Higher Dietary Choline and Betaine Intakes are Associated with Better Body Composition in the Adult Population of Newfoundland, Canada

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Gao, Xiang ^a,b   Wang, Yongbo ^b,c   Randell, Edward ^b   Pedram, Pardis ^b   Yi, Yanqing ^b   Gulliver, Wayne ^b   Sun, Guang ^b  

^a OCEAN UNIVERSITY OF CHINA   (China)

^b MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CHOLINE;

ADULT; AGE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CALORIC INTAKE; CANADA; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIETARY INTAKE; FEMALE; GENDER; HUMAN; MALE; PHYSICAL ACTIVITY; WAIST CIRCUMFERENCE; WAIST HIP RATIO; X RAY SPECTROMETRY; BODY WEIGHT; DIET; DRUG EFFECTS; MIDDLE AGED; NEWFOUNDLAND AND LABRADOR; PHOTON ABSORPTIOMETRY; QUESTIONNAIRE;

ABSORPTIOMETRY, PHOTON; ADULT; BETAINE; BODY COMPOSITION; BODY WEIGHT; CHOLINE; CROSS-SECTIONAL STUDIES; DIET; FEMALE; HUMANS; MALE; MIDDLE AGED; NEWFOUNDLAND AND LABRADOR; SURVEYS AND QUESTIONNAIRES; WAIST CIRCUMFERENCE; WAIST-HIP RATIO;

EID: 84969888726     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0155403     Document Type: Article

References (72)

1. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004; 4: 579-591. PMID: 15286738
2. Kopelman PG. Obesity as a medical problem. Nature. 2000; 404: 635-643. PMID: 10766250
3. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. The Lancet. 2014; 384: 766-781.
4. Morris MJ, Beilharz JE, Maniam J, Reichelt AC, Westbrook RF. Why is obesity such a problem in the 21st century? The intersection of palatable food, cues and reward pathways, stress, and cognition. Neurosci Biobehav Rev. 2014 Dec 10. doi: 10.1016/j.neubiorev.2014.12.002
5. Schoeller DA, Buchholz AC. Energetics of obesity and weight control: does diet composition matter? J Am Diet Assoc. 2005; 105: S24-28. PMID: 15867892
6. Hu FB. Diet, nutrition, and obesity. Obesity Epidemiology. Oxford University Press: New York 2008: 275-300.
7. García OP, Long KZ, Rosado JL. Impact of micronutrient deficiencies on obesity. Nutr Rev. 2009; 67: 559-572. doi: 10.1111/j.1753-4887.2009.00228.x PMID: 19785688
8. García OP, Ronquillo D, del Carmen Caamaño M, Martínez G, Camacho M, López V, et al. Zinc, iron and vitamins A, C and E are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children. Nutrients. 2013; 5: 5012-5030. doi: 10.3390/nu5125012 PMID: 24335710
9. Nagata C, Wada K, Tamura T, Konishi K, Kawachi T, Tsuji M, et al. Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Mortality Risk in Japanese Men and Women. The Journal of nutrition. 2015; 145: 1787-1792. doi: 10.3945/jn.114.209296 PMID: 26063062
10. Vennemann FBC, Ioannidou S, Valsta LM, Dumas C, Marga C, Mensink GBM, et al. Dietary intake and food sources of choline in European populations. Brit J Nutr. 2015; 114: 2046-2055. doi: 10.1017/S0007114515003700 PMID: 26423357
11. Wallace T C, Fulgoni V L III. Assessment of Total Choline Intakes in the United States. J Am Coll Nutr. 2016; 35: 108-112. doi: 10.1080/07315724.2015.1080127 PMID: 26886842
12. Ueland PM. Choline and betaine in health and disease. J Inherit Metab Dis. 2011; 34: 3-15. doi: 10.1007/s10545-010-9088-4 PMID: 20446114
13. Zeisel SH, Da Costa KA. Choline: an essential nutrient for public health. Nutrition reviews 2009; 67:615-623. doi: 10.1111/j.1753-4887.2009.00246.x PMID: 19906248
14. Penry J, Manore M. Choline: an important micronutirent for maximal endurance-exercise performance? Int J Sport Nutr Exerc Metab. 2008; 18: 191-203. PMID: 18458362
15. Leermakers ETM, Moreira EM, Kiefte-de Jong JC, et al. Effects of choline on health across the life course: a systematic review. Nutr Rev. 2015; 73: 500-522. doi: 10.1093/nutrit/nuv010 PMID: 26108618
16. Craig SA. Betaine in human nutrition. Am J Clin Nutr 2004; 80:539-549. PMID: 15321791
17. Buchman AL, Dubin MD, Moukarzel AA, Jenden DJ, Roch M, Rice KM, et al. Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation. Hepatology. 1995; 22: 1399-1403. PMID: 7590654
18. Rajaie S, Esmaillzadeh A. Dietary choline and betaine intakes and risk of cardiovascular diseases: review of epidemiological evidence. ARYA atherosclerosis. 2011; 7: 78. PMID: 22577451
19. Konstantinova SV, Tell GS, Vollset SE, Nygard O, Bleie Ø, Ueland PM. Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr. 2008; 138: 914-20. PMID: 18424601
20. Hongu N, Sachan DS. Caffeine, carnitine and choline supplementation of rats decreases body fat and serum leptin concentration as does exercise. J Nutr. 2000; 130: 152-157. PMID: 10720162
21. Siljander-Rasi H, Peuranen S, Tiihonen K. Effect of equimolar dietary betaine and choline addition on performance, carcass quality and physiological parameters of pigs. J Anim Sci, 2003; 76: 55-62.
22. Daily JW, Hongu N, Mynatt RL, Sachan DS. Choline supplementation increases tissue concentrations of carnitine and lowers body fat in guinea pigs. J Nutr Biochem 1998; 9: 464-70.
23. Saunderson CL, Mackinlay J. Changes in body-weight, composition and hepatic enzyme activities in response to dietary methionine, betaine and choline levels in growing chicks. Br J Nutr. 1990; 63: 339-49. PMID: 1692235
24. Hassan RA, Attia YA, El-Ganzory EH. Growth, carcass quality and serum constituents of slow growing chicks as affected by betaine addition to diets containing 1. Different levels of choline. Int. J. Poult. Sci. 2005; 4: 840-850.
25. Pollmann DS, Danielson DM, Peo ER. Effects of microbial feed additives on performance of starter and growing-finishing pigs. J Anim Sci. 1980; 51: 577-581.
26. Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem. 2010; 43:732-744. doi: 10.1016/j.clinbiochem.2010.03.009 PMID: 20346934
