메뉴 건너뛰기




Volumn 22, Issue 7, 2013, Pages 1063-1075

Cord-blood-derived mesenchymal stromal cells downmodulate CD4+ T-cell activation by inducing il-10-producing th1 cells

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD4 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CXCR3; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GAMMA INTERFERON RECEPTOR 1; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 10; INTERLEUKIN 12 RECEPTOR BETA2; INTERLEUKIN 13; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 7; JANUS KINASE 2; OX40 LIGAND; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TOLL LIKE RECEPTOR 6; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR; UNINDEXED DRUG;

EID: 84875927209     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2012.0315     Document Type: Article
Times cited : (33)

References (50)
  • 1
    • 84857032992 scopus 로고    scopus 로고
    • Mesenchymal stromal cell therapy: A revolution in Regenerative Medicine?
    • Bernardo ME, D Pagliara and F Locatelli. (2012). Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine? Bone Marrow Transplant 47:164-171.
    • (2012) Bone Marrow Transplant , vol.47 , pp. 164-171
    • Bernardo, M.E.1    Pagliara, D.2    Locatelli, F.3
  • 2
    • 77952584405 scopus 로고    scopus 로고
    • Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLAmismatched allogeneic transplantation following nonmyeloablative conditioning
    • Baron F, C Lechanteur, E Willems, F Bruck, E Baudoux, L Seidel, JF Vanbellinghen, K Hafraoui, M Lejeune, et al. (2010). Cotransplantation of mesenchymal stem cells might prevent death from graft-versus-host disease (GVHD) without abrogating graft-versus-tumor effects after HLAmismatched allogeneic transplantation following nonmyeloablative conditioning. Biol Blood Marrow Transplant 16:838-847.
    • (2010) Biol Blood Marrow Transplant , vol.16 , pp. 838-847
    • Baron, F.1    Lechanteur, C.2    Willems, E.3    Bruck, F.4    Baudoux, E.5    Seidel, L.6    Vanbellinghen, J.F.7    Hafraoui, K.8    Lejeune, M.9
  • 6
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study
    • Le Blanc K, F Frassoni, L Ball, F Locatelli, H Roelofs, I Lewis, E Lanino, B Sundberg, ME Bernardo, et al. (2008). Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371:1579-1586.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3    Locatelli, F.4    Roelofs, H.5    Lewis, I.6    Lanino, E.7    Sundberg, B.8    Bernardo, M.E.9
  • 7
    • 36348977575 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stromal cells
    • Nauta AJ and WE Fibbe. (2007). Immunomodulatory properties of mesenchymal stromal cells. Blood 110:3499-3506.
    • (2007) Blood , vol.110 , pp. 3499-3506
    • Nauta, A.J.1    Fibbe, W.E.2
  • 8
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, C Carlo-Stella, M Magni, M Milanesi, PD Longoni, P Matteucci, S Grisanti and AM Gianni. (2002). Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838-3843.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3    Milanesi, M.4    Longoni, P.D.5    Matteucci, P.6    Grisanti, S.7    Gianni, A.M.8
  • 9
    • 0038204193 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigenspecific T cells to their cognate peptide
    • Krampera M, S Glennie, J Dyson, D Scott, R Laylor, E Simpson and F Dazzi. (2003). Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigenspecific T cells to their cognate peptide. Blood 101:3722-3729.
    • (2003) Blood , vol.101 , pp. 3722-3729
    • Krampera, M.1    Glennie, S.2    Dyson, J.3    Scott, D.4    Laylor, R.5    Simpson, E.6    Dazzi, F.7
  • 10
    • 0042740515 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex
    • Le Blanc K, L Tammik, B Sundberg, SE Haynesworth and O Ringden. (2003). Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 57:11-20.
    • (2003) Scand J Immunol , vol.57 , pp. 11-20
    • Le Blanc, K.1    Tammik, L.2    Sundberg, B.3    Haynesworth, S.E.4    Ringden, O.5
  • 11
    • 79960378245 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells: Agents of immune modulation
    • English K and BP Mahon. (2011). Allogeneic mesenchymal stem cells: agents of immune modulation. J Cell Biochem 112:1963-1968.
