Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 27, 2015, Pages 8373-8378

  Mallis, Robert J ^a   Bai, Ke ^b   Arthanari, Haribabu ^a   Hussey, Rebecca E ^c   Handley, Maris ^c   Li, Zhenhai ^b   Chingozha, Loice ^d   Duke Cohan, Jonathan S ^a,c   Lu, Hang ^d   Wang, Jia Huai ^a,c   Zhu, Cheng ^b   Wagner, Gerhard ^a   Reinherz, Ellis L ^a,c   Garcia, Kenan ^e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d Georgia Institute of Technology   (United States)

^e STANFORD UNIVERSITY   (United States)

Author keywords

Biomembrane force probe; NMR spectroscopy; Pre T cell receptor; Repertoire selection; Thymic development

Indexed keywords

ALPHABETA T CELL RECEPTOR; B LYMPHOCYTE RECEPTOR; HETERODIMER; MAJOR HISTOCOMPATIBILITY ANTIGEN; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG; CALCIUM; COMPLEMENTARITY DETERMINING REGION; HISTOCOMPATIBILITY ANTIGEN; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE; PROTEIN BINDING;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; CALCIUM TRANSPORT; CELL MATURATION; CONTROLLED STUDY; GENE REARRANGEMENT; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; THYMOCYTE; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CHEMICAL STRUCTURE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; CYTOLOGY; EMBRYOLOGY; FLOW CYTOMETRY; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN MULTIMERIZATION; SEQUENCE HOMOLOGY; THYMUS;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM; CELL DIFFERENTIATION; CELLS, CULTURED; COMPLEMENTARITY DETERMINING REGIONS; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS; LIGANDS; LYMPHOCYTE ACTIVATION; MAGNETIC RESONANCE SPECTROSCOPY; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, IMMUNOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEQUENCE HOMOLOGY, AMINO ACID; THYMOCYTES; THYMUS GLAND;

EID: 84936818790     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1504971112     Document Type: Article

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