-
1
-
-
84889608694
-
EAACI position statement on asthma exacerbations and severe asthma
-
Custovic A, Johnston SL, Pavord I, et al. EAACI position statement on asthma exacerbations and severe asthma. Allergy. 2013;68:1520-1531.
-
(2013)
Allergy.
, vol.68
, pp. 1520-1531
-
-
Custovic, A.1
Johnston, S.L.2
Pavord, I.3
-
3
-
-
0038179363
-
A comprehensive study of the direct and indirect costs of adult asthma
-
Cisternas MG, Blanc PD, Yen IH, et al. A comprehensive study of the direct and indirect costs of adult asthma. J Allergy Clin Immunol. 2003;111:1212-1218.
-
(2003)
J Allergy Clin Immunol.
, vol.111
, pp. 1212-1218
-
-
Cisternas, M.G.1
Blanc, P.D.2
Yen, I.H.3
-
4
-
-
10744231300
-
The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma
-
European Network for Understanding Mechanisms of Severe Asthma. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J. 2003;22:470-477.
-
(2003)
Eur Respir J.
, vol.22
, pp. 470-477
-
-
European Network for Understanding Mechanisms of Severe Asthma1
-
5
-
-
77956827165
-
Refractory asthma in the UK: Cross-sectional findings from a UK multicentre registry
-
Heaney LG, Brightling CE, Menzies-Gow A, Stevenson M, Niven RM. Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry. Thorax. 2010;65:787-794.
-
(2010)
Thorax.
, vol.65
, pp. 787-794
-
-
Heaney, L.G.1
Brightling, C.E.2
Menzies-Gow, A.3
Stevenson, M.4
Niven, R.M.5
-
6
-
-
33845987340
-
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
-
Moore WC, Bleecker ER, Curran-Everett D, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol. 2007;119(2):405-413.
-
(2007)
J Allergy Clin Immunol.
, vol.119
, Issue.2
, pp. 405-413
-
-
Moore, W.C.1
Bleecker, E.R.2
Curran-Everett, D.3
-
7
-
-
0036810356
-
Mechanisms involved in the side effects of glucocorticoids
-
Schäcke H, Döcke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther. 2002;96:23-43.
-
(2002)
Pharmacol Ther.
, vol.96
, pp. 23-43
-
-
Schäcke, H.1
Döcke, W.D.2
Asadullah, K.3
-
8
-
-
84893513577
-
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
-
Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43:343-373.
-
(2014)
Eur Respir J.
, vol.43
, pp. 343-373
-
-
Chung, K.F.1
Wenzel, S.E.2
Brozek, J.L.3
-
9
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009;360:973-984.
-
(2009)
N Engl J Med.
, vol.360
, pp. 973-984
-
-
Haldar, P.1
Brightling, C.E.2
Hargadon, B.3
-
10
-
-
84865145614
-
Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
-
Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380:651-659.
-
(2012)
Lancet.
, vol.380
, pp. 651-659
-
-
Pavord, I.D.1
Korn, S.2
Howarth, P.3
-
11
-
-
76749166956
-
IgE, mast cells, basophils, and eosinophils
-
Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S73-S80.
-
(2010)
J Allergy Clin Immunol.
, vol.125
, Issue.2
, pp. S73-S80
-
-
Stone, K.D.1
Prussin, C.2
Metcalfe, D.D.3
-
13
-
-
0025037094
-
Eosinophilic inflammation in asthma
-
Bousquet J, Chanez P, Lacoste JY, et al. Eosinophilic inflammation in asthma. N Engl J Med. 1990;323(15):1033-1039.
-
(1990)
N Engl J Med.
, vol.323
, Issue.15
, pp. 1033-1039
-
-
Bousquet, J.1
Chanez, P.2
Lacoste, J.Y.3
-
14
-
-
0036346110
-
New insights into the relationship between airway inflammation and asthma
-
Wardlaw AJ, Brightling CE, Green R, Woltmann G, Bradding P, Pavord ID. New insights into the relationship between airway inflammation and asthma. Clin Sci (Lond). 2002;103(2):201-211.