    • (2011) J Cell Biochem , vol.112 , pp. 1963-1968
    • English, K.1    Mahon, B.P.2
  • 13
    • 38349053355 scopus 로고    scopus 로고
    • Human leukocyte antigen- G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4 + CD25highFOXP3 + regulatory T cells
    • Selmani Z, A Naji, I Zidi, B Favier, E Gaiffe, L Obert, C Borg, P Saas, P Tiberghien, et al. (2008). Human leukocyte antigen- G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4 + CD25highFOXP3 + regulatory T cells. Stem Cells 26:212-222.
    • (2008) Stem Cells , vol.26 , pp. 212-222
    • Selmani, Z.1    Naji, A.2    Zidi, I.3    Favier, B.4    Gaiffe, E.5    Obert, L.6    Borg, C.7    Saas, P.8    Tiberghien, P.9
  • 14
    • 77950551326 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Current understanding and clinical status
    • Salem HK and C Thiemermann. (2010). Mesenchymal stromal cells: current understanding and clinical status. Stem Cells 28:585-596.
    • (2010) Stem Cells , vol.28 , pp. 585-596
    • Salem, H.K.1    Thiemermann, C.2
  • 15
    • 84862841834 scopus 로고    scopus 로고
    • Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute graftversus- host disease in a xenogenic mouse model
    • Gregoire-Gauthier JL, S Selleri, FO Fontaine, MM Dieng, N Patey, GV Despars, CM Beaus Jour and L Haddad. (2012). Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute graftversus- host disease in a xenogenic mouse model. Stem Cells Dev. 21:1616-1626
    • (2012) Stem Cells Dev. , vol.21 , pp. 1616-1626
    • Gregoire-Gauthier, J.L.1    Selleri, S.2    Fontaine, F.O.3    Dieng, M.M.4    Patey, N.5    Despars, G.V.6    Beaus Jour, C.M.7    Haddad, L.8
  • 16
    • 79957713226 scopus 로고    scopus 로고
    • The Th1 life cycle: Molecular control of IFN-gamma to IL-10 switching
    • Cope A, G Le Friec, J Cardone and C Kemper. (2011). The Th1 life cycle: molecular control of IFN-gamma to IL-10 switching. Trends Immunol 32:278-286.
    • (2011) Trends Immunol , vol.32 , pp. 278-286
    • Cope, A.1    Le Friec, G.2    Cardone, J.3    Kemper, C.4
  • 18
    • 66049149509 scopus 로고    scopus 로고
    • Identification and characterization of IL-10/IFN-gammaproducing effector-like T cells with regulatory function in human blood
    • Haringer B, L Lozza, B Steckel and J Geginat. (2009). Identification and characterization of IL-10/IFN-gammaproducing effector-like T cells with regulatory function in human blood. J Exp Med 206:1009-1017.
    • (2009) J Exp Med , vol.206 , pp. 1009-1017
    • Haringer, B.1    Lozza, L.2    Steckel, B.3    Geginat, J.4
  • 19
    • 61849123247 scopus 로고    scopus 로고
    • Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25(High) forkhead box P3 + regulatory T cells
    • English K, JM Ryan, L Tobin, MJ Murphy, FP Barry and BP Mahon. (2009). Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25(High) forkhead box P3 + regulatory T cells. Clin Exp Immunol 156:149-160.
    • (2009) Clin Exp Immunol , vol.156 , pp. 149-160
    • English, K.1    Ryan, J.M.2    Tobin, L.3    Murphy, M.J.4    Barry, F.P.5    Mahon, B.P.6
  • 20
    • 34548739534 scopus 로고    scopus 로고
    • Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction
    • Prevosto C, M Zancolli, P Canevali, MR Zocchi and A Poggi. (2007). Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica 92:881-888.
    • (2007) Haematologica , vol.92 , pp. 881-888
    • Prevosto, C.1    Zancolli, M.2    Canevali, P.3    Zocchi, M.R.4    Poggi, A.5
  • 21
    • 79955971620 scopus 로고    scopus 로고
    • The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells
    • Mougiakakos D, R Jitschin, CC Johansson, R Okita, R Kiessling and K Le Blanc. (2011). The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells. Blood 117:4826-4835.
