-
2
-
-
84871499151
-
Emerging monoclonal antibodies and related agents for the treatment of chronic lymphocytic leukemia
-
Robak T. Emerging monoclonal antibodies and related agents for the treatment of chronic lymphocytic leukemia. Future Oncol. 2013;9(1):69-91.
-
(2013)
Future Oncol
, vol.9
, Issue.1
, pp. 69-91
-
-
Robak, T.1
-
3
-
-
84855699822
-
My treatment approach to hairy cell leukemia
-
Naik RR, Saven A. My treatment approach to hairy cell leukemia. Mayo Clin Proc. 2012;87(1):67-76.
-
(2012)
Mayo Clin Proc
, vol.87
, Issue.1
, pp. 67-76
-
-
Naik, R.R.1
Saven, A.2
-
4
-
-
80054037204
-
Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates
-
FitzGerald DJ, Wayne AS, Kreitman RJ, Pastan I. Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates. Cancer Res. 2011;71(20):6300-6309.
-
(2011)
Cancer Res
, vol.71
, Issue.20
, pp. 6300-6309
-
-
FitzGerald, D.J.1
Wayne, A.S.2
Kreitman, R.J.3
Pastan, I.4
-
5
-
-
84874866559
-
Antibody-drug conjugates for the treatment of B-cell non-Hodgkin's lymphoma and leukemia
-
Chu YW, Polson A. Antibody-drug conjugates for the treatment of B-cell non-Hodgkin's lymphoma and leukemia. Future Oncol. 2013;9(3):355-368.
-
(2013)
Future Oncol
, vol.9
, Issue.3
, pp. 355-368
-
-
Chu, Y.W.1
Polson, A.2
-
7
-
-
84882737653
-
Immunotoxins: The role of the toxin
-
Antignani A, Fitzgerald D. Immunotoxins: the role of the toxin. Toxins (Basel). 2013;5(8):1486-1502.
-
(2013)
Toxins (Basel)
, vol.5
, Issue.8
, pp. 1486-1502
-
-
Antignani, A.1
Fitzgerald, D.2
-
9
-
-
0025923704
-
Anti-MY9-blocked-ricin: An immunotoxin for selective targeting of acute myeloid leukemia cells
-
Roy DC, Griffin JD, Belvin M, Blättler WA, Lambert JM, Ritz J. Anti-MY9-blocked-ricin: an immunotoxin for selective targeting of acute myeloid leukemia cells. Blood. 1991;77(11):2404-2412.
-
(1991)
Blood
, vol.77
, Issue.11
, pp. 2404-2412
-
-
Roy, D.C.1
Griffin, J.D.2
Belvin, M.3
Blättler, W.A.4
Lambert, J.M.5
Ritz, J.6
-
10
-
-
51049120495
-
Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity
-
Du X, Beers R, Fitzgerald DJ, Pastan I. Differential cellular internalization of anti-CD19 and -CD22 immunotoxins results in different cytotoxic activity. Cancer Res. 2008;68(15):6300-6305.
-
(2008)
Cancer Res
, vol.68
, Issue.15
, pp. 6300-6305
-
-
Du, X.1
Beers, R.2
Fitzgerald, D.J.3
Pastan, I.4
-
11
-
-
33645500289
-
Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
-
Erickson HK, Park PU, Widdison WC, et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res. 2006;66(8):4426-4433.
-
(2006)
Cancer Res
, vol.66
, Issue.8
, pp. 4426-4433
-
-
Erickson, H.K.1
Park, P.U.2
Widdison, W.C.3
-
12
-
-
33744537358
-
Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates
-
DOI 10.1074/jbc.M510026200
-
Sutherland MS, Sanderson RJ, Gordon KA, et al. Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates. J Biol Chem. 2006;281(15):10540-10547. (Pubitemid 43864594)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.15
, pp. 10540-10547
-
-
Kung, S.M.S.1
Sanderson, R.J.2
Gordon, K.A.3
Andreyka, J.4
Cerveny, C.G.5
Yu, C.6
Lewis, T.S.7
Meyer, D.L.8
Zabinski, R.F.9
Doronina, S.O.10
Senter, P.D.11
Law, C.-L.12
Wahl, A.F.13
-
13
-
-
65549146468
-
A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity
-
Weldon JE, Xiang L, Chertov O, et al. A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. Blood. 2009;113(16):3792-3800.
