Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion

Journal of Immunology

Volumn 186, Issue 11, 2011, Pages 6445-6453

  Laarman, Alexander J ^a   Ruyken, Maartje ^a   Malone, Cheryl L ^b   Van Strijp, Jos A G ^a   Horswill, Alexander R ^b   Rooijakkers, Suzan H M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUREOLYSIN; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C5A; COMPLEMENT FACTOR H; COMPLEMENT FACTOR I; METALLOPROTEINASE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; COMPLEMENT DEPOSITION; COMPLEMENT INHIBITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IMMUNE EVASION; IMMUNE RESPONSE; INHIBITION KINETICS; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN SECRETION; SERUM; STAPHYLOCOCCUS AUREUS; SUPERNATANT;

BACTERIAL PROTEINS; BLOTTING, WESTERN; COMPLEMENT ACTIVATION; COMPLEMENT C3; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT C3A; COMPLEMENT C3B; CYTOTOXICITY, IMMUNOLOGIC; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; METALLOENDOPEPTIDASES; MUTATION; NEUTROPHILS; PHAGOCYTOSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; U937 CELLS;

EID: 79958050684     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002948     Document Type: Article

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