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Volumn 6, Issue , 2016, Pages

Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; MIXED FUNCTION OXIDASE; NERVE PROTEIN; ONCOPROTEIN; SIGNAL PEPTIDE; SLIT HOMOLOG 2 PROTEIN; TET1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXA9; ZNF382 PROTEIN, HUMAN;

EID: 84971328511     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep26591     Document Type: Article
Times cited : (113)

References (58)
  • 1
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones, P. A., Baylin, S. B. The epigenomics of cancer. Cell 128, 683-692, doi: 10.1016/j.cell.2007.01.029 (2007).
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 2
    • 84922621952 scopus 로고    scopus 로고
    • Function and information content of DNA methylation
    • Schubeler, D. Function and information content of DNA methylation. Nature 517, 321-326, doi: 10.1038/nature14192 (2015).
    • (2015) Nature , vol.517 , pp. 321-326
    • Schubeler, D.1
  • 3
    • 84863770814 scopus 로고    scopus 로고
    • Cancer genetics and epigenetics: Two sides of the same coin?
    • You, J. S., Jones, P. A. Cancer genetics and epigenetics: two sides of the same coin? Cancer cell 22, 9-20, doi: 10.1016/j. ccr.2012.06.008 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 9-20
    • You, J.S.1    Jones, P.A.2
  • 4
    • 84928890627 scopus 로고    scopus 로고
    • Genetic alterations of DNA methylation machinery in human diseases
    • Hamidi, T., Singh, A. K., Chen, T. Genetic alterations of DNA methylation machinery in human diseases. Epigenomics 7, 247-265, doi: 10.2217/epi.14.80 (2015).
    • (2015) Epigenomics , vol.7 , pp. 247-265
    • Hamidi, T.1    Singh, A.K.2    Chen, T.3
  • 5
    • 84875490185 scopus 로고    scopus 로고
    • Cancer genome landscapes
    • Vogelstein, B. et al. Cancer genome landscapes. Science 339, 1546-1558, doi: 10.1126/science.1235122 (2013).
    • (2013) Science , vol.339 , pp. 1546-1558
    • Vogelstein, B.1
  • 6
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani, M. et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930-935, doi: 10.1126/science.1170116 (2009).
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1
  • 7
    • 84255200412 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations
    • Jin, S. G. et al. 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer research 71, 7360-7365, doi: 10.1158/0008-5472.CAN-11-2023 (2011).
    • (2011) Cancer Research , vol.71 , pp. 7360-7365
    • Jin, S.G.1
  • 8
    • 84856058152 scopus 로고    scopus 로고
    • Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers
    • Haffner, M. C. et al. Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. Oncotarget 2, 627-637 (2011).
    • (2011) Oncotarget , vol.2 , pp. 627-637
    • Haffner, M.C.1
  • 9
    • 84863393235 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation
    • Kudo, Y. et al. Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation. Cancer science 103, 670-676, doi: 10.1111/j.1349-7006.2012.02213.x (2012).
    • (2012) Cancer Science , vol.103 , pp. 670-676
    • Kudo, Y.1
  • 10
    • 84911493925 scopus 로고    scopus 로고
    • 5-Hydroxymethylcytosine is a predominantly stable DNA modification
    • Bachman, M. et al. 5-Hydroxymethylcytosine is a predominantly stable DNA modification. Nature chemistry 6, 1049-1055, doi: 10.1038/nchem.2064 (2014).
    • (2014) Nature Chemistry , vol.6 , pp. 1049-1055
    • Bachman, M.1
  • 11
    • 84866419591 scopus 로고    scopus 로고
    • Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
    • Lian, C. G. et al. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell 150, 1135-1146, doi: 10.1016/j. cell.2012.07.033 (2012).
    • (2012) Cell , vol.150 , pp. 1135-1146
    • Lian, C.G.1
  • 12
    • 84860749868 scopus 로고    scopus 로고
    • Tet family proteins and 5-hydroxymethylcytosine in development and disease
    • Tan, L., Shi, Y. G. Tet family proteins and 5-hydroxymethylcytosine in development and disease. Development 139, 1895-1902, doi: 10.1242/dev.070771 (2012).