-
(2009)
Blood
, vol.113
, Issue.16
, pp. 3792-3800
-
-
Weldon, J.E.1
Xiang, L.2
Chertov, O.3
-
14
-
-
0025243542
-
Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol
-
Ogata M, Chaudhary VK, Pastan I, FitzGerald DJ. Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol. J Biol Chem. 1990;265(33):20678- 20685. (Pubitemid 120014061)
-
(1990)
Journal of Biological Chemistry
, vol.265
, Issue.33
, pp. 20678-20685
-
-
Ogata, M.1
Chaudhary, V.K.2
Pastan, I.3
FitzGerald, D.J.4
-
15
-
-
80051469646
-
Genome-wide RNAi screens identify genes required for Ricin and PE intoxications
-
Moreau D, Kumar P, Wang SC, et al. Genome-wide RNAi screens identify genes required for Ricin and PE intoxications. Dev Cell. 2011;21(2):231-244.
-
(2011)
Dev Cell
, vol.21
, Issue.2
, pp. 231-244
-
-
Moreau, D.1
Kumar, P.2
Wang, S.C.3
-
16
-
-
0029826702
-
Pseudomonas exotoxin exhibits increased sensitivity to furin when sequences at the cleavage site are mutated to resemble the arginine-rich loop of diphtheria toxin
-
Chiron MF, Ogata M, FitzGerald DJ. Pseudomonas exotoxin exhibits increased sensitivity to furin when sequences at the cleavage site are mutated to resemble the arginine-rich loop of diphtheria toxin. Mol Microbiol. 1996;22(4):769-778. (Pubitemid 26385245)
-
(1996)
Molecular Microbiology
, vol.22
, Issue.4
, pp. 769-778
-
-
Chiron, M.F.1
Ogata, M.2
FitzGerald, D.J.3
-
17
-
-
0033554871
-
Reduction of furin-nicked Pseudomonas exotoxin A: An unfolding story
-
McKee ML, FitzGerald DJ. Reduction of furin-nicked Pseudomonas exotoxin A: an unfolding story. Biochemistry. 1999;38(50):16507-16513.
-
(1999)
Biochemistry
, vol.38
, Issue.50
, pp. 16507-16513
-
-
McKee, M.L.1
FitzGerald, D.J.2
-
18
-
-
77955890953
-
Interleukin-2 receptor signaling: At the interface between tolerance and immunity
-
Malek TR, Castro I. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity. 2010;33(2):153-165.
-
(2010)
Immunity
, vol.33
, Issue.2
, pp. 153-165
-
-
Malek, T.R.1
Castro, I.2
-
19
-
-
70350645181
-
Denileukin diftitox: A novel immunotoxin
-
Manoukian G, Hagemeister F. Denileukin diftitox: a novel immunotoxin. Expert Opin Biol Ther. 2009;9(11):1445-1451.
-
(2009)
Expert Opin Biol Ther
, vol.9
, Issue.11
, pp. 1445-1451
-
-
Manoukian, G.1
Hagemeister, F.2
-
20
-
-
33646344736
-
Phase II clinical studies of denileukin diftitox diphtheria toxin fusion protein in patients with previously treated chronic lymphocytic leukemia
-
DOI 10.1002/cncr.21851
-
Frankel AE, Surendranathan A, Black JH, White A, Ganjoo K, Cripe LD. Phase II clinical studies of denileukin diftitox diphtheria toxin fusion protein in patients with previously treated chronic lymphocytic leukemia. Cancer. 2006;106(10):2158-2164. (Pubitemid 43673237)
-
(2006)
Cancer
, vol.106
, Issue.10
, pp. 2158-2164
-
-
Frankel, A.E.1
Surendranathan, A.2
Black, J.H.3
White, A.4
Ganjoo, K.5
Cripe, L.D.6
-
21
-
-
77954455336
-
Modified DT-IL2 fusion toxin targeting uniquely IL2Ralpha expressing leukemia cell lines - Construction and characterization
-
Potala S, Verma RS. Modified DT-IL2 fusion toxin targeting uniquely IL2Ralpha expressing leukemia cell lines - Construction and characterization. J Biotechnol. 2010;148(2-3):147-155.
