메뉴 건너뛰기




Volumn 533, Issue , 2016, Pages 411-415

An obligatory role for neurotensin in high-fat-diet-induced obesity

(26)  Li, Jing a,b   Song, Jun a,b   Zaytseva, Yekaterina Y a,b   Liu, Yajuan b   Rychahou, Piotr a,b   Jiang, Kai b   Starr, Marlene E a   Kim, Ji Tae a,b   Harris, Jennifer W a,b   Yiannikouris, Frederique B a   Katz, Wendy S a   Nilsson, Peter M c,d   Orho Melander, Marju c   Chen, Jing a,e   Zhu, Haining a,e   Fahrenholz, Timothy a,b   Higashi, Richard M a,b   Gao, Tianyan a,b   Morris, Andrew J f   Cassis, Lisa A a   more..


Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; NEUROTENSIN; NEUROTENSIN RECEPTOR; NEUROTENSIN RECEPTOR 1; PRO NEUROTENSIN; PROTEIN PRECURSOR; SORTILIN; UNCLASSIFIED DRUG; PRONEUROTENSIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

EID: 84969924791     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17662     Document Type: Article
Times cited : (207)

References (64)
  • 2
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman, P. G. Obesity as a medical problem. Nature 404, 635-643 (2000).
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 3
    • 64649083354 scopus 로고    scopus 로고
    • The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis
    • Guh, D. P. et al. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 9, 88 (2009).
    • (2009) BMC Public Health , vol.9 , pp. 88
    • Guh, D.P.1
  • 4
    • 0017658933 scopus 로고
    • Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistry
    • Polak, J. M. et al. Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistry. Nature 270, 183-184 (1977).
    • (1977) Nature , vol.270 , pp. 183-184
    • Polak, J.M.1
  • 5
    • 0019801211 scopus 로고
    • Elevation of plasma neurotensin during lipid perfusion of rat small intestine
    • Ferris, C. F., Hammer, R. A. & Leeman, S. E. Elevation of plasma neurotensin during lipid perfusion of rat small intestine. Peptides 2 (suppl. 2), 263-266 (1981).
    • (1981) Peptides , vol.2 , pp. 263-266
    • Ferris, C.F.1    Hammer, R.A.2    Leeman, S.E.3
  • 6
    • 0022996353 scopus 로고
    • Neurotensin stimulates [3H]oleic acid translocation across rat small intestine
    • Armstrong, M. J., Parker, M. C., Ferris, C. F. & Leeman, S. E. Neurotensin stimulates [3H]oleic acid translocation across rat small intestine. Am. J. Physiol. 251, G823-G829 (1986).
    • (1986) Am. J. Physiol. , vol.251 , pp. G823-G829
    • Armstrong, M.J.1    Parker, M.C.2    Ferris, C.F.3    Leeman, S.E.4
  • 7
    • 33748940753 scopus 로고    scopus 로고
    • Neurotensin and growth of normal and neoplastic tissues
    • Evers, B. M. Neurotensin and growth of normal and neoplastic tissues. Peptides 27, 2424-2433 (2006).
    • (2006) Peptides , vol.27 , pp. 2424-2433
    • Evers, B.M.1
  • 9
    • 84867177612 scopus 로고    scopus 로고
    • Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality
    • Melander, O. et al. Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality. J. Am. Med. Assoc. 308, 1469-1475 (2012).
    • (2012) J. Am. Med. Assoc. , vol.308 , pp. 1469-1475
    • Melander, O.1
  • 11
    • 41849095954 scopus 로고    scopus 로고
    • Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis
    • Piliponsky, A. M. et al. Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nature Med. 14, 392-398 (2008).
    • (2008) Nature Med. , vol.14 , pp. 392-398
    • Piliponsky, A.M.1
  • 12
    • 0035847242 scopus 로고    scopus 로고
    • Evidence that neurotensin mediates the central effect of leptin on food intake in rat
    • Sahu, A., Carraway, R. E. & Wang, Y. P. Evidence that neurotensin mediates the central effect of leptin on food intake in rat. Brain Res. 888, 343-347 (2001).
