메뉴 건너뛰기




Volumn 137, Issue 3, 2016, Pages 667-679

Leveraging gene-environment interactions and endotypes for asthma gene discovery

Author keywords

17q asthma locus; Asthma; CDHR3; gene environment interactions; genome wide association study; rhinovirus

Indexed keywords

INTERLEUKIN 13;

EID: 84973575283     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.01.006     Document Type: Review
Times cited : (89)

References (95)
  • 1
    • 56549099067 scopus 로고    scopus 로고
    • Sex-specific genetic architecture of human disease
    • C. Ober, D.A. Loisel, and Y. Gilad Sex-specific genetic architecture of human disease Nat Rev Genet 9 2008 911 922
    • (2008) Nat Rev Genet , vol.9 , pp. 911-922
    • Ober, C.1    Loisel, D.A.2    Gilad, Y.3
  • 2
    • 52049087356 scopus 로고    scopus 로고
    • Endotyping asthma: New insights into key pathogenic mechanisms in a complex, heterogeneous disease
    • G.P. Anderson Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease Lancet 372 2008 1107 1119
    • (2008) Lancet , vol.372 , pp. 1107-1119
    • Anderson, G.P.1
  • 3
    • 77956305779 scopus 로고    scopus 로고
    • Risk for asthma in offspring of asthmatic mothers versus fathers: A meta-analysis
    • R.H. Lim, L. Kobzik, and M. Dahl Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis PLoS One 5 2010 e10134
    • (2010) PLoS One , vol.5 , pp. e10134
    • Lim, R.H.1    Kobzik, L.2    Dahl, M.3
  • 4
    • 78649512314 scopus 로고    scopus 로고
    • Farm living: Effects on childhood asthma and allergy
    • E. von Mutius, and D. Vercelli Farm living: effects on childhood asthma and allergy Nat Rev Immunol 10 2010 861 868
    • (2010) Nat Rev Immunol , vol.10 , pp. 861-868
    • Von Mutius, E.1    Vercelli, D.2
  • 5
    • 34247466932 scopus 로고    scopus 로고
    • Gut microbiota composition and development of atopic manifestations in infancy: The KOALA Birth Cohort Study
    • J. Penders, C. Thijs, P.A. van den Brandt, I. Kummeling, B. Snijders, F. Stelma, and et al. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study Gut 56 2007 661 667
    • (2007) Gut , vol.56 , pp. 661-667
    • Penders, J.1    Thijs, C.2    Van Den Brandt, P.A.3    Kummeling, I.4    Snijders, B.5    Stelma, F.6
  • 6
    • 80052272960 scopus 로고    scopus 로고
    • Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age
    • e1-5
    • H. Bisgaard, N. Li, K. Bonnelykke, B.L. Chawes, T. Skov, G. Paludan-Muller, and et al. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age J Allergy Clin Immunol 128 2011 646 652 e1-5
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 646-652
    • Bisgaard, H.1    Li, N.2    Bonnelykke, K.3    Chawes, B.L.4    Skov, T.5    Paludan-Muller, G.6
  • 7
    • 84920493187 scopus 로고    scopus 로고
    • The gut microbiota and inflammatory noncommunicable diseases: Associations and potentials for gut microbiota therapies
    • C.E. West, H. Renz, M.C. Jenmalm, A.L. Kozyrskyj, K.J. Allen, P. Vuillermin, and et al. The gut microbiota and inflammatory noncommunicable diseases: associations and potentials for gut microbiota therapies J Allergy Clin Immunol 135 2015 3 14
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 3-14
    • West, C.E.1    Renz, H.2    Jenmalm, M.C.3    Kozyrskyj, A.L.4    Allen, K.J.5    Vuillermin, P.6
  • 9
    • 74849131700 scopus 로고    scopus 로고
    • Intrauterine effects of maternal smoking on sensitization, asthma, and chronic obstructive pulmonary disease
    • M.N. Hylkema, and M.J. Blacquiere Intrauterine effects of maternal smoking on sensitization, asthma, and chronic obstructive pulmonary disease Proc Am Thorac Soc 6 2009 660 662
    • (2009) Proc Am Thorac Soc , vol.6 , pp. 660-662
    • Hylkema, M.N.1    Blacquiere, M.J.2
  • 10
    • 35648960877 scopus 로고    scopus 로고
    • Is Vitamin D deficiency to blame for the asthma epidemic?
