Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity

Journal of Hepatology

Volumn 62, Issue 1, 2015, Pages 175-181

  Rabinowich, Liane ^a   Fishman, Sigal ^a   Hubel, Einav ^a   Thurm, Tamar ^b   Park, Woo Jae ^c,d   Pewzner Jung, Yael ^c   Saroha, Ashish ^c   Erez, Noam ^a   Halpern, Zamir ^a   Futerman, Anthony H ^c   Zvibel, Isabel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d Gachon University   (South Korea)

Author keywords

Acid sphingomyelinase; Ceramide synthesis; Hepatic steatosis; Insulin resistance; Sortilin

Indexed keywords

CERAMIDE; CERAMIDE SYNTHASE 5 6; CYTOKINE; GLUCOSE; INSULIN; PROTEIN KINASE B; SORTILIN; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE ACYLTRANSFERASE; UNCLASSIFIED DRUG; RNA; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; FATTY LIVER; GENE EXPRESSION; GLUCOSE TRANSPORT; INFLAMMATION; INSULIN RESPONSE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRAABDOMINAL FAT; LIPOGENESIS; LIVER METABOLISM; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEADY STATE; WEIGHT GAIN; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; COMPLICATION; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; INSULIN RESISTANCE; LIPID METABOLISM; LIVER CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FATTY LIVER; GENE EXPRESSION REGULATION; HEPATOCYTES; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; RNA;

EID: 84918582466     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.08.030     Document Type: Article

References (30)

1. A. Berrington de Gonzalez, P. Hartge, J.R. Cerhan, A.J. Flint, L. Hannan, and R.J. MacInnis Body-mass index and mortality among 1.46 million white adults N Engl J Med 363 2010 2211 2219
2. T.E. Willnow, and C.M. Petersen Nykjaer A.VPS10P-domain receptors - regulators of neuronal viability and function Nat Rev Neurosci 9 2008 899 909
3. K. Musunuru, A. Strong, M. Frank-Kamenetsky, N.E. Lee, T. Ahfeldt, and K.V. Sachs From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus Nature 466 2010 714 719
4. M. Kjolby, O.M. Andersen, T. Breiderhoff, A.W. Fjorback, K.M. Pedersen, and P. Madsen Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export Cell Metab 12 2010 213 223
5. P. Linsel-Nitschke, J. Heeren, Z. Aherrahrou, P. Bruse, C. Gieger, and T. Illig Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease Atherosclerosis 208 2010 183 189
6. A. Strong, Q. Ding, A.C. Edmondson, J.S. Millar, K.V. Sachs, and X. Li Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism J Clin Invest 122 2012 2807 2816
7. M. Canuel, Y. Libin, and C.R. Morales The interactomics of sortilin: an ancient lysosomal receptor evolving new functions Histol Histopathol 24 2009 481 492
8. A. Wähe, B. Kasmaseapour, C. Schmaderer, D. Liebl, K. Sandhoff, and A. Nykjaer Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin J Cell Sci 123 2010 2502 2511
9. S. Lefrancois, J. Zeng, A.J. Hassan, M. Canuel, and C.R. Morales The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin EMBO J 22 2003 6430 6437
10. B. Henry, R. Ziobro, K.A. Becker, R. Kolesnick, and E. Gulbins Acid sphingomyelinase Handb Exp Pharmacol 215 2013 77 88
11. M.V. Airola, and Y.A. Hannun Sphingolipid metabolism and neutral sphingomyelinases Handb Exp Pharmacol 215 2013 57 76
12. A. Herschkovitz, Y.F. Liu, E. Ilan, D. Ronen, S. Boura-Halfon, and Y. Zick Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance J Biol Chem 282 2007 18018 18027
13. J.R. Ussher, T.R. Koves, V.J. Cadete, L. Zhang, J.S. Jaswal, and S.J. Swyrd Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption Diabetes 59 2010 2453 2464
14. S. Stratford, K.L. Hoehn, F. Liu, and S.A. Summers Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B J Biol Chem 279 2004 36608 36615
15. G.M. Deevska, K.A. Rozenova, N.V. Giltiay, M.A. Chambers, J. White, and B.B. Boyanovsky Acid sphingomyelinase deficiency prevents diet-induced hepatic triacylglycerol accumulation and hyperglycemia in mice J Biol Chem 284 2009 8359 8368
16. P. Jansen, K. Giehl, J.R. Nyengaard, K. Teng, O. Lioubinski, and S.S. Sjoegaard Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury Nat Neurosci 10 2007 1449 1457
17. G.D. Block, J. Locker, W.C. Bowen, B.E. Petersen, S. Katyal, and S.C. Strom Population expansion, clonal growth and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF, and TGF in a chemically defined (HGM) medium J Cell Biol 132 1996 1133 1149
18. 14C]hexanoyl) sphingolipids to assay sphingolipid metabolism Methods Enzymol 209 1992 437 446
19. Y. Pewzner-Jung, H. Park, E.L. Laviad, L.C. Silva, S. Lahiri, and J. Stiban A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways J Biol Chem 285 2010 10902 10910
20. F. Hu, T. Padukkavidana, C.B. Vaegter, O.A. Brady, Y. Zheng, and I.R. Mackenzie Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin Neuron 68 2010 654 667
21. E.L. Smith, and E.H. Schuchman The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases FASEB J 22 2008 3419 3431
22. S.A. Summers Sphingolipids and IR: the five Ws Curr Opin Lipidol 21 2010 128 135
23. B.T. Bikman, and S.A. Summers Ceramides as modulators of cellular and whole-body metabolism J Clin Invest 121 2011 4222 4230
24. J.A. Chavez, and S.A. Summers A ceramide-centric view of IR Cell Metab 15 2012 585 594
25. K. Kitatani, J. Idkowiak-Baldys, and Y.A. Hannun The sphingolipid salvage pathway in ceramide metabolism and signaling Cell Signal 20 2008 1010 1018
26. J.W. Park, W.J. Park, and A.H. Futerman Ceramide synthases as potential targets for therapeutic intervention in human diseases Biochim Biophys Acta 2013 10.1016/j.bbalip.2013.08.019 pii: S1388-1981(13)00190-X, [Epub ahead of print]
27. J.W. Park, W.J. Park, Y. Kuperman, S. Boura-Halfon, and Y. Pewzner-Jung Futerman AH Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes Hepatology 57 2013 525 532
28. R. Cinar, G. Godlewski, J. Liu, J. Tam, T. Jourdan, and B. Mukhopadhyay Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides Hepatology 59 2014 143 153
29. N. Kumashiro, D.M. Erion, D. Zhang, M. Kahn, S.A. Beddow, and X. Chu Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease Proc Natl Acad Sci U S A 108 2011 16381 16385
30. A.L. Birkenfeld, and G.I. Shulman Non alcoholic fatty liver disease, hepatic insulin resistance and type 2 diabetes Hepatology 59 2014 713 723