Biosynthesis of versipelostatin: Identification of an enzyme-catalyzed [4+2]-cycloaddition required for macrocyclization of spirotetronate-containing polyketides

Journal of the American Chemical Society

Volumn 137, Issue 2, 2015, Pages 572-575

  Hashimoto, Takuya ^a   Hashimoto, Junko ^b   Teruya, Kuniko ^c   Hirano, Takashi ^c   Shin Ya, Kazuo ^d   Ikeda, Haruo ^e   Liu, Hung Wen ^f   Nishiyama, Makoto ^a   Kuzuyama, Tomohisa ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Koto ku   (Japan)

^c Okinawa Institute of Advanced Sciences Okinawa Life Science Research Center   (Japan)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^e KITASATO UNIVERSITY   (Japan)

^f The University of Texas at Austin   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; ENZYMES; GENE EXPRESSION; KETONES; MUSCULOSKELETAL SYSTEM; OLEFINS;

BACTERIAL ARTIFICIAL CHROMOSOMES; BIOSYNTHETIC GENE CLUSTER; CONJUGATED DIENE; HETEROLOGOUS EXPRESSION; MACRO-CYCLIZATION; MACROCYCLICS; STEREO-SELECTIVE; VERSIPELOSTATIN;

BIOSYNTHESIS;

MALONYL COENZYME A; POLYKETIDE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; VERSIPELOSTATIN; MACROLIDE; OLIGOSACCHARIDE; SPIRO COMPOUND;

ACETYLATION; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; BACTERIAL GENOME; BIOINFORMATICS; BIOSYNTHESIS; CATALYSIS; CONFORMATION; CYCLIZATION; CYCLOADDITION; DNA SEQUENCE; ESCHERICHIA COLI; GENE CLUSTER; GENE EXPRESSION; GENE ISOLATION; GENE SEQUENCE; HETEROLOGOUS EXPRESSION; HYDROGEN BOND; METABOLITE; NONHUMAN; OPEN READING FRAME; STEREOCHEMISTRY; STREPTOMYCES; STREPTOMYCES ALBUS; STREPTOMYCES VERSIPELLIS; BIOCATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MULTIGENE FAMILY; STEREOISOMERISM;

BIOCATALYSIS; CYCLOADDITION REACTION; MACROLIDES; MULTIGENE FAMILY; OLIGOSACCHARIDES; POLYKETIDES; SPIRO COMPOUNDS; STEREOISOMERISM; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 84921516173     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja510711x     Document Type: Article

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