Central and peripheral neurotoxic effects of ivermectin in rats

Journal of Veterinary Medical Science

Volumn 73, Issue 5, 2011, Pages 591-599

  Trailović, Saša M ^a   Nedeljković, Jelena Trailović ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Flumazenil; GABA; Isolated ileum; Ivermectin; Thiopentone

Indexed keywords

ANTIDOTE; ANTIPARASITIC AGENT; ATROPINE; CENTRAL DEPRESSANT AGENT; FLUMAZENIL; IVERMECTIN; THIOPENTAL;

ANIMAL; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; GASTROINTESTINAL MOTILITY; GUINEA PIG; ILEUM; MALE; PERIPHERAL NEUROPATHY; RAT; WISTAR RAT;

ADJUVANTS, ANESTHESIA; ANIMALS; ANTIDOTES; ANTIPARASITIC AGENTS; ATROPINE; CENTRAL NERVOUS SYSTEM DISEASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FLUMAZENIL; GASTROINTESTINAL MOTILITY; GUINEA PIGS; ILEUM; IVERMECTIN; MALE; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, WISTAR; THIOPENTAL;

ANIMALIA; CAVIA; MAMMALIA; RATTUS;

EID: 79958042916     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.10-0424     Document Type: Article

References (45)

1. Abalis, I. M., Eldefrawi, A. T. and Eldefrawi, M. E. 1986. Actions of avermectin B1a on the gamma-aminobutyric acid A receptor and chloride channels in rat brain. J. Biochem. Toxicol. 1: 69-82.
2. Amin, J. and Weiss, D. S. 1993. GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital. Nature 366: 510-511.
3. Basudde, C. D. 1989. Clinical signs and biochemical changes in calves caused by injection of ivermectin. Vet. Q. 11: 29-32.
4. Bloomquist, J. R. 1992. Intrinsic lethality of chloride-channeldirected insecticides and convulsants in mammals. Toxicol. Lett. 60: 289-298.
5. Bourke, C. A. 1995. The clinical differentiation of nervous and muscular locomotordisorders of sheep in Australia. Aust. Vet. J. 62: 228-234.
6. Campbell, W. C. and Benz, G. W. 1984. Ivermectin: a review of efficacy and safety. J. Vet. Pharmacol. Ther. 7: 1-16.
7. Carmichael, F. J. and Haas, D. A. 1998. General Anestetics. pp. 261-282. In: Principles of Medical Pharmacology. 6th ed. (Kalant H., and Roschlau W.H.E. eds.), Oxford University Press, New York.
8. Charney, D. S., Mihic, S. J. and Harris, R. A. 2006. Hypnotics and sedatives. pp. 401-429. In: The Pharmacological Basis of Therapeutics. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th ed. (Brunton, L. L. ed.), McGraw-Hill Medical Publishing Division, New York.
9. Chaudhuri, L. and Ganguly, D. K. 1994. Involvement of gamma-aminobutyric acid in the stimulatory effect of metoclopramide on gastrointestinal motility. Life Sci. 54: 253-259.
10. Coccini, T., Candura, S. M., Manzo, L., Costa, L. G. and Tonini, M. 1993. Interaction of the neurotoxic pesticides ivermectin and lindane with the enteric GABAA receptor-ionophore complex in guinea pig. Eur. J. Pharmacol. 248: 1-6.
11. Davanger, S., Ottersen, O. P. and Storm-Mathisen, J. 1987. Immunocytochemical localization of GABA in cat myenteric plexus. Neurosci. Lett. 73: 27-32.
12. Dawson, G. R., Wafford, K. A., Smith, A., Marshall, G. R., Bayley, P. J., Schaeffer, J. M., Meineke, P. T. and McKernan, R. M. 2000. Anticonvulsant and adverse effects avermectin analogs in mice are mediated through γ-aminobutyric acid receptor. Neurosci. Lett. 250: 1051-1060.
13. Duce, I. R. and Scott, R. H. 1985. Action of dihydroavermectin B, on insect muscle. Br. J. Pharmacol. 85: 395-401.
14. Edwards, G. 2003. Ivermectin: does P-glycoprotein play a role in neurotoxicity? Filaria J. 24: 2 (Suppl 1): S8.
15. Forshaw, P. J., Lister, T. and Ray, E. D. 2000. The role of voltage-gated chloride channels in type II pyrethroid insecticide poisoning. Toxicol. Appl. Pharmacol. 163: 1-8.
16. Giotti, A., Luzzi, S., Spagnesi, S. and Zilletti, L. 1983. GABAA and GABAB receptor mediated effects in guinea-pig ileum. Br. J. Pharmacol. 78: 469-478.
17. Hullihan, J. P., Spector, S., Taniguchi, T. and Wang, J. K. 1983. The binding of [3H]-diazepam to guinea-pig ileal longitudinal muscle and the in vitro inhibition of contraction by benzodiazepines. Br. J. Pharmacol. 78: 321-327.
