메뉴 건너뛰기




Volumn 8, Issue 6, 2016, Pages

CD133, selectively targeting the root of cancer

Author keywords

BIKE; Cancer stem cell; CD133; Relapse; Targeted therapies

Indexed keywords

CD133 ANTIGEN; TUMOR MARKER;

EID: 84971260415     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins8060165     Document Type: Review
Times cited : (83)

References (136)
  • 1
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • [CrossRef] [PubMed]
    • Bonnet, D, Dick, J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3, 730-737. [CrossRef] [PubMed]
    • (1997) Nat. Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 2
    • 43749084585 scopus 로고    scopus 로고
    • Recent advances in cancer stem cells
    • [CrossRef] [PubMed]
    • Cho, R.W, Clarke, M.F. Recent advances in cancer stem cells. Curr. Opin. Genet. Dev. 2008, 18, 48-53. [CrossRef] [PubMed]
    • (2008) Curr. Opin. Genet. Dev , vol.18 , pp. 48-53
    • Cho, R.W.1    Clarke, M.F.2
  • 3
    • 45549096766 scopus 로고    scopus 로고
    • Cancer stem cells: A step toward the cure
    • [CrossRef] [PubMed]
    • Boman, B.M, Wicha, M.S. Cancer stem cells: A step toward the cure. J. Clin. Oncol. 2008, 26, 2795-2799. [CrossRef] [PubMed]
    • (2008) J. Clin. Oncol , vol.26 , pp. 2795-2799
    • Boman, B.M.1    Wicha, M.S.2
  • 7
    • 78751640633 scopus 로고    scopus 로고
    • Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133+ glioma stem cells to temozolomide therapy
    • [CrossRef] [PubMed]
    • Ulasov, I.V, Nandi, S, Dey, M, Sonabend, A.M, Lesniak, M.S. Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133+ glioma stem cells to temozolomide therapy. Mol. Med. 2011, 17, 103-112. [CrossRef] [PubMed]
    • (2011) Mol. Med , vol.17 , pp. 103-112
    • Ulasov, I.V.1    Nandi, S.2    Dey, M.3    Sonabend, A.M.4    Lesniak, M.S.5
  • 8
    • 33750686955 scopus 로고    scopus 로고
    • The hedgehog signaling pathway in cancer
    • [CrossRef] [PubMed]
    • Evangelista, M, Tian, H, de Sauvage, F.J. The hedgehog signaling pathway in cancer. Clin. Cancer Res. 2006, 12, 5924-5928. [CrossRef] [PubMed]
    • (2006) Clin. Cancer Res , vol.12 , pp. 5924-5928
    • Evangelista, M.1    Tian, H.2    De Sauvage, F.J.3
  • 9
    • 58049201990 scopus 로고    scopus 로고
    • The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma
    • [CrossRef] [PubMed]
    • Rappa, G, Fodstad, O, Lorico, A. The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells. 2008, 26, 3008-3017. [CrossRef] [PubMed]
    • (2008) Stem Cells , vol.26 , pp. 3008-3017
    • Rappa, G.1    Fodstad, O.2    Lorico, A.3
  • 12
    • 70349100257 scopus 로고    scopus 로고
    • CD133 as a Marker for Cancer Stem Cells: Progresses and Concerns
    • [CrossRef] [PubMed]
    • Wu, Y.J, Wu, P.Y. CD133 as a Marker for Cancer Stem Cells: Progresses and Concerns. Stem Cells Dev. 2009, 18, 1127-1134. [CrossRef] [PubMed]
    • (2009) Stem Cells Dev. , vol.18 , pp. 1127-1134
    • Wu, Y.J.1    Wu, P.Y.2
  • 13
    • 53849134099 scopus 로고    scopus 로고
    • CD133 expression is an independent prognostic marker for low survival in colorectal cancer
    • [CrossRef] [PubMed]
    • Horst, D, Kriegl, L, Engel, J, Kirchner, T, Jung, A. CD133 expression is an independent prognostic marker for low survival in colorectal cancer. Br. J. Cancer 2008, 99, 1285-1289. [CrossRef] [PubMed]
    • (2008) Br. J. Cancer , vol.99 , pp. 1285-1289
    • Horst, D.1    Kriegl, L.2    Engel, J.3    Kirchner, T.4    Jung, A.5
  • 14
    • 84929326575 scopus 로고    scopus 로고
    • Do relevant markers of cancer stem cells CD133 and Nestin indicate a poor prognosis in glioma patients? A systematic review and meta-analysis
    • [CrossRef] [PubMed]
    • Wu, B, Sun, C, Feng, F, Ge, M, Xia, L. Do relevant markers of cancer stem cells CD133 and Nestin indicate a poor prognosis in glioma patients? A systematic review and meta-analysis. J. Exp. Clin. Cancer Res. 2015, 34, 44. [CrossRef] [PubMed]
    • (2015) J. Exp. Clin. Cancer Res , vol.34 , pp. 44
    • Wu, B.1    Sun, C.2    Feng, F.3    Ge, M.4    Xia, L.5
  • 15
    • 84944276652 scopus 로고    scopus 로고
    • Clinicopathological significance and prognostic value of the expression of the cancer stem cell marker CD133 in hepatocellular carcinoma: A meta-analysis
    • [CrossRef] [PubMed]
    • Zhong, C, Wu, J.D, Fang, M.M, Pu, L.Y. Clinicopathological significance and prognostic value of the expression of the cancer stem cell marker CD133 in hepatocellular carcinoma: A meta-analysis. Tumour Biol. 2015, 36, 7623-7630. [CrossRef] [PubMed]
    • (2015) Tumour Biol. , vol.36 , pp. 7623-7630
    • Zhong, C.1    Wu, J.D.2    Fang, M.M.3    Pu, L.Y.4
  • 16
    • 84971353298 scopus 로고    scopus 로고
    • An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells
    • [CrossRef]
    • Waldron N, V.D. An Old Idea Tackling a New Problem: Targeted Toxins Specific for Cancer Stem Cells. Antibodies 2013, 2, 82-89. [CrossRef]
    • (2013) Antibodies , vol.2 , pp. 82-89
    • Waldron, N.1
  • 17
    • 0347994955 scopus 로고    scopus 로고
    • Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain
    • [CrossRef] [PubMed]
    • Finney, H.M, Akbar, A.N, Lawson, A.D. Activation of resting human primary T cells with chimeric receptors: Costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain. J. Immunol. 2004, 172, 104-113. [CrossRef] [PubMed]
    • (2004) J. Immunol , vol.172 , pp. 104-113
    • Finney, H.M.1    Akbar, A.N.2    Lawson, A.D.3
  • 18
    • 3042551216 scopus 로고    scopus 로고
    • Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia
    • [CrossRef] [PubMed]
    • Imai, C, Mihara, K, Andreansky, M, Nicholson, I.C, Pui, C.H, Geiger, T.L, Campana, D. Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia. Leukemia 2004, 18, 676-684. [CrossRef] [PubMed]
    • (2004) Leukemia , vol.18 , pp. 676-684
    • Imai, C.1    Mihara, K.2    Reansky, M.3    Nicholson, I.C.4    Pui, C.H.5    Geiger, T.L.6    Campana, D.7