    • A.A. Litonjua, and S.T. Weiss Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol 120 2007 1031 1035
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 1031-1035
    • Litonjua, A.A.1    Weiss, S.T.2
  • 11
    • 47249092403 scopus 로고    scopus 로고
    • Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial
    • S.F. Olsen, M.L. Osterdal, J.D. Salvig, L.M. Mortensen, D. Rytter, N.J. Secher, and et al. Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial Am J Clin Nutr 88 2008 167 175
    • (2008) Am J Clin Nutr , vol.88 , pp. 167-175
    • Olsen, S.F.1    Osterdal, M.L.2    Salvig, J.D.3    Mortensen, L.M.4    Rytter, D.5    Secher, N.J.6
  • 12
    • 84893097134 scopus 로고    scopus 로고
    • Fish and fish oil intake in relation to risk of asthma: A systematic review and meta-analysis
    • H. Yang, P. Xun, and K. He Fish and fish oil intake in relation to risk of asthma: a systematic review and meta-analysis PLoS One 8 2013 e80048
    • (2013) PLoS One , vol.8 , pp. e80048
    • Yang, H.1    Xun, P.2    He, K.3
  • 13
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • J.F. Bach The effect of infections on susceptibility to autoimmune and allergic diseases N Engl J Med 347 2002 911 920
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 14
    • 79952103287 scopus 로고    scopus 로고
    • Gene-environment interactions in human disease: Nuisance or opportunity?
    • C. Ober, and D. Vercelli Gene-environment interactions in human disease: nuisance or opportunity? Trends Genet 27 2011 107 115
    • (2011) Trends Genet , vol.27 , pp. 107-115
    • Ober, C.1    Vercelli, D.2
  • 19
    • 77952557918 scopus 로고    scopus 로고
    • Missing heritability and strategies for finding the underlying causes of complex disease
    • E.E. Eichler, J. Flint, G. Gibson, A. Kong, S.M. Leal, J.H. Moore, and et al. Missing heritability and strategies for finding the underlying causes of complex disease Nat Rev Genet 11 2010 446 450
    • (2010) Nat Rev Genet , vol.11 , pp. 446-450
    • Eichler, E.E.1    Flint, J.2    Gibson, G.3    Kong, A.4    Leal, S.M.5    Moore, J.H.6
  • 22
    • 84895813269 scopus 로고    scopus 로고
    • Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: A genetic study
    • V.E. Ortega, G.A. Hawkins, W.C. Moore, A.T. Hastie, E.J. Ampleford, W.W. Busse, and et al. Effect of rare variants in ADRB2 on risk of severe exacerbations and symptom control during longacting beta agonist treatment in a multiethnic asthma population: a genetic study Lancet Respir Med 2 2014 204 213
    • (2014) Lancet Respir Med , vol.2 , pp. 204-213
    • Ortega, V.E.1    Hawkins, G.A.2    Moore, W.C.3    Hastie, A.T.4    Ampleford, E.J.5    Busse, W.W.6
  • 23
    • 84922746494 scopus 로고    scopus 로고
    • Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma
    • C. Igartua, R.A. Myers, R.A. Mathias, M. Pino-Yanes, C. Eng, P.E. Graves, and et al. Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma Nat Commun 6 2015 5965
    • (2015) Nat Commun , vol.6 , pp. 5965
    • Igartua, C.1    Myers, R.A.2    Mathias, R.A.3    Pino-Yanes, M.4    Eng, C.5    Graves, P.E.6
  • 24
    • 15944383403 scopus 로고    scopus 로고
    • Gene-environment interactions in human diseases
    • D.J. Hunter Gene-environment interactions in human diseases Nat Rev Genet 6 2005 287 298
    • (2005) Nat Rev Genet , vol.6 , pp. 287-298
    • Hunter, D.J.1
  • 25
    • 78650923970 scopus 로고    scopus 로고
    • Gene-environment interaction for childhood asthma and exposure to farming in Central Europe
    • e1-4
