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Volumn 40, Issue 7, 2016, Pages 1143-1149

Treatment with TUG891, a free fatty acid receptor 4 agonist, restores adipose tissue metabolic dysfunction following chronic sleep fragmentation in mice

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; HUMAN INSULIN; PROTEIN INHIBITOR; PROTEIN KINASE B; TUG891; UNCLASSIFIED DRUG; 3-(4-((4-FLUORO-4'-METHYL-(1,1'-BIPHENYL)-2-YL)METHOXY)PHENYL)PROPANOIC ACID; BIPHENYL DERIVATIVE; G PROTEIN COUPLED RECEPTOR; INSULIN; O3FAR1 PROTEIN, MOUSE; PHENYLPROPIONIC ACID DERIVATIVE;

EID: 84973162103     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2016.37     Document Type: Article
Times cited : (24)

References (48)
  • 2
    • 80052021813 scopus 로고    scopus 로고
    • Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases
    • Talukdar S, Olefsky JM, Osborn O. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci 2011; 32: 543-550
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 543-550
    • Talukdar, S.1    Olefsky, J.M.2    Osborn, O.3
  • 3
    • 77956165390 scopus 로고    scopus 로고
    • GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulinsensitizing effects
    • Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulinsensitizing effects. Cell 2010; 142: 687-698
    • (2010) Cell , vol.142 , pp. 687-698
    • Oh, D.Y.1    Talukdar, S.2    Bae, E.J.3    Imamura, T.4    Morinaga, H.5    Fan, W.6
  • 5
    • 84937576781 scopus 로고    scopus 로고
    • Dietary fatty acids and their potential for controlling metabolic diseases through activation of FFA4/GPR120
    • Ulven T, Christiansen E. Dietary fatty acids and their potential for controlling metabolic diseases through activation of FFA4/GPR120. Annu Rev Nutr 2015; 35: 239-263
    • (2015) Annu Rev Nutr , vol.35 , pp. 239-263
    • Ulven, T.1    Christiansen, E.2
  • 8
    • 84901846320 scopus 로고    scopus 로고
    • G-protein-coupled receptors for free fatty acids: Nutritional and therapeutic targets
    • Milligan G, Ulven T, Murdoch H, Hudson BD. G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets. Br J Nutr 2014; 111 (Suppl 1): S3-S7
    • (2014) Br J Nutr , vol.111 , pp. S3-S7
    • Milligan, G.1    Ulven, T.2    Murdoch, H.3    Hudson, B.D.4
  • 10
    • 84881341125 scopus 로고    scopus 로고
    • Obstructive sleep apnea: A cardiometabolic risk in obesity and the metabolic syndrome
    • Drager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol 2013; 62: 569-576
    • (2013) J Am Coll Cardiol , vol.62 , pp. 569-576
    • Drager, L.F.1    Togeiro, S.M.2    Polotsky, V.Y.3    Lorenzi-Filho, G.4
  • 11
    • 84881246895 scopus 로고    scopus 로고
    • Obstructive sleep apnoea in adults: A common chronic condition in need of a comprehensive chronic condition management approach
    • Heatley EM, Harris M, Battersby M, McEvoy RD, Chai-Coetzer CL, Antic NA. Obstructive sleep apnoea in adults: a common chronic condition in need of a comprehensive chronic condition management approach. Sleep Med Rev 2013; 17: 349-355
    • (2013) Sleep Med Rev , vol.17 , pp. 349-355
    • Heatley, E.M.1    Harris, M.2    Battersby, M.3    McEvoy, R.D.4    Chai-Coetzer, C.L.5    Antic, N.A.6
  • 12
    • 84865712590 scopus 로고    scopus 로고
    • American academy of pediatrics diagnosis and management of childhood obstructive sleep apnea syndrome