  • 20
    • 84959357452 scopus 로고    scopus 로고
    • Preclinical targeting of human T cell malignancies using CD4-specific chimeric antigen receptor (CAR)-engineered T cells
    • [CrossRef] [PubMed]
    • Pinz, K, Liu, H, Golightly, M, Jares, A, Lan, F, Zieve, G.W, Hagag, N, Schuster, M, Firor, A.E, Jiang, X, et al. Preclinical targeting of human T cell malignancies using CD4-specific chimeric antigen receptor (CAR)-engineered T cells. Leukemia 2015, 30, 701-707. [CrossRef] [PubMed]
    • (2015) Leukemia , vol.30 , pp. 701-707
    • Pinz, K.1    Liu, H.2    Golightly, M.3    Jares, A.4    Lan, F.5    Zieve, G.W.6    Hagag, N.7    Schuster, M.8    Firor, A.E.9    Jiang, X.10
  • 21
    • 84924750926 scopus 로고    scopus 로고
    • Going viral: Chimeric antigen receptor T-cell therapy for hematological malignancies
    • [CrossRef] [PubMed]
    • Gill, S, June, C.H. Going viral: Chimeric antigen receptor T-cell therapy for hematological malignancies. Immunol. Rev. 2015, 263, 68-89. [CrossRef] [PubMed]
    • (2015) Immunol. Rev , vol.263 , pp. 68-89
    • Gill, S.1    June, C.H.2
  • 22
    • 84921655004 scopus 로고    scopus 로고
    • Clinical translational research of chimeric antigen receptor-T (CAR-T) cells for the treatment of relapsed and refractory B-cell lymphoma/leukemia
    • [PubMed]
    • Yuan, S.Z, Su, H. Clinical translational research of chimeric antigen receptor-T (CAR-T) cells for the treatment of relapsed and refractory B-cell lymphoma/leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2014, 22, 1137-1141. [PubMed]
    • (2014) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.22 , pp. 1137-1141
    • Yuan, S.Z.1    Su, H.2
  • 23
    • 0035320526 scopus 로고    scopus 로고
    • A fresh look at tumor immunosurveillance and immunotherapy
    • [CrossRef] [PubMed]
    • Smyth, M.J, Godfrey, D.I, Trapani, J.A. A fresh look at tumor immunosurveillance and immunotherapy. Nat. Immunol. 2001, 2, 293-299. [CrossRef] [PubMed]
    • (2001) Nat. Immunol , vol.2 , pp. 293-299
    • Smyth, M.J.1    Godfrey, D.I.2    Trapani, J.A.3
  • 24
    • 0033827327 scopus 로고    scopus 로고
    • Exposing tumor cells to killer cell attack
    • [CrossRef] [PubMed]
    • Watzl, C, Long, E.O. Exposing tumor cells to killer cell attack. Nat. Med. 2000, 6, 867-868. [CrossRef] [PubMed]
    • (2000) Nat. Med , vol.6 , pp. 867-868
    • Watzl, C.1    Long, E.O.2
  • 25
    • 0035914132 scopus 로고    scopus 로고
    • Stress, NK receptors, and immune surveillance
    • [CrossRef] [PubMed]
    • Pardoll, D.M. Stress, NK receptors, and immune surveillance. Science 2001, 294, 534-536. [CrossRef] [PubMed]
    • (2001) Science , vol.294 , pp. 534-536
    • Pardoll, D.M.1
  • 26
    • 0032425063 scopus 로고    scopus 로고
    • Tumor immunology: The glass is half full
    • [CrossRef]
    • Sogn, J.A. Tumor immunology: The glass is half full. Immunity 1998, 9, 757-763. [CrossRef]
    • (1998) Immunity , vol.9 , pp. 757-763
    • Sogn, J.A.1
  • 27
    • 0031888608 scopus 로고    scopus 로고
    • Immunological ignorance of silent antigens as an explanation of tumor evasion
    • [CrossRef]
    • Chen, L. Immunological ignorance of silent antigens as an explanation of tumor evasion. Immunol. Today 1998, 19, 27-30. [CrossRef]
    • (1998) Immunol. Today , vol.19 , pp. 27-30
    • Chen, L.1
  • 28
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • [CrossRef] [PubMed]
    • Dunn, G.P, Old, L.J, Schreiber, R.D. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004, 21, 137-148. [CrossRef] [PubMed]
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 29
    • 0014841406 scopus 로고
    • A stochastic model of the growth of cancer in cancer
    • Lyer, K.S, Saksena, V.N. A stochastic model of the growth of cancer in cancer. Biometrics 1970, 26, 401-410.
    • (1970) Biometrics , vol.26 , pp. 401-410
    • Lyer, K.S.1    Saksena, V.N.2
  • 30
    • 84965845423 scopus 로고
    • Studies on a Transplantable Embryoma of the Mouse. Cancer Res
    • Jackson, E.B, Brues, A.M. Studies on a Transplantable Embryoma of the Mouse. Cancer Res. Treat. 1941, 1, 494-498.
    • (1941) Treat , vol.1 , pp. 494-498
    • Jackson, E.B.1    Brues, A.M.2
  • 31
    • 0141577218 scopus 로고
    • Further evidence favoring the concept of the stem cell in ascites tumors of rats
    • [CrossRef] [PubMed]
    • Makino, S. Further evidence favoring the concept of the stem cell in ascites tumors of rats. Ann. N. Y. Acad. Sci. 1956, 63, 818-830. [CrossRef] [PubMed]
    • (1956) Ann. N. Y. Acad. Sci , vol.63 , pp. 818-830
    • Makino, S.1
  • 34
    • 33748375376 scopus 로고    scopus 로고
    • Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases
    • [CrossRef] [PubMed]
    • Mehra, N, Penning, M, Maas, J, Beerepoot, L.V, van Daal, N, van Gils, C.H, Giles, R.H, Voest, E.E. Progenitor marker CD133 mRNA is elevated in peripheral blood of cancer patients with bone metastases. Clin. Cancer Res. 2006, 12, 4859-4866. [CrossRef] [PubMed]
    • (2006) Clin. Cancer Res , vol.12 , pp. 4859-4866
    • Mehra, N.1    Penning, M.2    Maas, J.3    Beerepoot, L.V.4    Van Daal, N.5    Van Gils, C.H.6    Giles, R.H.7    Voest, E.E.8
  • 38
    • 34248140257 scopus 로고    scopus 로고
    • Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
    • [CrossRef] [PubMed]
    • Miki, J, Furusato, B, Li, H, Gu, Y, Takahashi, H, Egawa, S, Sesterhenn, I.A, McLeod, D.G, Srivastava, S, Rhim, J.S. Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens. Cancer Res. 2007, 67, 3153-3161. [CrossRef] [PubMed]
    • (2007) Cancer Res , vol.67 , pp. 3153-3161
    • Miki, J.1    Furusato, B.2    Li, H.3    Gu, Y.4    Takahashi, H.5    Egawa, S.6    Sesterhenn, I.A.7    McLeod, D.G.8    Srivastava, S.9    Rhim, J.S.10
  • 41
    • 34548217968 scopus 로고    scopus 로고
    • Human breast cancer stem cell markers CD44 and CD24: Enriching for cells with functional properties in mice or in man?