-
(2010)
J Biotechnol
, vol.148
, Issue.2-3
, pp. 147-155
-
-
Potala, S.1
Verma, R.S.2
-
22
-
-
0034001076
-
Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies
-
Kreitman RJ, Wilson WH, White JD, et al. Phase I trial of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) in patients with hematologic malignancies. J Clin Oncol. 2000;18(8):1622-1636. (Pubitemid 30220540)
-
(2000)
Journal of Clinical Oncology
, vol.18
, Issue.8
, pp. 1622-1636
-
-
Kreitman, R.J.1
Wilson, W.H.2
White, J.D.3
Stetler-Stevenson, M.4
Jaffe, E.S.5
Giardina, S.6
Waldmann, T.A.7
Pastan, I.8
-
23
-
-
84855431169
-
Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy
-
Singh R, Zhang Y, Pastan I, Kreitman RJ. Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy. Clin Cancer Res. 2012;18(1):152-160.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.1
, pp. 152-160
-
-
Singh, R.1
Zhang, Y.2
Pastan, I.3
Kreitman, R.J.4
-
24
-
-
84899053685
-
Regression of adult T-cell leukemia with anti-CD25 recombinant immunotoxin LMB-2 preceded by chemotherapy
-
[abstract]. Abstract 2575
-
Kreitman RJ, Singh R, Stetler-Stevenson M, Waldmann TA, Pastan I. Regression of adult T-cell leukemia with anti-CD25 recombinant immunotoxin LMB-2 preceded by chemotherapy [abstract]. Blood. 2011;118(21). Abstract 2575.
-
(2011)
Blood
, vol.118
, Issue.21
-
-
Kreitman, R.J.1
Singh, R.2
Stetler-Stevenson, M.3
Waldmann, T.A.4
Pastan, I.5
-
25
-
-
0027374447
-
A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy
-
Amlot PL, Stone MJ, Cunningham D, et al. A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy. Blood. 1993;82(9):2624-2633. (Pubitemid 23318068)
-
(1993)
Blood
, vol.82
, Issue.9
, pp. 2624-2633
-
-
Amlot, P.L.1
Stone, M.J.2
Cunningham, D.3
Fay, J.4
Newman, J.5
Collins, R.6
May, R.7
McCarthy, M.8
Richardson, J.9
Ghetie, V.10
Ramilo, O.11
Thorpe, P.E.12
Uhr, J.W.13
Vitetta, E.S.14
-
26
-
-
0034092593
-
A phase I study of combination therapy with immunotoxins IgG-HD37- deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma
-
Messmann RA, Vitetta ES, Headlee D, et al. A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma. Clin Cancer Res. 2000;6(4):1302-1313. (Pubitemid 30226212)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.4
, pp. 1302-1313
-
-
Messmann, R.A.1
Vitetta, E.S.2
Headlee, D.3
Senderowicz, A.M.4
Figg, W.D.5
Schindler, J.6
Michiel, D.F.7
Creekmore, S.8
Steinberg, S.M.9
Kohler, D.10
Jaffe, E.S.11
Stetler-Stevenson, M.12
Chen, H.13
Ghetie, V.14
Sausville, E.A.15
-
27
-
-
84863025438
-
Immunotoxins constructed with chimeric, short-lived anti-CD22 monoclonal antibodies induce less vascular leak without loss of cytotoxicity
-
Liu XY, Pop LM, Schindler J, Vitetta ES. Immunotoxins constructed with chimeric, short-lived anti-CD22 monoclonal antibodies induce less vascular leak without loss of cytotoxicity. MAbs. 2012;4(1):57-68.
-
(2012)
MAbs
, vol.4
, Issue.1
, pp. 57-68
-
-
Liu, X.Y.1
Pop, L.M.2
Schindler, J.3
Vitetta, E.S.4
-
28
-
-
0030954684
-
Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors
-
Mansfield E, Amlot P, Pastan I, FitzGerald DJ. Recombinant RFB4 immunotoxins exhibit potent cytotoxic activity for CD22-bearing cells and tumors. Blood. 1997;90(5):2020-2026. (Pubitemid 27377315)
-
(1997)
Blood
, vol.90
, Issue.5
, pp. 2020-2026
-
-
Mansfield, E.1
Amlot, P.2
Pastan, I.3
FitzGerald, D.J.4
-
29
-
-
0035954624
-
Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia
-
DOI 10.1056/NEJM200107263450402
-
Kreitman RJ, Wilson WH, Bergeron K, et al. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. N Engl J Med. 2001;345(4):241-247. (Pubitemid 32695063)
-
(2001)
New England Journal of Medicine
, vol.345
, Issue.4
, pp. 241-247
-
-
Kreitman, R.J.1
Wilson, W.H.2
Bergeron, K.3
Raggio, M.4
Stetler-Stevenson, M.5
Fitzgerald, D.J.6
Pastan, I.7
-
30
-
-
67649933809
-
Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia
-
Kreitman RJ, Stetler-Stevenson M, Margulies I, et al. Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. J Clin Oncol. 2009;27(18):2983-2990.