    • (2012) Development , vol.139 , pp. 1895-1902
    • Tan, L.1    Shi, Y.G.2
  • 13
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo, J. U., Su, Y., Zhong, C., Ming, G. L., Song, H. Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145, 423-434, doi: 10.1016/j.cell.2011.03.022 (2011).
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 14
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • Delhommeau, F. et al. Mutation in TET2 in myeloid cancers. The New England journal of medicine 360, 2289-2301, doi: 10.1056/NEJMoa0810069 (2009).
    • (2009) The New England Journal of Medicine , vol.360 , pp. 2289-2301
    • Delhommeau, F.1
  • 15
    • 80054046273 scopus 로고    scopus 로고
    • Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia
    • Konstandin, N. et al. Genomic 5-hydroxymethylcytosine levels correlate with TET2 mutations and a distinct global gene expression pattern in secondary acute myeloid leukemia. Leukemia 25, 1649-1652, doi: 10.1038/leu.2011.134 (2011).
    • (2011) Leukemia , vol.25 , pp. 1649-1652
    • Konstandin, N.1
  • 16
    • 79960064353 scopus 로고    scopus 로고
    • Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
    • Moran-Crusio, K. et al. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer cell 20, 11-24, doi: 10.1016/j.ccr.2011.06.001 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 11-24
    • Moran-Crusio, K.1
  • 17
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5 mC to 5 hmC conversion, ES-cell self-renewal and inner cell mass specification
    • Ito, S. et al. Role of Tet proteins in 5 mC to 5 hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466, 1129-1133, doi: 10.1038/nature09303 (2010).
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1
  • 18
    • 84890568163 scopus 로고    scopus 로고
    • Role of Tet1 in erasure of genomic imprinting
    • Yamaguchi, S., Shen, L., Liu, Y., Sendler, D., Zhang, Y. Role of Tet1 in erasure of genomic imprinting. Nature 504, 460-464, doi: 10.1038/nature12805 (2013).
    • (2013) Nature , vol.504 , pp. 460-464
    • Yamaguchi, S.1    Shen, L.2    Liu, Y.3    Sendler, D.4    Zhang, Y.5
  • 19
    • 79956292024 scopus 로고    scopus 로고
    • Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
    • Wu, H. et al. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 473, 389-393, doi: 10.1038/nature09934 (2011).
    • (2011) Nature , vol.473 , pp. 389-393
    • Wu, H.1
  • 20
    • 79961139741 scopus 로고    scopus 로고
    • Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development
    • Dawlaty, M. M. et al. Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell 9, 166-175, doi: 10.1016/j.stem.2011.07.010 (2011).
    • (2011) Cell Stem Cell , vol.9 , pp. 166-175
    • Dawlaty, M.M.1
  • 21
    • 84874771985 scopus 로고    scopus 로고
    • Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives
    • Spruijt, C. G. et al. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell 152, 1146-1159, doi: 10.1016/j. cell.2013.02.004 (2013).
    • (2013) Cell , vol.152 , pp. 1146-1159
    • Spruijt, C.G.1
  • 22
    • 84873411803 scopus 로고    scopus 로고
    • Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation
    • Yang, H. et al. Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene 32, 663-669, doi: 10.1038/onc.2012.67 (2013).
    • (2013) Oncogene , vol.32 , pp. 663-669
    • Yang, H.1
  • 23
    • 84938953616 scopus 로고    scopus 로고
    • TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway
    • Neri, F. et al. TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway. Oncogene, doi: 10.1038/onc.2014.356 (2014).
    • (2014) Oncogene
    • Neri, F.1
  • 24
    • 84879001094 scopus 로고    scopus 로고
    • HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis
    • Sun, M. et al. HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. Proceedings of the National Academy of Sciences of the United States of America 110, 9920-9925, doi: 10.1073/pnas.1305172110 (2013).
    • (2013) Proceedings of the National Academy of Sciences of the United States of America , vol.110 , pp. 9920-9925
    • Sun, M.1
  • 25
    • 84866908544 scopus 로고    scopus 로고
    • TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases
    • Hsu, C. H. et al. TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases. Cell reports 2, 568-579, doi: 10.1016/j.celrep.2012.08.030 (2012).
    • (2012) Cell Reports , vol.2 , pp. 568-579
    • Hsu, C.H.1
  • 26
    • 84915798721 scopus 로고    scopus 로고
    • Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation
    • Wu, B. K., Brenner, C. Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation. Cell reports 9, 1827-1840, doi: 10.1016/j.celrep.2014.10.063 (2014).
