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Volumn 90, Issue 12, 2016, Pages 5665-5676

Short intracellular HIV-1 transcripts as biomarkers of residual immune activation in patients on antiretroviral therapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; BIOLOGICAL MARKER; CD38 ANTIGEN; CD38 PROTEIN, HUMAN; HLA DR ANTIGEN; MEMBRANE PROTEIN; VIRUS RNA;

EID: 84971421783     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03158-15     Document Type: Article
Times cited : (28)

References (54)
  • 2
    • 84886790685 scopus 로고    scopus 로고
    • The end of AIDS: HIV infection as a chronic disease
    • Deeks SG, Lewin SR, Havlir DV. 2013. The end of AIDS: HIV infection as a chronic disease. Lancet 382:1525-1533. http://dx.doi.org/10.1016/S0140-6736(13)61809-7.
    • (2013) Lancet , vol.382 , pp. 1525-1533
    • Deeks, S.G.1    Lewin, S.R.2    Havlir, D.V.3
  • 3
    • 57349124803 scopus 로고    scopus 로고
    • The role of HIV in serious diseases other than AIDS
    • Phillips AN, Neaton J, Lundgren JD. 2008. The role of HIV in serious diseases other than AIDS. AIDS 22:2409-2418. http://dx.doi.org/10.1097/QAD.0b013e3283174636.
    • (2008) AIDS , vol.22 , pp. 2409-2418
    • Phillips, A.N.1    Neaton, J.2    Lundgren, J.D.3
  • 4
    • 84865282827 scopus 로고    scopus 로고
    • Immunosenescence and HIV
    • Deeks SG, Verdin E, McCune JM. 2012. Immunosenescence and HIV. Curr Opin Immunol 24:501-506. http://dx.doi.org/10.1016/j.coi.2012.05.004.
    • (2012) Curr Opin Immunol , vol.24 , pp. 501-506
    • Deeks, S.G.1    Verdin, E.2    McCune, J.M.3
  • 6
    • 84876415088 scopus 로고    scopus 로고
    • How to best measure HIV reservoirs?
    • Rouzioux C, Richman D. 2013. How to best measure HIV reservoirs? Curr Opin HIV AIDS 8:170-175. http://dx.doi.org/10.1097/COH.0b013e32835fc619.
    • (2013) Curr Opin HIV AIDS , vol.8 , pp. 170-175
    • Rouzioux, C.1    Richman, D.2
  • 8
    • 79952204267 scopus 로고    scopus 로고
    • Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure
    • Sharkey M, Babic DZ, Greenough T, Gulick R, Kuritzkes DR, Stevenson M. 2011. Episomal viral cDNAs identify a reservoir that fuels viral rebound after treatment interruption and that contributes to treatment failure. PLoS Pathog 7:e1001303. http://dx.doi.org/10.1371/journal.ppat.1001303.
    • (2011) PLoS Pathog , vol.7
    • Sharkey, M.1    Babic, D.Z.2    Greenough, T.3    Gulick, R.4    Kuritzkes, D.R.5    Stevenson, M.6
  • 10
    • 0036838605 scopus 로고    scopus 로고
    • A sensitive, quantitative assay for human immunodeficiency virus type 1 integration
    • O'Doherty U, Swiggard WJ, Jeyakumar D, McGain D, Malim MH. 2002. A sensitive, quantitative assay for human immunodeficiency virus type 1 integration. J Virol 76:10942-10950. http://dx.doi.org/10.1128/JVI.76.21.10942-10950.2002.
    • (2002) J Virol , vol.76 , pp. 10942-10950
    • O'Doherty, U.1    Swiggard, W.J.2    Jeyakumar, D.3    McGain, D.4    Malim, M.H.5
  • 11
    • 84876111496 scopus 로고    scopus 로고
    • Cell-associated HIV RNA: a dynamic biomarker of viral persistence
    • Pasternak AO, Lukashov VV, Berkhout B. 2013. Cell-associated HIV RNA: a dynamic biomarker of viral persistence. Retrovirology 10:41. http://dx.doi.org/10.1186/1742-4690-10-41.