    • [CrossRef] [PubMed]
    • Fillmore, C, Kuperwasser, C. Human breast cancer stem cell markers CD44 and CD24: Enriching for cells with functional properties in mice or in man? Breast Cancer Res. 2007, 9, 303. [CrossRef] [PubMed]
    • (2007) Breast Cancer Res , vol.9 , pp. 303
    • Fillmore, C.1    Kuperwasser, C.2
  • 42
    • 70449719361 scopus 로고    scopus 로고
    • Identification of human pancreatic cancer stem cells
    • [PubMed]
    • Li, C, Lee, C.J, Simeone, D.M. Identification of human pancreatic cancer stem cells. Methods Mol. Biol. 2009, 568, 161-173. [PubMed]
    • (2009) Methods Mol. Biol , vol.568 , pp. 161-173
    • Li, C.1    Lee, C.J.2    Simeone, D.M.3
  • 43
    • 23844513413 scopus 로고    scopus 로고
    • Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis
    • [CrossRef] [PubMed]
    • Kucia, M, Reca, R, Miekus, K, Wanzeck, J, Wojakowski, W, Janowska-Wieczorek, A, Ratajczak, J, Ratajczak, M.Z. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005, 23, 879-894. [CrossRef] [PubMed]
    • (2005) Stem Cells , vol.23 , pp. 879-894
    • Kucia, M.1    Reca, R.2    Miekus, K.3    Wanzeck, J.4    Wojakowski, W.5    Janowska-Wieczorek, A.6    Ratajczak, J.7    Ratajczak, M.Z.8
  • 44
    • 84883171439 scopus 로고    scopus 로고
    • The Role of chemokine receptor CXCR4 in breast cancer metastasis
    • [PubMed]
    • Mukherjee, D, Zhao, J. The Role of chemokine receptor CXCR4 in breast cancer metastasis. Am. J. Cancer Res. 2013, 3, 46-57. [PubMed]
    • (2013) Am. J. Cancer Res , vol.3 , pp. 46-57
    • Mukherjee, D.1    Zhao, J.2
  • 45
    • 84861774808 scopus 로고    scopus 로고
    • CXCR4-positive subset of glioma is enriched for cancer stem cells
    • [CrossRef] [PubMed]
    • Zheng, X, Xie, Q, Li, S, Zhang, W. CXCR4-positive subset of glioma is enriched for cancer stem cells. Oncol. Res. 2011, 19, 555-561. [CrossRef] [PubMed]
    • (2011) Oncol. Res , vol.19 , pp. 555-561
    • Zheng, X.1    Xie, Q.2    Li, S.3    Zhang, W.4
  • 46
    • 84942886878 scopus 로고    scopus 로고
    • Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM—Lung Cancer-Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis
    • [CrossRef] [PubMed]
    • Bertolini, G, D’Amico, L, Moro, M, Landoni, E, Perego, P, Miceli, R, Gatti, L, Andriani, F, Wong, D, Caserini, R, et al. Microenvironment-Modulated Metastatic CD133+/CXCR4+/EpCAM—Lung Cancer-Initiating Cells Sustain Tumor Dissemination and Correlate with Poor Prognosis. Cancer Res. 2015, 75, 3636-3649. [CrossRef] [PubMed]
    • (2015) Cancer Res , vol.75 , pp. 3636-3649
    • Bertolini, G.1    D’Amico, L.2    Moro, M.3    Landoni, E.4    Perego, P.5    Miceli, R.6    Gatti, L.7    Riani, F.8    Wong, D.9    Caserini, R.10
  • 47
    • 69549114870 scopus 로고    scopus 로고
    • Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
    • [CrossRef] [PubMed]
    • Chan, K.S, Espinosa, I, Chao, M, Wong, D, Ailles, L, Diehn, M, Gill, H, Presti, J., Jr, Chang, H.Y, van de Rijn, M, et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc. Natl. Acad. Sci. USA 2009, 106, 14016-14021. [CrossRef] [PubMed]
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14016-14021
    • Chan, K.S.1    Espinosa, I.2    Chao, M.3    Wong, D.4    Ailles, L.5    Diehn, M.6    Gill, H.7    Presti, J.8    Chang, H.Y.9    Van De Rijn, M.10
  • 48
    • 84946751807 scopus 로고    scopus 로고
    • HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
    • [CrossRef] [PubMed]
    • Zhang, H, Lu, H, Xiang, L, Bullen, J.W, Zhang, C, Samanta, D, Gilkes, D.M, He, J, Semenza, G.L. HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells. Proc. Natl. Acad. Sci. USA 2015, 112, E6215-E6223. [CrossRef] [PubMed]
    • (2015) Proc. Natl. Acad. Sci. USA , vol.112 , pp. E6215-E6223
    • Zhang, H.1    Lu, H.2    Xiang, L.3    Bullen, J.W.4    Zhang, C.5    Samanta, D.6    Gilkes, D.M.7    He, J.8    Semenza, G.L.9
  • 51
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • [CrossRef] [PubMed]
    • Zhang, S, Balch, C, Chan, M.W, Lai, H.C, Matei, D, Schilder, J.M, Yan, P.S, Huang, T.H, Nephew, K.P. Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res. 2008, 68, 4311-4320. [CrossRef] [PubMed]
    • (2008) Cancer Res , vol.68 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3    Lai, H.C.4    Matei, D.5    Schilder, J.M.6    Yan, P.S.7    Huang, T.H.8    Nephew, K.P.9
  • 52
    • 77950832189 scopus 로고    scopus 로고
    • Lung cancer stem cells as a target for therapy
    • [CrossRef] [PubMed]
    • Gorelik, E, Lokshin, A, Levina, V. Lung cancer stem cells as a target for therapy. Anticancer Agents Med. Chem. 2010, 10, 164-171. [CrossRef] [PubMed]
    • (2010) Anticancer Agents Med. Chem , vol.10 , pp. 164-171
    • Gorelik, E.1    Lokshin, A.2    Levina, V.3
  • 53
    • 84873026180 scopus 로고    scopus 로고
    • Evaluation of characteristics of CD44+ CD117+ ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures
    • [CrossRef] [PubMed]
    • Chen, J, Wang, J, Chen, D, Yang, J, Yang, C, Zhang, Y, Zhang, H, Dou, J. Evaluation of characteristics of CD44+ CD117+ ovarian cancer stem cells in three dimensional basement membrane extract scaffold versus two dimensional monocultures. BMC Cell. Biol. 2013, 14, 7. [CrossRef] [PubMed]
