MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 35, 2013, Pages 14290-14295

  Burr, Marian L ^a   Van Den Boomen, Dick J H ^a   Bye, Helen ^a   Antrobus, Robin ^a   Wiertz, Emmanuel J ^b   Lehner, Paul J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; GLYCAN; POLYUBIQUITIN; PROTEIN P97; PROTEINASE; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE E3; HLA ANTIGEN CLASS 1; NUCLEAR PROTEIN; P97 ATPASE; SYVN1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CYTOSOL; DEGRADATION; ENDOPLASMIC RETICULUM; FEMALE; GLYCOSYLATION; HELA CELL; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; UBIQUITINATION; WILD TYPE; HELA CELL LINE; METABOLISM; NUCLEOTIDE SEQUENCE;

ADENOSINE TRIPHOSPHATASES; BASE SEQUENCE; ENDOPLASMIC RETICULUM; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; NUCLEAR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84883327585     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303380110     Document Type: Article

References (28)

1. Hegde RS, Ploegh HL (2010) Quality and quantity control at the endoplasmic reticulum. Curr Opin Cell Biol 22(4):437-446.
2. Ye Y, Meyer HH, Rapoport TA (2001) The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol. Nature 414(6864):652-656.
3. Jarosch E, et al. (2002) Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat Cell Biol 4(2):134-139.
4. Bays NW, Wilhovsky SK, Goradia A, Hodgkiss-Harlow K, Hampton RY (2001) HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol Biol Cell 12(12):4114-4128.
5. Vashist S, Ng DT (2004) Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J Cell Biol 165(1):41-52.
6. Carvalho P, Goder V, Rapoport TA (2006) Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126(2):361-373.
7. Cormier JH, Tamura T, Sunryd JC, Hebert DN (2009) EDEM1 recognition and delivery of misfolded proteins to the SEL1L-containing ERAD complex. Mol Cell 34(5):627-633.
8. Hosokawa N, Kamiya Y, Kato K (2010) The role of MRH domain-containing lectins in ERAD. Glycobiology 20(6):651-660.
9. Chen X, et al. (2011) Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol 192(5):825-838.
10. Burr ML, et al. (2011) HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation. Proc Natl Acad Sci USA 108(5): 2034-2039.
11. Tyler RE, et al. (2012) Unassembled CD147 is an endogenous endoplasmic reticulumassociated degradation substrate. Mol Biol Cell 23(24):4668-4678.
12. Hughes EA, Hammond C, Cresswell P (1997) Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome. Proc Natl Acad Sci USA 94(5):1896-1901.
13. Bernasconi R, Galli C, Calanca V, Nakajima T, Molinari M (2010) Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates. J Cell Biol 188(2):223-235.
14. Okuda-Shimizu Y, Hendershot LM (2007) Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp. Mol Cell 28(4):544-554.
15. Hewitt EW, et al. (2002) Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation. EMBO J 21(10):2418-2429.
16. Wang X, et al. (2007) Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J Cell Biol 177(4): 613-624.
17. Carvalho P, Stanley AM, Rapoport TA (2010) Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p. Cell 143(4):579-591.
18. Ishikura S, Weissman AM, Bonifacino JS (2010) Serine residues in the cytosolic tail of the T-cell antigen receptor alpha-chain mediate ubiquitination and endoplasmic reticulumassociated degradation of the unassembled protein. J Biol Chem 285(31):23916-23924.
19. Shimizu Y, Okuda-Shimizu Y, Hendershot LM (2010) Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids. Mol Cell 40(6):917-926.
20. Wang X, et al. (2009) Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates. J Cell Biol 187(5):655-668.
21. Stagg HR, et al. (2009) The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER. J Cell Biol 186(5):685-692.
22. Story CM, Furman MH, Ploegh HL (1999) The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products. Proc Natl Acad Sci USA 96(15):8516-8521.
23. Shamu CE, Story CM, Rapoport TA, Ploegh HL (1999) The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol 147(1):45-58.
24. Hassink GC, Barel MT, Van Voorden SB, Kikkert M, Wiertz EJ (2006) Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11. J Biol Chem 281(40):30063-30071.
25. Barel MT, et al. (2003) Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation. J Immunol 171(12):6757-6765.
26. Furman MH, Loureiro J, Ploegh HL, Tortorella D (2003) Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. J Biol Chem 278(37):34804-34811.
27. Chen B, et al. (2006) The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site. Proc Natl Acad Sci USA 103(2):341-346.
28. Bonifacino JS, Cosson P, Klausner RD (1990) Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains. Cell 63(3):503-513.