    • (2013) Retrovirology , vol.10 , pp. 41
    • Pasternak, A.O.1    Lukashov, V.V.2    Berkhout, B.3
  • 13
    • 0026439078 scopus 로고
    • Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1
    • Seshamma T, Bagasra O, Trono D, Baltimore D, Pomerantz RJ. 1992. Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1. Proc Natl Acad Sci U S A 89:10663-10667. http://dx.doi.org/10.1073/pnas.89.22.10663.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 10663-10667
    • Seshamma, T.1    Bagasra, O.2    Trono, D.3    Baltimore, D.4    Pomerantz, R.J.5
  • 15
    • 49049107011 scopus 로고    scopus 로고
    • Highly sensitive methods based on seminested real-time reverse transcription-PCR for quantitation of human immunodeficiency virus type 1 unspliced and multiply spliced RNA and proviral DNA
    • Pasternak AO, Adema KW, Bakker M, Jurriaans S, Berkhout B, Cornelissen M, Lukashov VV. 2008. Highly sensitive methods based on seminested real-time reverse transcription-PCR for quantitation of human immunodeficiency virus type 1 unspliced and multiply spliced RNA and proviral DNA. J Clin Microbiol 46:2206-2211. http://dx.doi.org/10.1128/JCM.00055-08.
    • (2008) J Clin Microbiol , vol.46 , pp. 2206-2211
    • Pasternak, A.O.1    Adema, K.W.2    Bakker, M.3    Jurriaans, S.4    Berkhout, B.5    Cornelissen, M.6    Lukashov, V.V.7
  • 16
    • 59349092367 scopus 로고    scopus 로고
    • Biphasic decay kinetics suggest progressive slowing in turnover of latently HIV-1 infected cells during antiretroviral therapy
    • Fischer M, Joos B, Niederost B, Kaiser P, Hafner R, von Wyl V, Ackermann M, Weber R, Gunthard HF. 2008. Biphasic decay kinetics suggest progressive slowing in turnover of latently HIV-1 infected cells during antiretroviral therapy. Retrovirology 5:107. http://dx.doi.org/10.1186/1742-4690-5-107.
    • (2008) Retrovirology , vol.5 , pp. 107
    • Fischer, M.1    Joos, B.2    Niederost, B.3    Kaiser, P.4    Hafner, R.5    von Wyl, V.6    Ackermann, M.7    Weber, R.8    Gunthard, H.F.9
  • 18
    • 79957966626 scopus 로고    scopus 로고
    • Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy
    • Chun TW, Murray D, Justement JS, Hallahan CW, Moir S, Kovacs C, Fauci AS. 2011. Relationship between residual plasma viremia and the size of HIV proviral DNA reservoirs in infected individuals receiving effective antiretroviral therapy. J Infect Dis 204:135-138. http://dx.doi.org/10.1093/infdis/jir208.
    • (2011) J Infect Dis , vol.204 , pp. 135-138
    • Chun, T.W.1    Murray, D.2    Justement, J.S.3    Hallahan, C.W.4    Moir, S.5    Kovacs, C.6    Fauci, A.S.7
  • 19
    • 0027504250 scopus 로고
    • Peripheral blood mononuclear cell human immunodeficiency virus type 1 proviralDNAquantification by polymerase chain reaction: relationship to immunodeficiency and drug effect
    • Montoya JG, Wood R, Katzenstein D, Holodny M, Merigan TC. 1993. Peripheral blood mononuclear cell human immunodeficiency virus type 1 proviralDNAquantification by polymerase chain reaction: relationship to immunodeficiency and drug effect. J Clin Microbiol 31:2692-2696.