    • (2011) Blood , vol.117 , pp. 4826-4835
    • Mougiakakos, D.1    Jitschin, R.2    Johansson, C.C.3    Okita, R.4    Kiessling, R.5    Le Blanc, K.6
  • 22
    • 58149306013 scopus 로고    scopus 로고
    • In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure
    • Meiler F, J Zumkehr, S Klunker, B Ruckert, CA Akdis and M Akdis. (2008). In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 205:2887- 2898.
    • (2008) J Exp Med , vol.205 , pp. 2887-2898
    • Meiler, F.1    Zumkehr, J.2    Klunker, S.3    Ruckert, B.4    Akdis, C.A.5    Akdis, M.6
  • 23
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva M, JR Christensen, M Veldhoen, TL Murphy, KM Murphy and A O'Garra. (2009). Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31:209-219.
    • (2009) Immunity , vol.31 , pp. 209-219
    • Saraiva, M.1    Christensen, J.R.2    Veldhoen, M.3    Murphy, T.L.4    Murphy, K.M.5    O'Garra, A.6
  • 24
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M and A O'Garra. (2010). The regulation of IL-10 production by immune cells. Nat Rev Immunol 10:170-181.
    • (2010) Nat Rev Immunol , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 27
    • 67650379009 scopus 로고    scopus 로고
    • Overview of stem cell therapy for Crohn's disease
    • Dryden GW. (2009). Overview of stem cell therapy for Crohn's disease. Expert Opin Biol Ther 9:841-847.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 841-847
    • Dryden, G.W.1
  • 30
    • 79955137985 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients
    • Davatchi F, BS Abdollahi, M Mohyeddin, F Shahram and B Nikbin. (2011). Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis 14:211-215.
    • (2011) Int J Rheum Dis , vol.14 , pp. 211-215
    • Davatchi, F.1    Abdollahi, B.S.2    Mohyeddin, M.3    Shahram, F.4    Nikbin, B.5
  • 32
    • 77949308137 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially
    • Prasanna SJ, D Gopalakrishnan, SR Shankar and AB Vasandan. (2010). Pro-inflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS One 5:e9016.
    • (2010) PLoS One , vol.5
    • Prasanna, S.J.1    Gopalakrishnan, D.2    Shankar, S.R.3    Vasandan, A.B.4
  • 33
    • 22144473736 scopus 로고    scopus 로고
    • Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells
    • Groh ME, B Maitra, E Szekely and ON Koc. (2005). Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells. Exp Hematol 33: 928-934.
    • (2005) Exp Hematol , vol.33 , pp. 928-934
    • Groh, M.E.1    Maitra, B.2    Szekely, E.3    Koc, O.N.4
  • 34
  • 35
    • 0037037582 scopus 로고    scopus 로고
    • Interferon gamma is required for activation-induced death of T lymphocytes
    • Refaeli Y, L Van Parijs, SI Alexander and AK Abbas. (2002). Interferon gamma is required for activation-induced death of T lymphocytes. J Exp Med 196:999-1005.
    • (2002) J Exp Med , vol.196 , pp. 999-1005
    • Refaeli, Y.1    Van Parijs, L.2    Alexander, S.I.3    Abbas, A.K.4
  • 36
    • 70849116391 scopus 로고    scopus 로고
    • Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: The importance of low cell ratio and role of interleukin-6
    • Najar M, R Rouas, G Raicevic, HI Boufker, P Lewalle, N Meuleman, D Bron, M Toungouz, P Martiat and L Lagneaux. (2009). Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6. Cytotherapy 11:570-583.
    • (2009) Cytotherapy , vol.11 , pp. 570-583
    • Najar, M.1    Rouas, R.2    Raicevic, G.3    Boufker, H.I.4    Lewalle, P.5    Meuleman, N.6    Bron, D.7    Toungouz, M.8    Martiat, P.9    Lagneaux, L.10
  • 38
    • 77953116038 scopus 로고    scopus 로고
    • Cutting edge: Human latency-associated peptide + T cells: A novel regulatory T cell subset
    • Gandhi R, MF Farez, Y Wang, D Kozoriz, FJ Quintana and HL Weiner. (2010). Cutting edge: human latency-associated peptide + T cells: a novel regulatory T cell subset. J Immunol 184:4620-4624.