    • (2013) BMC Cell. Biol , vol.14 , pp. 7
    • Chen, J.1    Wang, J.2    Chen, D.3    Yang, J.4    Yang, C.5    Zhang, Y.6    Zhang, H.7    Dou, J.8
  • 54
    • 84869225084 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer
    • [CrossRef] [PubMed]
    • Lin, C.W, Liao, M.Y, Lin, W.W, Wang, Y.P, Lu, T.Y, Wu, H.C. Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer. J. Biol. Chem. 2012, 287, 39449-39459. [CrossRef] [PubMed]
    • (2012) J. Biol. Chem. , vol.287 , pp. 39449-39459
    • Lin, C.W.1    Liao, M.Y.2    Lin, W.W.3    Wang, Y.P.4    Lu, T.Y.5    Wu, H.C.6
  • 55
    • 84880270290 scopus 로고    scopus 로고
    • Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
    • [CrossRef] [PubMed]
    • Baccelli, I, Schneeweiss, A, Riethdorf, S, Stenzinger, A, Schillert, A, Vogel, V, Klein, C, Saini, M, Bauerle, T, Wallwiener, M, et al. Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nat. Biotechnol. 2013, 31, 539-544. [CrossRef] [PubMed]
    • (2013) Nat. Biotechnol , vol.31 , pp. 539-544
    • Baccelli, I.1    Schneeweiss, A.2    Riethdorf, S.3    Stenzinger, A.4    Schillert, A.5    Vogel, V.6    Klein, C.7    Saini, M.8    Bauerle, T.9    Wallwiener, M.10
  • 56
    • 84879092200 scopus 로고    scopus 로고
    • HER2 and breast cancer stem cells: More than meets the eye
    • [CrossRef] [PubMed]
    • Korkaya, H, Wicha, M.S. HER2 and breast cancer stem cells: More than meets the eye. Cancer Res. 2013, 73, 3489-3493. [CrossRef] [PubMed]
    • (2013) Cancer Res. , vol.73 , pp. 3489-3493
    • Korkaya, H.1    Wicha, M.S.2
  • 57
    • 79955105128 scopus 로고    scopus 로고
    • MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells
    • [CrossRef] [PubMed]
    • Ponnusamy, M.P, Seshacharyulu, P, Vaz, A, Dey, P, Batra, S.K. MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells. J. Ovarian Res. 2011, 4, 7. [CrossRef] [PubMed]
    • (2011) J. Ovarian Res , vol.4 , pp. 7
    • Ponnusamy, M.P.1    Seshacharyulu, P.2    Vaz, A.3    Dey, P.4    Batra, S.K.5
  • 59
    • 77953163539 scopus 로고    scopus 로고
    • CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer
    • [CrossRef] [PubMed]
    • Meyer, M.J, Fleming, J.M, Lin, A.F, Hussnain, S.A, Ginsburg, E, Vonderhaar, B.K. CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. Cancer Res. 2010, 70, 4624-4633. [CrossRef] [PubMed]
    • (2010) Cancer Res , vol.70 , pp. 4624-4633
    • Meyer, M.J.1    Fleming, J.M.2    Lin, A.F.3    Hussnain, S.A.4    Ginsburg, E.5    Vonderhaar, B.K.6
  • 61
    • 44849108126 scopus 로고    scopus 로고
    • Expression profiling of CD133+ and CD133- epithelial cells from human prostate
    • [CrossRef] [PubMed]
    • Shepherd, C.J, Rizzo, S, Ledaki, I, Davies, M, Brewer, D, Attard, G, de Bono, J, Hudson, D.L. Expression profiling of CD133+ and CD133- epithelial cells from human prostate. Prostate 2008, 68, 1007-1024. [CrossRef] [PubMed]
    • (2008) Prostate , vol.68 , pp. 1007-1024
    • Shepherd, C.J.1    Rizzo, S.2    Ledaki, I.3    Davies, M.4    Brewer, D.5    Attard, G.6    De Bono, J.7    Hudson, D.L.8
  • 63
    • 34548627210 scopus 로고    scopus 로고
    • Tumorigenic stem and progenitor cells: Implications for the therapeutic index of anti-cancer agents
    • [CrossRef] [PubMed]
    • Donnenberg, V.S, Landreneau, R.J, Donnenberg, A.D. Tumorigenic stem and progenitor cells: Implications for the therapeutic index of anti-cancer agents. J. Control. Release. 2007, 122, 385-391. [CrossRef] [PubMed]
    • (2007) J. Control. Release , vol.122 , pp. 385-391
    • Donnenberg, V.S.1    Landreneau, R.J.2    Donnenberg, A.D.3
  • 66
    • 41149178767 scopus 로고    scopus 로고
    • Expression of the “stem cell marker” CD133 in pancreas and pancreatic ductal adenocarcinomas
    • [CrossRef] [PubMed]
    • Immervoll, H, Hoem, D, Sakariassen, P.O, Steffensen, O.J, Molven, A. Expression of the “stem cell marker” CD133 in pancreas and pancreatic ductal adenocarcinomas. BMC Cancer. 2008, 8, 48. [CrossRef] [PubMed]
    • (2008) BMC Cancer , vol.8 , pp. 48
    • Immervoll, H.1    Hoem, D.2    Sakariassen, P.O.3    Steffensen, O.J.4    Molven, A.5
  • 67
    • 42149158769 scopus 로고    scopus 로고
    • CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer
    • [CrossRef] [PubMed]
    • Maeda, S, Shinchi, H, Kurahara, H, Mataki, Y, Maemura, K, Sato, M, Natsugoe, S, Aikou, T, Takao, S. CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer. Br. J. Cancer 2008, 98, 1389-1397. [CrossRef] [PubMed]
    • (2008) Br. J. Cancer , vol.98 , pp. 1389-1397
    • Maeda, S.1    Shinchi, H.2    Kurahara, H.3    Mataki, Y.4    Maemura, K.5    Sato, M.6    Natsugoe, S.7    Aikou, T.8    Takao, S.9
  • 69
    • 34249980343 scopus 로고    scopus 로고
    • Identification and characterization of tumorigenic liver cancer stem/progenitor cells
    • [CrossRef] [PubMed]
    • Ma, S, Chan, K.W, Hu, L, Lee, T.K, Wo, J.Y, Ng, I.O, Zheng, B.J, Guan, X.Y. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007, 132, 2542-2556. [CrossRef] [PubMed]
    • (2007) Gastroenterology , vol.132 , pp. 2542-2556
    • Ma, S.1    Chan, K.W.2    Hu, L.3    Lee, T.K.4    Wo, J.Y.5    Ng, I.O.6    Zheng, B.J.7    Guan, X.Y.8
  • 72
