A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 22, 2016, Pages E3081-E3090

  Zeng, Menglong ^a   Shang, Yuan ^a   Guo, Tingfeng ^a   He, Qinghai ^a   Yung, Wing Ho ^b   Liu, Kai ^a   Zhang, Mingjie ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b Prince of Wales Hospital   (Hong Kong)

Author keywords

PDZ; SAPAP; Shank; Specific interaction; Synapse

Indexed keywords

NEUROLIGIN 1; SCAFFOLD PROTEIN; SHANK PROTEIN; SYNAPSE ASSOCIATED PROTEIN 90 POSTSYNAPTIC DENSITY 95 ASSOCIATED PROTEIN; UNCLASSIFIED DRUG; NERVE PROTEIN; PROTEIN BINDING; SAPAP PROTEINS; SHANK1 PROTEIN, MOUSE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENDRITIC SPINE; GENE DOSAGE; GENE DUPLICATION; HYDROPHOBICITY; IN VITRO STUDY; ISOTHERMAL TITRATION CALORIMETRY; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NONHUMAN; PDZ DOMAIN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SYNAPSE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMISTRY; COPY NUMBER VARIATION; CYTOLOGY; FEMALE; GENETICS; HIPPOCAMPUS; HUMAN; IMMUNOPRECIPITATION; METABOLISM; NERVE CELL; PHYSIOLOGY; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA COPY NUMBER VARIATIONS; FEMALE; HIPPOCAMPUS; HUMANS; IMMUNOPRECIPITATION; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURONS; PDZ DOMAINS; PROTEIN BINDING; PROTEIN CONFORMATION; SYNAPSES;

EID: 84973137968     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1523265113     Document Type: Article

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