Iron overload induced by ferric ammonium citrate triggers reactive oxygen species-mediated apoptosis via both extrinsic and intrinsic pathways in human hepatic cells

Human and Experimental Toxicology

Volumn 35, Issue 6, 2016, Pages 598-607

  Li, S W ^a   Liu, C M ^a   Guo, J ^a   Marcondes, A M ^b   Deeg, J ^b,c   Li, X ^a   Guan, F ^a  

^a JIANGNAN UNIVERSITY   (China)

^b USA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

antioxidant; apoptosis; Iron overload; NF B; p38 MAPK; reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; DEATH RECEPTOR; FAS ANTIGEN; FERRIC AMMONIUM CITRATE; GLUTATHIONE; I KAPPA B ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; NUCLEAR FACTOR; PROTEIN BID; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; FERRIC ION; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON; QUATERNARY AMMONIUM DERIVATIVE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IRON OVERLOAD; LIVER CELL; LIVER INJURY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; IMMUNOLOGY; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; FERRIC COMPOUNDS; HEPATOCYTES; HUMANS; IRON; NF-KAPPA B; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; QUATERNARY AMMONIUM COMPOUNDS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84971265142     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327115597312     Document Type: Article

References (32)

1. Corey SJ, Minden MD, Barber DL, et al.Myelodysplastic syndromes: the complexity of stem-cell diseases. Nat Rev Canc 2007; 7: 118-129.
2. Locasciulli A, Oneto R, Bacigalupo A, et al.Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation. Haematologica 2007; 92: 11-18.
3. Armand P, Kim HT, Cutler CS, et al.Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation. Blood 2007; 109: 4586-4588.
4. Platzbecker U, Bornhäuser M, Germing U, et al.Red blood cell transfusion dependence and outcome after allogeneic peripheral blood stem cell transplantation in patients with de novo myelodysplastic syndrome (MDS). Biol Blood Marrow Transplant 2008; 14: 1217-1225.
5. Lieu PT, Heiskala M, Peterson PA, et al.The roles of iron in health and disease. Mol Aspects Med 2001; 22: 1-87.
6. Dixon SJ, Stockwell BR,. The role of iron and reactive oxygen species in cell death. Nat Chem Biol 2014; 10: 9-17.
7. Smith MA, Harris PL, Sayre LM, et al.Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc Natl Acad Sci 1997; 94: 9866-9868.
8. Bacon BR, Tavill AS, Brittenham GM, et al.Hepatic lipid peroxidation in vivo in rats with chronic iron overload. J Clin Invest 1983; 71: 429.
9. Chen M-P, Cabantchik ZI, Chan S, et al.Iron overload and apoptosis of HL-1 cardiomyocytes: effects of calcium channel blockade. PloS one 2014; 9: e112915.
10. You L-H, Li F, Wang L, et al.Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson's disease. Neuroscience 2015; 284: 234-246.
11. Bhattacharyya S, Ghosh J, Sil PC,. Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: beneficial role of glycine. Free Radical Res 2012; 46: 1296-1307.
12. Li X, Xu F, Karoopongse E, et al.Allogeneic transplantation, Fas signaling, and dysregulation of hepcidin. Biol Blood Marrow Transplant: J Am Soci Blood Marrow Transplant 2013; 19: 1210-1219.
13. Ito K, Hirao A, Arai F, et al.Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med 2006; 12: 446-451.
14. Qing Y, Liang Y, Du Q, et al.Apoptosis induced by trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-kappaB and MAPKs signaling pathways. Arch Toxicol 2013; 87: 1273-1285.
15. Li H, Zhu H, Xu C-J, et al.Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 1998; 94: 491-501.
16. Laport GG, Sandmaier BM, Storer BE, et al.Reduced-intensity conditioning followed by allogeneic hematopoietic cell transplantation for adult patients with myelodysplastic syndrome and myeloproliferative disorders. Biol Blood Marrow Transplant 2008; 14: 246-255.
17. Sahlstedt L, Ebeling F, Von Bonsdorff L, et al.Non-transferrin-bound iron during allogeneic stem cell transplantation. Br J Haematol 2001; 113: 836-838.
18. Galaris D, Pantopoulos K,. Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Laborat Sci 2008; 45: 1-23.
19. Yakes FM, Van Houten B,. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci 1997; 94: 514-519.
20. Lu W, Zhao M, Rajbhandary S, et al.Free iron catalyzes oxidative damage to hematopoietic cells/mesenchymal stem cells in vitro and suppresses hematopoiesis in iron overload patients. Eur J Haematol 2013; 91: 249-261.
21. Doyard M, Fatih N, Monnier A, et al.Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells. Osteoporosis Int 2012; 23: 2435-2445.
22. Zhang W, Liu HT,. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 2002; 12: 9-18.
23. Wagner EF, Nebreda ÁR,. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Canc 2009; 9: 537-549.
24. Fujiwara T, Kanazawa S, Ichibori R, et al.l -Arginine stimulates fibroblast proliferation through the GPRC6A-ERK1/2 and PI3K/Akt pathway. PloS one 2014; 9: e92168.
25. Lenardo MJ, Baltimore D,. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989; 58: 227-229.
26. Karin M, Ben-Neriah Y,. Phosphorylation meets ubiquitination: the control of NF-κB activity. Ann Rev Immunol 2000; 18: 621-663.
27. Nolan Y, Vereker E, Lynch AM, et al.Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus. Exp Neurol 2003; 184: 794-804.
28. Baeza-Raja B, Munoz-Canoves P,. p38 MAPK-induced nuclear factor-kappaB activity is required for skeletal muscle differentiation: role of interleukin-6. Mol Biol Cell 2004; 15: 2013-2026.
29. Guha M, Kumar S, Choubey V, et al.Apoptosis in liver during malaria: role of oxidative stress and implication of mitochondrial pathway. FASEB J 2006; 20: 1224-1226.
30. Jin Z, El-Deiry WS,. Overview of cell death signaling pathways. Canc Biol Ther 2005; 4: 147-171.
31. Barkett M, Gilmore TD,. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 1999; 18: 6910-6924.
32. Mayo MW, Baldwin AS,. The transcription factor NF-κB: control of oncogenesis and cancer therapy resistance. Biochim Biophys (BBA)-Rev Canc 2000; 1470: M55-M62.