    • M.J. Ege, D.P. Strachan, W.O. Cookson, M.F. Moffatt, I. Gut, M. Lathrop, and et al. Gene-environment interaction for childhood asthma and exposure to farming in Central Europe J Allergy Clin Immunol 127 2011 138 144 e1-4
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 138-144
    • Ege, M.J.1    Strachan, D.P.2    Cookson, W.O.3    Moffatt, M.F.4    Gut, I.5    Lathrop, M.6
  • 28
    • 84973519679 scopus 로고    scopus 로고
    • Asthma genetics in the post-genome-wide association study (GWAS) era
    • [In press]
    • C. Ober Asthma genetics in the post-genome-wide association study (GWAS) era ATS J 2016 [In press]
    • (2016) ATS J
    • Ober, C.1
  • 29
    • 43249129715 scopus 로고    scopus 로고
    • Gene-environment interaction in yeast gene expression
    • E.N. Smith, and L. Kruglyak Gene-environment interaction in yeast gene expression PLoS Biol 6 2008 e83
    • (2008) PLoS Biol , vol.6 , pp. e83
    • Smith, E.N.1    Kruglyak, L.2
  • 30
    • 77957828103 scopus 로고    scopus 로고
    • Association of bacteria and viruses with wheezy episodes in young children: Prospective birth cohort study
    • H. Bisgaard, M.N. Hermansen, K. Bonnelykke, J. Stokholm, F. Baty, N.L. Skytt, and et al. Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study BMJ 341 2010 c4978
    • (2010) BMJ , vol.341 , pp. c4978
    • Bisgaard, H.1    Hermansen, M.N.2    Bonnelykke, K.3    Stokholm, J.4    Baty, F.5    Skytt, N.L.6
  • 31
    • 0028990124 scopus 로고
    • Community study of role of viral infections in exacerbations of asthma in 9-11 year old children
    • S.L. Johnston, P.K. Pattemore, G. Sanderson, S. Smith, F. Lampe, L. Josephs, and et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children BMJ 310 1995 1225 1229
    • (1995) BMJ , vol.310 , pp. 1225-1229
    • Johnston, S.L.1    Pattemore, P.K.2    Sanderson, G.3    Smith, S.4    Lampe, F.5    Josephs, L.6
  • 39
    • 69349084304 scopus 로고    scopus 로고
    • 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry
    • J.H. Flory, P.M. Sleiman, J.D. Christie, K. Annaiah, J. Bradfield, C.E. Kim, and et al. 17q12-21 variants interact with smoke exposure as a risk factor for pediatric asthma but are equally associated with early-onset versus late-onset asthma in North Americans of European ancestry J Allergy Clin Immunol 124 2009 605 607
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 605-607
    • Flory, J.H.1    Sleiman, P.M.2    Christie, J.D.3    Annaiah, K.4    Bradfield, J.5    Kim, C.E.6
  • 40
    • 77954651403 scopus 로고    scopus 로고
    • 17q21 variants modify the association between early respiratory infections and asthma
    • L.A. Smit, E. Bouzigon, I. Pin, V. Siroux, F. Monier, H. Aschard, and et al. 17q21 variants modify the association between early respiratory infections and asthma Eur Respir J 36 2010 57 64
    • (2010) Eur Respir J , vol.36 , pp. 57-64
    • Smit, L.A.1    Bouzigon, E.2    Pin, I.3    Siroux, V.4    Monier, F.5    Aschard, H.6
  • 41
    • 84984832210 scopus 로고    scopus 로고
    • The early development of wheeze: Environmental determinants and genetic susceptibility at 17q21
    • [Epub ahead of print]
    • G.J. Loss, M. Depner, A.J. Hose, J. Genuneit, A.M. Karvonen, A. Hyvarinen, and et al. The early development of wheeze: environmental determinants and genetic susceptibility at 17q21 Am J Respir Crit Care Med 2015 [Epub ahead of print]
    • (2015) Am J Respir Crit Care Med
    • Loss, G.J.1    Depner, M.2    Hose, A.J.3    Genuneit, J.4    Karvonen, A.M.5    Hyvarinen, A.6
  • 42
    • 84937023870 scopus 로고    scopus 로고
    • Association between respiratory infections in early life and later asthma is independent of virus type