27. Chen YM, Liu Y, Liu YH, Wang X, Guan K, Zhu HI. Higher serum concentrations of betaine rather than choline is associated with better profiles of DXA-derived body fat and fat distribution in Chinese adults. Int J Obes. 2015; 39: 465-471.
28. Cholewa JM, Wyszczelska-Rokiel M, Glowacki R, Jakubowski H, Matthews T, Wood R, et al. Effects of betaine on body composition, performance, and homocysteine thiolactone. J Int Soc Sports Nutr. 2013; 10: 39. doi: 10.1186/1550-2783-10-39 PMID: 23967897
29. Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr. 2002; 76: 961-967. PMID: 12399266
30. Favero S, Roschel H, Artioli G, Ugrinowitsch C, Tricoli V, Costa A, et al. Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance. Amino Acids. 2012; 42: 2299-2305. doi: 10.1007/s00726-011-0972-5 PMID: 21744011
31. Sun G, French CR, Martin GR, Younghusband B, Green RC, Xie YG, et al. Comparison of multifrequency bioelectrical impedance analysis with dual-energy X-ray absorptiometry for assessment of percentage body fat in a large, healthy population. Am J Clin Nutr. 2005; 81:74-78. PMID: 15640463
32. Sun G, Vasdev S, Martin G, Gadag V, Zhang HW. Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance and β-cell function in the Newfoundland population. Diabetes. 2005; 54: 3336-3339. PMID: 16249463
33. Kennedy AP, Shea JL, Sun G. Comparison of the classification of obesity by BMI vs. dual-energy X-ray absorptiometry in the newfoundland population. Obesity. 2009; 17: 2094-2099. doi: 10.1038/oby.2009.101 PMID: 19360011
34. Shea JL, King MT, Yi Y, Gulliver W, Sun G. Body fat percentage is associated with cardiometabolic dysregulation in BMI-defined normal weight subjects. Nutr Metab Cardiovasc Dis. 2012; 22:741-747. doi: 10.1016/j.numecd.2010.11.009 PMID: 21215604
35. Fontaine-Bisson B, Thorburn J, Gregory A, Zhang H and Sun G. Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the Newfoundland CODING study. Am J Clin Nutr. 2014; 99:384-391. doi: 10.3945/ajcn.113.073387 PMID: 24305679
36. Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982; 36:936-942. PMID: 7137077
37. Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol. 1985; 122: 51-65. PMID: 4014201
38. Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, et al. Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires: the Eating at America's Table Study. Am J Epidemiol. 2001; 154:1089-1099. PMID: 11744511
39. Cahill F, Shahidi M, Shea J, Wadden D, Gulliver W, Randell E, et al. High Dietary magnesium intake is associated with low insulin resistance in the Newfoundland population. PLoS One. 2013, 8:e58278. doi: 10.1371/journal.pone.0058278 PMID: 23472169
40. Pedram P, Sun G. Hormonal and Dietary Characteristics in Obese Human Subjects with and without Food Addiction. Nutrients. 2014; 7: 223-238. doi: 10.3390/nu7010223 PMID: 25558907
41. WHO. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation. WHO Technical Report Series 894. Geneva: World Health Organization, 2000.
42. Bray GA. Contemporary Diagnosis and Management of Obesity and the Metabolic Syndrome. 3rd edn. Handbooks in Health Care: Newtown, PA, 2003.
43. Pocock SJ, Collier TJ, Dandreo KJ, Stavola BL, Goldman MB, Kalish LA, Kasten LE, McCormack VA. Issues in the reporting of epidemiological studies: a survey of recent practice. BmJ, 2004; 329: 883. PMID: 15469946
44. Mann CJ. Observational research methods. Research design II: cohort, cross sectional, and case-control studies. Emergency Medicine Journal. 2003; 20: 54-60. PMID: 12533370
45. Jackson AS, Stanforth PR, Gagnon J, Rankinen T, Leon AS, Rao DC, et al. The effect of sex, age and race on estimating percentage body fat from body mass index: The Heritage Family Study. International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity. 2002; 26: 789-96.
46. Klesges RC, Klesges LM, Haddock CK, Eck LH. A longitudinal analysis of the impact of dietary intake and physical activity on weight change in adults. Am J Clin Nutr. 1992; 55: 818-822. PMID: 1550064
47. Westerterp KR, Goran MI. Relationship between physical activity related energy expenditure and body composition: a gender difference. International journal of obesity 1997; 21:184-188. PMID: 9080256
48. Lovejoy JC. The influence of sex hormones on obesity across the female life span. J Womens Health. 1998; 7:1247-1256. PMID: 9929857
49. Slattery ML, McDonald A, Bild DE, Caan BJ, Hilner JE, Jacobs DR, et al. Associations of body fat and its distribution with dietary intake, physical activity, alcohol, and smoking in blacks and whites. Am J Clin Nut. 1992; 55: 943-949.
