SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense

EMBO Reports

Volumn 17, Issue 6, 2016, Pages 811-822

  Zhou, Lisha ^a   Wang, Fang ^a   Sun, Renqiang ^a   Chen, Xiufei ^a   Zhang, Mengli ^a   Xu, Qi ^a   Wang, Yi ^a   Wang, Shiwen ^a   Xiong, Yue ^a,b   Guan, Kun Liang ^a,c   Yang, Pengyuan ^a   Yu, Hongxiu ^a   Ye, Dan ^a,d  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d FUDAN UNIVERSITY   (China)

Author keywords

glutarylation; NADPH; oxidative stress; SIRT5; succinylation

Indexed keywords

CASPASE 3; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SIRTUIN 5; SUCCINYL COENZYME A; TYROSINE 3 MONOOXYGENASE; ANTIOXIDANT; GLUTATHIONE; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SIRT5 PROTEIN, HUMAN; SIRTUIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BASAL METABOLIC RATE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DESUCCINYLATION; ENZYME INHIBITION; FEMALE; GENE INACTIVATION; GENE SILENCING; HEK293 CELL LINE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HOMEOSTASIS; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; MUTATION; OXIDATION REDUCTION REACTION; PROTEIN PROCESSING;

ANIMALS; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; GENE KNOCKDOWN TECHNIQUES; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUTATHIONE; HUMANS; ISOCITRATE DEHYDROGENASE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MUTATION; NADP; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REACTIVE OXYGEN SPECIES; SIRTUINS;

EID: 84971505030     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201541643     Document Type: Article

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