Staphylococcus aureus dynamically adapts global regulators and virulence factor expression in the course from acute to chronic infection

Current Genetics

Volumn 62, Issue 1, 2016, Pages 15-17

  Tuchscherr, Lorena ^a   Löffler, Bettina ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Cells; Persistence; SigB; Staphylococcus aureus

Indexed keywords

ADHESIN; STAPHYLOCOCCUS TOXIN; VIRULENCE FACTOR; BACTERIAL PROTEIN; SIGB PROTEIN, BACTERIA; SIGMA FACTOR;

ADAPTATION; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; UPREGULATION; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; PHYSIOLOGY;

ADAPTATION, BIOLOGICAL; ANIMALS; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; SIGMA FACTOR; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE FACTORS;

EID: 84955696498     PISSN: 01728083     EISSN: 14320983     Source Type: Journal    
DOI: 10.1007/s00294-015-0503-0     Document Type: Article

References (17)

1. Hecker M, Reder A, Fuchs S, Pagels M, Engelmann S (2009) Physiological proteomics and stress/starvation responses in Bacillus subtilis and Staphylococcus aureus. Res Microbiol 160:245–258
2. Horst SA, Hoerr V, Beineke A, Kreis C, Tuchscherr L, Kalinka J, Lehne S, Schleicher I, Kohler G, Fuchs T et al (2012) A novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection: an integrated view of disease pathogenesis. Am J Pathol 181:1206–1214
3. Kriegeskorte A, Konig S, Sander G, Pirkl A, Mahabir E, Proctor RA, von Eiff C, Peters G, Becker K (2011) Small colony variants of Staphylococcus aureus reveal distinct protein profiles. Proteomics 11:2476–2490
4. Lew DP, Waldvogel FA (2004) Osteomyelitis. Lancet 364:369–379
5. Lowy FD (1998) Staphylococcus aureus infections. N Engl J Med 339:520–532
6. Mitchell G, Lamontagne CA, Brouillette E, Grondin G, Talbot BG, Grandbois M, Malouin F (2008) Staphylococcus aureus SigB activity promotes a strong fibronectin–bacterium interaction which may sustain host tissue colonization by small-colony variants isolated from cystic fibrosis patients. Mol Microbiol 70:1540–1555
7. Mitchell G, Seguin DL, Asselin AE, Deziel E, Cantin AM, Frost EH, Michaud S, Malouin F (2010a) Staphylococcus aureus sigma B-dependent emergence of small-colony variants and biofilm production following exposure to Pseudomonas aeruginosa 4-hydroxy-2-heptylquinoline-N-oxide. BMC Microbiol 10:33
8. Mitchell G, Brouillette E, Seguin DL, Asselin AE, Jacob CL, Malouin F (2010b) A role for sigma factor B in the emergence of Staphylococcus aureus small-colony variants and elevated biofilm production resulting from an exposure to aminoglycosides. Microb Pathog 48:18–27
9. Mitchell G, Fugere A, Pepin GK, Brouillette E, Frost EH, Cantin AM, Malouin F (2013) SigB is a dominant regulator of virulence in Staphylococcus aureus small-colony variants. PLoS ONE 8:e65018
10. Novick RP, Geisinger E (2008) Quorum sensing in staphylococci. Annu Rev Genet 42:541–564
11. Proctor RA, von Eiff C, Kahl BC, Becker K, McNamara P, Herrmann M, Peters G (2006) Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections. Nat Rev Microbiol 4:295–305
12. Sendi P, Proctor RA (2009) Staphylococcus aureus as an intracellular pathogen: the role of small colony variants. Trends Microbiol 17:54–58
13. Tuchscherr L, Heitmann V, Hussain M, Viemann D, Roth J, von Eiff C, Peters G, Becker K, Löffler B (2010) Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence. J Infect Dis 202:1031–1040
14. Tuchscherr L, Medina E, Hussain M, Völker W, Heitmann V, Niemann S, Holzinger D, Roth J, Proctor RA, Becker K et al (2011) Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection. EMBO Mol Med 3:129–141
15. Tuchscherr L, Bischoff M, Lattar SM, Noto LM, Pfortner H, Niemann S, Geraci J, Van de Vyver H, Fraunholz MJ, Cheung AL et al (2015) Sigma factor SigB is crucial to mediate Staphylococcus aureus adaptation during chronic infections. PLoS Pathog 11:e1004870
16. von Eiff C, Heilmann C, Proctor RA, Woltz C, Peters G, Götz F (1997) A site-directed Staphylococcus aureushemB mutant is a small-colony variant which persists intracellularly. J Bacteriol 179:4706–4712
17. Werdan K, Dietz S, Löffler B, Niemann S, Bushnaq H, Silber RE, Peters G, Muller-Werdan U (2014) Mechanisms of infective endocarditis: pathogen–host interaction and risk states. Nat Rev Cardiol 11:35–50