.4
Clutinger, C.K.5
Tigno, X.T.6
Hansen, B.C.7
Shanafelt, A.B.8
Etgen, G.J.9
-
16
-
-
79960726293
-
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo
-
Fisher FM, Estall JL, Adams AC, et al. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 2011;152(8):2996-3004.
-
(2011)
Endocrinology
, vol.152
, Issue.8
, pp. 2996-3004
-
-
Fisher, F.M.1
Estall, J.L.2
Adams, A.C.3
-
17
-
-
70350455732
-
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models-association with liver and adipose tissue effects
-
Xu J, Stanislaus S, Chinookoswong N, et al. Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models-association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab. 2009;297(5):E1105-E1114.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
, Issue.5
-
-
Xu, J.1
Stanislaus, S.2
Chinookoswong, N.3
-
18
-
-
54449091729
-
Hepatocyte nuclear factor 4α is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H
-
Luebke-Wheeler J, Zhang K, Battle M, et al. Hepatocyte nuclear factor 4α is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 2008;48(4):1242-1250.
-
(2008)
Hepatology
, vol.48
, Issue.4
, pp. 1242-1250
-
-
Luebke-Wheeler, J.1
Zhang, K.2
Battle, M.3
-
19
-
-
79251525864
-
Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease
-
Zheng Z, Zhang C, Zhang K. Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. Methods Enzymol. 2011;489:329-348.
-
(2011)
Methods Enzymol
, vol.489
, pp. 329-348
-
-
Zheng, Z.1
Zhang, C.2
Zhang, K.3
-
20
-
-
0023634643
-
Quantitative assessment of atherosclerotic lesions in mice
-
DOI 10.1016/0021-9150(87)90202-4
-
Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68(3):231-240. (Pubitemid 17159775)
-
(1987)
Atherosclerosis
, vol.68
, Issue.3
, pp. 231-240
-
-
Paigen, B.1
Morrow, A.2
Holmes, P.A.3
Mitchell, D.4
Williams, R.A.5
-
21
-
-
36348935003
-
Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet
-
DOI 10.1002/hep.21874
-
Matsuzawa N, Takamura T, Kurita S, et al. Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology. 2007;46(5):1392-1403. (Pubitemid 350155521)
-
(2007)
Hepatology
, vol.46
, Issue.5
, pp. 1392-1403
-
-
Matsuzawa, N.1
Takamura, T.2
Kurita, S.3
Misu, H.4
Ota, T.5
Ando, H.6
Yokoyama, M.7
Honda, M.8
Zen, Y.9
Nakanuma, Y.10
Miyamoto, K.-I.11
Kaneko, S.12
-
22
-
-
34447265235
-
PPARalpha is a key regulator of hepatic FGF21
-
DOI 10.1016/j.bbrc.2007.06.068, PII S0006291X07013083
-
Lundåsen T, Hunt MC, Nilsson LM, et al. PPARα is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 2007;360(2): 437-440. (Pubitemid 47039157)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.360
, Issue.2
, pp. 437-440
-
-
Lundasen, T.1
Hunt, M.C.2
Nilsson, L.-M.3
Sanyal, S.4
Angelin, B.5
Alexson, S.E.H.6
Rudling, M.7
-
23
-
-
20144368638
-
Integrated genomic and proteomic analyses of gene expression in mammalian cells
-
DOI 10.1074/mcp.M400055-MCP200
-
Tian Q, Stepaniants SB, Mao M, et al. Integrated genomic and proteomic analyses of gene expression in mammalian cells. Mol Cell Proteomics. 2004;3(10):960-969. (Pubitemid 40361231)
-
(2004)
Molecular and Cellular Proteomics
, vol.3
, Issue.10
, pp. 960-969
-
-
Tian, Q.1
Stepaniants, S.B.2
Mao, M.3
Weng, L.4
Feetham, M.C.5
Doyle, M.J.6
Yi, E.C.7
Dai, H.8
Thorsson, V.9
Eng, J.10
Goodlett, D.11
Berger, J.P.12
Gunter, B.13
Linseley, P.S.14
Stoughton, R.B.15
Aebersold, R.16
Collins, S.J.17
Hanlon, W.A.18
Hood, L.E.19
-
24
-
-
84858987289
-
Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model
-
Lee JS, Zheng Z, Mendez R, Ha SW, Xie Y, Zhang K. Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model. Toxicol Lett. 2012;211(1):29-38.
-
(2012)
Toxicol Lett
, vol.211
, Issue.1
, pp. 29-38
-
-
Lee, J.S.1
Zheng, Z.2
Mendez, R.3
Ha, S.W.4
Xie, Y.5
Zhang, K.6
-
25
-
-
84856777771
-
Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptorα in mouse liver reveals extensive sharing of binding sites
-
Boergesen M, Pedersen TÅ, Gross B, et al. Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptorα in mouse liver reveals extensive sharing of binding sites. Mol Cell Biol. 2012;32(4):852-867.
-
(2012)
Mol Cell Biol
, vol.32
, Issue.4
, pp. 852-867
-
-
Boergesen, M.1
Pedersen, T.Å.2
Gross, B.3
-
26
-
-
0023791609
-
Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene
-
Quinn PG, Wong TW, Magnuson MA, Shabb JB, Granner DK. Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol. 1988;8(8):3467-3475.
-
(1988)
Mol Cell Biol
, vol.8
, Issue.8
, pp. 3467-3475
-
-
Quinn, P.G.1
Wong, T.W.2
Magnuson, M.A.3
Shabb, J.B.4
Granner, D.K.5
-
27
-
-
57349098220
-
Fibroblast growth factor 21 corrects obesity in mice
-
Coskun T, Bina HA, Schneider MA, et al. Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008;149(12):6018-6027.
-
(2008)
Endocrinology
, vol.149
, Issue.12
, pp. 6018-6027
-
-
Coskun, T.1
Bina, H.A.2
Schneider, M.A.3
-
28
-
-
75449094816
-
Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
-
Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications. Hepatology. 2010;51(2):679-689.
-
(2010)
Hepatology
, vol.51
, Issue.2
, pp. 679-689
-
-
Fabbrini, E.1
Sullivan, S.2
Klein, S.3
-
29
-
-
73449099559
-
The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARα
-
Danno H, Ishii KA, Nakagawa Y, et al. The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARα. Biochem Biophys Res Commun. 2010; 391(2):1222-1227.
-
(2010)
Biochem Biophys Res Commun
, vol.391
, Issue.2
, pp. 1222-1227
-
-
Danno, H.1
Ishii, K.A.2
Nakagawa, Y.3
|