메뉴 건너뛰기




Volumn 7, Issue 13, 2016, Pages 16217-16226

Ribosomal protein L4 is a novel regulator of the MDM2-p53 loop

Author keywords

MDM2; p53; Ribosome proteins; RPL4; Ubiquitination

Indexed keywords

PROTEIN MDM2; PROTEIN P53; RIBOSOMAL PROTEIN L11; RIBOSOMAL PROTEIN L4; RIBOSOMAL PROTEIN L5; RIBOSOME PROTEIN; UNCLASSIFIED DRUG; MDM2 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN;

EID: 84971592090     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7479     Document Type: Article
Times cited : (43)

References (48)
  • 1
    • 77951431225 scopus 로고    scopus 로고
    • Ribosomopathies: human disorders of ribosome dysfunction
    • Narla A, Ebert BL. Ribosomopathies: human disorders of ribosome dysfunction. Blood. 2010;115:3196-3205.
    • (2010) Blood , vol.115 , pp. 3196-3205
    • Narla, A.1    Ebert, B.L.2
  • 2
    • 84894419714 scopus 로고    scopus 로고
    • The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders
    • Raiser DM, Narla A, Ebert BL. The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders. Leuk Lymphoma. 2014;55:491-500.
    • (2014) Leuk Lymphoma , vol.55 , pp. 491-500
    • Raiser, D.M.1    Narla, A.2    Ebert, B.L.3
  • 3
    • 84922812674 scopus 로고    scopus 로고
    • Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications
    • Wang W, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications. Med Res Rev. 2015;35:225-285.
    • (2015) Med Res Rev , vol.35 , pp. 225-285
    • Wang, W.1    Jensen, J.P.2    Ludwig, R.L.3    Vousden, K.H.4    Weissman, A.M.5
  • 4
    • 0034708458 scopus 로고    scopus 로고
    • Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
    • Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem. 2000;275:8945-8951.
    • (2000) J Biol Chem , vol.275 , pp. 8945-8951
    • Fang, S.1    Jensen, J.P.2    Ludwig, R.L.3    Vousden, K.H.4    Weissman, A.M.5
  • 5
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 1997;420:25-27.
    • (1997) FEBS Lett , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 6
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 1997;387:296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 7
  • 9
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the Light: The Growing Complexity of p53
    • Vousden KH, Prives C. Blinded by the Light: The Growing Complexity of p53. Cell. 2009;137:413-431.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 10
    • 0033611568 scopus 로고    scopus 로고
    • p53 represses ribosomal gene transcription
    • Budde A, Grummt I. p53 represses ribosomal gene transcription. Oncogene. 1999;18:1119-1124.
    • (1999) Oncogene , vol.18 , pp. 1119-1124
    • Budde, A.1    Grummt, I.2
  • 12
    • 0033867975 scopus 로고    scopus 로고
    • Repression of RNA polymerase I transcription by the tumor suppressor p53
    • Zhai W, Comai L. Repression of RNA polymerase I transcription by the tumor suppressor p53. Mol Cell Biol. 2000;20:5930-5938.
    • (2000) Mol Cell Biol , vol.20 , pp. 5930-5938
    • Zhai, W.1    Comai, L.2
  • 13
    • 84897077346 scopus 로고    scopus 로고
    • Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
    • Bursac S, Brdovcak MC, Donati G, Volarevic S. Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis. Biochim Biophys Acta. 2014;1842:817-830.
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 817-830
    • Bursac, S.1    Brdovcak, M.C.2    Donati, G.3    Volarevic, S.4
  • 14
    • 84905085696 scopus 로고    scopus 로고
    • p53 and ribosome biogenesis stress: the essentials
    • Golomb L, Volarevic S, Oren M. p53 and ribosome biogenesis stress: the essentials. FEBS Lett. 2014;588:2571-2579.
    • (2014) FEBS Lett , vol.588 , pp. 2571-2579
    • Golomb, L.1    Volarevic, S.2    Oren, M.3
