Novel CD7-specific nanobody-based immunotoxins potently enhanced apoptosis of CD7-positive malignant cells

Oncotarget

Volumn 7, Issue 23, 2016, Pages 34070-34083

  Tang, Jinle ^a   Li, Jialu ^a   Zhu, Xuejun ^c   Yu, Yuan ^a   Chen, Dan ^b   Yuan, Lei ^d   Gu, Zhenyang ^d   Zhang, Xingding ^a,b,f   Qi, Lin ^b   Gong, Zhishu ^g   Jiang, Pengjun ^c   Yu, Juhua ^c   Meng, Huimin ^a   An, Gangli ^a   Zheng, Huyong ^e   Yang, Lin ^a,b,f  

^a SOOCHOW UNIVERSITY   (China)

^b Suzhou Cancer Immunotherapy and Diagnosis Engineering Center   (China)

^c Jiangsu Traditional Chinese Medical Hospital   (China)

^d CHINESE PLA GENERAL HOSPITAL   (China)

^e CAPITAL MEDICAL UNIVERSITY   (China)

^f UNIVERSITY OF TEXAS   (United States)

^g The Medical Group of Zhengzhou First People's Hospital   (China)

Author keywords

Immunotoxin; Leukemia; Nanobody; Target delivery drug; VHH

Indexed keywords

CD7 ANTIGEN; NANOBODY; PG001 ANTIBODY; PG002 ANTIBODY; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; IMMUNOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG MECHANISM; EMBRYO; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; MOUSE; NONHUMAN; SURVIVAL TIME; ANIMAL; DRUG EFFECTS; DRUG SCREENING; NONOBESE DIABETIC MOUSE; SCID MOUSE; T CELL LEUKEMIA; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD7; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; HUMANS; IMMUNOTOXINS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; MICE; MICE, INBRED NOD; MICE, SCID; SINGLE-DOMAIN ANTIBODIES; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84973664289     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8710     Document Type: Article

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