DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 20, 2016, Pages 5610-5615

  Liu, Yang ^a   Blanchfield, Lori ^b   Pui Yan Ma, Victor ^a   Andargachew, Rakieb ^b   Galior, Kornelia ^a   Liu, Zheng ^a   Evavold, Brian ^b   Salaita, Khalid ^a,c  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Emory University   (United States)

Author keywords

Antigen discrimination; Cell migration; Mechanotransduction; Molecular tension sensor; T cell receptor

Indexed keywords

ACTIN RELATED PROTEIN 2-3 COMPLEX; CALCIUM ION; CD8 ANTIGEN; GOLD NANOPARTICLE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MYOSIN ADENOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN KINASE; PROTEIN CDC42; PROTEIN KINASE LCK; T LYMPHOCYTE RECEPTOR; CALCIUM; DNA; GOLD; LYMPHOCYTE ANTIGEN RECEPTOR; METAL NANOPARTICLE;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CALCIUM SIGNALING; CELL JUNCTION; CELL MIGRATION; DNA HAIRPIN; FLUORESCENCE RESONANCE ENERGY TRANSFER; IMMUNE RESPONSE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MECHANOTRANSDUCTION; MICROSCOPY; PRIORITY JOURNAL; SENSOR; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TENSION; BIOMECHANICS; HUMAN; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY;

ANTIGENS, CD8; BIOMECHANICAL PHENOMENA; CALCIUM; DNA; GOLD; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MECHANOTRANSDUCTION, CELLULAR; METAL NANOPARTICLES; RECEPTORS, ANTIGEN, T-CELL;

EID: 84969793694     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1600163113     Document Type: Article

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