Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 20, 2016, Pages 5748-5753

  Su, Zhenwei ^a   Brown, Emily C ^a   Wang, Weiwei ^a   MacKinnon, Roderick ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

HERG safety assay; K+ channel screening; LFA; Liposome flux assay

Indexed keywords

LIPOSOME; POTASSIUM CHANNEL; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL BLOCKING AGENT; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; BIOLOGY; CALCIUM CONDUCTANCE; CELL FREE SYSTEM; FLUX ASSAY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIPOSOME FLUX ASSAY; MOUSE; NERVE CELL INHIBITION; NEWBORN; NONHUMAN; POTASSIUM CONDUCTANCE; POTASSIUM TRANSPORT; PRIORITY JOURNAL; GENETICS; HEART ARRHYTHMIA; PATCH CLAMP TECHNIQUE;

ARRHYTHMIAS, CARDIAC; ETHER-A-GO-GO POTASSIUM CHANNELS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 84969752680     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1602815113     Document Type: Article

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