-
(2002)
Clin Sci (Lond).
, vol.103
, Issue.2
, pp. 201-211
-
-
Wardlaw, A.J.1
Brightling, C.E.2
Green, R.3
Woltmann, G.4
Bradding, P.5
Pavord, I.D.6
-
15
-
-
0032875377
-
Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
-
Wenzel SE, Schwartz LB, Langmack EL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med. 1999;160(3):1001-1008.
-
(1999)
Am J Respir Crit Care Med.
, vol.160
, Issue.3
, pp. 1001-1008
-
-
Wenzel, S.E.1
Schwartz, L.B.2
Langmack, E.L.3
-
16
-
-
69249150516
-
T-helper type 2-driven inflammation defines major subphenotypes of asthma
-
Woodruff PG, Modrek B, Choy DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009;180(5):388-395.
-
(2009)
Am J Respir Crit Care Med.
, vol.180
, Issue.5
, pp. 388-395
-
-
Woodruff, P.G.1
Modrek, B.2
Choy, D.F.3
-
17
-
-
22144452574
-
Severe asthma in adults
-
Wenzel S. Severe asthma in adults. Am J Respir Crit Care Med. 2005;172(2):149-160.
-
(2005)
Am J Respir Crit Care Med.
, vol.172
, Issue.2
, pp. 149-160
-
-
Wenzel, S.1
-
18
-
-
84973462203
-
-
Napoli, Italy: Idelson-Gnocchi; ISBN 9788879475419
-
Becchetti E, Bani D, Baroni T. Istologia Umana. Napoli, Italy: Idelson-Gnocchi; 2011:393-394. ISBN 9788879475419.
-
(2011)
Istologia Umana
, pp. 393-394
-
-
Becchetti, E.1
Bani, D.2
Baroni, T.3
-
20
-
-
84860010929
-
Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor
-
Molfino NA, Gossage D, Kolbeck R, Parker JM, Geba GP. Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clin Exp Allergy. 2012;42:712-737.
-
(2012)
Clin Exp Allergy.
, vol.42
, pp. 712-737
-
-
Molfino, N.A.1
Gossage, D.2
Kolbeck, R.3
Parker, J.M.4
Geba, G.P.5
-
21
-
-
0034655647
-
Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist
-
Rossjohn J, McKinstry WJ, Woodcock JM, et al. Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist. Blood. 2000;95:2491-2498.
-
(2000)
Blood.
, vol.95
, pp. 2491-2498
-
-
Rossjohn, J.1
McKinstry, W.J.2
Woodcock, J.M.3
-
22
-
-
0043271086
-
Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: Significance for mobilization of haemopoietic progenitor cells in allergic inflammation
-
Sehmi R, Dorman S, Baatjes A, et al. Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation. Immunology. 2003;109:536-546.
-
(2003)
Immunology.
, vol.109
, pp. 536-546
-
-
Sehmi, R.1
Dorman, S.2
Baatjes, A.3
-
23
-
-
0037222932
-
The CCR3 receptor is involved in eosinophil differentiation and is up-regulated by Th2 cytokines in CD34+ progenitor cells
-
Lamkhioued B, Abdelilah SG, Hamid Q, Mansour N, Delespesse G, Renzi PM. The CCR3 receptor is involved in eosinophil differentiation and is up-regulated by Th2 cytokines in CD34+ progenitor cells. J Immunol. 2003;170:537-547.
-
(2003)
J Immunol.
, vol.170
, pp. 537-547
-
-
Lamkhioued, B.1
Abdelilah, S.G.2
Hamid, Q.3
Mansour, N.4
Delespesse, G.5
Renzi, P.M.6
-
24
-
-
0042573806
-
Association of interleukin-5 and eotaxin with acute exacerbation of asthma
-
Park SW, Kim DJ, Chang HS, et al. Association of interleukin-5 and eotaxin with acute exacerbation of asthma. Int Arch Allergy Immunol. 2003;131:283-290.