    • Marcus CL, Brooks LJ, Draper KA, Gozal D, Halbower AC, Jones J, et al. American Academy of Pediatrics. Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics 2012; 130: e714-e755
    • (2012) Pediatrics , vol.130 , pp. e714-e755
    • Marcus, C.L.1    Brooks, L.J.2    Draper, K.A.3    Gozal, D.4    Halbower, A.C.5    Jones, J.6
  • 13
    • 77950520275 scopus 로고    scopus 로고
    • Dietary and physical activity patterns in children with obstructive sleep apnea
    • 730.e1-730.e3
    • Spruyt K, Sans Capdevila O, Serpero LD, Kheirandish-Gozal L, Gozal D. Dietary and physical activity patterns in children with obstructive sleep apnea. J Pediatr 2010; 156: 724-730, 730.e1-730.e3
    • (2010) J Pediatr , vol.156 , pp. 724-730
    • Spruyt, K.1    Sans Capdevila, O.2    Serpero, L.D.3    Kheirandish-Gozal, L.4    Gozal, D.5
  • 15
    • 84898927417 scopus 로고    scopus 로고
    • Liking for high fat foods in patients with obstructive sleep apnoea
    • Smith SS, Waight C, Doyle G, Rossa KR, Sullivan KA. Liking for high fat foods in patients with obstructive sleep apnoea. Appetite 2014; 78: 185-192
    • (2014) Appetite , vol.78 , pp. 185-192
    • Smith, S.S.1    Waight, C.2    Doyle, G.3    Rossa, K.R.4    Sullivan, K.A.5
  • 16
    • 84946499740 scopus 로고    scopus 로고
    • Obesity and altered sleep: A pathway to metabolic derangements in children?
    • Hakim F, Kheirandish-Gozal L, Gozal D. Obesity and altered sleep: a pathway to metabolic derangements in children?. Semin Pediatr Neurol 2015; 22: 77-85
    • (2015) Semin Pediatr Neurol , vol.22 , pp. 77-85
    • Hakim, F.1    Kheirandish-Gozal, L.2    Gozal, D.3
  • 17
    • 84979854859 scopus 로고    scopus 로고
    • Metabolic and glycemic sequelae of sleep disturbances in children and adults
    • Koren D, O'Sullivan KL, Mokhlesi B. Metabolic and glycemic sequelae of sleep disturbances in children and adults. Curr Diab Rep 2015; 15: 562
    • (2015) Curr Diab Rep , vol.15 , pp. 562
    • Koren, D.1    O'Sullivan, K.L.2    Mokhlesi, B.3
  • 18
    • 84899680775 scopus 로고    scopus 로고
    • Obstructive sleep apnea and obesity are associated with reduced GPR 120 plasma levels in children
    • Gozal D, Kheirandish-Gozal L, Carreras A, Khalyfa A, Peris E. Obstructive sleep apnea and obesity are associated with reduced GPR 120 plasma levels in children. Sleep 2014; 37: 935-941
    • (2014) Sleep , vol.37 , pp. 935-941
    • Gozal, D.1    Kheirandish-Gozal, L.2    Carreras, A.3    Khalyfa, A.4    Peris, E.5
  • 19
    • 84920385377 scopus 로고    scopus 로고
    • Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice
    • Hakim F, Wang Y, Carreras A, Hirotsu C, Zhang J, Peris E, et al. Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice. Sleep 2015; 38: 31-40
    • (2015) Sleep , vol.38 , pp. 31-40
    • Hakim, F.1    Wang, Y.2    Carreras, A.3    Hirotsu, C.4    Zhang, J.5    Peris, E.6
  • 20
    • 84899677318 scopus 로고    scopus 로고
    • Sleep fragmentation in mice induces nicotinamide adenine dinucleotide phosphate oxidase 2-dependent mobilization, proliferation, and differentiation of adipocyte progenitors in visceral white adipose tissue
    • Khalyfa A, Wang Y, Zhang SX, Qiao Z, Abdelkarim A, Gozal D. Sleep fragmentation in mice induces nicotinamide adenine dinucleotide phosphate oxidase 2-dependent mobilization, proliferation, and differentiation of adipocyte progenitors in visceral white adipose tissue. Sleep 2014; 37: 999-1009