    • (2014) Cell Reports , vol.9 , pp. 1827-1840
    • Wu, B.K.1    Brenner, C.2
  • 27
    • 84880570961 scopus 로고    scopus 로고
    • MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
    • Song, S. J. et al. MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell 154, 311-324, doi: 10.1016/j.cell.2013.06.026 (2013).
    • (2013) Cell , vol.154 , pp. 311-324
    • Song, S.J.1
  • 28
    • 84895911033 scopus 로고    scopus 로고
    • Regulation of TET protein stability by calpains
    • Wang, Y., Zhang, Y. Regulation of TET protein stability by calpains. Cell reports 6, 278-284, doi: 10.1016/j.celrep.2013.12.031 (2014).
    • (2014) Cell Reports , vol.6 , pp. 278-284
    • Wang, Y.1    Zhang, Y.2
  • 29
    • 84864120277 scopus 로고    scopus 로고
    • Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas
    • Muller, T. et al. Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas. The American journal of pathology 181, 675-683, doi: 10.1016/j.ajpath.2012.04.017 (2012).
    • (2012) The American Journal of Pathology , vol.181 , pp. 675-683
    • Muller, T.1
  • 30
    • 84956611822 scopus 로고    scopus 로고
    • Loss of nuclear localization of TET2 in colorectal cancer
    • Huang, Y. et al. Loss of nuclear localization of TET2 in colorectal cancer. Clin Epigenetics 8, 9, doi: 10.1186/s13148-016-0176-7 (2016).
    • (2016) Clin Epigenetics , vol.8 , pp. 9
    • Huang, Y.1
  • 31
    • 84939801715 scopus 로고    scopus 로고
    • Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes
    • Li, L. et al. Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes. Epigenomics 7, 155-173, doi: 10.2217/epi.14.79 (2015).
    • (2015) Epigenomics , vol.7 , pp. 155-173
    • Li, L.1
  • 32
    • 84921989642 scopus 로고    scopus 로고
    • Connections between TET proteins and aberrant DNA modification in cancer
    • Huang, Y., Rao, A. Connections between TET proteins and aberrant DNA modification in cancer. Trends Genet 30, 464-474, doi: 10.1016/j.tig.2014.07.005 (2014).
    • (2014) Trends Genet , vol.30 , pp. 464-474
    • Huang, Y.1    Rao, A.2
  • 33
    • 84957599270 scopus 로고    scopus 로고
    • TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues
    • Neri, F. et al. TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues. Nucleic acids research, doi: 10.1093/nar/gkv392 (2015).
    • (2015) Nucleic Acids Research
    • Neri, F.1
  • 34
    • 84916900267 scopus 로고    scopus 로고
    • Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription
    • Ciccarone, F. et al. Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription. Oncotarget 5, 10356-10367, doi: 10.18632/oncotarget.1905 (2014).
    • (2014) Oncotarget , vol.5 , pp. 10356-10367
    • Ciccarone, F.1
  • 35
    • 84951757632 scopus 로고    scopus 로고
    • Decreased expression of ten-eleven translocation 2 protein is associated with progressive disease and death in patients with mucosis fungoides
    • Gambichler, T. et al. Decreased expression of ten-eleven translocation 2 protein is associated with progressive disease and death in patients with mucosis fungoides. Br J Dermatol, doi: 10.1111/bjd.14174 (2015).
    • (2015) Br J Dermatol
    • Gambichler, T.1
  • 36
    • 84947775916 scopus 로고    scopus 로고
    • Decrease of 5 hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3?-shore
    • Park, J. L. et al. Decrease of 5 hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3?-shore. Oncotarget 6, 37647-37662, doi: 10.18632/oncotarget.6069 (2015).
    • (2015) Oncotarget , vol.6 , pp. 37647-37662
    • Park, J.L.1
  • 37
    • 84939252236 scopus 로고    scopus 로고
    • Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype
    • Tsai, K. W. et al. Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype. Breast Cancer Res Treat 153, 219-234, doi: 10.1007/s10549-015-3525-x (2015).