-
(2003)
Int Arch Allergy Immunol.
, vol.131
, pp. 283-290
-
-
Park, S.W.1
Kim, D.J.2
Chang, H.S.3
-
25
-
-
6644229440
-
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response
-
Leckie MJ, ten Brinke A, Khan J, et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 2000;356:2144-2148.
-
(2000)
Lancet.
, vol.356
, pp. 2144-2148
-
-
Leckie, M.J.1
ten Brinke, A.2
Khan, J.3
-
26
-
-
0037590906
-
Anti-interleukin-5 monoclonal antibodies: Preclinical and clinical evidence in asthma models
-
Leckie MJ. Anti-interleukin-5 monoclonal antibodies: preclinical and clinical evidence in asthma models. Am J Respir Med. 2003;2:245-259.
-
(2003)
Am J Respir Med.
, vol.2
, pp. 245-259
-
-
Leckie, M.J.1
-
27
-
-
36749065556
-
A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma
-
Flood-Page P, Swenson C, Faiferman I, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med. 2007;176(11):1062-1071.
-
(2007)
Am J Respir Crit Care Med.
, vol.176
, Issue.11
, pp. 1062-1071
-
-
Flood-Page, P.1
Swenson, C.2
Faiferman, I.3
-
28
-
-
0037393468
-
Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
-
Menzies-Gow A, Flood-Page P, Sehmi R, et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol. 2003;111:714-719.
-
(2003)
J Allergy Clin Immunol.
, vol.111
, pp. 714-719
-
-
Menzies-Gow, A.1
Flood-Page, P.2
Sehmi, R.3
-
29
-
-
61849155730
-
Mepolizumab for prednisone dependent asthma with sputum eosinophilia
-
Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone dependent asthma with sputum eosinophilia. N Engl J Med. 2009;360:985-993.
-
(2009)
N Engl J Med.
, vol.360
, pp. 985-993
-
-
Nair, P.1
Pizzichini, M.M.2
Kjarsgaard, M.3
-
30
-
-
0032732953
-
Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys
-
Zia-Amirhosseini P, Minthorn E, Benincosa LJ, et al. Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. J Pharmacol Exp Ther. 1999;291(3):1060-1067.
-
(1999)
J Pharmacol Exp Ther.
, vol.291
, Issue.3
, pp. 1060-1067
-
-
Zia-Amirhosseini, P.1
Minthorn, E.2
Benincosa, L.J.3
-
31
-
-
40949146020
-
Treatment of patients with the hypereosinophilic syndrome with mepolizumab
-
Rothenberg ME, Klion AD, Roufosse FE, et al. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med. 2008;358(12):1215-1228.
-
(2008)
N Engl J Med.
, vol.358
, Issue.12
, pp. 1215-1228
-
-
Rothenberg, M.E.1
Klion, A.D.2
Roufosse, F.E.3
-
32
-
-
84973511585
-
-
FDA News Release. November 4. Accessed January 10, 2016
-
U.S. Food and Drug Administration. FDA approves Nucala to treat severe asthma. FDA News Release. 2015 November 4. Available from http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm471031.htm. Accessed January 10, 2016.
-
(2015)
FDA approves Nucala to treat severe asthma
-
-
-
33
-
-
84973511584
-
-
updated on 15/04/2016] http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003860/human_med_. Accessed May 5, 2016
-
http://www.ema.europa.eu/ema. Nucala authorisation details [updated on 15/04/2016]. Available from: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/003860/human_med_. Accessed May 5, 2016.
