Higher serum concentrations of betaine rather than choline is associated with better profiles of DXA-derived body fat and fat distribution in Chinese adults

International Journal of Obesity

Volumn 39, Issue 3, 2015, Pages 465-471

  Chen, Y M ^a   Liu, Y ^a   Liu, Y H ^b   Wang, X ^c   Guan, K ^a   Zhu, H L ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^c HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE; CHOLINE;

ADULT; AGED; ARTICLE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS; BODY WEIGHT; CHINA; CHINESE; DUAL ENERGY X RAY ABSORPTIOMETRY; FAT MASS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMB; MALE; MIDDLE AGED; OBESITY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; TRUNK; WAIST CIRCUMFERENCE; WAIST HIP RATIO; BLOOD; COHORT ANALYSIS; EPIDEMIOLOGY; PHOTON ABSORPTIOMETRY; PROCEDURES;

ANIMALIA;

ABSORPTIOMETRY, PHOTON; ADULT; AGED; BETAINE; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS INDEX; CHINA; CHOLINE; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED;

EID: 84924736736     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2014.158     Document Type: Article

References (28)

1. Zeisel SH, Blusztajn JK. Choline and human nutrition. Annu Rev Nutr 1994; 14: 269-296
2. Craig SA. Betaine in human nutrition. Am J Clin Nutr 2004; 80: 539-549
3. Ueland PM. Choline and betaine in health and disease. J Inherit Metab Dis 2011; 34: 3-15
4. Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem 2010; 43: 732-744
5. Konstantinova SV, Tell GS, Vollset SE, Nygard O, Bleie O, Ueland PM. Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr 2008; 138: 914-920
6. Lever M, George PM, Dellow WJ, Scott RS, Chambers ST. Homocysteine, glycine betaine, and N, N-dimethylglycine in patients attending a lipid clinic. Metabolism 2005; 54: 1-14
7. Schwab U, Torronen A, Toppinen L, Alfthan G, Saarinen M, Aro A, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002; 76: 961-967
8. Liu J, Zeng FF, Liu ZM, Zhang CX, Ling WH, Chen YM. Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-Analysis of 61 prospective studies. Lipids Health Dis 2013; 12: 159
9. Cholewa JM, Wyszczelska-Rokiel M, Glowacki R, Jakubowski H, Matthews T, Wood R, et al. Effects of betaine on body composition, performance, and homocysteine thiolactone. J Int Soc Sports Nutr 2013; 10: 39
10. Zhang C, Rexrode KM, van Dam RM, Li TY, Hu FB. Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women. Circulation 2008; 117: 1658-1667
11. Staiano AE, Reeder BA, Elliott S, Joffres MR, Pahwa P, Kirkland SA, et al. Body mass index versus waist circumference as predictors of mortality in Canadian adults. Int J Obesity 2012; 36: 1450-1454
12. Liu YH, Xu Y, Wen YB, Guan K, Ling WH, He LP, et al. Association of weightadjusted body fat and fat distribution with bone mineral density in middle-Aged Chinese adults: a cross-sectional study. PLoS One 2013; 8: e63339
13. Zhang CX, Ho SC. Validity and reproducibility of a food frequency questionnaire among Chinese women in Guangdong province. Asia Pac J Clin Nutr 2009; 18: 240-250
14. Wang P, Chen YM, He LP, Chen CG, Zhang B, Xue WQ, et al. Association of natural intake of dietary plant sterols with carotid intima-media thickness and blood lipids in Chinese adults: a cross-section study. PLoS One 2012; 7: e32736
15. Ainsworth BE, Haskell WL, Herrmann SD, Meckes N, Bassett DR Jr, Tudor-Locke C, et al. Compendium of physical activities: a second update of codes and MET values. Med Sci Sports Exerc 2011; 43: 1575-1581
16. Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-Throughput method based on normal-phase chromatography-Tandem mass spectrometry. Clin Chem 2003; 49: 286-294
17. Wang LJ, Zhang HW, Zhou JY, Liu Y, Yang Y, Chen XL, et al. Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. J Nutr Biochem 2014; 25: 329-336
18. Cadogan DJ, Campbell RG, Harrison D, Edwards AC. The effects of betaine on the growth performance and carcass characteristics of female pigs. Manipulating Pig Production. Australian Pig Association: Attwood, Victoria, Australia, 1993; p219
19. Eklund M, Bauer E, Wamatu J, Mosenthin R. Potential nutritional and physiological functions of betaine in livestock. Nutr Res Rev 2005; 18: 31-48
20. Sales J. A meta-Analysis of the effects of dietary betaine supplementation on finishing performance and carcass characteristics of pigs. Anim Feed Sci Technol 2011; 165: 68-78
21. Wang YZ, Xu ZR, Feng J. The effect of betaine and dl-methionine on growth performance and carcass characteristics in meat ducks. Anim Feed Sci Technol 2004; 116: 151-159
22. Zou XT, Lu JJ. Effects of betaine on the regulation of the lipid metabolism in laying hen. Sci Agric Sin 2002; 35: 325-330
23. Prospective Studies Collaboration, Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, et al. Body mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.Lancet 2009; 373: 1083-1096
24. Lawrence BV, Schinckel AP, Adeola O, Cera K. Impact of betaine on pig finishing performance and carcass composition. J Anim Sci 2002; 80: 475-482
25. Huang QC, Xu ZR, Han XY, Li WF. Effect of dietary betaine supplementation on lipogenic enzyme activities and fatty acid synthase mRNA expression in finishing pigs. Anim Feed Sci Technol 2008; 140: 365-375
26. Xing J, Kang L, Jiang Y. Effect of dietary betaine supplementation on lipogenesis gene expression and CpG methylation of lipoprotein lipase gene in broilers. Mol Biol Rep 2011; 38: 1975-1981
27. Huang QC, Xu ZR, Han XY, Li WF. Changes in hormones, growth factor and lipid metabolism in finishing pigs fed betaine. Livest Sci 2006; 105: 78-85
28. Wu G, Zhang L, Li T, Lopaschuk G, Vance DE, Jacobs RL. Choline deficiency attenuates body weight gain and improves glucose tolerance in ob/ob mice. J Obes 2012; 2012: 319172