Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing

European Journal of Pharmacology

Volumn 727, Issue 1, 2014, Pages 1-7

  Sakurai, Taku ^a   Davenport, Richard ^b   Stafford, Stuart ^b   Grosse, Johannes ^b   Ogawa, Kazumasa ^a   Cameron, Jennifer ^b   Parton, Laura ^b   Sykes, Andy ^b   Mack, Stephen ^b   Bousba, Sarah ^b   Parmar, Alka ^b   Harrison, David ^b   Dickson, Louise ^b   Leveridge, Mathew ^b   Matsui, Junji ^a   Barnes, Matt ^b  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b Takeda Cambridge   (United Kingdom)

Author keywords

Dyslipidemia; GPCR; GPR81; HTS; Lipolysis

Indexed keywords

ANTILIPEMIC AGENT; G PROTEIN COUPLED RECEPTOR; G PROTEIN-COUPLED RECEPTOR 81, MOUSE; GPR81 PROTEIN, HUMAN; LACTIC ACID; THIAZOLE DERIVATIVE;

129 MOUSE; 3T3 CELL LINE; ADIPOCYTE; AGONISTS; ANIMAL; C57BL MOUSE; DEFICIENCY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; FLUSHING; GENETIC TRANSFECTION; GENETICS; HIGH THROUGHPUT SCREENING; INTRAPERITONEAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; LIPOLYSIS; MALE; METABOLISM; MOUSE; PREVENTION AND CONTROL; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE, WHITE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FLUSHING; HIGH-THROUGHPUT SCREENING ASSAYS; HYPOLIPIDEMIC AGENTS; INJECTIONS, INTRAPERITONEAL; LACTIC ACID; LIPOLYSIS; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRANSFECTION;

EID: 84893452211     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.01.029     Document Type: Article

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