Enhanced formation and disordered regulation of NETs in myeloperoxidase-ANCA-associated microscopic polyangiitis

Journal of the American Society of Nephrology

Volumn 25, Issue 5, 2014, Pages 990-997

  Nakazawa, Daigo ^a   Shida, Haruki ^a   Tomaru, Utano ^a   Yoshida, Masaharu ^b   Nishio, Saori ^a   Atsumi, Tatsuya ^a   Ishizu, Akihiro ^c  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL UNIVERSITY HACHIOJI MEDICAL CENTER   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; IMMUNOGLOBULIN G; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PEROXIDASE;

ADULT; AGED; ANTIBODY AFFINITY; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; EXTRACELLULAR TRAP; FEMALE; HUMAN; HUMAN CELL; MALE; MICROSCOPIC POLYANGIITIS; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; SYSTEMIC LUPUS ERYTHEMATOSUS; VASCULITIS; BIOSYNTHESIS; CASE CONTROL STUDY; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; UPREGULATION; VERY ELDERLY;

ANCA; IMMUNOLOGY; PATHOLOGY; VASCULITIS;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTIBODY AFFINITY; CASE-CONTROL STUDIES; DEOXYRIBONUCLEASE I; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MICROSCOPIC POLYANGIITIS; MIDDLE AGED; NEUTROPHILS; PEROXIDASE; UP-REGULATION;

EID: 84906565772     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013060606     Document Type: Article

References (25)

1. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CG, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DG, Specks U, Stone JH, Takahashi K, Watts RA: 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 65: 1-11, 2013
2. Falk RJ, Terrell RS, Charles LA, Jennette JC: Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci U S A 87: 4115-4119, 1990
3. Csernok E: Anti-neutrophil cytoplasmic antibodies and pathogenesis of small vessel vasculitides. Autoimmun Rev 2: 158-164, 2003
4. Chen M, Gao Y, Guo XH, Zhao MH: Propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis. Nat Rev Nephrol 8: 476-483, 2012
5. Nakazawa D, Tomaru U, Suzuki A,Masuda S, Hasegawa R, Kobayashi T, Nishio S, Kasahara M, Ishizu A: Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: Implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 64: 3779-3787, 2012
6. RadicM, KaplanMJ: JumbledNETs promote vasculitis. Arthritis Rheum 64: 3498-3501, 2012
7. Ray K: Autoimmunity: disordered NETs implicated in pathogenesis of MPO-ANCA-associated vasculitis. Nat Rev Rheumatol 8: 501, 2012
8. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A: Neutrophil extracellular traps kill bacteria. Science 303: 1532-1535, 2004
9. Fuchs TA, Abed U, Goosmann C, Hurwitz R, Schulze I, Wahn V, Weinrauch Y, Brinkmann V, Zychlinsky A: Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 176: 231-241, 2007
10. Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE: Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15: 623-625, 2009
11. Sangaletti S, Tripodo C, Chiodoni C, Guarnotta C, Cappetti B, Casalini P, Piconese S, Parenza M, Guiducci C, Vitali C, Colombo MP: Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood 120: 3007-3018, 2012
12. Nakazawa D, Tomaru U, Ishizu A: Possible implication of disordered neutrophil extracellular traps in the pathogenesis of MPO-ANCA-associated vasculitis. Clin Exp Nephrol 17:631-633, 2013.
13. Li P, Li M, Lindberg MR, Kennett MJ, Xiong N, Wang Y: PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J ExpMed 207: 1853-1862, 2010
14. Nakazawa D, Tomaru U, Yamamoto C, Jodo S, Ishizu A: Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis. Front Immunol 3: 333, 2012
15. De'Oliviera J, Gaskin G, Dash A, Rees AJ, Pusey CD: Relationship between disease activity and anti-neutrophil cytoplasmic antibody concentration in long-term management of systemic vasculitis. Am J Kidney Dis 25: 380-389, 1995
16. YoshidaM, SasakiM, Nakabayashi I, AkashiM, Tomiyasu T, Yoshikawa N, Kojima T, Ohno N, Yamada M: Two types of myeloperoxidase-antineutrophil cytoplasmic autoantibodies with a high affinity and a low affinity in small vessel vasculitis. Clin Exp Rheumatol 27[Suppl 52]: S28-S32, 2009
17. Hakkim A, Fürnrohr BG, Amann K, Laube B, Abed UA, Brinkmann V, Herrmann M, Voll RE, Zychlinsky A: Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis. Proc Natl Acad Sci U S A 107: 9813-9818, 2010
18. Sallai K, Nagy E, Derfalvy B, Müzes G, Gergely P: Antinucleosome antibodies and decreased deoxyribonuclease activity in sera of patients with systemic lupus erythematosus. Clin Diagn Lab Immunol 12: 56-59, 2005
19. Shao WH, Cohen PL: Disturbances of apoptotic cell clearance in systemic lupus erythematosus. Arthritis Res Ther 13: 202, 2011
20. Villanueva E, Yalavarthi S, Berthier CC, Hodgin JB, Khandpur R, Lin AM, Rubin CJ, ZhaoW, Olsen SH, KlinkerM, Shealy D, Denny MF, Plumas J, Chaperot L, Kretzler M, Bruce AT, Kaplan MJ: Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus. J Immunol 187: 538-552, 2011
21. Leffler J, Martin M, Gullstrand B, Tydén H, Lood C, Truedsson L, Bengtsson AA, Blom AM: Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease. J Immunol 188: 3522-3531, 2012
22. Khandpur R, Carmona-Rivera C, Vivekanandan-Giri A, Gizinski A, Yalavarthi S, Knight JS, Friday S, Li S, Patel RM, Subramanian V, Thompson P, Chen P, Fox DA, Pennathur S, Kaplan MJ: NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci Transl Med 5: 178ra40, 2013.
23. Almyroudis NG, Grimm MJ, Davidson BA, Röhm M, Urban CF, Segal BH: NETosis and NADPH oxidase: At the intersection of host defense, inflammation, and injury. Front Immunol 4: 45, 2013
24. Vlahos R, Stambas J, Bozinovski S, Broughton BR, Drummond GR, Selemidis S: Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation. PLoS Pathog 7: e1001271, 2011
25. Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ: Suppressionof colitis inmicebyCl-amidine:Anovel peptidylarginine deiminase inhibitor. Am J Physiol Gastrointest Liver Physiol 300: G929-G938, 2011