    • K. Bonnelykke, N.H. Vissing, A. Sevelsted, S.L. Johnston, and H. Bisgaard Association between respiratory infections in early life and later asthma is independent of virus type J Allergy Clin Immunol 136 2015 81 86.e4
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 81-86e4
    • Bonnelykke, K.1    Vissing, N.H.2    Sevelsted, A.3    Johnston, S.L.4    Bisgaard, H.5
  • 43
    • 84891372721 scopus 로고    scopus 로고
    • A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
    • K. Bonnelykke, P. Sleiman, K. Nielsen, E. Kreiner-Moller, J.M. Mercader, D. Belgrave, and et al. A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations Nat Genet 46 2014 51 55
    • (2014) Nat Genet , vol.46 , pp. 51-55
    • Bonnelykke, K.1    Sleiman, P.2    Nielsen, K.3    Kreiner-Moller, E.4    Mercader, J.M.5    Belgrave, D.6
  • 44
    • 80052259316 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations
    • D.G. Torgerson, E.J. Ampleford, G.Y. Chiu, W.J. Gauderman, C.R. Gignoux, P.E. Graves, and et al. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations Nat Genet 43 2011 887 892
    • (2011) Nat Genet , vol.43 , pp. 887-892
    • Torgerson, D.G.1    Ampleford, E.J.2    Chiu, G.Y.3    Gauderman, W.J.4    Gignoux, C.R.5    Graves, P.E.6
  • 45
    • 20144376345 scopus 로고    scopus 로고
    • Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
    • I. Yanai, H. Benjamin, M. Shmoish, V. Chalifa-Caspi, M. Shklar, R. Ophir, and et al. Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification Bioinformatics 21 2005 650 659
    • (2005) Bioinformatics , vol.21 , pp. 650-659
    • Yanai, I.1    Benjamin, H.2    Shmoish, M.3    Chalifa-Caspi, V.4    Shklar, M.5    Ophir, R.6
  • 46
    • 34347370805 scopus 로고    scopus 로고
    • Transcriptional profiling of mucociliary differentiation in human airway epithelial cells
    • A.J. Ross, L.A. Dailey, L.E. Brighton, and R.B. Devlin Transcriptional profiling of mucociliary differentiation in human airway epithelial cells Am J Respir Cell Mol Biol 37 2007 169 185
    • (2007) Am J Respir Cell Mol Biol , vol.37 , pp. 169-185
    • Ross, A.J.1    Dailey, L.A.2    Brighton, L.E.3    Devlin, R.B.4
  • 47
    • 56949084416 scopus 로고    scopus 로고
    • Molecular evolution of the cadherin superfamily
    • P. Hulpiau, and F. van Roy Molecular evolution of the cadherin superfamily Int J Biochem Cell Biol 41 2009 349 369
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 349-369
    • Hulpiau, P.1    Van Roy, F.2
  • 48
    • 84928689999 scopus 로고    scopus 로고
    • Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication
    • Y.A. Bochkov, K. Watters, S. Ashraf, T.F. Griggs, M.K. Devries, D.J. Jackson, and et al. Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication Proc Natl Acad Sci U S A 112 2015 5485 5490
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 5485-5490
    • Bochkov, Y.A.1    Watters, K.2    Ashraf, S.3    Griggs, T.F.4    Devries, M.K.5    Jackson, D.J.6
  • 49
    • 84890052055 scopus 로고    scopus 로고
    • Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions
    • D.W. Cox, J. Bizzintino, G. Ferrari, S.K. Khoo, G. Zhang, S. Whelan, and et al. Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions Am J Respir Crit Care Med 188 2013 1358 1364
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 1358-1364
    • Cox, D.W.1    Bizzintino, J.2    Ferrari, G.3    Khoo, S.K.4    Zhang, G.5    Whelan, S.6
  • 50
    • 79955674573 scopus 로고    scopus 로고
    • Association between human rhinovirus C and severity of acute asthma in children
    • J. Bizzintino, W.M. Lee, I.A. Laing, F. Vang, T. Pappas, G. Zhang, and et al. Association between human rhinovirus C and severity of acute asthma in children Eur Respir J 37 2011 1037 1042