    • (2001) Brain Res. , vol.888 , pp. 343-347
    • Sahu, A.1    Carraway, R.E.2    Wang, Y.P.3
  • 13
    • 0034685687 scopus 로고    scopus 로고
    • A novel neurotensin peptide analog given extracranially decreases food intake and weight in rodents
    • Boules, M. et al. A novel neurotensin peptide analog given extracranially decreases food intake and weight in rodents. Brain Res. 865, 35-44 (2000).
    • (2000) Brain Res. , vol.865 , pp. 35-44
    • Boules, M.1
  • 14
    • 67650445631 scopus 로고    scopus 로고
    • Peripheral and central administration of xenin and neurotensin suppress food intake in rodents
    • Cooke, J. H. et al. Peripheral and central administration of xenin and neurotensin suppress food intake in rodents. Obesity (Silver Spring) 17, 1135-1143 (2009).
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1135-1143
    • Cooke, J.H.1
  • 15
    • 0036787390 scopus 로고    scopus 로고
    • Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line
    • Martin, S., Navarro, V., Vincent, J. P. & Mazella, J. Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. Gastroenterology 123, 1135-1143 (2002).
    • (2002) Gastroenterology , vol.123 , pp. 1135-1143
    • Martin, S.1    Navarro, V.2    Vincent, J.P.3    Mazella, J.4
  • 16
    • 84918582466 scopus 로고    scopus 로고
    • Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity
    • Rabinowich, L. et al. Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity. J. Hepatol. 62, 175-181 (2015).
    • (2015) J. Hepatol. , vol.62 , pp. 175-181
    • Rabinowich, L.1
  • 17
    • 75749104187 scopus 로고    scopus 로고
    • AMPK as a mediator of hormonal signalling
    • Lim, C. T., Kola, B. & Korbonits, M. AMPK as a mediator of hormonal signalling. J. Mol. Endocrinol. 44, 87-97 (2010).
    • (2010) J. Mol. Endocrinol. , vol.44 , pp. 87-97
    • Lim, C.T.1    Kola, B.2    Korbonits, M.3
  • 18
    • 33745204479 scopus 로고    scopus 로고
    • AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
    • Xue, B. & Kahn, B. B. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J. Physiol. 574, 73-83 (2006).
    • (2006) J. Physiol. , vol.574 , pp. 73-83
    • Xue, B.1    Kahn, B.B.2
  • 19
    • 84907545906 scopus 로고    scopus 로고
    • AMPK: Positive and negative regulation, and its role in wholebody energy homeostasis
    • Hardie, D. G. AMPK: positive and negative regulation, and its role in wholebody energy homeostasis. Curr. Opin. Cell Biol. 33, 1-7 (2015).
    • (2015) Curr. Opin. Cell Biol. , vol.33 , pp. 1-7
    • Hardie, D.G.1
  • 20
    • 84866404225 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase kinase 2: Roles in signaling and pathophysiology
    • Racioppi, L. & Means, A. R. Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. J. Biol. Chem. 287, 31658-31665 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 31658-31665
    • Racioppi, L.1    Means, A.R.2
  • 21
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford, D. B. & Shaw, R. J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nature Rev. Cancer 9, 563-575 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 22
    • 83355168712 scopus 로고    scopus 로고
    • Heterogeneous expression of drosophila gustatory receptors in enteroendocrine cells
    • Park, J. H. & Kwon, J. Y. Heterogeneous expression of Drosophila gustatory receptors in enteroendocrine cells. PLoS ONE 6, e29022 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e29022
    • Park, J.H.1    Kwon, J.Y.2
  • 23
    • 31444452338 scopus 로고    scopus 로고
    • Evidence that stem cells reside in the adult drosophila midgut epithelium
    • Micchelli, C. A. & Perrimon, N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature 439, 475-479 (2006).
    • (2006) Nature , vol.439 , pp. 475-479
    • Micchelli, C.A.1    Perrimon, N.2
  • 24
    • 31444444485 scopus 로고    scopus 로고
    • The adult drosophila posterior midgut is maintained by pluripotent stem cells
    • Ohlstein, B. & Spradling, A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature 439, 470-474 (2006).