    • (1993) J Clin Microbiol , vol.31 , pp. 2692-2696
    • Montoya, J.G.1    Wood, R.2    Katzenstein, D.3    Holodny, M.4    Merigan, T.C.5
  • 20
    • 0028301838 scopus 로고
    • Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts
    • Adams M, Sharmeen L, Kimpton J, Romeo JM, Garcia JV, Peterlin BM, Groudine M, Emerman M. 1994. Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts. Proc Natl Acad Sci U S A 91:3862-3866. http://dx.doi.org/10.1073/pnas.91.9.3862.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3862-3866
    • Adams, M.1    Sharmeen, L.2    Kimpton, J.3    Romeo, J.M.4    Garcia, J.V.5    Peterlin, B.M.6    Groudine, M.7    Emerman, M.8
  • 21
    • 0025817413 scopus 로고
    • The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation
    • Feinberg MB, Baltimore D, Frankel AD. 1991. The role of Tat in the human immunodeficiency virus life cycle indicates a primary effect on transcriptional elongation. Proc Natl Acad Sci U S A 88:4045-4049. http://dx.doi.org/10.1073/pnas.88.9.4045.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 4045-4049
    • Feinberg, M.B.1    Baltimore, D.2    Frankel, A.D.3
  • 22
    • 0032087891 scopus 로고    scopus 로고
    • Transcriptional pausing at +62 of the HIV-1 nascent RNA modulates formation of the TAR RNA structure
    • Palangat M, Meier TI, Keene RG, Landick R. 1998. Transcriptional pausing at +62 of the HIV-1 nascent RNA modulates formation of the TAR RNA structure. Mol Cell 1:1033-1042. http://dx.doi.org/10.1016/S1097-2765(00)80103-3.
    • (1998) Mol Cell , vol.1 , pp. 1033-1042
    • Palangat, M.1    Meier, T.I.2    Keene, R.G.3    Landick, R.4
  • 23
    • 84899641394 scopus 로고    scopus 로고
    • 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts
    • Mizutani T, Ishizaka A, Suzuki Y, Iba H. 2014. 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcripts. FEBS Lett 588:1630-1636. http://dx.doi.org/10.1016/j.febslet.2014.01.067.
    • (2014) FEBS Lett , vol.588 , pp. 1630-1636
    • Mizutani, T.1    Ishizaka, A.2    Suzuki, Y.3    Iba, H.4
  • 24
    • 0025837425 scopus 로고
    • DNase I-hypersensitive sites are associated with both long terminal repeats and with the intragenic enhancer of integrated human immunodeficiency virus type 1
    • Verdin E. 1991. DNase I-hypersensitive sites are associated with both long terminal repeats and with the intragenic enhancer of integrated human immunodeficiency virus type 1. J Virol 65:6790-6799.
    • (1991) J Virol , vol.65 , pp. 6790-6799
    • Verdin, E.1
  • 25
    • 0027258123 scopus 로고
    • Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation
    • Verdin E, Paras P, Jr, Van Lint C. 1993. Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation. EMBO J 12:3249-3259.
    • (1993) EMBO J , vol.12 , pp. 3249-3259
    • Verdin, E.1    Paras, P.2    Van Lint, C.3
  • 26
    • 0029919356 scopus 로고    scopus 로고
    • Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation
    • Van Lint C, Emiliani S, Ott M, Verdin E. 1996. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J 15:1112-1120.
    • (1996) EMBO J , vol.15 , pp. 1112-1120
    • Van Lint, C.1    Emiliani, S.2    Ott, M.3    Verdin, E.4
  • 27
    • 0346993663 scopus 로고    scopus 로고
    • Recruitment of SWI/SNF to the human immunodeficiency virus type 1 promoter
    • Henderson A, Holloway A, Reeves R, Tremethick DJ. 2004. Recruitment of SWI/SNF to the human immunodeficiency virus type 1 promoter. Mol Cell Biol 24:389-397. http://dx.doi.org/10.1128/MCB.24.1.389-397.2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 389-397
    • Henderson, A.1    Holloway, A.2    Reeves, R.3    Tremethick, D.J.4
  • 28
    • 33746021681 scopus 로고    scopus 로고
    • The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter
    • Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E. 2006. The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem 281:19960-19968. http://dx.doi.org/10.1074/jbc.M603336200.