    • 84885026715 scopus 로고    scopus 로고
    • CD133: To be or not to be, is this the real question
    • [PubMed]
    • Irollo, E, Pirozzi, G. CD133: To be or not to be, is this the real question? Am. J. Transl. Res. 2013, 5, 563-581. [PubMed]
    • (2013) Am. J. Transl. Res , vol.5 , pp. 563-581
    • Irollo, E.1    Pirozzi, G.2
  • 75
    • 84872902302 scopus 로고    scopus 로고
    • CD133 as a biomarker for putative cancer stem cells in solid tumours: Limitations, problems and challenges
    • [CrossRef] [PubMed]
    • Grosse-Gehling, P, Fargeas, C.A, Dittfeld, C, Garbe, Y, Alison, M.R, Corbeil, D, Kunz-Schughart, L.A. CD133 as a biomarker for putative cancer stem cells in solid tumours: Limitations, problems and challenges. J. Pathol. 2013, 229, 355-378. [CrossRef] [PubMed]
    • (2013) J. Pathol , vol.229 , pp. 355-378
    • Grosse-Gehling, P.1    Fargeas, C.A.2    Dittfeld, C.3    Garbe, Y.4    Alison, M.R.5    Corbeil, D.6    Kunz-Schughart, L.A.7
  • 76
    • 84879375174 scopus 로고    scopus 로고
    • TGF-beta1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction
    • [CrossRef] [PubMed]
    • Tirino, V, Camerlingo, R, Bifulco, K, Irollo, E, Montella, R, Paino, F, Sessa, G, Carriero, M.V, Normanno, N, Rocco, G, et al. TGF-beta1 exposure induces epithelial to mesenchymal transition both in CSCs and non-CSCs of the A549 cell line, leading to an increase of migration ability in the CD133+ A549 cell fraction. Cell. Death Dis. 2013, 4, e620. [CrossRef] [PubMed]
    • (2013) Cell. Death Dis , vol.4
    • Tirino, V.1    Camerlingo, R.2    Bifulco, K.3    Irollo, E.4    Montella, R.5    Paino, F.6    Sessa, G.7    Carriero, M.V.8    Normanno, N.9    Rocco, G.10
  • 77
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • [CrossRef] [PubMed]
    • O’Brien, C.A, Pollett, A, Gallinger, S, Dick, J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445, 106-110. [CrossRef] [PubMed]
    • (2007) Nature , vol.445 , pp. 106-110
    • O’Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 79
    • 80054003177 scopus 로고    scopus 로고
    • Targeting tumor-initiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenotransplant model of human head and neck cancer
    • [CrossRef] [PubMed]
    • Waldron, N.N, Kaufman, D.S, Oh, S, Inde, Z, Hexum, M.K, Ohlfest, J.R, Vallera, D.A. Targeting tumor-initiating cancer cells with dCD133KDEL shows impressive tumor reductions in a xenotransplant model of human head and neck cancer. Mol. Cancer Ther. 2011, 10, 1829-1838. [CrossRef] [PubMed]
    • (2011) Mol. Cancer Ther , vol.10 , pp. 1829-1838
    • Waldron, N.N.1    Kaufman, D.S.2    Oh, S.3    Inde, Z.4    Hexum, M.K.5    Ohlfest, J.R.6    Vallera, D.A.7
  • 80
    • 12944253116 scopus 로고    scopus 로고
    • Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors
    • [PubMed]
    • Peichev, M, Naiyer, A.J, Pereira, D, Zhu, Z, Lane, W.J, Williams, M, Oz, M.C, Hicklin, D.J, Witte, L, Moore, M.A, et al. Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 2000, 95, 952-958. [PubMed]
    • (2000) Blood , vol.95 , pp. 952-958
    • Peichev, M.1    Naiyer, A.J.2    Pereira, D.3    Zhu, Z.4    Lane, W.J.5    Williams, M.6    Oz, M.C.7    Hicklin, D.J.8    Witte, L.9    Moore, M.A.10
  • 85
    • 0037418271 scopus 로고    scopus 로고
    • A human peripheral blood monocyte-derived subset acts as pluripotent stem cells
    • [CrossRef] [PubMed]
    • Zhao, Y, Glesne, D, Huberman, E. A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc. Natl. Acad. Sci. USA 2003, 100, 2426-2431. [CrossRef] [PubMed]
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2426-2431
    • Zhao, Y.1    Glesne, D.2    Huberman, E.3
  • 86
    • 0345688062 scopus 로고    scopus 로고
    • Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells
    • [CrossRef] [PubMed]
    • Urbich, C, Heeschen, C, Aicher, A, Dernbach, E, Zeiher, A.M, Dimmeler, S. Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation 2003, 108, 2511-2516. [CrossRef] [PubMed]
    • (2003) Circulation , vol.108 , pp. 2511-2516
    • Urbich, C.1    Heeschen, C.2    Aicher, A.3    Dernbach, E.4    Zeiher, A.M.5    Dimmeler, S.6
  • 87
    • 0347717672 scopus 로고    scopus 로고
    • Dedifferentiation of lineage-committed cells by a small molecule
    • [CrossRef] [PubMed]
    • Chen, S, Zhang, Q, Wu, X, Schultz, P.G, Ding, S. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc. 2004, 126, 410-411. [CrossRef] [PubMed]
    • (2004) J. Am. Chem. Soc , vol.126 , pp. 410-411
    • Chen, S.1    Zhang, Q.2    Wu, X.3    Schultz, P.G.4    Ding, S.5
  • 89
    • 0034772645 scopus 로고    scopus 로고
    • Differentiation and expansion of endothelial cells from human bone marrow CD133+ cells
    • [CrossRef] [PubMed]
    • Quirici, N, Soligo, D, Caneva, L, Servida, F, Bossolasco, P, Deliliers, G.L. Differentiation and expansion of endothelial cells from human bone marrow CD133+ cells. Br. J. Haematol. 2001, 115, 186-194. [CrossRef] [PubMed]
    • (2001) Br. J. Haematol , vol.115 , pp. 186-194
    • Quirici, N.1    Soligo, D.2    Caneva, L.3    Servida, F.4    Bossolasco, P.5    Deliliers, G.L.6
  • 90
    • 84868130835 scopus 로고    scopus 로고
    • CD133: Holy of grail of neuro-oncology or promiscuous red-herring?
