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Volumn 30, Issue 2, 2013, Pages 205-209

Development of VEGFR2-specific Nanobody Pseudomonas exotoxin A conjugated to provide efficient inhibition of tumor cell growth

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS TARGETING; ANIMAL MODEL; ANTIGEN-BINDING; CELL SURFACES; HEAVY-CHAIN ANTIBODIES; IMMUNOTOXINS; IN-VITRO; NEOVASCULARIZATION; PSEUDOMONAS EXOTOXIN A; SINGLE DOMAINS; TUMOR CELLS; TUMOR METASTASIS; TUMOR THERAPY; TUMOR VASCULATURE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR; VEGFR-2;

EID: 84872382607     PISSN: 18716784     EISSN: 18764347     Source Type: Journal    
DOI: 10.1016/j.nbt.2012.09.002     Document Type: Article
Times cited : (80)

References (26)
  • 1
    • 70349961520 scopus 로고    scopus 로고
    • Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo
    • Andersson Y., et al. Synergistic anti-cancer effects of immunotoxin and cyclosporin in vitro and in vivo. Br. J. Cancer 2009, 101:1307-1315.
    • (2009) Br. J. Cancer , vol.101 , pp. 1307-1315
    • Andersson, Y.1
  • 2
    • 80052531606 scopus 로고    scopus 로고
    • Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma
    • Risberg K., et al. Synergistic anticancer effects of the 9.2.27PE immunotoxin and ABT-737 in melanoma. PLoS One 2011, 6:e24012.
    • (2011) PLoS One , vol.6
    • Risberg, K.1
  • 3
    • 0038290547 scopus 로고    scopus 로고
    • Immunotoxins containing Pseudomonas exotoxin A: a short history
    • Pastan I. Immunotoxins containing Pseudomonas exotoxin A: a short history. Cancer Immunol. Immunother. 2003, 52:338-341.
    • (2003) Cancer Immunol. Immunother. , vol.52 , pp. 338-341
    • Pastan, I.1
  • 4
    • 26044464496 scopus 로고    scopus 로고
    • Preparation and characterization of fusion protein truncated Pseudomonas Exotoxin A (PE38KDEL) in Escherichia coli
    • Song S., et al. Preparation and characterization of fusion protein truncated Pseudomonas Exotoxin A (PE38KDEL) in Escherichia coli. Protein Expr. Purif. 2005, 44:52-57.
    • (2005) Protein Expr. Purif. , vol.44 , pp. 52-57
    • Song, S.1
  • 5
    • 33748309412 scopus 로고    scopus 로고
    • Immunotoxins for targeted cancer therapy
    • Kreitman R.J. Immunotoxins for targeted cancer therapy. AAPS J. 2006, 8:E532-E551.
    • (2006) AAPS J. , vol.8
    • Kreitman, R.J.1
  • 6
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: mechanisms of anti-tumour activity
    • Ellis L.M., Hicklin D.J. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat. Rev. Cancer 2008, 8:579-591.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 7
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: an organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat. Rev. Drug Discov. 2007, 6:273-286.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 273-286
    • Folkman, J.1
  • 8
    • 84857060448 scopus 로고    scopus 로고
    • Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor
    • Behdani M., et al. Generation and characterization of a functional Nanobody against the vascular endothelial growth factor receptor-2; angiogenesis cell receptor. Mol. Immunol. 2012, 50:35-41.
    • (2012) Mol. Immunol. , vol.50 , pp. 35-41
    • Behdani, M.1
  • 9
    • 0035213434 scopus 로고    scopus 로고
    • Targeting endothelial cells overexpressing VEGFR-2: selective toxicity of Shiga-like toxin-VEGF fusion proteins
    • Backer M.V., Backer J.M. Targeting endothelial cells overexpressing VEGFR-2: selective toxicity of Shiga-like toxin-VEGF fusion proteins. Bioconjug. Chem. 2001, 12:1066-1073.
    • (2001) Bioconjug. Chem. , vol.12 , pp. 1066-1073
    • Backer, M.V.1    Backer, J.M.2
  • 10
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 11
    • 84855525590 scopus 로고    scopus 로고
    • Angiogenesis and invasion in cancer
    • Bikfalvi A. Angiogenesis and invasion in cancer. Handb. Clin. Neurol. 2012, 104:35-43.
    • (2012) Handb. Clin. Neurol. , vol.104 , pp. 35-43
    • Bikfalvi, A.1
  • 12
    • 80053483270 scopus 로고    scopus 로고
    • Targeting the tumor microenvironment: focus on angiogenesis
    • Fan F., et al. Targeting the tumor microenvironment: focus on angiogenesis. J. Oncol. 2012, 2012:281261.
    • (2012) J. Oncol. , vol.2012 , pp. 281261
    • Fan, F.1
  • 13
    • 77952679681 scopus 로고    scopus 로고
    • Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: a review of the current knowledge
    • Vermeulen P.B., et al. Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: a review of the current knowledge. Cancer 2010, 116(11 Suppl.):2748-2754.
