Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming

Oncotarget

Volumn 7, Issue 21, 2016, Pages 30193-30210

  Selleri, Silvia ^a,b   Bifsha, Panojot ^a,b   Civini, Sara ^c   Pacelli, Consiglia ^b   Dieng, Mame Massar ^a,d   Lemieux, William ^a,b   Jin, Ping ^c   Bazin, Renée ^e   Patey, Natacha ^b   Marincola, Francesco M ^c,f   Moldovan, Florina ^a,b   Zaouter, Charlotte ^a   Trudeau, Louis Eric ^b   Benabdhalla, Basma ^a   Louis, Isabelle ^a,b   Beauséjour, Christian ^a,b   Stroncek, David ^c   Le Deist, Françoise ^a,b   Haddad, Elie ^a,b  

^a UNIVERSITY OF MONTREAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NEW YORK UNIVERSITY ABU DHABI   (United Arab Emirates)

^e HÉMA QUÉBEC   (Canada)

^f SIDRA MEDICAL AND RESEARCH CENTER   (Qatar)

Author keywords

Dendritic cell differentiation; Immune response; Immunity; Immunology and Microbiology Section; Lactate; M2 macrophages; Mesenchymal stromal cells; Metabolism

Indexed keywords

ANTIGEN; CELL SURFACE MARKER; LACTATE DEHYDROGENASE; LACTIC ACID; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL METABOLISM; CELL RESPIRATION; CELL STRUCTURE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLAMMATION; MACROPHAGE; MACROPHAGE MIGRATION; MESENCHYMAL STROMA CELL; MONOCYTE; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; TH2 CELL; TISSUE INJURY; UMBILICAL CORD; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PROCEDURES; SCID MOUSE; SECRETION (PROCESS);

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; GENE EXPRESSION PROFILING; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-4; LACTIC ACID; MACROPHAGES; MESENCHYMAL STROMAL CELLS; MICE, INBRED C57BL; MICE, SCID; MONOCYTES; UMBILICAL CORD;

EID: 84971505796     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.8623     Document Type: Article

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