-
(2009)
J Clin Oncol
, vol.27
, Issue.18
, pp. 2983-2990
-
-
Kreitman, R.J.1
Stetler-Stevenson, M.2
Margulies, I.3
-
31
-
-
84874027123
-
Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
-
Haso W, Lee DW, Shah NN, et al. Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia. Blood. 2013;121(7):1165-1174.
-
(2013)
Blood
, vol.121
, Issue.7
, pp. 1165-1174
-
-
Haso, W.1
Lee, D.W.2
Shah, N.N.3
-
32
-
-
77949679970
-
Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: Preclinical studies and phase I clinical trial
-
Wayne AS, Kreitman RJ, Findley HW, et al. Anti-CD22 immunotoxin RFB4(dsFv)-PE38 (BL22) for CD22-positive hematologic malignancies of childhood: preclinical studies and phase I clinical trial. Clin Cancer Res. 2010;16(6):1894-1903.
-
(2010)
Clin Cancer Res
, vol.16
, Issue.6
, pp. 1894-1903
-
-
Wayne, A.S.1
Kreitman, R.J.2
Findley, H.W.3
-
33
-
-
0036554968
-
Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display
-
Salvatore G, Beers R, Margulies I, Kreitman RJ, Pastan I. Improved cytotoxic activity toward cell lines and fresh leukemia cells of a mutant anti-CD22 immunotoxin obtained by antibody phage display. Clin Cancer Res. 2002;8(4):995-1002. (Pubitemid 35177347)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.4
, pp. 995-1002
-
-
Salvatore, G.1
Beers, R.2
Margulies, I.3
Kreitman, R.J.4
Pastan, I.5
-
34
-
-
80054118081
-
Antibody fusion proteins: Anti-CD22 recombinant immunotoxin moxetumomab pasudotox
-
Kreitman RJ, Pastan I. Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox. Clin Cancer Res. 2011;17(20):6398-6405.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.20
, pp. 6398-6405
-
-
Kreitman, R.J.1
Pastan, I.2
-
35
-
-
84861542159
-
Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia
-
Kreitman RJ, Tallman MS, Robak T, et al. Phase I trial of anti-CD22 recombinant immunotoxin moxetumomab pasudotox (CAT-8015 or HA22) in patients with hairy cell leukemia. J Clin Oncol. 2012;30(15):1822-1828.
-
(2012)
J Clin Oncol
, vol.30
, Issue.15
, pp. 1822-1828
-
-
Kreitman, R.J.1
Tallman, M.S.2
Robak, T.3
-
36
-
-
84883873669
-
Hairy cell leukemia-new genes, new targets
-
Kreitman RJ. Hairy cell leukemia-new genes, new targets. Curr Hematol Malig Rep. 2013;8(3):184-195.
-
(2013)
Curr Hematol Malig Rep
, vol.8
, Issue.3
, pp. 184-195
-
-
Kreitman, R.J.1
-
37
-
-
84859156821
-
A novel anti-CD22 immunotoxin, moxetumomab pasudotox: Phase I study in pediatric acute lymphoblastic leukemia (ALL)
-
[abstract]. Abstract 248
-
Wayne AS, Bhojwani D, Silverman LB, et al. A novel anti-CD22 immunotoxin, moxetumomab pasudotox: Phase I study in pediatric acute lymphoblastic leukemia (ALL) [abstract]. Blood. 2011;118(21):1317a. Abstract 248.
-
(2011)
Blood
, vol.118
, Issue.21
-
-
Wayne, A.S.1
Bhojwani, D.2
Silverman, L.B.3
-
38
-
-
67650125751
-
Pre-clinical evaluation of the anti-CD22 immunotoxin CAT-8015 in combination with chemotherapy agents for childhood B-precursor acute lymphoblastic leukemia (Pre-B ALL)
-
[abstract]. Abstract 865
-
Ahuja Y, Stetler-Stevenson M, Kreitman RJ, Pastan I, Wayne AS. Pre-clinical evaluation of the anti-CD22 immunotoxin CAT-8015 in combination with chemotherapy agents for childhood B-precursor acute lymphoblastic leukemia (Pre-B ALL) [abstract]. Blood. 2007;110(11):265a. Abstract 865.
-
(2007)
Blood
, vol.110
, Issue.11
-
-
Ahuja, Y.1
Stetler-Stevenson, M.2
Kreitman, R.J.3
Pastan, I.4
Wayne, A.S.5
-
39
-
-
73949122603
-
A phase 1 study of Combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia
-
Herrera L, Bostrom B, Gore L, et al. A phase 1 study of Combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2009;31(12):936-941.