-
Nucala authorisation details
-
-
-
34
-
-
84919774163
-
Characterisation of an OCS-dependent severe asthma population treated with mepolizumab
-
Prazma CM, Wenzel S, Barnes N, Douglass JA, Hartley BF, Ortega H. Characterisation of an OCS-dependent severe asthma population treated with mepolizumab. Thorax. 2014;69(12):1141-1142.
-
(2014)
Thorax.
, vol.69
, Issue.12
, pp. 1141-1142
-
-
Prazma, C.M.1
Wenzel, S.2
Barnes, N.3
Douglass, J.A.4
Hartley, B.F.5
Ortega, H.6
-
36
-
-
84907424177
-
Mepolizumab treatment in patients with severe eosinophilic asthma
-
Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014;371(13):1198-1207.
-
(2014)
N Engl J Med.
, vol.371
, Issue.13
, pp. 1198-1207
-
-
Ortega, H.G.1
Liu, M.C.2
Pavord, I.D.3
-
37
-
-
84907423833
-
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma
-
Bel EH, Wenzel SE, Thompson PJ, et al. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med. 2014;371(13):1189-2119.
-
(2014)
N Engl J Med.
, vol.371
, Issue.13
, pp. 1189-2119
-
-
Bel, E.H.1
Wenzel, S.E.2
Thompson, P.J.3
-
38
-
-
85029872288
-
Mepolizumab versus placebo for asthma
-
Powell C, Milan SJ, Dwan K, Bax L, Walters N. Mepolizumab versus placebo for asthma. Cochrane Database Syst Rev. 2015;7:CD010834.
-
(2015)
Cochrane Database Syst Rev.
, vol.7
-
-
Powell, C.1
Milan, S.J.2
Dwan, K.3
Bax, L.4
Walters, N.5
-
40
-
-
84871187792
-
Importance of fiberoptic bronchoscopy in identifying asthma phenotypes to direct personalized therapy
-
Lommatzsch SE, Martin RJ, Good JT Jr. Importance of fiberoptic bronchoscopy in identifying asthma phenotypes to direct personalized therapy. Curr Opin Pulm Med. 2013;19(1):42-48.
-
(2013)
Curr Opin Pulm Med.
, vol.19
, Issue.1
, pp. 42-48
-
-
Lommatzsch, S.E.1
Martin, R.J.2
Good, J.T.3
-
41
-
-
0030294245
-
Bronchoscopy as a research tool for the study of asthma pathogenesis and effects of antiasthma drugs
-
discussion S64-S66
-
Djukanović R. Bronchoscopy as a research tool for the study of asthma pathogenesis and effects of antiasthma drugs. J Allergy Clin Immunol. 1996;98(5 Pt 2):S41-S45; discussion S64-S66.
-
(1996)
J Allergy Clin Immunol.
, vol.98
, Issue.5
, pp. S41-S45
-
-
Djukanović, R.1
-
42
-
-
84903608027
-
Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma
-
Katz LE, Gleich GJ, Hartley BF, Yancey SW, Ortega HG. Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma. Ann Am Thorac Soc. 2014;11(4):531-536.
-
(2014)
Ann Am Thorac Soc.
, vol.11
, Issue.4
, pp. 531-536
-
-
Katz, L.E.1
Gleich, G.J.2
Hartley, B.F.3
Yancey, S.W.4
Ortega, H.G.5
-
43
-
-
0031900026
-
Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma
-
Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax. 1998;53(2):91-95.
-
(1998)
Thorax.
, vol.53
, Issue.2
, pp. 91-95
-
-
Jatakanon, A.1
Lim, S.2
Kharitonov, S.A.3
Chung, K.F.4
Barnes, P.J.5
-
44
-
-
78649530294
-
Exhaled nitric oxide thresholds associated with a sputum eosinophil count $3% in a cohort of unselected patients with asthma
-
Schleich FN, Seidel L, Sele J, et al. Exhaled nitric oxide thresholds associated with a sputum eosinophil count $3% in a cohort of unselected patients with asthma. Thorax. 2010;65(12):1039-1044.