    • (2015) Breast Cancer Res Treat , vol.153 , pp. 219-234
    • Tsai, K.W.1
  • 38
    • 84931571827 scopus 로고    scopus 로고
    • Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer
    • Rawluszko-Wieczorek, A. A. et al. Clinical significance of DNA methylation mRNA levels of TET family members in colorectal cancer. Journal of cancer research and clinical oncology, doi: 10.1007/s00432-014-1901-2 (2015).
    • (2015) Journal of Cancer Research and Clinical Oncology
    • Rawluszko-Wieczorek, A.A.1
  • 39
    • 84942065023 scopus 로고    scopus 로고
    • Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer
    • Ichimura, N. et al. Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer. Cancer Prev Res (Phila) 8, 702-711, doi: 10.1158/1940-6207.CAPR-14-0306 (2015).
    • (2015) Cancer Prev Res (Phila) , vol.8 , pp. 702-711
    • Ichimura, N.1
  • 40
    • 84940534189 scopus 로고    scopus 로고
    • Restored expression levels of TET1 decrease the proliferation and migration of renal carcinoma cells
    • Fan, M., He, X., Xu, X. Restored expression levels of TET1 decrease the proliferation and migration of renal carcinoma cells. Mol Med Rep, doi: 10.3892/mmr.2015.4058 (2015).
    • (2015) Mol Med Rep
    • Fan, M.1    He, X.2    Xu, X.3
  • 41
    • 84929895270 scopus 로고    scopus 로고
    • TET1 is a tumor suppressor of hematopoietic malignancy
    • Cimmino, L. et al. TET1 is a tumor suppressor of hematopoietic malignancy. Nat Immunol 16, 653-662, doi: 10.1038/ni.3148 (2015).
    • (2015) Nat Immunol , vol.16 , pp. 653-662
    • Cimmino, L.1
  • 42
    • 84883064448 scopus 로고    scopus 로고
    • Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells
    • Neri, F. et al. Genome-wide analysis identifies a functional association of Tet1 and Polycomb repressive complex 2 in mouse embryonic stem cells. Genome biology 14, R91, doi: 10.1186/gb-2013-14-8-r91 (2013).
    • (2013) Genome Biology , vol.14 , pp. R91
    • Neri, F.1
  • 43
    • 84891523954 scopus 로고    scopus 로고
    • PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells
    • Okashita, N. et al. PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells. Development 141, 269-280, doi: 10.1242/dev.099622 (2014).
    • (2014) Development , vol.141 , pp. 269-280
    • Okashita, N.1
  • 44
    • 79956302047 scopus 로고    scopus 로고
    • TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
    • Williams, K. et al. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature 473, 343-348, doi: 10.1038/nature10066 (2011).
    • (2011) Nature , vol.473 , pp. 343-348
    • Williams, K.1
  • 45
    • 84455167621 scopus 로고    scopus 로고
    • Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells
    • Yildirim, O. et al. Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell 147, 1498-1510, doi: 10.1016/j.cell.2011.11.054 (2011).
    • (2011) Cell , vol.147 , pp. 1498-1510
    • Yildirim, O.1
  • 46
    • 24344465856 scopus 로고    scopus 로고
    • Epigenetic changes in virus-associated human cancers
    • Li, H. P., Leu, Y. W., Chang, Y. S. Epigenetic changes in virus-associated human cancers. Cell Res 15, 262-271, doi: 10.1038/sj. cr.7290295 (2005).
    • (2005) Cell Res , vol.15 , pp. 262-271
    • Li, H.P.1    Leu, Y.W.2    Chang, Y.S.3
  • 47
    • 0037162536 scopus 로고    scopus 로고
    • The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases
    • Tsai, C. N., Tsai, C. L., Tse, K. P., Chang, H. Y., Chang, Y. S. The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases. Proceedings of the National Academy of Sciences of the United States of America 99, 10084-10089, doi: 10.1073/pnas.152059399 (2002).
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , pp. 10084-10089
    • Tsai, C.N.1    Tsai, C.L.2    Tse, K.P.3    Chang, H.Y.4    Chang, Y.S.5
  • 48
    • 0036889153 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein i promoter by activating the transcription factor MTF-1 and forming an open chromatin structure
    • Ghoshal, K. et al. Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Mol Cell Biol 22, 8302-8319 (2002).