    • (2011) Eur Respir J , vol.37 , pp. 1037-1042
    • Bizzintino, J.1    Lee, W.M.2    Laing, I.A.3    Vang, F.4    Pappas, T.5    Zhang, G.6
  • 52
    • 84943383139 scopus 로고    scopus 로고
    • Revisiting the hygiene hypothesis for allergy and asthma
    • A.H. Liu Revisiting the hygiene hypothesis for allergy and asthma J Allergy Clin Immunol 136 2015 860 865
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 860-865
    • Liu, A.H.1
  • 53
    • 0037136585 scopus 로고    scopus 로고
    • Environmental exposure to endotoxin and its relation to asthma in school-age children
    • C. Braun-Fahrlander, J. Riedler, U. Herz, W. Eder, M. Waser, L. Grize, and et al. Environmental exposure to endotoxin and its relation to asthma in school-age children N Engl J Med 347 2002 869 877
    • (2002) N Engl J Med , vol.347 , pp. 869-877
    • Braun-Fahrlander, C.1    Riedler, J.2    Herz, U.3    Eder, W.4    Waser, M.5    Grize, L.6
  • 54
    • 33747143424 scopus 로고    scopus 로고
    • Endotoxin exposure, CD14, and allergic disease: An interaction between genes and the environment
    • A. Simpson, S.L. John, F. Jury, R. Niven, A. Woodcock, W.E. Ollier, and et al. Endotoxin exposure, CD14, and allergic disease: an interaction between genes and the environment Am J Respir Crit Care Med 174 2006 386 392
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 386-392
    • Simpson, A.1    John, S.L.2    Jury, F.3    Niven, R.4    Woodcock, A.5    Ollier, W.E.6
  • 55
    • 0033129061 scopus 로고    scopus 로고
    • A polymorphism∗in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin e
    • M. Baldini, I.C. Lohman, M. Halonen, R.P. Erickson, P.G. Holt, and F.D. Martinez A polymorphism∗in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E Am J Respir Cell Mol Biol 20 1999 976 983
    • (1999) Am J Respir Cell Mol Biol , vol.20 , pp. 976-983
    • Baldini, M.1    Lohman, I.C.2    Halonen, M.3    Erickson, R.P.4    Holt, P.G.5    Martinez, F.D.6
  • 56
    • 20444500048 scopus 로고    scopus 로고
    • Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study
    • A. Zambelli-Weiner, E. Ehrlich, M.L. Stockton, A.V. Grant, S. Zhang, P.N. Levett, and et al. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study J Allergy Clin Immunol 115 2005 1203 1209
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 1203-1209
    • Zambelli-Weiner, A.1    Ehrlich, E.2    Stockton, M.L.3    Grant, A.V.4    Zhang, S.5    Levett, P.N.6
  • 60
    • 33746846152 scopus 로고    scopus 로고
    • Association between exposure to farming, allergies and genetic variation in CARD4/NOD1
    • W. Eder, W. Klimecki, L. Yu, E. von Mutius, J. Riedler, C. Braun-Fahrlander, and et al. Association between exposure to farming, allergies and genetic variation in CARD4/NOD1 Allergy 61 2006 1117 1124
    • (2006) Allergy , vol.61 , pp. 1117-1124
    • Eder, W.1    Klimecki, W.2    Yu, L.3    Von Mutius, E.4    Riedler, J.5    Braun-Fahrlander, C.6
  • 61
    • 84941102754 scopus 로고    scopus 로고
    • Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells
    • M.J. Schuijs, M.A. Willart, K. Vergote, D. Gras, K. Deswarte, M.J. Ege, and et al. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells Science 349 2015 1106 1110
    • (2015) Science , vol.349 , pp. 1106-1110
    • Schuijs, M.J.1    Willart, M.A.2    Vergote, K.3    Gras, D.4    Deswarte, K.5    Ege, M.J.6
  • 62
    • 68149139538 scopus 로고    scopus 로고
    • The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
    • L. Vereecke, R. Beyaert, and G. van Loo The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology Trends Immunol 30 2009 383 391