-
(2009)
J Pediatr Hematol Oncol
, vol.31
, Issue.12
, pp. 936-941
-
-
Herrera, L.1
Bostrom, B.2
Gore, L.3
-
40
-
-
79960843919
-
A phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia
-
Schindler J, Gajavelli S, Ravandi F, et al. A phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia. Br J Haematol. 2011;154(4):471-476.
-
(2011)
Br J Haematol
, vol.154
, Issue.4
, pp. 471-476
-
-
Schindler, J.1
Gajavelli, S.2
Ravandi, F.3
-
41
-
-
84865734833
-
Synergy of sequential administration of a deglycosylated ricin A chain-containing combined anti-CD19 and anti-CD22 immunotoxin (Combotox) and cytarabine in a murine model of advanced acute lymphoblastic leukemia
-
Barta SK, Zou Y, Schindler J, et al. Synergy of sequential administration of a deglycosylated ricin A chain-containing combined anti-CD19 and anti-CD22 immunotoxin (Combotox) and cytarabine in a murine model of advanced acute lymphoblastic leukemia. Leuk Lymphoma. 2012;53(10):1999-2003.
-
(2012)
Leuk Lymphoma
, vol.53
, Issue.10
, pp. 1999-2003
-
-
Barta, S.K.1
Zou, Y.2
Schindler, J.3
-
42
-
-
67549102111
-
Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy
-
Vallera DA, Chen H, Sicheneder AR, Panoskaltsis-Mortari A, Taras EP. Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy. Leuk Res. 2009;33(9):1233-1242.
-
(2009)
Leuk Res
, vol.33
, Issue.9
, pp. 1233-1242
-
-
Vallera, D.A.1
Chen, H.2
Sicheneder, A.R.3
Panoskaltsis-Mortari, A.4
Taras, E.P.5
-
43
-
-
64249158870
-
Anti-CD3 recombinant diphtheria immunotoxin therapy of cutaneous T cell lymphoma
-
Frankel AE, Zuckero SL, Mankin AA, et al. Anti-CD3 recombinant diphtheria immunotoxin therapy of cutaneous T cell lymphoma. Curr Drug Targets. 2009;10(2):104-109.
-
(2009)
Curr Drug Targets
, vol.10
, Issue.2
, pp. 104-109
-
-
Frankel, A.E.1
Zuckero, S.L.2
Mankin, A.A.3
-
44
-
-
84875233141
-
Phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM-195/rGEL), in patients with advanced myeloid malignancies
-
Borthakur G, Rosenblum MG, Talpaz M, et al. Phase 1 study of an anti-CD33 immunotoxin, humanized monoclonal antibody M195 conjugated to recombinant gelonin (HUM-195/rGEL), in patients with advanced myeloid malignancies. Haematologica. 2013;98(2):217-221.
-
(2013)
Haematologica
, vol.98
, Issue.2
, pp. 217-221
-
-
Borthakur, G.1
Rosenblum, M.G.2
Talpaz, M.3
-
45
-
-
84883706233
-
A new recombinant immunotoxin hscFv-ETA' demonstrates specific cytotoxicity against chronic myeloid leukemia cells in vitro
-
Zhu X, Tao K, Li Y, et al. A new recombinant immunotoxin hscFv-ETA' demonstrates specific cytotoxicity against chronic myeloid leukemia cells in vitro. Immunol Lett. 2013;154(1-2):18-24.
-
(2013)
Immunol Lett
, vol.154
, Issue.1-2
, pp. 18-24
-
-
Zhu, X.1
Tao, K.2
Li, Y.3
-
46
-
-
80054687655
-
3A4, a new potential target for B and myeloid lineage leukemias
-
Li S, Tang Y, Zhang J, Guo X, Shen H. 3A4, a new potential target for B and myeloid lineage leukemias. J Drug Target. 2011;19(9):797-804.
-
(2011)
J Drug Target
, vol.19
, Issue.9
, pp. 797-804
-
-
Li, S.1
Tang, Y.2
Zhang, J.3
Guo, X.4
Shen, H.5
-
47
-
-
84870952546
-
Efficacy of a CD22-targeted antibody-saporin conjugate in a xenograft model of precursor-B cell acute lymphoblastic leukemia
-
Kato J, Satake N, O'Donnell RT, Abuhay M, Lewis C, Tuscano JM. Efficacy of a CD22-targeted antibody-saporin conjugate in a xenograft model of precursor-B cell acute lymphoblastic leukemia. Leuk Res. 2013;37(1):83-88.
