T cell receptor dwell times control the kinase activity of Zap70

Nature Immunology

Volumn 16, Issue 9, 2015, Pages 961-969

  Klammt, Christian ^a   Novotna, Lucie ^a   Li, Dongyang T ^a   Wolf, Miriam ^a   Blount, Amy ^a   Zhang, Kai ^b   Fitchett, Jonathan R ^b   Lillemeier, Bjorn F ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR; CD3 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; BIOTINYLATION; CATALYSIS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; GEL PERMEATION CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; WILD TYPE; CELL MEMBRANE; GENETICS; HUMAN; MASS SPECTROMETRY; METABOLISM; MOLECULAR DYNAMICS; MUTATION; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; TIME;

ANTIGENS, CD3; CELL MEMBRANE; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MASS SPECTROMETRY; MOLECULAR DYNAMICS SIMULATION; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANTIGEN, T-CELL; TIME FACTORS; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 84939650638     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3231     Document Type: Article

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