    • (2010) J Immunol , vol.184 , pp. 4620-4624
    • Gandhi, R.1    Farez, M.F.2    Wang, Y.3    Kozoriz, D.4    Quintana, F.J.5    Weiner, H.L.6
  • 39
    • 59849119691 scopus 로고    scopus 로고
    • CD69 + CD4+ CD25 - T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1
    • Han Y, Q Guo, M Zhang, Z Chen and X Cao. (2009). CD69 + CD4+ CD25 - T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J Immunol 182:111-120.
    • (2009) J Immunol , vol.182 , pp. 111-120
    • Han, Y.1    Guo, Q.2    Zhang, M.3    Chen, Z.4    Cao, X.5
  • 40
    • 83555172436 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stem cells: Cytokines and factors
    • Soleymaninejadian E, K Pramanik and E Samadian. (2012). Immunomodulatory properties of mesenchymal stem cells: cytokines and factors. Am J Reprod Immunol 67:1-8.
    • (2012) Am J Reprod Immunol , vol.67 , pp. 1-8
    • Soleymaninejadian, E.1    Pramanik, K.2    Samadian, E.3
  • 42
    • 78149439868 scopus 로고    scopus 로고
    • Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells
    • Gieseke F, J Bohringer, R Bussolari, M Dominici, R Handgretinger and I Muller. (2010). Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells. Blood 116:3770-3779.
    • (2010) Blood , vol.116 , pp. 3770-3779
    • Gieseke, F.1    Bohringer, J.2    Bussolari, R.3    Dominici, M.4    Handgretinger, R.5    Muller, I.6
  • 43
    • 34447298069 scopus 로고    scopus 로고
    • Interferon- gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells
    • Ryan JM, F Barry, JM Murphy and BP Mahon. (2007). Interferon- gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol 149:353-363.
    • (2007) Clin Exp Immunol , vol.149 , pp. 353-363
    • Ryan, J.M.1    Barry, F.2    Murphy, J.M.3    Mahon, B.P.4
  • 44
    • 84856960632 scopus 로고    scopus 로고
    • Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation
    • Francois M, R Romieu-Mourez, M Li and J Galipeau. (2012). Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther 20:187-195.
    • (2012) Mol Ther , vol.20 , pp. 187-195
    • Francois, M.1    Romieu-Mourez, R.2    Li, M.3    Galipeau, J.4
  • 45
    • 14944339174 scopus 로고    scopus 로고
    • Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness
    • Beyth S, Z Borovsky, D Mevorach, M Liebergall, Z Gazit, H Aslan, E Galun and J Rachmilewitz. (2005). Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness. Blood 105:2214-2219.
    • (2005) Blood , vol.105 , pp. 2214-2219
    • Beyth, S.1    Borovsky, Z.2    Mevorach, D.3    Liebergall, M.4    Gazit, Z.5    Aslan, H.6    Galun, E.7    Rachmilewitz, J.8
  • 47
    • 84868368929 scopus 로고    scopus 로고
    • CD4( + )CD25( + )Foxp3( + )IFNgamma( + ) Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLC
    • Daniel V, M Sadeghi, H Wang and G Opelz. (2012). CD4( + )CD25( + )Foxp3( + )IFNgamma( + ) Treg are immunosuppressive in vitro and increase with intensity of the alloresponse in pretransplant MLC. Transpl Immunol. 27:114-121.
    • (2012) Transpl Immunol. , vol.27 , pp. 114-121
    • Daniel, V.1    Sadeghi, M.2    Wang, H.3    Opelz, G.4
  • 48
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S and MF Pittenger. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815-1822.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 50
    • 69249227552 scopus 로고    scopus 로고
    • MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: Central role of MSC-derived prostaglandin E2
    • Spaggiari GM, H Abdelrazik, F Becchetti and L Moretta. (2009). MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood 113:6576-6583.
    • (2009) Blood , vol.113 , pp. 6576-6583
    • Spaggiari, G.M.1    Abdelrazik, H.2    Becchetti, F.3    Moretta, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.