    • (2006) Nature , vol.439 , pp. 470-474
    • Ohlstein, B.1    Spradling, A.2
  • 25
    • 78049425280 scopus 로고    scopus 로고
    • High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in drosophila
    • Birse, R. T. et al. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metab. 12, 533-544 (2010).
    • (2010) Cell Metab. , vol.12 , pp. 533-544
    • Birse, R.T.1
  • 26
    • 0034824368 scopus 로고    scopus 로고
    • Neuropeptides and neuropeptide receptors in the drosophila melanogaster genome
    • Hewes, R. S. & Taghert, P. H. Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome. Genome Res. 11, 1126-1142 (2001).
    • (2001) Genome Res. , vol.11 , pp. 1126-1142
    • Hewes, R.S.1    Taghert, P.H.2
  • 27
    • 0037143740 scopus 로고    scopus 로고
    • Identification of G protein-coupled receptors for drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution
    • Park, Y., Kim, Y. J. & Adams, M. E. Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc. Natl Acad. Sci. USA 99, 11423-11428 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 11423-11428
    • Park, Y.1    Kim, Y.J.2    Adams, M.E.3
  • 28
    • 84908006199 scopus 로고    scopus 로고
    • Control of lipid metabolism by tachykinin in drosophila
    • Song, W., Veenstra, J. A. & Perrimon, N. Control of lipid metabolism by tachykinin in Drosophila. Cell Reports 9, 40-47 (2014).
    • (2014) Cell Reports , vol.9 , pp. 40-47
    • Song, W.1    Veenstra, J.A.2    Perrimon, N.3
  • 29
    • 84907984367 scopus 로고    scopus 로고
    • Enteroendocrine cells support intestinal stem-cellmediated homeostasis in drosophila
    • Amcheslavsky, A. et al. Enteroendocrine cells support intestinal stem-cellmediated homeostasis in Drosophila. Cell Reports 9, 32-39 (2014).
    • (2014) Cell Reports , vol.9 , pp. 32-39
    • Amcheslavsky, A.1
  • 30
    • 42649105456 scopus 로고    scopus 로고
    • Hypothalamic CaMKK2 contributes to the regulation of energy balance
    • Anderson, K. A. et al. Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab. 7, 377-388 (2008).
    • (2008) Cell Metab. , vol.7 , pp. 377-388
    • Anderson, K.A.1
  • 31
    • 33646810117 scopus 로고    scopus 로고
    • Amphetamine-elicited striatal fos expression is attenuated in neurotensin null mutant mice
    • Fadel, J., Dobner, P. R. & Deutch, A. Y. Amphetamine-elicited striatal Fos expression is attenuated in neurotensin null mutant mice. Neurosci. Lett. 402, 97-101 (2006).
    • (2006) Neurosci. Lett. , vol.402 , pp. 97-101
    • Fadel, J.1    Dobner, P.R.2    Deutch, A.Y.3
  • 32
    • 0028354069 scopus 로고
    • SR 48692, a non-peptide neurotensin receptor antagonist differentially affects neurotensin-induced behaviour and changes in dopaminergic transmission
    • Steinberg, R. et al. SR 48692, a non-peptide neurotensin receptor antagonist differentially affects neurotensin-induced behaviour and changes in dopaminergic transmission. Neuroscience 59, 921-929 (1994).
    • (1994) Neuroscience , vol.59 , pp. 921-929
    • Steinberg, R.1
  • 33
    • 0035957855 scopus 로고    scopus 로고
    • The neurotensin antagonist SR 48692 attenuates haloperidol-induced striatal fos expression in the rat
    • Fadel, J., Dobner, P. R. & Deutch, A. Y. The neurotensin antagonist SR 48692 attenuates haloperidol-induced striatal Fos expression in the rat. Neurosci. Lett. 303, 17-20 (2001).