    • (2006) J Biol Chem , vol.281 , pp. 19960-19968
    • Mahmoudi, T.1    Parra, M.2    Vries, R.G.3    Kauder, S.E.4    Verrijzer, C.P.5    Ott, M.6    Verdin, E.7
  • 29
    • 0036232430 scopus 로고    scopus 로고
    • Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat
    • He G, Margolis DM. 2002. Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat. Mol Cell Biol 22:2965-2973. http://dx.doi.org/10.1128/MCB.22.9.2965-2973.2002.
    • (2002) Mol Cell Biol , vol.22 , pp. 2965-2973
    • He, G.1    Margolis, D.M.2
  • 30
    • 70350312832 scopus 로고    scopus 로고
    • Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of human immunodeficiency virus type 1 transcripts
    • Mizutani T, Ishizaka A, Tomizawa M, Okazaki T, Yamamichi N, Kawana-Tachikawa A, Iwamoto A, Iba H. 2009. Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of human immunodeficiency virus type 1 transcripts. J Virol 83:11569-11580. http://dx.doi.org/10.1128/JVI.00742-09.
    • (2009) J Virol , vol.83 , pp. 11569-11580
    • Mizutani, T.1    Ishizaka, A.2    Tomizawa, M.3    Okazaki, T.4    Yamamichi, N.5    Kawana-Tachikawa, A.6    Iwamoto, A.7    Iba, H.8
  • 31
    • 0345218311 scopus 로고    scopus 로고
    • Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)
    • Garcia-Rodriguez C, Rao A. 1998. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). J Exp Med 187:2031-2036. http://dx.doi.org/10.1084/jem.187.12.2031.
    • (1998) J Exp Med , vol.187 , pp. 2031-2036
    • Garcia-Rodriguez, C.1    Rao, A.2
  • 32
    • 84859510075 scopus 로고    scopus 로고
    • Double plant homeodomain (PHD) finger proteins DPF3a and-3b are required as transcriptional coactivators in SWI/SNF complexdependent activation of NF-κB RelA/p50 heterodimer
    • Ishizaka A, Mizutani T, Kobayashi K, Tando T, Sakurai K, Fujiwara T, Iba H. 2012. Double plant homeodomain (PHD) finger proteins DPF3a and-3b are required as transcriptional coactivators in SWI/SNF complexdependent activation of NF-κB RelA/p50 heterodimer. J Biol Chem 287: 11924-11933. http://dx.doi.org/10.1074/jbc.M111.322792.
    • (2012) J Biol Chem , vol.287 , pp. 11924-11933
    • Ishizaka, A.1    Mizutani, T.2    Kobayashi, K.3    Tando, T.4    Sakurai, K.5    Fujiwara, T.6    Iba, H.7
  • 33
    • 0029956642 scopus 로고    scopus 로고
    • Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain
    • Parada CA, Roeder RG. 1996. Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. Nature 384:375-378. http://dx.doi.org/10.1038/384375a0.
    • (1996) Nature , vol.384 , pp. 375-378
    • Parada, C.A.1    Roeder, R.G.2
  • 34
    • 0032506242 scopus 로고    scopus 로고
    • HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter
    • Marzio G, Tyagi M, Gutierrez MI, Giacca M. 1998. HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter. Proc Natl Acad SciUSA95:13519-13524. http://dx.doi.org/10.1073/pnas.95.23.13519.
    • (1998) Proc Natl Acad SciUSA , vol.95 , pp. 13519-13524
    • Marzio, G.1    Tyagi, M.2    Gutierrez, M.I.3    Giacca, M.4
  • 38
    • 3543069879 scopus 로고    scopus 로고
    • Seventeen-colour flow cytometry: unravelling the immune system
    • Perfetto SP, Chattopadhyay PK, Roederer M. 2004. Seventeen-colour flow cytometry: unravelling the immune system. Nat Rev Immunol 4:648-655. http://dx.doi.org/10.1038/nri1416.