-
(2013)
Leuk Res
, vol.37
, Issue.1
, pp. 83-88
-
-
Kato, J.1
Satake, N.2
O'Donnell, R.T.3
Abuhay, M.4
Lewis, C.5
Tuscano, J.M.6
-
48
-
-
84871429839
-
Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies
-
Dave H, Anver MR, Butcher DO, et al. Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies. PLoS ONE. 2012;7(12):e52655.
-
(2012)
PLoS ONE
, vol.7
, Issue.12
-
-
Dave, H.1
Anver, M.R.2
Butcher, D.O.3
-
49
-
-
84860907341
-
Targeting malignant B cells with an immunotoxin against ROR1
-
Baskar S, Wiestner A, Wilson WH, Pastan I, Rader C. Targeting malignant B cells with an immunotoxin against ROR1. MAbs. 2012;4(3):349-361.
-
(2012)
MAbs
, vol.4
, Issue.3
, pp. 349-361
-
-
Baskar, S.1
Wiestner, A.2
Wilson, W.H.3
Pastan, I.4
Rader, C.5
-
50
-
-
79959712029
-
In vivo efficacy of the recombinant anti-CD64 immunotoxin H22(scFv)-ETA' in a human acute myeloid leukemia xenograft tumor model
-
Tur MK, Huhn M, Jost E, Thepen T, Brümmendorf TH, Barth S. In vivo efficacy of the recombinant anti-CD64 immunotoxin H22(scFv)-ETA' in a human acute myeloid leukemia xenograft tumor model. Int J Cancer. 2011;129(5):1277- 1282.
-
(2011)
Int J Cancer
, vol.129
, Issue.5
, pp. 1277-1282
-
-
Tur, M.K.1
Huhn, M.2
Jost, E.3
Thepen, T.4
Brümmendorf, T.H.5
Barth, S.6
-
51
-
-
70449331656
-
ATG-saporin-S6 immunotoxin: A new potent and selective drug to eliminate activated lymphocytes and lymphoma cells
-
Polito L, Bortolotti M, Farini V, Pedrazzi M, Tazzari PL, Bolognesi A. ATG-saporin-S6 immunotoxin: a new potent and selective drug to eliminate activated lymphocytes and lymphoma cells. Br J Haematol. 2009;147(5):710-718.
-
(2009)
Br J Haematol
, vol.147
, Issue.5
, pp. 710-718
-
-
Polito, L.1
Bortolotti, M.2
Farini, V.3
Pedrazzi, M.4
Tazzari, P.L.5
Bolognesi, A.6
-
52
-
-
79954602517
-
Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies
-
Dalmazzo LF, Santana-Lemos BA, Jácomo RH, et al. Antibody-targeted horseradish peroxidase associated with indole-3-acetic acid induces apoptosis in vitro in hematological malignancies. Leuk Res. 2011;35(5):657-662.
-
(2011)
Leuk Res
, vol.35
, Issue.5
, pp. 657-662
-
-
Dalmazzo, L.F.1
Santana-Lemos, B.A.2
Jácomo, R.H.3
-
53
-
-
84878725509
-
GM-CSF-DFF40: A novel humanized immunotoxin induces apoptosis in acute myeloid leukemia cells
-
Mathew M, Zaineb KC, Verma RS. GM-CSF-DFF40: a novel humanized immunotoxin induces apoptosis in acute myeloid leukemia cells. Apoptosis. 2013;18(7):882-895.
-
(2013)
Apoptosis
, vol.18
, Issue.7
, pp. 882-895
-
-
Mathew, M.1
Zaineb, K.C.2
Verma, R.S.3
-
54
-
-
84887208545
-
Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells
-
Schiffer S, Letzian S, Jost E, et al. Granzyme M as a novel effector molecule for human cytolytic fusion proteins: CD64-specific cytotoxicity of Gm-H22(scFv) against leukemic cells. Cancer Lett. 2013;341(2):178-185.
-
(2013)
Cancer Lett
, vol.341
, Issue.2
, pp. 178-185
-
-
Schiffer, S.1
Letzian, S.2
Jost, E.3
-
55
-
-
68749099507
-
A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability
-
ten Cate B, Bremer E, de Bruyn M, et al. A novel AML-selective TRAIL fusion protein that is superior to Gemtuzumab Ozogamicin in terms of in vitro selectivity, activity and stability. Leukemia. 2009;23(8):1389-1397.
-
(2009)
Leukemia
, vol.23
, Issue.8
, pp. 1389-1397
-
-
Ten Cate, B.1
Bremer, E.2
De Bruyn, M.3
-
56
-
-
80052572908
-
The improvement of an anti-CD22 immunotoxin: Conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan
-
Kawa S, Onda M, Ho M, Kreitman RJ, Bera TK, Pastan I. The improvement of an anti-CD22 immunotoxin: conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan. MAbs. 2011;3(5):479-486.