    • (2001) Neurosci. Lett. , vol.303 , pp. 17-20
    • Fadel, J.1    Dobner, P.R.2    Deutch, A.Y.3
  • 35
    • 33744812402 scopus 로고    scopus 로고
    • Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via rho/ROK/PKC-δ pathway activation
    • Song, J., Li, J., Lulla, A., Evers, B. M. & Chung, D. H. Protein kinase D protects against oxidative stress-induced intestinal epithelial cell injury via Rho/ROK/PKC-δ pathway activation. Am. J. Physiol. Cell Physiol. 290, C1469-C1476 (2006).
    • (2006) Am. J. Physiol. Cell Physiol. , vol.290 , pp. C1469-C1476
    • Song, J.1    Li, J.2    Lulla, A.3    Evers, B.M.4    Chung, D.H.5
  • 36
    • 79959817119 scopus 로고    scopus 로고
    • MTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-jun pathway in the human endocrine cell line BON
    • Li, J. et al. mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Am. J. Physiol. Cell Physiol. 301, C213-C226 (2011).
    • (2011) Am. J. Physiol. Cell Physiol. , vol.301 , pp. C213-C226
    • Li, J.1
  • 37
    • 33845977351 scopus 로고    scopus 로고
    • Cyclic adenosine 5′-monophosphate-stimulated neurotensin secretion is mediated through rap1 downstream of both epac and protein kinase A signaling pathways
    • Li, J. et al. Cyclic adenosine 5′-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways. Mol. Endocrinol. 21, 159-171 (2007).
    • (2007) Mol. Endocrinol. , vol.21 , pp. 159-171
    • Li, J.1
  • 38
    • 84855311145 scopus 로고    scopus 로고
    • Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice
    • Yiannikouris, F. et al. Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 302, R244-R251 (2012).
    • (2012) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.302 , pp. R244-R251
    • Yiannikouris, F.1
  • 39
    • 84884147849 scopus 로고    scopus 로고
    • Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice
    • Salous, A. K. et al. Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice. J. Lipid Res. 54, 2775-2784 (2013).
    • (2013) J. Lipid Res. , vol.54 , pp. 2775-2784
    • Salous, A.K.1
  • 40
    • 84884578809 scopus 로고    scopus 로고
    • Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway
    • Onono, F. et al. Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. J. Biol. Chem. 288, 27444-27455 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 27444-27455
    • Onono, F.1
  • 41
    • 0019382757 scopus 로고
    • The "Swiss roll": A simple technique for histological studies of the rodent intestine
    • Moolenbeek, C. & Ruitenberg, E. J. The "Swiss roll": a simple technique for histological studies of the rodent intestine. Lab. Anim. 15, 57-59 (1981).
    • (1981) Lab. Anim. , vol.15 , pp. 57-59
    • Moolenbeek, C.1    Ruitenberg, E.J.2
  • 42
    • 79957448371 scopus 로고    scopus 로고
    • Stable isotope resolved metabolomics of lung cancer in a SCID mouse model
    • Fan, T. W., Lane, A. N., Higashi, R. M. & Yan, J. Stable isotope resolved metabolomics of lung cancer in a SCID mouse model. Metabolomics 7, 257-269 (2011).
    • (2011) Metabolomics , vol.7 , pp. 257-269
    • Fan, T.W.1    Lane, A.N.2    Higashi, R.M.3    Yan, J.4
  • 43
    • 70349286417 scopus 로고    scopus 로고
    • Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR
    • Lane, A. N., Fan, T. W., Xie, Z., Moseley, H. N. & Higashi, R. M. Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR. Anal. Chim. Acta 651, 201-208 (2009).
    • (2009) Anal. Chim. Acta , vol.651 , pp. 201-208
    • Lane, A.N.1    Fan, T.W.2    Xie, Z.3    Moseley, H.N.4    Higashi, R.M.5
  • 44
    • 60649099790 scopus 로고    scopus 로고
    • Drosophila HNF4 regulates lipid mobilization and β-oxidation
    • Palanker, L., Tennessen, J. M., Lam, G. & Thummel, C. S. Drosophila HNF4 regulates lipid mobilization and β-oxidation. Cell Metab. 9, 228-239 (2009).
