Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: A report from the European Group for Blood and Marrow Transplantation

Haematologica

Volumn 92, Issue 1, 2007, Pages 11-18

  Locasciulli, Anna ^a,b   Oneto, Rosi ^a   Bacigalupo, Andrea ^a   Socié, Gerard ^a   Korthof, Elisabeth ^a   Bekassy, Albert ^a   Schrezenmeier, Hubert ^a   Passweg, Jakob ^a   Führer, Monika ^a  

^a BMT Unit   (Italy)

^b SAN CAMILLO FORLANINI HOSPITAL   (Italy)

Author keywords

Acquired aplastic anemia; BMT; Immunosuppression

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN A; GRANULOCYTE COLONY STIMULATING FACTOR; LYMPHOCYTE ANTIBODY; METHOTREXATE;

ADOLESCENT; ADULT; AGED; ALLOGENIC BONE MARROW TRANSPLANTATION; APLASTIC ANEMIA; ARTICLE; BONE MARROW TRANSPLANTATION; CAUSE OF DEATH; CHILD; CONTROLLED STUDY; DIAGNOSTIC TEST; FEMALE; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; OVERALL SURVIVAL; PROPHYLAXIS; SURVIVAL RATE; TREATMENT FAILURE; TREATMENT OUTCOME; WHOLE BODY RADIATION;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANEMIA, APLASTIC; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; EUROPE; FAMILY HEALTH; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFANT; MIDDLE AGED; RETROSPECTIVE STUDIES; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 33846898991     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.10075     Document Type: Article

References (28)

