The novel endocrine disruptor tolylfluanid impairs insulin signaling in primary rodent and human adipocytes through a reduction in insulin receptor substrate-1 levels

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 6, 2012, Pages 952-960

  Sargis, Robert M ^a,b   Neel, Brian A ^b   Brock, Clifton O ^c   Lin, Yuxi ^b   Hickey, Allison T ^c   Carlton, Daniel A ^c   Brady, Matthew J ^a,b  

^a University of Chicago ^*  (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Adipocyte; Environmental endocrine disruption; Insulin resistance

Indexed keywords

ENDOCRINE DISRUPTOR; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LEPTIN; PHENYLSULFAMIDE FUNGICIDE TOLYLFLUANID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; ENDOCRINE FUNCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT;

ADIPOCYTES; ANILINE COMPOUNDS; ANIMALS; CELLS, CULTURED; ENDOCRINE DISRUPTORS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; LEPTIN; MALE; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTOR, INSULIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONAMIDES;

MAMMALIA; MURINAE; RODENTIA;

EID: 84859094567     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.02.015     Document Type: Article

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