Inhibition of bile canalicular network formation in rat sandwich cultured hepatocytes by drugs associated with risk of severe liver injury

Toxicology in Vitro

Volumn 35, Issue , 2016, Pages 121-130

  Takemura, Akinori ^a   Izaki, Aya ^a   Sekine, Shuichi ^a   Ito, Kousei ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Bile canaliculus; Cholestasis; Hepatotoxicity; In vitro screening; Jaundice; Sandwich cultured hepatocytes

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMIODARONE; AMITRIPTYLINE; BENZBROMARONE; CARBAMAZEPINE; CHLORPROMAZINE; CYCLOSPORIN A; ERYTHROMYCIN; ETHINYLESTRADIOL; FENOFIBRATE; FLUTAMIDE; GLIBENCLAMIDE; HALOPERIDOL; IMIPRAMINE; INDOMETACIN; LACTOSE DEHYDROGENASE; OXIDOREDUCTASE; PHENFORMIN; PHENYTOIN; PIOGLITAZONE; PIROXICAM; ROSIGLITAZONE; TETRACYCLINE; TICLOPIDINE; TROGLITAZONE; UNCLASSIFIED DRUG; VERAPAMIL; LACTATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE CANALICULUS; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE SEVERITY; DRUG POTENCY; IC50; IMMUNOFLUORESCENCE; IN VITRO STUDY; INHIBITION CONSTANT; LIVER CELL CULTURE; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; RISK ASSESSMENT; RISK FACTOR; TOXIC HEPATITIS; ANIMAL; CELL CULTURE; CELL SURVIVAL; DRUG EFFECTS; LIVER CELL; METABOLISM; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; BILE CANALICULI; CELL SURVIVAL; CELLS, CULTURED; CHEMICAL AND DRUG INDUCED LIVER INJURY; HEPATOCYTES; L-LACTATE DEHYDROGENASE; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84973380304     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2016.05.016     Document Type: Article

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