    • (2009) Cell Metab. , vol.9 , pp. 228-239
    • Palanker, L.1    Tennessen, J.M.2    Lam, G.3    Thummel, C.S.4
  • 45
    • 62349102527 scopus 로고    scopus 로고
    • PP4 and PP2A regulate hedgehog signaling by controlling smo and Ci phosphorylation
    • Jia, H., Liu, Y., Yan, W. & Jia, J. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development 136, 307-316 (2009).
    • (2009) Development , vol.136 , pp. 307-316
    • Jia, H.1    Liu, Y.2    Yan, W.3    Jia, J.4
  • 46
    • 34347375071 scopus 로고    scopus 로고
    • On why decreasing protein synthesis can increase lifespan
    • Hipkiss, A. R. On why decreasing protein synthesis can increase lifespan. Mech. Ageing Dev. 128, 412-414 (2007).
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 412-414
    • Hipkiss, A.R.1
  • 47
    • 84872137308 scopus 로고    scopus 로고
    • Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies
    • Stenesen, D. et al. Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cell Metab. 17, 101-112 (2013).
    • (2013) Cell Metab. , vol.17 , pp. 101-112
    • Stenesen, D.1
  • 48
    • 84922692543 scopus 로고    scopus 로고
    • Suppression of insulin production and secretion by a decretin hormone
    • Alfa, R. W. et al. Suppression of insulin production and secretion by a decretin hormone. Cell Metab. 21, 323-333 (2015).
    • (2015) Cell Metab. , vol.21 , pp. 323-333
    • Alfa, R.W.1
  • 49
    • 84855697910 scopus 로고    scopus 로고
    • A systematic analysis of drosophila gustatory receptor gene expression in abdominal neurons which project to the central nervous system
    • Park, J. H. & Kwon, J. Y. A systematic analysis of Drosophila gustatory receptor gene expression in abdominal neurons which project to the central nervous system. Mol. Cells 32, 375-381 (2011).
    • (2011) Mol. Cells , vol.32 , pp. 375-381
    • Park, J.H.1    Kwon, J.Y.2
  • 50
    • 84902185292 scopus 로고    scopus 로고
    • Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult drosophila midgut
    • Scopelliti, A. et al. Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut. Curr. Biol. 24, 1199-1211 (2014).
    • (2014) Curr. Biol. , vol.24 , pp. 1199-1211
    • Scopelliti, A.1
  • 51
    • 73949131456 scopus 로고    scopus 로고
    • Regulation of intestinal stem cells in mammals and drosophila
    • Wang, P. & Hou, S. X. Regulation of intestinal stem cells in mammals and Drosophila. J. Cell. Physiol. 222, 33-37 (2010).
    • (2010) J. Cell. Physiol. , vol.222 , pp. 33-37
    • Wang, P.1    Hou, S.X.2
  • 52
    • 64549110803 scopus 로고    scopus 로고
    • EGFR signaling regulates the proliferation of drosophila adult midgut progenitors
    • Jiang, H. & Edgar, B. A. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development 136, 483-493 (2009).
    • (2009) Development , vol.136 , pp. 483-493
    • Jiang, H.1    Edgar, B.A.2
  • 53
    • 78349307019 scopus 로고    scopus 로고
    • Proneural and abdominal hox inputs synergize to promote sensory organ formation in the drosophila abdomen
    • Gutzwiller, L. M. et al. Proneural and abdominal Hox inputs synergize to promote sensory organ formation in the Drosophila abdomen. Dev. Biol. 348, 231-243 (2010).
