Conversion of leucine to β-hydroxy-β-methylbutyrate by α-keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes

Journal of Cachexia, Sarcopenia and Muscle

Volumn 7, Issue 1, 2016, Pages 68-78

  Girón, María D ^a   Vílchez, José D ^a   Salto, Rafael ^a   Manzano, Manuel ^b   Sevillano, Natalia ^a   Campos, Nefertiti ^b   Argilés, Josep M ^c   Rueda, Ricardo ^b   López Pedrosa, José M ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b ABBOTT LABORATORIES   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

MTOR, leucine; Protein synthesis; Skeletal muscle; Hydroxy methylbutyrate

Indexed keywords

ALPHA KETO ISOCAPROATE DIOXYGENASE; BETA HYDROXY BETA METHYLBUTYRATE; DIOXYGENASE; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MUSCLE PROTEIN; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; IN VITRO STUDY; MUSCLE CELL; MUSCLE DEVELOPMENT; MUSCLE GROWTH; MYOBLAST; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WASTING SYNDROME;

EID: 84973256069     PISSN: 21905991     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcsm.12032     Document Type: Article

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