    • (2004) Nat Rev Immunol , vol.4 , pp. 648-655
    • Perfetto, S.P.1    Chattopadhyay, P.K.2    Roederer, M.3
  • 40
    • 0023874174 scopus 로고
    • Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate
    • Folks TM, Justement J, Kinter A, Schnittman S, Orenstein J, Poli G, Fauci AS. 1988. Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate. J Immunol 140:1117-1122.
    • (1988) J Immunol , vol.140 , pp. 1117-1122
    • Folks, T.M.1    Justement, J.2    Kinter, A.3    Schnittman, S.4    Orenstein, J.5    Poli, G.6    Fauci, A.S.7
  • 43
    • 0038701685 scopus 로고    scopus 로고
    • + T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
    • + T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 187:1534-1543. http://dx.doi.org/10.1086/374786.
    • (2003) J Infect Dis , vol.187 , pp. 1534-1543
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3    Bredt, B.4    Hagos, E.5    Lampiris, H.6    Deeks, S.G.7
  • 45
    • 0017361063 scopus 로고
    • The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response
    • Hay JB, Hobbs BB. 1977. The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response. J Exp Med 145: 31-44. http://dx.doi.org/10.1084/jem.145.1.31.
    • (1977) J Exp Med , vol.145 , pp. 31-44
    • Hay, J.B.1    Hobbs, B.B.2
  • 47
    • 84857479601 scopus 로고    scopus 로고
    • Lymphoid tissue damage in HIV-1 infection depletes naive T cells and limits T cell reconstitution after antiretroviral therapy
    • Zeng M, Southern PJ, Reilly CS, Beilman GJ, Chipman JG, Schacker TW, Haase AT. 2012. Lymphoid tissue damage in HIV-1 infection depletes naive T cells and limits T cell reconstitution after antiretroviral therapy. PLoS Pathog 8:e1002437. http://dx.doi.org/10.1371/journal.ppat.1002437.
    • (2012) PLoS Pathog , vol.8
    • Zeng, M.1    Southern, P.J.2    Reilly, C.S.3    Beilman, G.J.4    Chipman, J.G.5    Schacker, T.W.6    Haase, A.T.7
  • 48
    • 0030989529 scopus 로고    scopus 로고
    • Characterization of the solution complex between the interferoninduced, double-stranded RNA-activated protein kinase and HIV-I transactivating region RNA
    • Carpick BW, Graziano V, Schneider D, Maitra RK, Lee X, Williams BR. 1997. Characterization of the solution complex between the interferoninduced, double-stranded RNA-activated protein kinase and HIV-I transactivating region RNA. J Biol Chem 272:9510-9516. http://dx.doi.org/10.1074/jbc.272.14.9510.
    • (1997) J Biol Chem , vol.272 , pp. 9510-9516
    • Carpick, B.W.1    Graziano, V.2    Schneider, D.3    Maitra, R.K.4    Lee, X.5    Williams, B.R.6
  • 49
    • 0028332026 scopus 로고
    • Doublestranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB
    • Kumar A, Haque J, Lacoste J, Hiscott J, Williams BR. 1994. Doublestranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB. Proc Natl Acad Sci U S A 91:6288-6292.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6288-6292
    • Kumar, A.1    Haque, J.2    Lacoste, J.3    Hiscott, J.4    Williams, B.R.5
  • 51
    • 33646052566 scopus 로고    scopus 로고
    • Immunological recovery and antiretroviral therapy in HIV-1 infection
    • Battegay M, Nuesch R, Hirschel B, Kaufmann GR. 2006. Immunological recovery and antiretroviral therapy in HIV-1 infection. Lancet Infect Dis 6:280-287. http://dx.doi.org/10.1016/S1473-3099(06)70463-7.
    • (2006) Lancet Infect Dis , vol.6 , pp. 280-287
    • Battegay, M.1    Nuesch, R.2    Hirschel, B.3    Kaufmann, G.R.4


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