  • 15
    • 84897406530 scopus 로고    scopus 로고
    • Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability
    • Kim TH, Leslie P, Zhang Y. Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability. Oncotarget. 2014; 5:860-871. doi: 10.18632/oncotarget.1784.
    • (2014) Oncotarget , vol.5 , pp. 860-871
    • Kim, T.H.1    Leslie, P.2    Zhang, Y.3
  • 16
    • 7244238177 scopus 로고    scopus 로고
    • Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5
    • Dai MS, Lu H. Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem. 2004;279:44475-44482.
    • (2004) J Biol Chem , vol.279 , pp. 44475-44482
    • Dai, M.S.1    Lu, H.2
  • 17
    • 33747654496 scopus 로고    scopus 로고
    • Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism
    • Dai MS, Shi D, Jin Y, Sun XX, Zhang Y, Grossman SR, Lu H. Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. J Biol Chem. 2006;281:24304-24313.
    • (2006) J Biol Chem , vol.281 , pp. 24304-24313
    • Dai, M.S.1    Shi, D.2    Jin, Y.3    Sun, X.X.4    Zhang, Y.5    Grossman, S.R.6    Lu, H.7
  • 18
    • 4344685939 scopus 로고    scopus 로고
    • Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
    • Dai MS, Zeng SX, Jin Y, Sun XX, David L, Lu H. Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition. Mol Cell Biol. 2004;24:7654-7668.
    • (2004) Mol Cell Biol , vol.24 , pp. 7654-7668
    • Dai, M.S.1    Zeng, S.X.2    Jin, Y.3    Sun, X.X.4    David, L.5    Lu, H.6
  • 19
    • 4344660471 scopus 로고    scopus 로고
    • Inhibition of HDM2 and activation of p53 by ribosomal protein L23
    • Jin A, Itahana K, O'Keefe K, Zhang Y. Inhibition of HDM2 and activation of p53 by ribosomal protein L23. Mol Cell Biol. 2004;24:7669-7680.
    • (2004) Mol Cell Biol , vol.24 , pp. 7669-7680
    • Jin, A.1    Itahana, K.2    O'Keefe, K.3    Zhang, Y.4
  • 21
    • 0242721592 scopus 로고    scopus 로고
    • Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
    • Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003;23:8902-8912.
    • (2003) Mol Cell Biol , vol.23 , pp. 8902-8912
    • Zhang, Y.1    Wolf, G.W.2    Bhat, K.3    Jin, A.4    Allio, T.5    Burkhart, W.A.6    Xiong, Y.7
  • 22
    • 84861170072 scopus 로고    scopus 로고
    • Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint
    • Fumagalli S, Ivanenkov VV, Teng T, Thomas G. Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint. Genes Dev. 2012;26:1028-1040.
    • (2012) Genes Dev , vol.26 , pp. 1028-1040
    • Fumagalli, S.1    Ivanenkov, V.V.2    Teng, T.3    Thomas, G.4
  • 23
    • 34247204753 scopus 로고    scopus 로고
    • 5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction
    • Sun XX, Dai MS, Lu H. 5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction. J Biol Chem. 2007;282:8052-8059.
    • (2007) J Biol Chem , vol.282 , pp. 8052-8059
    • Sun, X.X.1    Dai, M.S.2    Lu, H.3
  • 24
    • 45549098246 scopus 로고    scopus 로고
    • Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11
    • Sun XX, Dai MS, Lu H. Mycophenolic acid activation of p53 requires ribosomal proteins L5 and L11. J Biol Chem. 2008;283:12387-12392.
    • (2008) J Biol Chem , vol.283 , pp. 12387-12392
    • Sun, X.X.1    Dai, M.S.2    Lu, H.3
  • 25
    • 77956518791 scopus 로고    scopus 로고
    • An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction
    • Macias E, Jin A, Deisenroth C, Bhat K, Mao H, Lindstrom MS, Zhang Y. An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell. 2010;18:231-243.
    • (2010) Cancer Cell , vol.18 , pp. 231-243
    • Macias, E.1    Jin, A.2    Deisenroth, C.3    Bhat, K.4    Mao, H.5    Lindstrom, M.S.6    Zhang, Y.7
  • 26
    • 84892443134 scopus 로고    scopus 로고
