A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation

Journal of Biological Chemistry

Volumn 285, Issue 13, 2010, Pages 9981-9994

  Bhattacharya, Shibani ^a   Dai, Zhongping ^b   Li, Jianquan ^b   Baxter, Sabine ^b   Callaway, David J E ^c   Cowburn, David ^a   Bu, Zimei ^b,d  

^a NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CITY COLLEGE OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOINHIBITION; BINDING AFFINITIES; BINDING MOTIF; COMPLEX FORMATIONS; CONFORMATIONAL SWITCHES; CYTOPLASMIC DOMAINS; CYTOSKELETONS; DOMAIN-DOMAIN INTERACTIONS; HIGH RESOLUTION; HUMAN DISEASE; HYDROPHOBIC INTERACTIONS; IN-CELL; INTRACELLULAR TRAFFICKING; INTRAMOLECULAR INTERACTIONS; ION CHANNEL; JOINT STRUCTURE; LIGAND-BINDING SITES; LINKER PROTEINS; MEMBRANE PROTEINS; MULTI DOMAINS; PHYSIOLOGICAL FUNCTIONS; PROTEIN STABILITY; REGULATORY FACTORS; SCAFFOLDING PROTEINS; SMALL ANGLE NEUTRON SCATTERING; SMALL ANGLE X-RAY SCATTERING; STRUCTURAL INFORMATION; SUBDOMAIN; TRANSMEMBRANES;

BINDING ENERGY; BIOLOGICAL MEMBRANES; COMPLEXATION; COMPUTERIZED TOMOGRAPHY; HYDROPHOBICITY; ION EXCHANGE; LAWS AND LEGISLATION; MAMMALS; NEUTRON SCATTERING; NUCLEAR MAGNETIC RESONANCE;

PROTEINS;

EZRIN; HELIX LOOP HELIX PROTEIN; PDZ PROTEIN; SCAFFOLD PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; ION; LIGAND; PHOSPHOPROTEIN; SODIUM HYDROGEN EXCHANGER REGULATORY FACTOR; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER REGULATORY FACTOR;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; LIGAND BINDING; MOLECULAR INTERACTION; MUTATIONAL ANALYSIS; NEUTRON SCATTERING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; RADIATION SCATTERING; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; CHEMISTRY; CYTOPLASM; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY;

MAMMALIA;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CYTOPLASM; GENE EXPRESSION REGULATION; HUMANS; IONS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOPROTEINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SCATTERING, RADIATION; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM-HYDROGEN ANTIPORTER; X-RAYS;

EID: 77951212822     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.074005     Document Type: Article

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