-
(2010)
Thorax.
, vol.65
, Issue.12
, pp. 1039-1044
-
-
Schleich, F.N.1
Seidel, L.2
Sele, J.3
-
45
-
-
84921321823
-
External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma
-
Wagener AH, de Nijs SB, Lutter R, et al. External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma. Thorax. 2015;70(2):115-120.
-
(2015)
Thorax.
, vol.70
, Issue.2
, pp. 115-120
-
-
Wagener, A.H.1
de Nijs, S.B.2
Lutter, R.3
-
46
-
-
84942809764
-
Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes
-
Westerhof GA, Korevaar DA, Amelink M, et al. Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes. Eur Respir J. 2015;46(3):688-696.
-
(2015)
Eur Respir J.
, vol.46
, Issue.3
, pp. 688-696
-
-
Westerhof, G.A.1
Korevaar, D.A.2
Amelink, M.3
-
48
-
-
84865696394
-
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
-
Jia G, Erickson RW, Choy DF, et al. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol. 2012;130(3):647-654.
-
(2012)
J Allergy Clin Immunol.
, vol.130
, Issue.3
, pp. 647-654
-
-
Jia, G.1
Erickson, R.W.2
Choy, D.F.3
-
49
-
-
0038643527
-
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
-
Kips JC, O' Connor BJ, Langley SJ, et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am J Respir Crit Care Med. 2003;167(12): 1655-1659.
-
(2003)
Am J Respir Crit Care Med.
, vol.167
, Issue.12
, pp. 1655-1659
-
-
Kips, J.C.1
O' Connor, B.J.2
Langley, S.J.3
-
50
-
-
0001269056
-
Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity
-
Egan R, Athwal D, Bodmer M, et al. Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity. Arzneimittelforschung. 1999;49:779-790.
-
(1999)
Arzneimittelforschung.
, vol.49
, pp. 779-790
-
-
Egan, R.1
Athwal, D.2
Bodmer, M.3
-
51
-
-
33750508779
-
Nasal IL-5 levels deter-mine the response to anti-IL-5 treatment in patients with nasal polyps
-
Gevaert P, Lang-Loidolt D, Lackner A, et al. Nasal IL-5 levels deter-mine the response to anti-IL-5 treatment in patients with nasal polyps. J Allergy Clin Immunol. 2006;118(5):1133-1141.
-
(2006)
J Allergy Clin Immunol.
, vol.118
, Issue.5
, pp. 1133-1141
-
-
Gevaert, P.1
Lang-Loidolt, D.2
Lackner, A.3
-
52
-
-
84924117461
-
A randomized phase 3 study of the efficacy and safety of reslizumab in subjects with asthma with elevated eosinophils
-
Bjermer CL, Maspero J, Ciesielska M, O'Brien C, Zangrilli J. A randomized phase 3 study of the efficacy and safety of reslizumab in subjects with asthma with elevated eosinophils. Eur Respir J. 2014;44(58):299.
-
(2014)
Eur Respir J.
, vol.44
, Issue.58
, pp. 299
-
-
Bjermer, C.L.1
Maspero, J.2
Ciesielska, M.3
O'Brien, C.4
Zangrilli, J.5
-
53
-
-
81455155725
-
Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
-
Castro M, Mathur S, Hargreave F, et al. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med. 2011;184(10):1125-1132.
-
(2011)
Am J Respir Crit Care Med.
, vol.184
, Issue.10
, pp. 1125-1132
-
-
Castro, M.1
Mathur, S.2
Hargreave, F.3
-
54
-
-
77952733788
-
MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
-
Kolbeck R, Kozhich A, Koike M, Peng L, Andersson CK, Damschroder MM. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol. 2010;125(6):1344-1353.
-
(2010)
J Allergy Clin Immunol.
