Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 5, 2015, Pages 1517-1522

  Das, Dibyendu Kumar ^a   Feng, Yinnian ^a   Mallis, Robert J ^b   Li, Xiaolong ^c   Keskin, Derin B ^b,d   Hussey, Rebecca E ^d   Brady, Sonia K ^a   Wang, Jia Huai ^c,d   Wagner, Gerhard ^b   Reinherz, Ellis L ^b,d   Lang, Matthew J ^a,e  

^a VANDERBILT UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Catch bond; Mechanosensor; Optical tweezers; Peptide discrimination; T cell receptor

Indexed keywords

HETERODIMER; SPACER DNA; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FORCE; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MECHANOTRANSDUCTION; OPTICAL TWEEZERS; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR BINDING; T LYMPHOCYTE; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; SEQUENCE HOMOLOGY;

MAMMALIA;

AMINO ACID SEQUENCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MODELS, MOLECULAR; OPTICAL TWEEZERS; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84922370601     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424829112     Document Type: Article

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