    • [CrossRef] [PubMed]
    • Donovan, L.K, Pilkington, G.J. CD133: Holy of grail of neuro-oncology or promiscuous red-herring? Cell. Prolif. 2012, 45, 527-537. [CrossRef] [PubMed]
    • (2012) Cell. Prolif , vol.45 , pp. 527-537
    • Donovan, L.K.1    Pilkington, G.J.2
  • 91
    • 33847005413 scopus 로고    scopus 로고
    • Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1
    • [CrossRef] [PubMed]
    • Dubreuil, V, Marzesco, A.M, Corbeil, D, Huttner, W.B, Wilsch-Brauninger, M. Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1. J. Cell. Biol. 2007, 176, 483-495. [CrossRef] [PubMed]
    • (2007) J. Cell. Biol , vol.176 , pp. 483-495
    • Dubreuil, V.1    Marzesco, A.M.2    Corbeil, D.3    Huttner, W.B.4    Wilsch-Brauninger, M.5
  • 92
    • 34547642139 scopus 로고    scopus 로고
    • E.V.S. Blood-brain barrier transport of therapeutics via receptor-mediation
    • [CrossRef] [PubMed]
    • A.R. Jones, E.V.S. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm. Res. 2007, 24, 1759-1771. [CrossRef] [PubMed]
    • (2007) Pharm. Res , vol.24 , pp. 1759-1771
    • Jones, A.R.1
  • 93
    • 77749271119 scopus 로고    scopus 로고
    • Macromolecular drug transport into the brain using targeted therapy
    • [CrossRef] [PubMed]
    • Lichota, J, Skjorringe, T, Thomsen, L.B, Moos, T. Macromolecular drug transport into the brain using targeted therapy. J. Neurochem. 2010, 113, 1-13. [CrossRef] [PubMed]
    • (2010) J. Neurochem , vol.113 , pp. 1-13
    • Lichota, J.1    Skjorringe, T.2    Thomsen, L.B.3    Moos, T.4
  • 94
    • 84879968745 scopus 로고    scopus 로고
    • Developing Therapeutic Antibodies for Neurodegenerative Disease
    • [CrossRef] [PubMed]
    • Yu, Y.J, Watts, R.J. Developing Therapeutic Antibodies for Neurodegenerative Disease. Neurotherapeutics 2013, 10, 459-472. [CrossRef] [PubMed]
    • (2013) Neurotherapeutics , vol.10 , pp. 459-472
    • Yu, Y.J.1    Watts, R.J.2
  • 96
    • 84879502917 scopus 로고    scopus 로고
    • The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action
    • [CrossRef] [PubMed]
    • Adini, A, Adini, I, Ghosh, K, Benny, O, Pravda, E, Hu, R, Luyindula, D, D’Amato, R.J. The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action. Angiogenesis 2013, 16, 405-416. [CrossRef] [PubMed]
    • (2013) Angiogenesis , vol.16 , pp. 405-416
    • Adini, A.1    Adini, I.2    Ghosh, K.3    Benny, O.4    Pravda, E.5    Hu, R.6    Luyindula, D.7    D’Amato, R.J.8
  • 97
    • 0141790758 scopus 로고    scopus 로고
    • Drug delivery and transport to solid tumors
    • [CrossRef] [PubMed]
    • Jang, S.H, Wientjes, M.G, Lu, D, Au, J.L.S. Drug delivery and transport to solid tumors. Pharm. Res. 2003, 20, 1337-1350. [CrossRef] [PubMed]
    • (2003) Pharm. Res , vol.20 , pp. 1337-1350
    • Jang, S.H.1    Wientjes, M.G.2    Lu, D.3    Au, J.L.S.4
  • 98
    • 84881305790 scopus 로고    scopus 로고
    • A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
    • [CrossRef] [PubMed]
    • Petersdorf, S.H, Kopecky, K.J, Slovak, M, Willman, C, Nevill, T, Brandwein, J, Larson, R.A, Erba, H.P, Stiff, P.J, Stuart, R.K, et al. A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood 2013, 121, 4854-4860. [CrossRef] [PubMed]
    • (2013) Blood , vol.121 , pp. 4854-4860
    • Petersdorf, S.H.1    Kopecky, K.J.2    Slovak, M.3    Willman, C.4    Nevill, T.5    Brandwein, J.6    Larson, R.A.7    Erba, H.P.8    Stiff, P.J.9    Stuart, R.K.10
  • 100
    • 84959468203 scopus 로고    scopus 로고
    • Potential for bispecific T-cell engagers: Role of blinatumomab in acute lymphoblastic leukemia
    • [PubMed]
    • Le Jeune, C, Thomas, X. Potential for bispecific T-cell engagers: Role of blinatumomab in acute lymphoblastic leukemia. Drug Des. Devel. Ther. 2016, 10, 757-765. [PubMed]
    • (2016) Drug Des. Devel. Ther , vol.10 , pp. 757-765
    • Le Jeune, C.1    Thomas, X.2
  • 101
    • 79959312575 scopus 로고    scopus 로고
    • Targeted Therapy With the T-Cell-Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival
    • [CrossRef] [PubMed]
    • Topp, M.S, Kufer, P, Gokbuget, N, Goebeler, M, Klinger, M, Neumann, S, Horst, H.A, Raff, T, Viardot, A, Schmid, M, et al. Targeted Therapy With the T-Cell-Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival. J. Clin. Oncol. 2011, 29, 2493-2498. [CrossRef] [PubMed]
    • (2011) J. Clin. Oncol , vol.29 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gokbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6    Horst, H.A.7    Raff, T.8    Viardot, A.9    Schmid, M.10
  • 103
    • 84880656646 scopus 로고    scopus 로고
    • A bispecific EpCAM/CD133-targeted toxin is effective against carcinoma
    • [CrossRef] [PubMed]
    • Waldron, N.N, Barsky, S.H, Dougherty, P.R, Vallera, D.A. A bispecific EpCAM/CD133-targeted toxin is effective against carcinoma. Target. Oncol. 2014, 9, 239-249. [CrossRef] [PubMed]
    • (2014) Target. Oncol , vol.9 , pp. 239-249
    • Waldron, N.N.1    Barsky, S.H.2    Dougherty, P.R.3    Vallera, D.A.4
  • 104
    • 84892938139 scopus 로고    scopus 로고
    • CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer
    • [CrossRef] [PubMed]
    • Swaminathan, S.K, Roger, E, Toti, U, Niu, L, Ohlfest, J.R, Panyam, J. CD133-targeted paclitaxel delivery inhibits local tumor recurrence in a mouse model of breast cancer. J. Control. Release 2013, 171, 280-287. [CrossRef] [PubMed]
    • (2013) J. Control. Release , vol.171 , pp. 280-287
    • Swaminathan, S.K.1    Roger, E.2    Toti, U.3    Niu, L.4    Ohlfest, J.R.5    Panyam, J.6
  • 105
    • 84975839987 scopus 로고    scopus 로고
    • Heterodimeric Bispecific Single Chain Variable Fragments (ScFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+ Colorectal Cancer Cells