    • 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint
    • Donati G, Peddigari S, Mercer CA, Thomas G. 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint. Cell Rep. 2013;4:87-98.
    • (2013) Cell Rep , vol.4 , pp. 87-98
    • Donati, G.1    Peddigari, S.2    Mercer, C.A.3    Thomas, G.4
  • 27
    • 84885833107 scopus 로고    scopus 로고
    • The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress
    • Sloan KE, Bohnsack MT, Watkins NJ. The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress. Cell Rep. 2013;5:237-247.
    • (2013) Cell Rep , vol.5 , pp. 237-247
    • Sloan, K.E.1    Bohnsack, M.T.2    Watkins, N.J.3
  • 28
    • 84860857365 scopus 로고    scopus 로고
    • Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA
    • Chen J, Guo K, Kastan MB. Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. J Biol Chem. 2012;287:16467-16476.
    • (2012) J Biol Chem , vol.287 , pp. 16467-16476
    • Chen, J.1    Guo, K.2    Kastan, M.B.3
  • 29
    • 84894236850 scopus 로고    scopus 로고
    • Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress
    • Bai D, Zhang J, Xiao W, Zheng X. Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress. Nucleic Acids Res. 2014;42:1799-1811.
    • (2014) Nucleic Acids Res , vol.42 , pp. 1799-1811
    • Bai, D.1    Zhang, J.2    Xiao, W.3    Zheng, X.4
  • 31
    • 34547620115 scopus 로고    scopus 로고
    • Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
    • Chen D, Zhang Z, Li M, Wang W, Li Y, Rayburn ER, Hill DL, Wang H, Zhang, R. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene. 2007;26:5029-5037.
    • (2007) Oncogene , vol.26 , pp. 5029-5037
    • Chen, D.1    Zhang, Z.2    Li, M.3    Wang, W.4    Li, Y.5    Rayburn, E.R.6    Hill, D.L.7    Wang, H.8    Zhang, R.9
  • 32
    • 84872619062 scopus 로고    scopus 로고
    • Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress
    • Zhou X, Hao Q, Liao J, Zhang Q, Lu H. Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress. Oncogene. 2013;32:388-396.
    • (2013) Oncogene , vol.32 , pp. 388-396
    • Zhou, X.1    Hao, Q.2    Liao, J.3    Zhang, Q.4    Lu, H.5
  • 33
    • 84879416965 scopus 로고    scopus 로고
    • Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop
    • Zhang X, Wang W, Wang H, Wang MH, Xu W, Zhang, R. Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop. Oncogene. 2013;32:2782-2791.
    • (2013) Oncogene , vol.32 , pp. 2782-2791
    • Zhang, X.1    Wang, W.2    Wang, H.3    Wang, M.H.4    Xu, W.5    Zhang, R.6
  • 34
    • 79954616063 scopus 로고    scopus 로고
    • Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator
    • Xiong X, Zhao Y, He H, Sun Y. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene. 2011;30:1798-1811.
    • (2011) Oncogene , vol.30 , pp. 1798-1811
    • Xiong, X.1    Zhao, Y.2    He, H.3    Sun, Y.4
  • 35
    • 79959570611 scopus 로고    scopus 로고
    • Interplay between ribosomal protein S27a and MDM2 in p53 activation in response to ribosomal stress
    • Sun XX, DeVine T, Challagundla KB, Dai MS. Interplay between ribosomal protein S27a and MDM2 in p53 activation in response to ribosomal stress. J Biol Chem. 2011;286:22730-22741.
    • (2011) J Biol Chem , vol.286 , pp. 22730-22741
    • Sun, X.X.1    DeVine, T.2    Challagundla, K.B.3    Dai, M.S.4
  • 36
    • 84899635884 scopus 로고    scopus 로고
    • The ribosomal protein S26 regulates p53 activity in response to DNA damage
    • Cui D, Li L, Lou H, Sun H, Ngai SM, Shao G, Tang J. The ribosomal protein S26 regulates p53 activity in response to DNA damage. Oncogene. 2014;33:2225-2235.
    • (2014) Oncogene , vol.33 , pp. 2225-2235
    • Cui, D.1    Li, L.2    Lou, H.3    Sun, H.4    Ngai, S.M.5    Shao, G.6    Tang, J.7
  • 37
