Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity

Applied Microbiology and Biotechnology

Volumn 100, Issue 19, 2016, Pages 8349-8357

  He, Wenni ^a   Liu, Miaomiao ^a,i,j   Li, Xiaolin ^b   Zhang, Xiaoping ^c   Abdel Mageed, Wael M ^d,e   Li, Li ^f   Wang, Wenzhao ^a   Zhang, Jingyu ^a   Han, Jianying ^a,i   Dai, Huanqin ^a   Quinn, Ronald J ^j   Liu, Hung wen ^g   Luo, Houwei ^h   Zhang, Lixin ^a   Liu, Xueting ^a  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b CROP RESEARCH INSTITUTE   (China)

^c SICHUAN AGRICULTURAL UNIVERSITY   (China)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e Assiut University   (Egypt)

^f INSTITUTE OF MATERIA MEDICA   (China)

^g The University of Texas at Austin   (United States)

^h CHINA PHARMACEUTICAL UNIVERSITY   (China)

ⁱ UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^j GRIFFITH UNIVERSITY   (Australia)

more..

Author keywords

Biotransformation; Hypocrea sp; Tanshinone IIA; 4+2 cycloaddition reaction

Indexed keywords

BIOCONVERSION; CATALYSIS; CYCLOADDITION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANTI-BACTERIAL ACTIVITY; ANTI-MRSA ACTIVITIES; BIOTRANSFORMATION; FUNGAL BIOTRANSFORMATION; HYPOCREA; MICROBIAL ENZYMES; TANSHINONE II A; [4+2] CYCLOADDITION REACTIONS;

ENZYMES;

ANTIINFECTIVE AGENT; CIPROFLOXACIN; ISONIAZID; MICROBIAL ENZYME; SORBICILLINOL; TANSHINONE IIA; TANSHISORBICIN; UNCLASSIFIED DRUG; VANCOMYCIN; ABIETANE DERIVATIVE; CYCLOHEXANONE DERIVATIVE; TANSHINONE;

ANTIMICROBIAL ACTIVITY; BIOTRANSFORMATION; CATALYSIS; ENZYME; FUNGUS; MASS SPECTROMETRY; METABOLITE; NUCLEAR MAGNETIC RESONANCE; REACTION KINETICS; SUBSTRATE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYCLOADDITION; DIELS ALDER REACTION; DRUG ISOLATION; DRUG TRANSFORMATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME MECHANISM; FUNGAL STRAIN; HYPOCREA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MYCOBACTERIUM BOVIS BCG; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; BIOTRANSFORMATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; MASS SPECTROMETRY; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR MODEL; TRICHODERMA;

FUNGI; HYPOCREA; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

ANTI-INFECTIVE AGENTS; BIOTRANSFORMATION; CYCLOADDITION REACTION; CYCLOHEXANONES; DITERPENES, ABIETANE; MASS SPECTROMETRY; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; TRICHODERMA;

EID: 84969785369     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-016-7488-6     Document Type: Article

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