    • [CrossRef] [PubMed]
    • Schmohl, J.U, Gleason, M.K, Dougherty, P.R, Miller, J.S, Vallera, D.A. Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+ Colorectal Cancer Cells. Target. Oncol. 2015, 14, 1-9. [CrossRef] [PubMed]
    • (2015) Target. Oncol , vol.14 , pp. 1-9
    • Schmohl, J.U.1    Gleason, M.K.2    Dougherty, P.R.3    Miller, J.S.4    Vallera, D.A.5
  • 106
    • 84933527123 scopus 로고    scopus 로고
    • Targeting CD133high Colorectal Cancer Cells In Vitro and In Vivo With an Asymmetric Bispecific Antibody
    • [CrossRef] [PubMed]
    • Zhao, L, Yang, Y, Zhou, P, Ma, H, Zhao, X, He, X, Wang, T, Zhang, J, Liu, Y, Zhang, T. Targeting CD133high Colorectal Cancer Cells In Vitro and In Vivo With an Asymmetric Bispecific Antibody. J. Immunother. 2015, 38, 217-228. [CrossRef] [PubMed]
    • (2015) J. Immunother , vol.38 , pp. 217-228
    • Zhao, L.1    Yang, Y.2    Zhou, P.3    Ma, H.4    Zhao, X.5    He, X.6    Wang, T.7    Zhang, J.8    Liu, Y.9    Zhang, T.10
  • 107
    • 84883244302 scopus 로고    scopus 로고
    • Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo
    • [CrossRef] [PubMed]
    • Huang, J, Li, C, Wang, Y, Lv, H, Guo, Y, Dai, H, Wicha, M.S, Chang, A.E, Li, Q. Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133(high) cancer stem cells in vitro and in vivo. Clin. Immunol. 2013, 149, 156-168. [CrossRef] [PubMed]
    • (2013) Clin. Immunol , vol.149 , pp. 156-168
    • Huang, J.1    Li, C.2    Wang, Y.3    Lv, H.4    Guo, Y.5    Dai, H.6    Wicha, M.S.7    Chang, A.E.8    Li, Q.9
  • 109
    • 0032032442 scopus 로고    scopus 로고
    • Accumulation of a recombinant immunotoxin in a tumor in vivo: Fewer than 1000 molecules per cell are sufficient for complete responses
    • [PubMed]
    • Kreitman, R.J, Pastan, I. Accumulation of a recombinant immunotoxin in a tumor in vivo: Fewer than 1000 molecules per cell are sufficient for complete responses. Cancer Res. 1998, 58, 968-975. [PubMed]
    • (1998) Cancer Res , vol.58 , pp. 968-975
    • Kreitman, R.J.1    Pastan, I.2
  • 110
    • 0026692120 scopus 로고
    • Recombinant toxins as novel therapeutic agents
    • [CrossRef] [PubMed]
    • Pastan, I, Chaudhary, V, FitzGerald, D.J. Recombinant toxins as novel therapeutic agents. Annu. Rev. Biochem. 1992, 61, 331-354. [CrossRef] [PubMed]
    • (1992) Annu. Rev. Biochem , vol.61 , pp. 331-354
    • Pastan, I.1    Chaudhary, V.2    Fitzgerald, D.J.3
  • 111
    • 0028951457 scopus 로고
    • Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor
    • [CrossRef] [PubMed]
    • Kreitman, R.J, Pastan, I. Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor. Biochem. J. 1995, 307, 29-37. [CrossRef] [PubMed]
    • (1995) Biochem. J. , vol.307 , pp. 29-37
    • Kreitman, R.J.1    Pastan, I.2
  • 113
    • 34548324283 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule: More than a carcinoma marker and adhesion molecule
    • [CrossRef] [PubMed]
    • Trzpis, M, McLaughlin, P.M, de Leij, L.M, Harmsen, M.C. Epithelial cell adhesion molecule: More than a carcinoma marker and adhesion molecule. Am. J. Pathol. 2007, 171, 386-395. [CrossRef] [PubMed]
    • (2007) Am. J. Pathol , vol.171 , pp. 386-395
    • Trzpis, M.1    McLaughlin, P.M.2    De Leij, L.M.3    Harmsen, M.C.4
  • 114
    • 67651003100 scopus 로고    scopus 로고
    • The emerging role of EpCAM in cancer and stem cell signaling
    • [CrossRef] [PubMed]
    • Munz, M, Baeuerle, P.A, Gires, O. The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 2009, 69, 5627-5629. [CrossRef] [PubMed]
    • (2009) Cancer Res , vol.69 , pp. 5627-5629
    • Munz, M.1    Baeuerle, P.A.2    Gires, O.3
  • 116
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • [CrossRef] [PubMed]
    • Visvader, J.E, Lindeman, G.J. Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat. Rev. Cancer. 2008, 8, 755-768. [CrossRef] [PubMed]
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 118
    • 84925091940 scopus 로고    scopus 로고
    • Bispecific T-cell engagers for cancer immunotherapy
    • [CrossRef] [PubMed]
    • Huehls, A.M, Coupet, T.A, Sentman, C.L. Bispecific T-cell engagers for cancer immunotherapy. Immunol. Cell. Biol. 2015, 93, 290-296. [CrossRef] [PubMed]
    • (2015) Immunol. Cell. Biol , vol.93 , pp. 290-296
    • Huehls, A.M.1    Coupet, T.A.2    Sentman, C.L.3
  • 119
    • 84916639631 scopus 로고    scopus 로고
    • Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia
    • [CrossRef] [PubMed]
    • Topp, M.S, Gokbuget, N, Zugmaier, G, Klappers, P, Stelljes, M, Neumann, S, Viardot, A, Marks, R, Diedrich, H, Faul, C, et al. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J. Clin. Oncol. 2014, 32, 4134-4140. [CrossRef] [PubMed]
    • (2014) J. Clin. Oncol , vol.32 , pp. 4134-4140
    • Topp, M.S.1    Gokbuget, N.2    Zugmaier, G.3    Klappers, P.4    Stelljes, M.5    Neumann, S.6    Viardot, A.7    Marks, R.8    Diedrich, H.9    Faul, C.10
  • 121
    • 23044491967 scopus 로고    scopus 로고
    • S100P promotes pancreatic cancer growth, survival, and invasion
    • [CrossRef] [PubMed]
    • Arumugam, T, Simeone, D.M, Van Golen, K, Logsdon, C.D. S100P promotes pancreatic cancer growth, survival, and invasion. Clin. Cancer Res. 2005, 11, 5356-5364. [CrossRef] [PubMed]
    • (2005) Clin. Cancer Res , vol.11 , pp. 5356-5364
    • Arumugam, T.1    Simeone, D.M.2    Van Golen, K.3    Logsdon, C.D.4
  • 122
    • 84863116714 scopus 로고    scopus 로고
    • Calcium-binding protein S100P and cancer: Mechanisms and clinical relevance
    • [CrossRef] [PubMed]