    • 84880753919 scopus 로고    scopus 로고
    • Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network
    • Daftuar L, Zhu Y, Jacq X, Prives C. Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network. PLoS One. 2013;8:e68667.
    • (2013) PLoS One , vol.8
    • Daftuar, L.1    Zhu, Y.2    Jacq, X.3    Prives, C.4
  • 38
    • 77955479087 scopus 로고    scopus 로고
    • Perturbation of 60S ribosomal biogenesis results in ribosomal protein L5 and L11-dependent p53 activation
    • Sun XX, Wang YG, Xirodimas DP, Dai MS. Perturbation of 60S ribosomal biogenesis results in ribosomal protein L5 and L11-dependent p53 activation. J Biol Chem. 2010;285:25812-25821.
    • (2010) J Biol Chem , vol.285 , pp. 25812-25821
    • Sun, X.X.1    Wang, Y.G.2    Xirodimas, D.P.3    Dai, M.S.4
  • 39
    • 79954616063 scopus 로고    scopus 로고
    • Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator
    • Xiong X, Zhao Y, He H, Sun Y. Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator. Oncogene. 2011;30:1798-1811.
    • (2011) Oncogene , vol.30 , pp. 1798-1811
    • Xiong, X.1    Zhao, Y.2    He, H.3    Sun, Y.4
  • 41
    • 84904307595 scopus 로고    scopus 로고
    • Autoactivation of the MDM2 E3 ligase by intramolecular interaction
    • Cheng Q, Song T, Chen L, Chen J. Autoactivation of the MDM2 E3 ligase by intramolecular interaction. Mol Cell Biol. 2014;34:2800-2810.
    • (2014) Mol Cell Biol , vol.34 , pp. 2800-2810
    • Cheng, Q.1    Song, T.2    Chen, L.3    Chen, J.4
  • 42
    • 0038788827 scopus 로고    scopus 로고
    • Critical contribution of the MDM2 acidic domain to p53 ubiquitination
    • Kawai H, Wiederschain D, Yuan ZM. Critical contribution of the MDM2 acidic domain to p53 ubiquitination. Mol Cell Biol. 2003;23:4939-4947.
    • (2003) Mol Cell Biol , vol.23 , pp. 4939-4947
    • Kawai, H.1    Wiederschain, D.2    Yuan, Z.M.3
  • 44
    • 33846617807 scopus 로고    scopus 로고
    • Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation
    • Lindstrom MS, Jin A, Deisenroth C, White Wolf G, Zhang Y. Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. Mol Cell Biol. 2007;27:1056-1068.
    • (2007) Mol Cell Biol , vol.27 , pp. 1056-1068
    • Lindstrom, M.S.1    Jin, A.2    Deisenroth, C.3    White Wolf, G.4    Zhang, Y.5
  • 45
    • 84925424005 scopus 로고    scopus 로고
    • The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc
    • Sun XX, He X, Yin L, Komada M, Sears RC, Dai MS. The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proc Natl Acad Sci U S A. 2015;112:3734-3739.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 3734-3739
    • Sun, X.X.1    He, X.2    Yin, L.3    Komada, M.4    Sears, R.C.5    Dai, M.S.6
  • 46
    • 84856415004 scopus 로고    scopus 로고
    • Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
    • Sun XX, Challagundla KB, Dai MS. Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1. EMBO J. 2012;31:576-592.
    • (2012) EMBO J , vol.31 , pp. 576-592
    • Sun, X.X.1    Challagundla, K.B.2    Dai, M.S.3
  • 47
    • 46149087535 scopus 로고    scopus 로고
    • Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2
    • Dai MS, Sun XX, Lu H. Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2. Mol Cell Biol. 2008;28:4365-4376.
    • (2008) Mol Cell Biol , vol.28 , pp. 4365-4376
    • Dai, M.S.1    Sun, X.X.2    Lu, H.3
  • 48
    • 34547151021 scopus 로고    scopus 로고
    • Inhibition of c-Myc activity by ribosomal protein L11
    • Dai MS, Arnold H, Sun XX, Sears R, Lu H. Inhibition of c-Myc activity by ribosomal protein L11. EMBO J. 2007;26:3332-3345.
    • (2007) EMBO J , vol.26 , pp. 3332-3345
    • Dai, M.S.1    Arnold, H.2    Sun, X.X.3    Sears, R.4    Lu, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.