50. Cheskin LJ, Bartlett SJ, Zayas R, Twilley CH, Allison DB, Contoreggi C. Prescription medications: a modifiable contributor to obesity. South Med J. 1999; 92: 898-904. PMID: 10498166
51. Suter PM, Tremblay A. Is alcohol consumption a risk factor for weight gain and obesity?. Crit Rev Clin Lab Sci. 2005; 42:197-227. PMID: 16047538
52. Hamlin JC, Pauly M, Melnyk S, Pavliv O, Starrett W, Crook TA, et al. Dietary intake and plasma levels of choline and betaine in children with autism spectrum disorders. Autism research and treatment 2013. doi: 10.1155/2013/578429
53. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6,Vitamin B-12, Pantothenic Acid, Biotin, and Choline. National Academy of Sciences. Washington, DC: Food and Nutrition Board, Institute of Medicine National Academic Press; 1998:390-422.
54. Wu G, Zhang L, Li T, Lopaschuk G, Vance DE, Jacobs RL. Choline deficiency attenuates body weight gain and improves glucose tolerance in ob/ob mice. Journal of obesity, 2012. doi: 10.1155/2012/319172
55. Jacobs RL, Zhao Y, Koonen DPY, Sletten T, Su B, Lingrell S, et al. Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J Biol Chem. 2010; 285:22403-22413. doi: 10.1074/jbc.M110.108514 PMID: 20452975
56. Raubenheimer PJ, Nyirenda MJ, Walker BR. A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet. Diabetes. 2006; 55:2015-2020. PMID: 16804070
57. Feng J, Xu ZR. Effect of betaine on muscle, liver and serum amino acid composition in finishing swine. J Zhejiang UnivAgric Life Sci. 2001; 27:107-110.
58. Harmeyer J. The physiological role of L-carnitine. Lohman Information. 2002; 27:15-21.
59. Daily JW, Sachan DS. Choline supplementation alters carnitine homeostasis in humans and guinea pigs. J. Nutr. 1995; 125:1938-1944. PMID: 7616311
60. Lawrence BV, Schinckel AP, Adeola O, Cera K. Impact of betaine on pig finishing performance and carcass composition. J Anim Sci. 2002; 80: 475-482. PMID: 11881932
61. Huang QC, Xu ZR, Han XY, Li WF. Effect of dietary betaine supplementation on lipogenic enzyme activities and fatty acid synthase mRNA expression in finishing pigs. Anim Feed Sci Technol. 2008; 140:365-375.
62. Xing J, Kang L, Jiang Y. Effect of dietary betaine supplementation on lipogenesis gene expression and CpG methylation of lipoprotein lipase gene in broilers. Mol Biol Rep. 2011; 38:1975-1981. doi: 10.1007/s11033-010-0319-4 PMID: 20845073
63. Huang QC, Xu ZR, Han XY, Li WF. Changes in hormones, growth factor and lipid metabolism infinishing pigs fed betaine. Livest Sci. 2006; 105:78-85.
64. Najib S, Sanchez-Margalet V. Homocysteine thiolactone inhibits insulin-stimulated DNA and protein synthesis: possible role of mitogen-activated protein kinase (MAPK), glycogen synthase kinase-3 (GSK-3) and p70 S6K phosphorylation. Journal of molecular endocrinology. 2005; 34:119-126. PMID: 15691882
65. Huang QC, Xu ZR, Han XY, Li WF. Effect of betaine on growth hormone pulsatile secretion and serum metabolites in finishing pigs. J Anim Physiol An N. 2007; 91: 85-90.
66. Apicella JM, Lee EC, Bailey BL, Saenz C, Anderson JM, Craig SAS, et al. Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise. Eur J Appl Physiol. 2013; 113: 793-802. doi: 10.1007/s00421-012-2492-8 PMID: 22976217
67. Slow S, Lever M, Chambers ST, GEORGE PM. Plasma dependent and independent accumulation of betaine in male and female rat tissues. Physiol Res. 2009; 58:403. PMID: 18637704
68. Stoll B, Gerok W, Lang F, Häussinger D. Liver cell volume and protein synthesis. Biochem J. 1992; 287:217-222. PMID: 1329728
69. Fontaine-Bisson B, Wolever TM, Connelly PW, Corey PN, El-Sohemy A. NF-kappaB - 94Ins/Del ATTG polymorphism modifies the association between dietary polyunsaturated fatty acids and HDL-cholesterol in two distinct populations. Atherosclerosis. 2009; 204: 465-470. doi: 10.1016/j.atherosclerosis.2008.10.037 PMID: 19070859
70. Paradis AM, Godin G, Lemieux S, Pérusse L, Vohl MC. Eating behaviours of non-obese individuals with and without familial history of obesity. Br J Nutr. 2009; 101:1103-1109. doi: 10.1017/S0007114508055645 PMID: 18782460
71. Eny KM, Wolever TM, Fontaine-Bisson B, El-Sohemy A. Genetic variant in the glucose transporter type 2 is associated with higher intakes of sugars in two distinct populations. Physiol Genomics. 2008; 33:355-360. doi: 10.1152/physiolgenomics.00148.2007 PMID: 18349384
72. Liu L, Wang PP, Roebothan B, Ryan A, Tucker SC, Colbourne J, et al. Assessing the validity of a self-administered food-frequency questionnaire (FFQ) in the adult population of Newfoundland and Labrador, Canada. Nutrition J. 2013; 12:49.