    • Jiang, H, Hu, H, Tong, X, Jiang, Q, Zhu, H, Zhang, S. Calcium-binding protein S100P and cancer: Mechanisms and clinical relevance. J. Cancer Res. Clin. Oncol. 2012, 138, 1-9. [CrossRef] [PubMed]
    • (2012) J. Cancer Res. Clin. Oncol , vol.138 , pp. 1-9
    • Jiang, H.1    Hu, H.2    Tong, X.3    Jiang, Q.4    Zhu, H.5    Zhang, S.6
  • 123
    • 2442689136 scopus 로고    scopus 로고
    • TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells
    • [CrossRef] [PubMed]
    • Papadakis, K.A, Prehn, J.L, Landers, C, Han, Q, Luo, X, Cha, S.C, Wei, P, Targan, S.R. TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. J. Immunol. 2004, 172, 7002-7007. [CrossRef] [PubMed]
    • (2004) J. Immunol , vol.172 , pp. 7002-7007
    • Papadakis, K.A.1    Prehn, J.L.2    Landers, C.3    Han, Q.4    Luo, X.5    Cha, S.C.6    Wei, P.7    Targan, S.R.8
  • 124
    • 84877872803 scopus 로고    scopus 로고
    • Heterodimeric bispecific single-chain variable-fragment antibodies against EpCAM and CD16 induce effective antibody-dependent cellular cytotoxicity against human carcinoma cells
    • [CrossRef] [PubMed]
    • Vallera, D.A, Zhang, B, Gleason, M.K, Oh, S, Weiner, L.M, Kaufman, D.S, McCullar, V, Miller, J.S, Verneris, M.R. Heterodimeric bispecific single-chain variable-fragment antibodies against EpCAM and CD16 induce effective antibody-dependent cellular cytotoxicity against human carcinoma cells. Cancer Biother. Radiopharm. 2013, 28, 274-282. [CrossRef] [PubMed]
    • (2013) Cancer Biother. Radiopharm , vol.28 , pp. 274-282
    • Vallera, D.A.1    Zhang, B.2    Gleason, M.K.3    Oh, S.4    Weiner, L.M.5    Kaufman, D.S.6    McCullar, V.7    Miller, J.S.8    Verneris, M.R.9
  • 125
    • 0038792094 scopus 로고    scopus 로고
    • IL-15 is an essential mediator of peripheral NK-cell homeostasis
    • [CrossRef] [PubMed]
    • Ranson, T, Vosshenrich, C.A, Corcuff, E, Richard, O, Muller, W, Di, S. IL-15 is an essential mediator of peripheral NK-cell homeostasis. Blood 2003, 101, 4887-4893. [CrossRef] [PubMed]
    • (2003) Blood , vol.101 , pp. 4887-4893
    • Ranson, T.1    Vosshenrich, C.A.2    Corcuff, E.3    Richard, O.4    Muller, W.5    Di, S.6
  • 127
    • 84911021644 scopus 로고    scopus 로고
    • Interleukin-15 in the treatment of cancer
    • [CrossRef] [PubMed]
    • Waldmann, T.A. Interleukin-15 in the treatment of cancer. Expert Rev. Clin. Immunol. 2014, 10, 1689-1701. [CrossRef] [PubMed]
    • (2014) Expert Rev. Clin. Immunol , vol.10 , pp. 1689-1701
    • Waldmann, T.A.1
  • 128
    • 47549086723 scopus 로고    scopus 로고
    • Interleukin 15 augments antitumor activity of cytokine gene-modified melanoma cell vaccines in a murine model
    • [CrossRef] [PubMed]
    • Basak, G.W, Zapala, L, Wysocki, P.J, Mackiewicz, A, Jakobisiak, M, Lasek, W. Interleukin 15 augments antitumor activity of cytokine gene-modified melanoma cell vaccines in a murine model. Oncol. Rep. 2008, 19, 1173-1179. [CrossRef] [PubMed]
    • (2008) Oncol. Rep , vol.19 , pp. 1173-1179
    • Basak, G.W.1    Zapala, L.2    Wysocki, P.J.3    Mackiewicz, A.4    Jakobisiak, M.5    Lasek, W.6
  • 129
    • 84982103393 scopus 로고    scopus 로고
    • Enhanced ADCC and NK cell activation of an anti-carcinoma bispecific antibody by genetic insertion of a modified IL-15 cross-linker
    • press, [CrossRef] [PubMed]
    • Schmohl, J.U, Felices, M, Taras, E, Miller, J.S, Vallera, D.A. Enhanced ADCC and NK cell activation of an anti-carcinoma bispecific antibody by genetic insertion of a modified IL-15 cross-linker. Mol. Ther. 2016. in press. [CrossRef] [PubMed]
    • (2016) Mol. Ther
    • Schmohl, J.U.1    Felices, M.2    Taras, E.3    Miller, J.S.4    Vallera, D.A.5
  • 130
    • 0028829105 scopus 로고
    • Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: Comparison with interleukin-2
    • [CrossRef] [PubMed]
    • Munger, W, DeJoy, S.Q, Jeyaseelan, R., Torley, L.W, Grabstein, K.H, Eisenmann, J, Paxton, R, Cox, T, Wick, M.M, Kerwar, S.S. Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: Comparison with interleukin-2. Cell. Immunol. 1995, 165, 289-293. [CrossRef] [PubMed]
    • (1995) Cell. Immunol , vol.165 , pp. 289-293
    • Munger, W.1    Dejoy, S.Q.2    Jeyaseelan, R.3    Torley, L.W.4    Grabstein, K.H.5    Eisenmann, J.6    Paxton, R.7    Cox, T.8    Wick, M.M.9    Kerwar, S.S.10
  • 132
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • [CrossRef] [PubMed]
    • Ellington, A.D, Szostak, J.W. In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346, 818-822. [CrossRef] [PubMed]
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 133
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • [CrossRef] [PubMed]
    • Tuerk, C, Gold, L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 1990, 249, 505-510. [CrossRef] [PubMed]
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 134
    • 80052566062 scopus 로고    scopus 로고
    • Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies
    • [CrossRef] [PubMed]
    • Shigdar, S, Ward, A.C, De, A, Yang, C.J, Wei, M, Duan, W. Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies. Br. J. Haematol. 2011, 155, 3-13. [CrossRef] [PubMed]
    • (2011) Br. J. Haematol , vol.155 , pp. 3-13
    • Shigdar, S.1    Ward, A.C.2    De, A.3    Yang, C.J.4    Wei, M.5    Duan, W.6
  • 135
    • 77958152852 scopus 로고    scopus 로고
    • Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals
    • [CrossRef] [PubMed]
    • Orava, E.W, Cicmil, N, Gariepy, J. Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals. Biochim. Biophys. Acta 2010, 1798, 2190-2200. [CrossRef] [PubMed]
    • (2010) Biochim. Biophys. Acta , vol.1798 , pp. 2190-2200
    • Orava, E.W.1    Cicmil, N.2    Gariepy, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.