1. Camitta BM, Thomas ED. Severe aplastic anemia : a prospective study of the effect of androgens or transplantation on haematological recovery and survival. Clin Haematol 1978;7:587-90.
2. Bacigalupo A, Chaple A, Hows J, VanLint MT, et al. Treatment of severe aplastic anaemia (AA) with antilymphocyte globulin (ALG) and methylprednisolone (Mpred) with or without androgens : a randomized trial from the EBMT-SAA working party. Br J Haematol 1993;83:143-51.
3. Young N, Griffith P, Brittain E, Elfenbein G, Gardner F, Huang A, et al. A multicenter trial of antilymphocyte globulin in aplastic anemia and related diseases. Blood 1988;72:1861-9.
4. Storb R, Leisenring W, Anasetti C, Appelbaum FR, Buckner CD, Bensinger WI, et al. Long-term follow-up of allogeneic marrow transplants in patients with aplastic anemia conditioned by cyclophosphamide combined with antithymocyte globulin. Blood 1997; 89:3899-91.
5. Ades L, Mary JY, Robin M, Ferry C, Porcher R, Esperou H, et al. Long-term outcome after bone marrow transplantation for severe aplastic anemia. Blood 2004;103:2490-7.
6. Klingemann HG, Storb R, Fefer A, Deeg HJ, Appelbaum FR, Buckner CD, et al. Bone marrow transplantation in patients aged 45 years and older. Blood 1986; 67:770-6.
7. Gluckman E, Horowitz MM, Champlin RE, Hows JM, Bacigalupo A, Biggs JC, et al. Bone marrow transplantation for severe aplastic anemia: influence of conditioning and graft-versus-host disease prophylaxis regimens on outcome. Blood 1992; 79:269-75.
8. Passweg JR, Socié G, Hinterberger W, Bacigalupo A, Biggs JC, Camitta BM, et al. Bone marrow transplantation for severe aplastic anemia: has outcome improved? Blood 1997;90:858-64.
9. Deeg HJ, Leisenring W, Storb R, Nims J, Flowers ME, Witherspoon RP, et al. Long-term outcome after marrow transplantation for severe aplastic anemia. Blood 1998;91:3637-45.
10. Tichelli A, Socie G, Henry-Amar M, Marsh J, Passweg J, Schrezenmeier H, et al. Effectiveness of immunosuppressive therapy in older patients with Aplastic Anemia. Ann Intern Med 1999; 130:193-201.
11. Storb R, Blume KG, O'Donnell MR, Chauncey T, Forman SJ, Deeg HJ, et al. Cyclophosphamide and antithymocyte globulin to condition patients with aplastic anemia for allogeneic marrow transplantations: the experience in four centers. Biol Blood Marrow Transplant 2001;7:39-44.
12. Bacigalupo A, Brand R, Oneto R, Bruno B, Socie G, Passweg J, et al. Treatment of acquired severe aplastic anemia: bone marrow transplantation compared with immunosuppressive therapy. The European Group for Blood and Marrow Transplantation experience. Semin Hematol 2000;37:69-80.
13. Socié G, Henry-Amar M, Bacigalupo A, Hows J, Tichelli A, Ljungman P, et al. Malignant tumors occurring after treatment of aplastic anemia. N Engl J Med 1993;329:1152-7.
14. Socie G, Salooja N, Cohen A, Rovelli A, Carreras E, Locasciulli A, et al. Late Effects Working Party of the European Study Group for Blood and Marrow? Transplantation. Nonmalignant late effects after allogeneic stem cell transplantation. Blood 2003;101:3373-85.
15. Schmitz N, Beksac M, Hasenclever D, Bacigalupo A, Ruutu T, Nagler A, et al. Transplantation of mobilized peripheral blood cells to HLA identical siblings with standard risk leukaemia. The European Group for Blood and Marrow Transplantation. Blood 2002; 100:761-7.
16. Bacigalupo A, Locatelli F, Lanino E, Marsh J, Socie G, Maury S, et al. Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation. Fludarabine, cyclophosphamide and anti-thymocyte globulin for alternative donor transplants in acquired severe aplastic anemia: a report from the EBMT-SAA Working Party. Bone Marrow Transplant 2005;36:947-50.
17. Frickhofen N, Heimpel H, Kaltwasser GP, Schrezenmeier H. Antithymocyte globulin with or withoutcyclosporine A: 11-year follow-up of a randomized trial comparing treatments of aplastic anemia. Blood 2003;101:1236-42.
18. Gluckman E, Rokicka-Milewska R, Hann I, et al. Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anemia. Br J Haematol 2002;119:1075-82
19. Bacigalupo A, Bruno B, Saracco P, Di Bona E, Locasciulli A, et al. For the European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italiano Trapianti di Midollo Osseo (GITMO). Antithymocyte globulin, cyclosporine, prednisone, and granulocyte colony-stimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. Blood 2000;95:1931-4.
20. Fuhrer M, Rampf U, Baumann I, Faldum A, Niemeyer C, Janka-Schaub G, et al. The German/Austrian Aplastic Anemia Working Group. Immunosuppressive therapy for aplastic anaemia in children: a more severe disease predicts better survival. Blood 2005;106:2102-4
21. Locasciulli A, van'tVeer, Bacigalupo A, Hows J, VanLint MT, Gluckman E, et al. Treatment with marrow transplantation or immunosuppression of childhood acquired severe aplastic anemia : a report from the EBMT SAA Working Party. Bone Marrow Transplant 1990;6:211-21.
22. Deeg HJ, Amylon ID, Harris RE, Collins R, Beatty PG, Feig S, et al. Marrow transplants from unrelated donors for patients with aplastic anemia: minimum effective dose of total body irradiation. Biol Blood Marrow Transplant 2001;7:208-15.
23. Gillio AP, Boulad F, Small TN, Kernan NA, Reyes B, Childs BH, et al. Comparison of long-term outcome of children with severe aplastic anemia treated with immunosuppression versus bone marrow transplantation. Biol Blood Marrow Transplant 1997;3:18-24.
24. Locasciulli A, Bruno B, Rambaldi A, Saracco P, Dufour C, Finelli C, et al. Treatment of severe aplastic anemia with antilymphocyte globulin, cyclosporine and two different dosage of granulocyte colony-stimulating factor: a GITMO prospective randomized study. Haematologica 2004;89: 1050-7.
25. Kojima S, Hibi S, Kosaka Y, Yamamoto M, Tsuchida M, Mugishima H, et al. Immunosuppressive therapy using antithymocyte globulin, cyclosporine, and danazol with or without human granulocyte colony-stimulating factor in children with acquired aplastic anemia. Blood 2000;96:2049-54.
26. Kodera Y, Morishima Y, Kato S, Akiyama Y, Sao H, Matsuyama T, et al. Analysis of 500 bone marrow transplants from unrelated donors (UR-BMT) facilitated by the Japan Marrow Donor Program: confirmation of UR-BMT as a standard therapy for patients with leukemia and aplastic anemia. Bone Marrow Transplant 1999;24:995-1003.
27. Deeg HJ, Amylon ID, Harris RE, Collins R, Beatty PG, Feig S, et al. Marrow transplants from unrelated donors for patients with aplastic anemia: minimum effective dose of total body irradiation. Biol Blood Marrow Transplant 2001;7:208-15.
28. Kojima S, Matsuyama T, Kato S, Kigasawa H, Kobayashi R, Kikuta A, et al. Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan Marrow Donor Program. Blood 2002;100:799-803.