    • (2014) Sleep , vol.37 , pp. 999-1009
    • Khalyfa, A.1    Wang, Y.2    Zhang, S.X.3    Qiao, Z.4    Abdelkarim, A.5    Gozal, D.6
  • 22
    • 84898022092 scopus 로고    scopus 로고
    • Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice
    • Zhang SX, Khalyfa A, Wang Y, Carreras A, Hakim F, Neel BA, et al. Sleep fragmentation promotes NADPH oxidase 2-mediated adipose tissue inflammation leading to insulin resistance in mice. Int J Obes (Lond) 2014; 38: 619-624
    • (2014) Int J Obes (Lond) , vol.38 , pp. 619-624
    • Zhang, S.X.1    Khalyfa, A.2    Wang, Y.3    Carreras, A.4    Hakim, F.5    Neel, B.A.6
  • 23
    • 84886060164 scopus 로고    scopus 로고
    • The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism
    • Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol 2013; 84: 710-725
    • (2013) Mol Pharmacol , vol.84 , pp. 710-725
    • Hudson, B.D.1    Shimpukade, B.2    Mackenzie, A.E.3    Butcher, A.J.4    Pediani, J.D.5    Christiansen, E.6
  • 24
    • 82555168382 scopus 로고    scopus 로고
    • Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse
    • Nair D, Zhang SX, Ramesh V, Hakim F, Kaushal N, Wang Y, et al. Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse. Am J Resp Crit Care Med 2011; 184: 1305-1312
    • (2011) Am J Resp Crit Care Med , vol.184 , pp. 1305-1312
    • Nair, D.1    Zhang, S.X.2    Ramesh, V.3    Hakim, F.4    Kaushal, N.5    Wang, Y.6
  • 25
    • 84860812158 scopus 로고    scopus 로고
    • Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-Alpha pathway
    • Ramesh V, Nair D, Zhang SX, Hakim F, Kaushal N, Kayali F, et al. Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-Alpha pathway. J Neuroinflamm 2012; 9: 91
    • (2012) J Neuroinflamm , vol.9 , pp. 91
    • Ramesh, V.1    Nair, D.2    Zhang, S.X.3    Hakim, F.4    Kaushal, N.5    Kayali, F.6
  • 26
    • 84866649279 scopus 로고    scopus 로고
    • TNF-α and temporal changes in sleep architecture in mice exposed to sleep fragmentation
    • Kaushal N, Ramesh V, Gozal D. TNF-α and temporal changes in sleep architecture in mice exposed to sleep fragmentation. PLoS One 2012; 7: e45610
    • (2012) PLoS One , vol.7 , pp. e45610
    • Kaushal, N.1    Ramesh, V.2    Gozal, D.3
  • 27
    • 84867273790 scopus 로고    scopus 로고
    • Metabolic effects of intermittent hypoxia in mice: Steady versus high-frequency applied hypoxia daily during the rest period
    • Carreras A, Kayali F, Zhang J, Hirotsu C, Wang Y, Gozal D. Metabolic effects of intermittent hypoxia in mice: steady versus high-frequency applied hypoxia daily during the rest period. Am J Physiol Regul Integr Comp Physiol 2012; 303: R700-R709
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.303 , pp. R700-R709
    • Carreras, A.1    Kayali, F.2    Zhang, J.3    Hirotsu, C.4    Wang, Y.5    Gozal, D.6
  • 28
    • 84859094567 scopus 로고    scopus 로고
    • The novel endocrine disruptor tolylfluanid impairs insulin signaling in primary rodent and human adipocytes through a reduction in insulin receptor substrate-1levels
    • Sargis RM, Neel BA, Brock CO, Lin Y, Hickey AT, Carlton DA, et al. The novel endocrine disruptor tolylfluanid impairs insulin signaling in primary rodent and human adipocytes through a reduction in insulin receptor substrate-1levels. Biochim Biophys Acta 2012; 1822: 952-960
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 952-960