    • (2002) Mol Cell Biol , vol.22 , pp. 8302-8319
    • Ghoshal, K.1
  • 49
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction?
    • Baylin, S. B., Ohm, J. E. Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 6, 107-116, doi: 10.1038/nrc1799 (2006).
    • (2006) Nat Rev Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 50
    • 34547619642 scopus 로고    scopus 로고
    • Epigenetic silencing of a Ca(2+ )-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers
    • Jin, H. et al. Epigenetic silencing of a Ca(2+ )-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proceedings of the National Academy of Sciences of the United States of America 104, 12353-12358, doi: 10.1073/pnas.0700153104 (2007).
    • (2007) Proceedings of the National Academy of Sciences of the United States of America , vol.104 , pp. 12353-12358
    • Jin, H.1
  • 51
    • 84865417923 scopus 로고    scopus 로고
    • The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/beta-catenin signaling and silenced in common carcinomas
    • Li, L. et al. The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/beta-catenin signaling and silenced in common carcinomas. Oncogene 31, 3901-3912, doi: 10.1038/onc.2011.541 (2012).
    • (2012) Oncogene , vol.31 , pp. 3901-3912
    • Li, L.1
  • 52
    • 84901686744 scopus 로고    scopus 로고
    • Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting beta-catenin and AKT signaling but frequently methylated in common carcinomas
    • Li, L. et al. Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting beta-catenin and AKT signaling but frequently methylated in common carcinomas. Cellular and molecular life sciences : CMLS 71, 2179-2192, doi: 10.1007/s00018-013-1485-z (2014).
    • (2014) Cellular and Molecular Life Sciences : CMLS , vol.71 , pp. 2179-2192
    • Li, L.1
  • 53
    • 33244483580 scopus 로고    scopus 로고
    • Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation
    • Ying, J. et al. Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Oncogene 25, 1070-1080, doi: 10.1038/sj.onc.1209154 (2006).
    • (2006) Oncogene , vol.25 , pp. 1070-1080
    • Ying, J.1
  • 54
    • 77956524968 scopus 로고    scopus 로고
    • Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis
    • Murray, P. G. et al. Epigenetic silencing of a proapoptotic cell adhesion molecule, the immunoglobulin superfamily member IGSF4, by promoter CpG methylation protects Hodgkin lymphoma cells from apoptosis. The American journal of pathology 177, 1480-1490, doi: 10.2353/ajpath.2010.100052 (2010).
    • (2010) The American Journal of Pathology , vol.177 , pp. 1480-1490
    • Murray, P.G.1
  • 55
    • 84872181780 scopus 로고    scopus 로고
    • Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas
    • Wang, Z. et al. Epigenetic silencing of the 3p22 tumor suppressor DLEC1 by promoter CpG methylation in non-Hodgkin and Hodgkin lymphomas. J Transl Med 10, 209, doi: 10.1186/1479-5876-10-209 (2012).
    • (2012) J Transl Med , vol.10 , pp. 209
    • Wang, Z.1
  • 56
    • 0344980092 scopus 로고    scopus 로고
    • Methylation status of the Epstein-Barr virus major latent promoter C in iatrogenic B cell lymphoproliferative disease. Application of PCR-based analysis
    • Tao, Q. et al. Methylation status of the Epstein-Barr virus major latent promoter C in iatrogenic B cell lymphoproliferative disease. Application of PCR-based analysis. The American journal of pathology 155, 619-625, doi: 10.1016/S0002-9440(10)65157-7 (1999).
    • (1999) The American Journal of Pathology , vol.155 , pp. 619-625
    • Tao, Q.1
  • 57
    • 0036712913 scopus 로고    scopus 로고
    • Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells
    • Tao, Q. et al. Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells. Human molecular genetics 11, 2091-2102 (2002).
    • (2002) Human Molecular Genetics , vol.11 , pp. 2091-2102
    • Tao, Q.1
  • 58
    • 84872194202 scopus 로고    scopus 로고
    • Cancer research in an era when epigenetics is no longer epi"-challenges and opportunities
    • Tao, Q. Cancer research in an era when epigenetics is no longer "epi"-challenges and opportunities. Chinese journal of cancer 32, 1-2, doi: 10.5732/cjc.012.10300 (2013).
    • (2013) Chinese Journal of Cancer , vol.32 , pp. 1-2
    • Tao, Q.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.