Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4 + 2] Cycloaddition

Journal of the American Chemical Society

Volumn 137, Issue 10, 2015, Pages 3494-3497

  Wever, Walter J ^a   Bogart, Jonathan W ^a   Baccile, Joshua A ^b   Chan, Andrew N ^c   Schroeder, Frank C ^b   Bowers, Albert A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Boyce Thompson Institute for Plant Research   (United States)

^c The University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACILLUS CEREUS; BACTERIOLOGY; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; CYCLOADDITION; ENZYMES; PEPTIDES;

BIOSYNTHETIC PATHWAY; CHEMICAL AND BIOLOGICALS; CHEMO-ENZYMATIC SYNTHESIS; CHEMOENZYMATIC ROUTE; NATIVE CHEMICAL LIGATION; PEPTIDE BIOSYNTHESIS; POST-TRANSLATIONAL MODIFICATIONS; [4 + 2] CYCLOADDITION;

C (PROGRAMMING LANGUAGE);

ENZYME; POLYPEPTIDE ANTIBIOTIC AGENT; SIGNAL PEPTIDE; THIAZOLE DERIVATIVE; BIOLOGICAL PRODUCT; PEPTIDE; THIOCILLIN;

AROMATIZATION; ARTICLE; CATALYSIS; CHEMICAL REACTION; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; ELIMINATION REACTION; LIQUID CHROMATOGRAPHY; NATIVE CHEMICAL LIGATION; PEPTIDE SYNTHESIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; REACTION ANALYSIS; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; AMINO ACID SEQUENCE; BIOCATALYSIS; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; SYNTHESIS;

AMINO ACID SEQUENCE; BIOCATALYSIS; BIOLOGICAL PRODUCTS; CYCLOADDITION REACTION; ENZYMES; MOLECULAR SEQUENCE DATA; PEPTIDES;

EID: 84925252380     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b00940     Document Type: Article

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