    • (2009) Trends Immunol , vol.30 , pp. 383-391
    • Vereecke, L.1    Beyaert, R.2    Van Loo, G.3
  • 63
    • 50449103533 scopus 로고    scopus 로고
    • Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    • S.L. Musone, K.E. Taylor, T.T. Lu, J. Nititham, R.C. Ferreira, W. Ortmann, and et al. Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus Nat Genet 40 2008 1062 1064
    • (2008) Nat Genet , vol.40 , pp. 1062-1064
    • Musone, S.L.1    Taylor, K.E.2    Lu, T.T.3    Nititham, J.4    Ferreira, R.C.5    Ortmann, W.6
  • 64
    • 73149110163 scopus 로고    scopus 로고
    • Host-microbial interactions in childhood atopy: Toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli
    • e1-5
    • J. Penders, C. Thijs, M. Mommers, E.E. Stobberingh, E. Dompeling, N.E. Reijmerink, and et al. Host-microbial interactions in childhood atopy: toll-like receptor 4 (TLR4), CD14, and fecal Escherichia coli J Allergy Clin Immunol 125 2010 231 236 e1-5
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 231-236
    • Penders, J.1    Thijs, C.2    Mommers, M.3    Stobberingh, E.E.4    Dompeling, E.5    Reijmerink, N.E.6
  • 66
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • L.A. Hindorff, P. Sethupathy, H.A. Junkins, E.M. Ramos, J.P. Mehta, F.S. Collins, and et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits Proc Natl Acad Sci U S A 106 2009 9362 9367
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3    Ramos, E.M.4    Mehta, J.P.5    Collins, F.S.6
  • 67
    • 77951439152 scopus 로고    scopus 로고
    • Trait-associated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS
    • D.L. Nicolae, E. Gamazon, W. Zhang, S. Duan, M.E. Dolan, and N.J. Cox Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS PLoS Genet 6 2010 e1000888
    • (2010) PLoS Genet , vol.6 , pp. e1000888
    • Nicolae, D.L.1    Gamazon, E.2    Zhang, W.3    Duan, S.4    Dolan, M.E.5    Cox, N.J.6
  • 68
    • 84922273141 scopus 로고    scopus 로고
    • Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
    • A. Gusev, S.H. Lee, G. Trynka, H. Finucane, B.J. Vilhjalmsson, H. Xu, and et al. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases Am J Hum Genet 95 2014 535 552
    • (2014) Am J Hum Genet , vol.95 , pp. 535-552
    • Gusev, A.1    Lee, S.H.2    Trynka, G.3    Finucane, H.4    Vilhjalmsson, B.J.5    Xu, H.6
  • 70
    • 84923276179 scopus 로고    scopus 로고
    • RNA splicing. the human splicing code reveals new insights into the genetic determinants of disease
    • H.Y. Xiong, B. Alipanahi, L.J. Lee, H. Bretschneider, D. Merico, R.K. Yuen, and et al. RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease Science 347 2015 1254806
    • (2015) Science , vol.347 , pp. 1254806
    • Xiong, H.Y.1    Alipanahi, B.2    Lee, L.J.3    Bretschneider, H.4    Merico, D.5    Yuen, R.K.6
  • 71
    • 84898723939 scopus 로고    scopus 로고
    • Joint analysis of functional genomic data and genome-wide association studies of 18 human traits
    • J.K. Pickrell Joint analysis of functional genomic data and genome-wide association studies of 18 human traits Am J Hum Genet 94 2014 559 573
    • (2014) Am J Hum Genet , vol.94 , pp. 559-573
    • Pickrell, J.K.1
  • 72
    • 84865822182 scopus 로고    scopus 로고
    • Systematic localization of common disease-associated variation in regulatory DNA
    • M.T. Maurano, R. Humbert, E. Rynes, R.E. Thurman, E. Haugen, H. Wang, and et al. Systematic localization of common disease-associated variation in regulatory DNA Science 337 2012 1190 1195
    • (2012) Science , vol.337 , pp. 1190-1195
    • Maurano, M.T.1    Humbert, R.2    Rynes, E.3    Thurman, R.E.4    Haugen, E.5    Wang, H.6
