Crystal structure of porcine mitochondrial NADP +-dependent isocitrate dehydrogenase complexed with Mn 2+ and isocitrate: Insights into the enzyme mechanism

Journal of Biological Chemistry

Volumn 277, Issue 45, 2002, Pages 43454-43462

  Ceccarelli, Christopher ^a   Grodsky, Neil B ^a   Ariyaratne, Nandana ^a   Colman, Roberta F ^a   Bahnson, Brian J ^a,b  

^a UNIVERSITY OF DELAWARE   (United States)

^b SUGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHORYLATION;

CRYSTAL STRUCTURE; ENZYMES; ESCHERICHIA COLI; MONOMERS; SUBSTITUTION REACTIONS;

BIOCHEMISTRY;

ISOCITRATE DEHYDROGENASE (NADP); ISOCITRIC ACID; MANGANESE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENIUM; SELENOMETHIONINE; THROMBIN;

ARTICLE; BACILLUS SUBTILIS; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ESCHERICHIA COLI; MITOCHONDRION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTON TRANSPORT; SEQUENCE ALIGNMENT; SWINE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ISOCITRATE DEHYDROGENASE; ISOCITRATES; KINETICS; MANGANESE; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMIDS; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SWINE;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; SUIDAE; SUS SCROFA;

EID: 0037044810     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207306200     Document Type: Article

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