    • Sargis, R.M.1    Neel, B.A.2    Brock, C.O.3    Lin, Y.4    Hickey, A.T.5    Carlton, D.A.6
  • 29
    • 84924668090 scopus 로고    scopus 로고
    • Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea
    • Carreras A, Zhang SX, Peris E, Qiao Z, Wang Y, Almendros I, et al. Effect of resveratrol on visceral white adipose tissue inflammation and insulin sensitivity in a mouse model of sleep apnea. Int J Obes (Lond) 2015; 39: 418-423
    • (2015) Int J Obes (Lond) , vol.39 , pp. 418-423
    • Carreras, A.1    Zhang, S.X.2    Peris, E.3    Qiao, Z.4    Wang, Y.5    Almendros, I.6
  • 30
    • 13444263540 scopus 로고    scopus 로고
    • Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
    • Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 2005; 11: 90-94
    • (2005) Nat Med , vol.11 , pp. 90-94
    • Hirasawa, A.1    Tsumaya, K.2    Awaji, T.3    Katsuma, S.4    Adachi, T.5    Yamada, M.6
  • 32
    • 84879582536 scopus 로고    scopus 로고
    • Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation
    • Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity 2013; 38: 1154-1163
    • (2013) Immunity , vol.38 , pp. 1154-1163
    • Yan, Y.1    Jiang, W.2    Spinetti, T.3    Tardivel, A.4    Castillo, R.5    Bourquin, C.6
  • 33
    • 84937576781 scopus 로고    scopus 로고
    • Dietary fatty acids and their potential for controlling etabolic diseases through activation of FFA4/GPR120
    • Ulven T, Christiansen E. Dietary fatty acids and their potential for controlling etabolic diseases through activation of FFA4/GPR120. Annu Rev Nutr 2015; 35: 239-263
    • (2015) Annu Rev Nutr , vol.35 , pp. 239-263
    • Ulven, T.1    Christiansen, E.2
  • 34
    • 84946090653 scopus 로고    scopus 로고
    • Diets containing alpha-linolenic (omega 3) or oleic (omega 9) fatty acids rescues obese mice from insulin resistance
    • Oliveira V, Marinho R, Vitorino D, Santos GA, Moraes JC, Dragano N, et al. Diets containing alpha-linolenic (omega 3) or oleic (omega 9) fatty acids rescues obese mice from insulin resistance. Endocrinology 2015; 156: 4033-4046
    • (2015) Endocrinology , vol.156 , pp. 4033-4046
    • Oliveira, V.1    Marinho, R.2    Vitorino, D.3    Santos, G.A.4    Moraes, J.C.5    Dragano, N.6
  • 35
    • 84939609969 scopus 로고    scopus 로고
    • Endogenous ligand for GPR120, docosahexaenoic acid, exerts benign metabolic effects on the skeletal muscles via AMP-Activated protein kinase pathway
    • Kim N, Lee JO, Lee HJ, Kim HI, Kim JK, Lee YW, et al. Endogenous ligand for GPR120, docosahexaenoic acid, exerts benign metabolic effects on the skeletal muscles via AMP-Activated protein kinase pathway. J Biol Chem 2015; 290: 20438-20447
    • (2015) J Biol Chem , vol.290 , pp. 20438-20447
    • Kim, N.1    Lee, J.O.2    Lee, H.J.3    Kim, H.I.4    Kim, J.K.5    Lee, Y.W.6
  • 36
    • 84930924216 scopus 로고    scopus 로고
    • Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases
    • Christiansen E, Watterson KR, Stocker CJ, Sokol E, Jenkins L, Simon K, et al. Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases. Br J Nutr 2015; 113: 1677-1688
    • (2015) Br J Nutr , vol.113 , pp. 1677-1688
    • Christiansen, E.1    Watterson, K.R.2    Stocker, C.J.3    Sokol, E.4    Jenkins, L.5    Simon, K.6
  • 37
    • 84863112820 scopus 로고    scopus 로고
    • Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota
    • Duca FA, Swartz TD, Sakar Y, Covasa M. Increased oral detection, but decreased intestinal signaling for fats in mice lacking gut microbiota. PLoS One 2012; 7: e39748
    • (2012) PLoS One , vol.7 , pp. e39748
    • Duca, F.A.1    Swartz, T.D.2    Sakar, Y.3    Covasa, M.4
  • 40
    • 84932139560 scopus 로고    scopus 로고
    • Contribution of the hypothalamus and gut to weight gain susceptibility and resistance in mice
    • Fam BC, Sgambellone R, Ruan Z, Proietto J, Andrikopoulos S. Contribution of the hypothalamus and gut to weight gain susceptibility and resistance in mice. J Endocrinol 2015; 225: 191-204
    • (2015) J Endocrinol , vol.225 , pp. 191-204
    • Fam, B.C.1    Sgambellone, R.2    Ruan, Z.3    Proietto, J.4    Andrikopoulos, S.5
  • 41
    • 84855971481 scopus 로고    scopus 로고
    • LA Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity
    • Cintra DE, Ropelle ER, Moraes JC, Pauli JR, Morari J, Souza CT, et al. LA. Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity. PLoS One 2012; 7: e30571
    • (2012) PLoS One , vol.7 , pp. e30571
    • Cintra, D.E.1    Ropelle, E.R.2    Moraes, J.C.3    Pauli, J.R.4    Morari, J.5    Souza, C.T.6
  • 42
    • 3042691508 scopus 로고    scopus 로고
    • Behavioral and physiologic responses to caloric restriction in mice
    • Overton JM, Williams TD. Behavioral and physiologic responses to caloric restriction in mice. Physiol Behav 2004; 81: 749-754
    • (2004) Physiol Behav , vol.81 , pp. 749-754
    • Overton, J.M.1    Williams, T.D.2
  • 43
    • 84971284861 scopus 로고    scopus 로고
    • Mining microarray datasets in nutrition: Expression of the GPR120 (n-3 fatty acid receptor/sensor) gene is down-regulated in human adipocytes by macrophage secretions
    • Trayhurn P, Denyer G. Mining microarray datasets in nutrition: expression of the GPR120 (n-3 fatty acid receptor/sensor) gene is down-regulated in human adipocytes by macrophage secretions. J Nutr Sci 2012; 1: e3
    • (2012) J Nutr Sci , vol.1 , pp. e3
    • Trayhurn, P.1    Denyer, G.2
  • 45
    • 23644446750 scopus 로고    scopus 로고
    • Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: Association with cytokine expression, insulin resistance, and reduction by pioglitazone
    • Di Gregorio GB, Yao-Borengasser A, Rasouli N, Varma V, Lu T, Miles LM, et al. Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Diabetes 2005; 54: 2305-2313
    • (2005) Diabetes , vol.54 , pp. 2305-2313
    • Di Gregorio, G.B.1    Yao-Borengasser, A.2    Rasouli, N.3    Varma, V.4    Lu, T.5    Miles, L.M.6
  • 46
    • 84940953781 scopus 로고    scopus 로고
    • The 'big bang' in obese fat: Events initiating obesity-induced adipose tissue inflammation
    • Wensveen FM, Valentić S, Šestan M, Turk Wensveen T, Polić B. The 'Big Bang' in obese fat: events initiating obesity-induced adipose tissue inflammation. Eur J Immunol 2015; 45: 2446-2456
    • (2015) Eur J Immunol , vol.45 , pp. 2446-2456
    • Wensveen, F.M.1    Valentić, S.2    Šestan, M.3    Turk Wensveen, T.4    Polić, B.5
  • 48
    • 84907991703 scopus 로고    scopus 로고
    • Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
    • Kratz M, Coats BR, Hisert KB, Hagman D, Mutskov V, Peris E, et al. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab 2014; 20: 614-625
    • (2014) Cell Metab , vol.20 , pp. 614-625
    • Kratz, M.1    Coats, B.R.2    Hisert, K.B.3    Hagman, D.4    Mutskov, V.5    Peris, E.6


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