-
(2011)
MAbs
, vol.3
, Issue.5
, pp. 479-486
-
-
Kawa, S.1
Onda, M.2
Ho, M.3
Kreitman, R.J.4
Bera, T.K.5
Pastan, I.6
-
57
-
-
79957468477
-
Immunotoxins with decreased immunogenicity and improved activity
-
Pastan I, Onda M, Weldon J, Fitzgerald D, Kreitman R. Immunotoxins with decreased immunogenicity and improved activity. Leuk Lymphoma. 2011;52(Suppl 2):87-90.
-
(2011)
Leuk Lymphoma
, vol.52
, Issue.SUPPL. 2
, pp. 87-90
-
-
Pastan, I.1
Onda, M.2
Weldon, J.3
Fitzgerald, D.4
Kreitman, R.5
-
58
-
-
79957484300
-
Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737
-
Fitzgerald DJ, Moskatel E, Ben-Josef G, et al. Enhancing immunotoxin cell-killing activity via combination therapy with ABT-737. Leuk Lymphoma. 2011;52(Suppl 2):79-81.
-
(2011)
Leuk Lymphoma
, vol.52
, Issue.SUPPL. 2
, pp. 79-81
-
-
Fitzgerald, D.J.1
Moskatel, E.2
Ben-Josef, G.3
-
59
-
-
84860589922
-
The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion
-
Biberacher V, Decker T, Oelsner M, et al. The cytotoxicity of anti-CD22 immunotoxin is enhanced by bryostatin 1 in B-cell lymphomas through CD22 upregulation and PKC-βII depletion. Haematologica. 2012;97(5):771-779.
-
(2012)
Haematologica
, vol.97
, Issue.5
, pp. 771-779
-
-
Biberacher, V.1
Decker, T.2
Oelsner, M.3
-
60
-
-
84886382139
-
Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression
-
Hassan R, Miller AC, Sharon E, et al. Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression. Sci Transl Med. 2013;5(208):208ra147.
-
(2013)
Sci Transl Med
, vol.5
, Issue.208
-
-
Hassan, R.1
Miller, A.C.2
Sharon, E.3
-
61
-
-
49649091350
-
An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes
-
Onda M, Beers R, Xiang L, Nagata S, Wang QC, Pastan I. An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proc Natl Acad Sci USA. 2008;105(32):11311-11316.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.32
, pp. 11311-11316
-
-
Onda, M.1
Beers, R.2
Xiang, L.3
Nagata, S.4
Wang, Q.C.5
Pastan, I.6
-
62
-
-
79955007493
-
Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes
-
Onda M, Beers R, Xiang L, et al. Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proc Natl Acad Sci USA. 2011;108(14):5742-5747.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.14
, pp. 5742-5747
-
-
Onda, M.1
Beers, R.2
Xiang, L.3
-
63
-
-
84863957822
-
Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes
-
Liu W, Onda M, Lee B, et al. Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. Proc Natl Acad Sci USA. 2012;109(29):11782-11787.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.29
, pp. 11782-11787
-
-
Liu, W.1
Onda, M.2
Lee, B.3
-
64
-
-
33745571528
-
Immunotoxin therapy of cancer
-
DOI 10.1038/nrc1891, PII N1891
-
Pastan I, Hassan R, Fitzgerald DJ, Kreitman RJ. Immunotoxin therapy of cancer. Nat Rev Cancer. 2006;6(7):559-565. (Pubitemid 43980544)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.7
, pp. 559-565
-
-
Pastan, I.1
Hassan, R.2
FitzGerald, D.J.3
Kreitman, R.J.4
-
65
-
-
0032213076
-
Comparison of recombinant immunotoxins against Le(Y) antigen expressing tumor cells: Influence of affinity, size, and stability
-
DOI 10.1021/bc980028o
-
Bera TK, Pastan I. Comparison of recombinant immunotoxins against LeY antigen expressing tumor cells: influence of affinity, size, and stability. Bioconjug Chem. 1998;9(6):736-743. (Pubitemid 28542241)
-
(1998)
Bioconjugate Chemistry
, vol.9
, Issue.6
, pp. 736-743
-
-
Bera, T.K.1
Pastan, I.2
-
66
-
-
77953653678
-
"Inclonals": IgGs and IgG-enzyme fusion proteins produced in an E. coli expression-refolding system
-
Hakim R, Benhar I. "Inclonals": IgGs and IgG-enzyme fusion proteins produced in an E. coli expression-refolding system. MAbs. 2009;1(3):281-287.
