Metformin Protects Cells from Mutant Huntingtin Toxicity Through Activation of AMPK and Modulation of Mitochondrial Dynamics

NeuroMolecular Medicine

Volumn 18, Issue 4, 2016, Pages 581-592

  Jin, Jing ^a   Gu, Hao ^a   Anders, Nicole M ^b   Ren, Tianhua ^a,c   Jiang, Mali ^a   Tao, Michael ^a   Peng, Qi ^a   Rudek, Michelle A ^a,b   Duan, Wenzhen ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

AMPK; Huntington s disease; Metformin; Mitochondria

Indexed keywords

ADENOSINE TRIPHOSPHATE; HUNTINGTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LACTATE DEHYDROGENASE; METFORMIN; NEUROPROTECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; ENZYME ACTIVATION; ENZYME RELEASE; HUNTINGTON CHOREA; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MOUSE MODEL; NEURAL STEM CELL; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SINGLE DRUG DOSE; STRIATAL PRECURSOR CELL; ANIMAL; DISEASE MODEL; DRUG EFFECT; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HUNTINGTIN PROTEIN; HUNTINGTON DISEASE; METFORMIN; MICE; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; NEUROPROTECTIVE AGENTS;

EID: 84969980451     PISSN: 15351084     EISSN: 15591174     Source Type: Journal    
DOI: 10.1007/s12017-016-8412-z     Document Type: Article

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