    • (2010) Cancer , vol.116 , Issue.11 SUPPL. , pp. 2748-2754
    • Vermeulen, P.B.1
  • 14
    • 33646155950 scopus 로고    scopus 로고
    • VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo
    • Tomanek R.J., et al. VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo. Circ. res. 2006, 98:947-953.
    • (2006) Circ. res. , vol.98 , pp. 947-953
    • Tomanek, R.J.1
  • 15
    • 16644395747 scopus 로고    scopus 로고
    • The role of VEGF in the regulation of physiological and pathological angiogenesis
    • Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS 2005, 94:209-231.
    • (2005) EXS , vol.94 , pp. 209-231
    • Ferrara, N.1
  • 16
    • 78650757871 scopus 로고    scopus 로고
    • VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis
    • Silva S.R., et al. VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis. Int. J. Cancer 2011, 128:1045-1056.
    • (2011) Int. J. Cancer , vol.128 , pp. 1045-1056
    • Silva, S.R.1
  • 17
    • 84855172198 scopus 로고    scopus 로고
    • VEGFR-2 expression in human melanoma: revised assessment
    • Molhoek K.R., et al. VEGFR-2 expression in human melanoma: revised assessment. Int. J. Cancer 2011, 129:2807-2815.
    • (2011) Int. J. Cancer , vol.129 , pp. 2807-2815
    • Molhoek, K.R.1
  • 18
    • 77958468825 scopus 로고    scopus 로고
    • VEGFR-2 expression in tumor tissue of breast cancer patients
    • Lushnikova A.A., et al. VEGFR-2 expression in tumor tissue of breast cancer patients. Dokl. Biol. Sci. 2010, 434:363-367.
    • (2010) Dokl. Biol. Sci. , vol.434 , pp. 363-367
    • Lushnikova, A.A.1
  • 19
    • 0035816148 scopus 로고    scopus 로고
    • Shiga-like toxin-VEGF fusion proteins are selectively cytotoxic to endothelial cells overexpressing VEGFR-2
    • Backera M.V., et al. Shiga-like toxin-VEGF fusion proteins are selectively cytotoxic to endothelial cells overexpressing VEGFR-2. J. Control. Release 2001, 74:349-355.
    • (2001) J. Control. Release , vol.74 , pp. 349-355
    • Backera, M.V.1
  • 20
    • 0032943892 scopus 로고    scopus 로고
    • Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells
    • Arora N., et al. Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells. Cancer Res. 1999, 59:183-188.
    • (1999) Cancer Res. , vol.59 , pp. 183-188
    • Arora, N.1
  • 21
    • 77956643638 scopus 로고    scopus 로고
    • Investigation of a plasmid containing a novel immunotoxin VEGF165-PE38 gene for antiangiogenic therapy in a malignant glioma model
    • Hu C., et al. Investigation of a plasmid containing a novel immunotoxin VEGF165-PE38 gene for antiangiogenic therapy in a malignant glioma model. Int. J. Cancer 2010, 127:2222-2229.
    • (2010) Int. J. Cancer , vol.127 , pp. 2222-2229
    • Hu, C.1
  • 22
    • 0034001076 scopus 로고    scopus 로고
    • Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies
    • Kreitman R.J., et al. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J. Clin. Oncol. 2000, 18:1622-1636.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1622-1636
    • Kreitman, R.J.1
  • 23
    • 67649933809 scopus 로고    scopus 로고
    • Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia
    • Kreitman R.J., et al. Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. J. Clin. Oncol. 2009, 27:2983-2990.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2983-2990
    • Kreitman, R.J.1
  • 24
    • 0029925934 scopus 로고    scopus 로고
    • Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin
    • Pai L.H., et al. Treatment of advanced solid tumors with immunotoxin LMB-1: an antibody linked to Pseudomonas exotoxin. Nat. Med. 1996, 2:350-353.
    • (1996) Nat. Med. , vol.2 , pp. 350-353
    • Pai, L.H.1
  • 25
    • 21844460516 scopus 로고    scopus 로고
    • Phase I trial of intravenous IL-4 Pseudomonas exotoxin protein (NBI-3001) in patients with advanced solid tumors that express the IL-4 receptor
    • Garland L., et al. Phase I trial of intravenous IL-4 Pseudomonas exotoxin protein (NBI-3001) in patients with advanced solid tumors that express the IL-4 receptor. J. Immunother. 2005, 28:376-381.
    • (2005) J. Immunother. , vol.28 , pp. 376-381
    • Garland, L.1
  • 26
    • 14844303575 scopus 로고    scopus 로고
    • Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma
    • Parney I.F., et al. Neuroradiographic changes following convection-enhanced delivery of the recombinant cytotoxin interleukin 13-PE38QQR for recurrent malignant glioma. J. Neurosurg. 2005, 102:267-275.
    • (2005) J. Neurosurg. , vol.102 , pp. 267-275
    • Parney, I.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.