Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

Science

Volumn 348, Issue 6242, 2015, Pages 1481-1485

  Tchasovnikarova, Iva A ^a   Timms, Richard T ^a   Matheson, Nicholas J ^a   Wals, Kim ^a   Antrobus, Robin ^a   Göttgens, Berthold ^a   Dougan, Gordon ^b   Dawson, Mark A ^c   Lehner, Paul J ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; HETEROCHROMATIN PROTEIN 1; HISTONE H3; M PHASE PHOSPHOPROTEIN 8; METHYLTRANSFERASE; PEPTIDES AND PROTEINS; PERIPHILIN; TRANSGENE ACTIVATION SUPPRESSOR; UNCLASSIFIED DRUG; GREEN FLUORESCENT PROTEIN, AEQUOREA VICTORIA; HETEROCHROMATIN; HISTONE; MPP8 PROTEIN, HUMAN; MULTIPROTEIN COMPLEX; NUCLEAR PROTEIN; PHOSPHOPROTEIN; PPHLN1 PROTEIN, HUMAN; PROTEIN METHYLTRANSFERASE; SETDB1 PROTEIN, HUMAN; TASOR PROTEIN, HUMAN; TUMOR ANTIGEN;

CYTOLOGY; ENZYME ACTIVITY; FLY; GENOMICS; PROTEIN;

ARTICLE; CELL NUCLEUS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DNA SEQUENCE; ENHANCER REGION; EPIGENETIC REPRESSION; FEMALE; GENE LOCUS; GENE LOSS; GENE SILENCING; GENETIC SCREENING; GENOMICS; HAPLOIDY; HELA CELL LINE; HETEROCHROMATIN; HISTONE METHYLATION; HUMAN; HUMAN CELL; NONHUMAN; POSITION EFFECT VARIEGATION; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RETROVIRIDAE; SPLEEN FOCUS FORMING VIRUS; TRANSCRIPTION INITIATION; ANIMAL; DROSOPHILA MELANOGASTER; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE;

DROSOPHILA MELANOGASTER;

ANIMALS; ANTIGENS, NEOPLASM; CHROMOSOMAL POSITION EFFECTS; CONSERVED SEQUENCE; DROSOPHILA MELANOGASTER; EVOLUTION, MOLECULAR; GENE SILENCING; GENES, REPORTER; GENETIC LOCI; GREEN FLUORESCENT PROTEINS; HELA CELLS; HETEROCHROMATIN; HISTONES; HUMANS; IMMUNOPRECIPITATION; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN METHYLTRANSFERASES;

EID: 84933565980     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaa7227     Document Type: Article

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