-
(2009)
MAbs
, vol.1
, Issue.3
, pp. 281-287
-
-
Hakim, R.1
Benhar, I.2
-
67
-
-
79959312575
-
Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
-
Topp MS, Kufer P, Gökbuget N, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol. 2011;29(18):2493-2498.
-
(2011)
J Clin Oncol
, vol.29
, Issue.18
, pp. 2493-2498
-
-
Topp, M.S.1
Kufer, P.2
Gökbuget, N.3
-
68
-
-
84876325876
-
Chimeric antigen receptor-modified T cells for acute lymphoid leukemia
-
Grupp SA, Kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 2013;368(16):1509-1518.
-
(2013)
N Engl J Med
, vol.368
, Issue.16
, pp. 1509-1518
-
-
Grupp, S.A.1
Kalos, M.2
Barrett, D.3
-
69
-
-
77954566553
-
Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia
-
Mussai FJ, Campana D, Bhojwani D, et al. Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia. Br J Haematol. 2010;150(3):352-358.
-
(2010)
Br J Haematol
, vol.150
, Issue.3
, pp. 352-358
-
-
Mussai, F.J.1
Campana, D.2
Bhojwani, D.3
-
70
-
-
84875677396
-
Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy
-
Hsieh YT, Gang EJ, Geng H, et al. Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013;121(10):1814-1818.
-
(2013)
Blood
, vol.121
, Issue.10
, pp. 1814-1818
-
-
Hsieh, Y.T.1
Gang, E.J.2
Geng, H.3
-
71
-
-
84875908777
-
Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy
-
Pramanik R, Sheng X, Ichihara B, Heisterkamp N, Mittelman SD. Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy. Leuk Res. 2013;37(5):503-509.
-
(2013)
Leuk Res
, vol.37
, Issue.5
, pp. 503-509
-
-
Pramanik, R.1
Sheng, X.2
Ichihara, B.3
Heisterkamp, N.4
Mittelman, S.D.5
-
72
-
-
76249099769
-
A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake
-
Zhang Y, Hansen JK, Xiang L, et al. A flow cytometry method to quantitate internalized immunotoxins shows that taxol synergistically increases cellular immunotoxins uptake. Cancer Res. 2010;70(3):1082-1089.
-
(2010)
Cancer Res
, vol.70
, Issue.3
, pp. 1082-1089
-
-
Zhang, Y.1
Hansen, J.K.2
Xiang, L.3
-
73
-
-
84886783613
-
Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8
-
Hu X, Wei H, Xiang L, et al. Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8. Leuk Res. 2013;37(11):1551-1556.
-
(2013)
Leuk Res
, vol.37
, Issue.11
, pp. 1551-1556
-
-
Hu, X.1
Wei, H.2
Xiang, L.3
-
74
-
-
84860805385
-
Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy
-
Wei H, Xiang L, Wayne AS, et al. Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy. Proc Natl Acad Sci USA. 2012;109(18):6898-6903.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.18
, pp. 6898-6903
-
-
Wei, H.1
Xiang, L.2
Wayne, A.S.3
-
75
-
-
84876938118
-
A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene
-
Wei H, Bera TK, Wayne AS, et al. A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene. J Biol Chem. 2013;288(17):12305-12312.
-
(2013)
J Biol Chem
, vol.288
, Issue.17
, pp. 12305-12312
-
-
Wei, H.1
Bera, T.K.2
Wayne, A.S.3
-
76
-
-
0037382907
-
Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice
-
DOI 10.1038/nbt800
-
Smallshaw JE, Ghetie V, Rizo J, et al. Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice. Nat Biotechnol. 2003;21(4):387-391. (Pubitemid 36397658)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.4
, pp. 387-391
-
-
Smallshaw, J.E.1
Ghetie, V.2
Rizo, J.3
Fulmer, J.R.4
Trahan, L.L.5
Ghetie, M.-A.6
Vitetta, E.S.7
-
77
-
-
0028087780
-
Prevention of immunotoxin-mediated vascular leak syndrome in rats with retention of antitumor activity
-
Siegall CB, Liggitt D, Chace D, Tepper MA, Fell HP. Prevention of immunotoxin-mediated vascular leak syndrome in rats with retention of antitumor activity. Proc Natl Acad Sci USA. 1994;91(20):9514-9518. (Pubitemid 24297945)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.20
, pp. 9514-9518
-
-
Siegall, C.B.1
Liggitt, D.2
Chace, D.3
Tepper, M.A.4
Fell, H.P.5
|