  • 73
  • 74
    • 84929001104 scopus 로고    scopus 로고
    • Human genomics. the genotype-tissue expression (GTEx) pilot analysis: Multitissue gene regulation in humans
    • GTEx Consortium Human genomics. The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans Science 348 2015 648 660
    • (2015) Science , vol.348 , pp. 648-660
  • 76
    • 77954524570 scopus 로고    scopus 로고
    • The ABCs of rhinoviruses, wheezing, and asthma
    • J.E. Gern The ABCs of rhinoviruses, wheezing, and asthma J Virol 84 2010 7418 7426
    • (2010) J Virol , vol.84 , pp. 7418-7426
    • Gern, J.E.1
  • 77
    • 0032937896 scopus 로고    scopus 로고
    • Association of rhinovirus infections with asthma
    • J.E. Gern, and W.W. Busse Association of rhinovirus infections with asthma Clin Microbiol Rev 12 1999 9 18
    • (1999) Clin Microbiol Rev , vol.12 , pp. 9-18
    • Gern, J.E.1    Busse, W.W.2
  • 78
    • 77952695527 scopus 로고    scopus 로고
    • The role of viruses in acute exacerbations of asthma
    • D.J. Jackson, and S.L. Johnston The role of viruses in acute exacerbations of asthma J Allergy Clin Immunol 125 2010 1178 1189
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1178-1189
    • Jackson, D.J.1    Johnston, S.L.2
  • 79
    • 84930336482 scopus 로고    scopus 로고
    • Host genetic variation influences gene expression response to rhinovirus infection
    • M. Caliskan, S.W. Baker, Y. Gilad, and C. Ober Host genetic variation influences gene expression response to rhinovirus infection PLoS Genet 11 2015 e1005111
    • (2015) PLoS Genet , vol.11 , pp. e1005111
    • Caliskan, M.1    Baker, S.W.2    Gilad, Y.3    Ober, C.4
  • 81
    • 84455202361 scopus 로고    scopus 로고
    • Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo
    • A. Bosco, S. Ehteshami, S. Panyala, and F.D. Martinez Interferon regulatory factor 7 is a major hub connecting interferon-mediated responses in virus-induced asthma exacerbations in vivo J Allergy Clin Immunol 129 2012 88 94
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 88-94
    • Bosco, A.1    Ehteshami, S.2    Panyala, S.3    Martinez, F.D.4
  • 83
    • 0034764068 scopus 로고    scopus 로고
    • Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types
    • J.H. Lee, N. Kaminski, G. Dolganov, G. Grunig, L. Koth, C. Solomon, and et al. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types Am J Respir Cell Mol Biol 25 2001 474 485
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 474-485
    • Lee, J.H.1    Kaminski, N.2    Dolganov, G.3    Grunig, G.4    Koth, L.5    Solomon, C.6
  • 85
    • 84862794288 scopus 로고    scopus 로고
    • Epigenetics, asthma, and allergic diseases: A review of the latest advancements
    • S. Lovinsky-Desir, and R.L. Miller Epigenetics, asthma, and allergic diseases: a review of the latest advancements Curr Allergy Asthma Rep 12 2012 211 220
    • (2012) Curr Allergy Asthma Rep , vol.12 , pp. 211-220
    • Lovinsky-Desir, S.1    Miller, R.L.2
  • 86
    • 84858148674 scopus 로고    scopus 로고
    • Epigenetics mediate environment: Gene effects on occupational sensitization
    • K.A. Pacheco Epigenetics mediate environment: gene effects on occupational sensitization Curr Opin Allergy Clin Immunol 12 2012 111 118
    • (2012) Curr Opin Allergy Clin Immunol , vol.12 , pp. 111-118
    • Pacheco, K.A.1
  • 87
    • 84863338135 scopus 로고    scopus 로고
    • Environmental chemical exposures and human epigenetics
    • L. Hou, X. Zhang, D. Wang, and A. Baccarelli Environmental chemical exposures and human epigenetics Int J Epidemiol 41 2012 79 105
    • (2012) Int J Epidemiol , vol.41 , pp. 79-105
