Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 22, 2016, Pages E3101-E3110

  Das, Sudip ^a   Lindemann, Claudia ^b   Young, Bernadette C ^c   Muller, Julius ^b   Österreich, Babett ^a   Ternette, Nicola ^b   Winkler, Ann Cathrin ^a   Paprotka, Kerstin ^a   Reinhardt, Richard ^d   Förstner, Konrad U ^a   Allen, Elizabeth ^b   Flaxman, Amy ^b   Yamaguchi, Yuko ^b   Rollier, Christine S ^e   Diemen, Pauline Van ^b   Blättner, Sebastian ^a   Remmele, Christian W ^a   Selle, Martina ^a   Dittrich, Marcus ^a   Müller, Tobias ^a   Vogel, Jörg ^a   Ohlsen, Knut ^a   Crook, Derrick W ^c   Massey, Ruth ^f   Wilson, Daniel J ^c,g   Rudel, Thomas ^a   Wyllie, David H ^b   Fraunholz, Martin J ^a   more..

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Churchill Hospital   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Max Planck Genome Centre Cologne   (Germany)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f University of Bath   (United Kingdom)

^g UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bloodstream infection; Rsp; SSR42; Staphylococcus aureus; Toxicity regulator

Indexed keywords

HYDROGEN PEROXIDE; LONG UNTRANSLATED RNA; BACTERIAL PROTEIN; MESSENGER RNA; UNTRANSLATED RNA; VIRULENCE FACTOR;

ABSCESS; ARTICLE; BACTEREMIA; BACTERIAL STRAIN; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE SEVERITY; DNA LIBRARY; FEMALE; GENE EXPRESSION; HELA CELL LINE; HEMOLYSIS; HUMAN; HUMAN CELL; LETHALITY; LOSS OF FUNCTION MUTATION; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; UPREGULATION; ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; COMPLICATION; GENE EXPRESSION REGULATION; GENETICS; MICROBIOLOGY; MOUSE; MUTATION; PATHOGENICITY; PATHOLOGY; PROTEOMICS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS INFECTION; VIRULENCE;

ABSCESS; ANIMALS; APOPTOSIS; BACTEREMIA; BACTERIAL PROTEINS; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HELA CELLS; HEMOLYSIS; HUMANS; MICE; MICE, INBRED BALB C; MUTATION; PROTEOMICS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, UNTRANSLATED; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE; VIRULENCE FACTORS;

EID: 84971433411     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1520255113     Document Type: Article

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