    • (2010) Dev. Biol. , vol.348 , pp. 231-243
    • Gutzwiller, L.M.1
  • 54
    • 84909606348 scopus 로고    scopus 로고
    • Hedgehog-regulated atypical PKC promotes phosphorylation and activation of smoothened and cubitus interruptus in drosophila
    • Jiang, K. et al. Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila. Proc. Natl Acad. Sci. USA 111, E4842-E4850 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. E4842-E4850
    • Jiang, K.1
  • 55
    • 34547621412 scopus 로고    scopus 로고
    • Fused-costal2 protein complex regulates hedgehog-induced smo phosphorylation and cell-surface accumulation
    • Liu, Y., Cao, X., Jiang, J. & Jia, J. Fused-Costal2 protein complex regulates Hedgehog-induced Smo phosphorylation and cell-surface accumulation. Genes Dev. 21, 1949-1963 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 1949-1963
    • Liu, Y.1    Cao, X.2    Jiang, J.3    Jia, J.4
  • 56
    • 84919338450 scopus 로고    scopus 로고
    • Self-assembled FUS binds active chromatin and regulates gene transcription
    • Yang, L., Gal, J., Chen, J. & Zhu, H. Self-assembled FUS binds active chromatin and regulates gene transcription. Proc. Natl Acad. Sci. USA 111, 17809-17814 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 17809-17814
    • Yang, L.1    Gal, J.2    Chen, J.3    Zhu, H.4
  • 57
    • 79953714910 scopus 로고    scopus 로고
    • Peptidomics and peptide hormone processing in the drosophila midgut
    • Reiher, W. et al. Peptidomics and peptide hormone processing in the Drosophila midgut. J. Proteome Res. 10, 1881-1892 (2011).
    • (2011) J. Proteome Res. , vol.10 , pp. 1881-1892
    • Reiher, W.1
  • 58
    • 0027343548 scopus 로고
    • Minisymposium: The malmö diet and cancer study. Design, biological bank and biomarker programme
    • Bergland, G. Minisymposium: The Malmö Diet and Cancer Study. Design, biological bank and biomarker programme. J. Intern. Med. 233, 39-79 (1993).
    • (1993) J. Intern. Med. , vol.233 , pp. 39-79
    • Bergland, G.1
  • 59
    • 49949084572 scopus 로고    scopus 로고
    • Lp-PLA2 activity and mass are associated with increased incidence of ischemic stroke: A populationbased cohort study from malmö, Sweden
    • Persson, M., Berglund, G., Nelson, J. J. & Hedblad, B. Lp-PLA2 activity and mass are associated with increased incidence of ischemic stroke: a populationbased cohort study from Malmö, Sweden. Atherosclerosis 200, 191-198 (2008).
    • (2008) Atherosclerosis , vol.200 , pp. 191-198
    • Persson, M.1    Berglund, G.2    Nelson, J.J.3    Hedblad, B.4
  • 60
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews, D. R. et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419 (1985).
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1
  • 61
    • 33645978121 scopus 로고    scopus 로고
    • Metabolic syndrome-A new world-wide definition. A consensus statement from the international diabetes federation
    • Alberti, K. G., Zimmet, P. & Shaw, J. Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet. Med. 23, 469-480 (2006).
    • (2006) Diabet. Med. , vol.23 , pp. 469-480
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 62
    • 33744988975 scopus 로고    scopus 로고
    • Proneurotensin 1-117, a stable neurotensin precursor fragment identified in human circulation
    • Ernst, A., Hellmich, S. & Bergmann, A. Proneurotensin 1-117, a stable neurotensin precursor fragment identified in human circulation. Peptides 27, 1787-1793 (2006).
    • (2006) Peptides , vol.27 , pp. 1787-1793
    • Ernst, A.1    Hellmich, S.2    Bergmann, A.3
  • 63
    • 77953124970 scopus 로고    scopus 로고
    • Plasma copeptin and the risk of diabetes mellitus
    • Enhörning, S. et al. Plasma copeptin and the risk of diabetes mellitus. Circulation 121, 2102-2108 (2010).
    • (2010) Circulation , vol.121 , pp. 2102-2108
    • Enhörning, S.1
  • 64
    • 84864444538 scopus 로고    scopus 로고
    • PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport
    • Li, J. et al. PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport. Mol. Endocrinol. 26, 1380-1393 (2012).
    • (2012) Mol. Endocrinol. , vol.26 , pp. 1380-1393
    • Li, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.