, vol.125
, Issue.6
, pp. 1344-1353
-
-
Kolbeck, R.1
Kozhich, A.2
Koike, M.3
Peng, L.4
Andersson, C.K.5
Damschroder, M.M.6
-
55
-
-
84055199162
-
Benralizumab-a humanized mAb to IL-5Ralpha with enhanced antibody-dependent cell-mediated cytotoxicity-a novel approach for the treatment of asthma
-
Ghazi A, Trikha A, Calhoun WJ. Benralizumab-a humanized mAb to IL-5Ralpha with enhanced antibody-dependent cell-mediated cytotoxicity-a novel approach for the treatment of asthma. Expert Opin Biol Ther. 2012;12(1):113-118.
-
(2012)
Expert Opin Biol Ther.
, vol.12
, Issue.1
, pp. 113-118
-
-
Ghazi, A.1
Trikha, A.2
Calhoun, W.J.3
-
56
-
-
84919382915
-
Benralizumab, an anti-interleukin 5 receptor alpha monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: A phase 2b randomised dose-ranging study
-
Castro M, Wenzel SE, Bleecker ER, et al. Benralizumab, an anti-interleukin 5 receptor alpha monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study. Lancet Respir Med. 2014;2(11):879-890.
-
(2014)
Lancet Respir Med.
, vol.2
, Issue.11
, pp. 879-890
-
-
Castro, M.1
Wenzel, S.E.2
Bleecker, E.R.3
-
57
-
-
84959475061
-
Reductions in eosinophil biomarkers by benralizumab in patients with asthma
-
Pham TH, Damera G, Newbold P, Ranade K. Reductions in eosinophil biomarkers by benralizumab in patients with asthma. Respir Med. 2016;111:21-29.
-
(2016)
Respir Med.
, vol.111
, pp. 21-29
-
-
Pham, T.H.1
Damera, G.2
Newbold, P.3
Ranade, K.4
-
58
-
-
84896701005
-
Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: A 12-month follow-up analysis
-
Haldar P, Brightling CE, Singapuri A. Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis. J Allergy Clin Immunol. 2014;133(3):921-923.
-
(2014)
J Allergy Clin Immunol.
, vol.133
, Issue.3
, pp. 921-923
-
-
Haldar, P.1
Brightling, C.E.2
Singapuri, A.3
-
59
-
-
9644287854
-
Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti-IL-5 antibody SCH55700
-
Kim YJ, Martin Prussin CB, Law MA, et al. Rebound eosinophilia after treatment of hypereosinophilic syndrome and eosinophilic gastroenteritis with monoclonal anti-IL-5 antibody SCH55700. J Allergy Clin Immunol. 2004;114:1449-1455.
-
(2004)
J Allergy Clin Immunol.
, vol.114
, pp. 1449-1455
-
-
Kim, Y.J.1
Martin Prussin, C.B.2
Law, M.A.3
-
63
-
-
84973453308
-
Cost-effectiveness of refractory asthma treatment strategies: A decision tree analysis
-
Philadelphia, PA
-
Bogart M, Roberts A, Wheeler S. Cost-effectiveness of refractory asthma treatment strategies: a decision tree analysis. In: ISPOR 20th Annual International Meeting, Philadelphia, PA; 2015.
-
(2015)
ISPOR 20th Annual International Meeting
-
-
Bogart, M.1
Roberts, A.2
Wheeler, S.3
-
65
-
-
84962016441
-
Comorbidity in severe asthma requiring systemic corticosteroid therapy: Cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry. British Thoracic Society Difficult Asthma Network
-
Sweeney J, Patterson CC, Menzies-Gow A, et al. Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry. British Thoracic Society Difficult Asthma Network. Thorax. 2016;71(4):339-346.
-
(2016)
Thorax.
, vol.71
, Issue.4
, pp. 339-346
-
-
Sweeney, J.1
Patterson, C.C.2
Menzies-Gow, A.3
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