    • Hou, L.1    Zhang, X.2    Wang, D.3    Baccarelli, A.4
  • 88
    • 84897997332 scopus 로고    scopus 로고
    • GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease
    • Y. Liu, X. Li, M.J. Aryee, T.J. Ekstrom, L. Padyukov, L. Klareskog, and et al. GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease Am J Hum Genet 94 2014 485 495
    • (2014) Am J Hum Genet , vol.94 , pp. 485-495
    • Liu, Y.1    Li, X.2    Aryee, M.J.3    Ekstrom, T.J.4    Padyukov, L.5    Klareskog, L.6
  • 89
    • 84904266885 scopus 로고    scopus 로고
    • The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes
    • A.L. Teh, H. Pan, L. Chen, M.L. Ong, S. Dogra, J. Wong, and et al. The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes Genome Res 24 2014 1064 1074
    • (2014) Genome Res , vol.24 , pp. 1064-1074
    • Teh, A.L.1    Pan, H.2    Chen, L.3    Ong, M.L.4    Dogra, S.5    Wong, J.6
  • 90
    • 84907584646 scopus 로고    scopus 로고
    • Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels
    • N.E. Banovich, X. Lan, G. McVicker, B. van de Geijn, J.F. Degner, J.D. Blischak, and et al. Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels PLoS Genet 10 2014 e1004663
    • (2014) PLoS Genet , vol.10 , pp. e1004663
    • Banovich, N.E.1    Lan, X.2    McVicker, G.3    Van De Geijn, B.4    Degner, J.F.5    Blischak, J.D.6
  • 91
    • 79960688508 scopus 로고    scopus 로고
    • DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
    • J.T. Bell, A.A. Pai, J.K. Pickrell, D.J. Gaffney, R. Pique-Regi, J.F. Degner, and et al. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines Genome Biol 12 2011 R10
    • (2011) Genome Biol , vol.12 , pp. R10
    • Bell, J.T.1    Pai, A.A.2    Pickrell, J.K.3    Gaffney, D.J.4    Pique-Regi, R.5    Degner, J.F.6
  • 92
    • 84879055641 scopus 로고    scopus 로고
    • Passive and active DNA methylation and the interplay with genetic variation in gene regulation
    • M. Gutierrez-Arcelus, T. Lappalainen, S.B. Montgomery, A. Buil, H. Ongen, A. Yurovsky, and et al. Passive and active DNA methylation and the interplay with genetic variation in gene regulation Elife 2 2013 e00523
    • (2013) Elife , vol.2 , pp. e00523
    • Gutierrez-Arcelus, M.1    Lappalainen, T.2    Montgomery, S.B.3    Buil, A.4    Ongen, H.5    Yurovsky, A.6
  • 93
    • 84923899955 scopus 로고    scopus 로고
    • Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci
    • M. Lemire, S.H. Zaidi, M. Ban, B. Ge, D. Aissi, M. Germain, and et al. Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci Nat Commun 6 2015 6326
    • (2015) Nat Commun , vol.6 , pp. 6326
    • Lemire, M.1    Zaidi, S.H.2    Ban, M.3    Ge, B.4    Aissi, D.5    Germain, M.6
  • 94
    • 84921320301 scopus 로고    scopus 로고
    • Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue
    • J. Shi, C.N. Marconett, J. Duan, P.L. Hyland, P. Li, Z. Wang, and et al. Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue Nat Commun 5 2014 3365
    • (2014) Nat Commun , vol.5 , pp. 3365
    • Shi, J.1    Marconett, C.N.2    Duan, J.3    Hyland, P.L.4    Li, P.5    Wang, Z.6
  • 95
    • 84928819497 scopus 로고    scopus 로고
    • An epigenome-wide association study of total serum immunoglobulin e concentration
    • L. Liang, S.A. Willis-Owen, C. Laprise, K.C. Wong, G.A. Davies, T.J. Hudson, and et al. An epigenome-wide association study of total serum immunoglobulin E concentration Nature 520 2015 670 674
    • (2015) Nature , vol.520 , pp. 670-674
    • Liang, L.1    Willis-Owen, S.A.2    Laprise, C.3    Wong, K.C.4    Davies, G.A.5    Hudson, T.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.