Enhancing the bioavailability of mebendazole by integrating the principles solid dispersion and nanocrystal techniques, for safe and effective management of human echinococcosis

Artificial Cells, Nanomedicine and Biotechnology

Volumn 44, Issue 3, 2016, Pages 937-942

  Chaudhary, Sushant ^a   Garg, Tarun ^a   Rath, Goutam ^a   Murthy, Rs Rayasa ^a   Goyal, Amit K ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

bioavailability; echinococcosis; mebendazole; nano crystals; polyethylene glycol; solid dispersion

Indexed keywords

DISPERSIONS; DISSOLUTION; MICROCOMPUTERS; NANOCRYSTALS; POLYETHYLENE GLYCOLS; POLYETHYLENES; SOLUBILITY; X RAY DIFFRACTION;

BIOAVAILABILITY; ECHINOCOCCOSIS; EFFECTIVE MANAGEMENT; ENHANCED DISSOLUTIONS; MEBENDAZOLE; PHARMACOKINETIC STUDIES; POWDER X-RAY DIFFRACTION (PXRD); SOLID DISPERSION;

BIOCHEMISTRY;

ATORVASTATIN; MACROGOL 4000; MEBENDAZOLE; NANOCRYSTAL; NANOPARTICLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SAFETY; DRUG SOLUBILITY; DRUG STORAGE; ECHINOCOCCOSIS; EXPERIMENTAL RABBIT; FEMALE; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PH; SURFACE AREA; TIME TO MAXIMUM PLASMA CONCENTRATION; X RAY POWDER DIFFRACTION; ANIMAL; CHEMISTRY; DISEASE MODEL; HUMAN; PRECLINICAL STUDY; RABBITS AND HARES;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ECHINOCOCCOSIS; FEMALE; HUMANS; MALE; MEBENDAZOLE; NANOPARTICLES; RABBITS;

EID: 84969960070     PISSN: 21691401     EISSN: 2169141X     Source Type: Journal    
DOI: 10.3109/21691401.2014.1000493     Document Type: Article

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