18. Hopkins, K. D., Marcella, K. L. and Strecker, A. E. 1990. Ivermectin toxicosis in a dog. J. Am. Vet. Med. Assoc. 197: 93-94.
19. Karns, P. A. and Luther, D. G. 1984. A survey at adverse effects associated with ivermectin use in Louisiana horses. J. Am. Vet. Med. Assoc. 185: 782-783.
20. Kerr, D. I. and Ong, J. 1986. Gamma-aminobutyric aciddependent motility induced by avermectin B1a in the isolated intestine of the guinea pig. Neurosci Lett. 65: 7-10.
21. Kerr, D. I., Humeniuk, R. E. and Ong, J. 1994. Gamma-guanidinobaclofen is a peripheral GABAB receptor agonist. Eur. J. Pharmacol. 262: 189-192.
22. Lankas, G. R., Cartwright, M. E. and Umbenhauer, D. 1997. Pglycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity. Toxicol. Appl. Pharmacol. 143:357-365.
23. Luzzi, S., Spagnesi, S., Franchi-Micheli, S., Rosi, E., Ciuffi M. and Zilletti, L. 1986. Diazepam potentiates GABA-contraction in guinea-pig ileum. Arch. Int. Pharmacody. Ther. 279: 29-39.
24. Lovell, R. A. 1990. Ivermectin and piperazine toxicoses in dogs and cats. Vet. Clin. North Am. Small Anim. Pract. 20: 453-468.
25. Matsumoto, K., Kasuya, M. and Fukuda, H. 1986. DIDS, an anion transport blocker, modulates ivermectin-induced enhancement of benzodiazepine receptor binding in rat brain. Gen. Pharmacol. 17: 519-523.
26. Muhammad, G., Abdul, J., Khan, M. Z. and Saqib, M. 2004. Use of neostigmine in massive ivermectin toxicity in cats. Vet. Hum. Toxicol. 46: 28-29.
27. Mealey, K. L., Bentjen, S. A., Gay, J. M. and Cantor, G. H. 2001. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 11: 727-733.
28. Mealey, K. L., Northrup, N. C. and Bentjen, S. A. 2003. Increased toxicity of P glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity. J. Am. Vet. Med. Assoc. 223: 1453-1455.
29. Merola, V., Khan, S. and Gwaltney-Brant S. 2009. Ivermectin toxicosis in dogs: a retrospective study. J. Am. Anim. Hosp. Assoc. 45: 106-111.
30. de Moura, R. S., Rios, A. A., de Oliveira, L. F., Resende, A. C., de Lemos, N. M., Santos, E. J., Correia, M. L. and Tano, T. 2001. The effects of nitric oxide synthase inhibitors on the sedative effect of clonidine. Anesth. Analg. 93: 1217-1221.
31. Ong, J. and Kerr, D. I. 1982. GABAA-and GABAB-receptormediated modification of intestinal motility. Eur. J. Pharmacol. 86: 9-17.
32. Payne, G. T. and Soderlund, D. M. 1991. Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. Biochem. Toxicol. 6: 283-292.
33. Pencheva, N., Itzev, D. and Milanov, P. 1999. Comparison of gamma-aminobutyric acid effects in different parts of the cat ileum. Eur. J. Pharmacol. 368: 49-56.
34. Pérez-Guerrero, C., Suárez. J., Herrera, M. D. and Marhuenda, E. 1997. Spasmolytic effects of tetrazepam on rat duodenum and guinea-pig ileum. Pharmacol Res. 35: 493-497.
35. Reinemeyer, C. R. and Courtney, C. H. 2001. Antinematodal drugs pp. 964-973. In: Veterinary Pharmacology and Therapeutics, 8th ed. (Adams, H. R. ed.), Iowa State University Press, Ames IA.
36. Robertson, B. 1989. Actions of anaesthetics and avermectin on GABAA chloride channels in mammalian dorsal root ganglion neurones. Br. J. Pharmacol. 98: 167-176.
37. Schonrock, B. and Bormann, J. 1993. Activation of Cl-channels by avermectin in rat cultured hippocampal neurons. Naunyn Schmiedebergs Arch. Pharmacol. 348: 628-632.
38. Saneford, E. S., Rehmtulla, A. J. and Gaylou, K. A. 1988. Ivermectin overdose and toxicosis in neonatal pigs. Can. Vet. J. 29: 735-736.
39. Sivine, F., Plume, C. and Ansay, M. 1985. Picrotoxin, the antidote to ivermectin in dogs. Vet. Rec. 116: 195-197.
40. Tanaca, C. 1985. γ-amminobutyric acid in peripheral tissues. Life Sci. 37: 2221-2235.
41. Trailović, S. M. and Varagić, V. M. 2007. The effect of ivermectin on convulsions in rats produced by lidocaine and strychnine. Vet. Res. Commun. 31: 863-872.
42. Trevor, A. 2006. Sedative-hypnotic drugs. pp. 374-363. In: Basic & Clinical Pharmacology, 10th ed. (Katzung, B.G. ed.). The McGraw-Hill Companies Inc. New York.
43. Villar, R., Laguna, M. R., Calleja, J. M. and Cadavid, I. 1992. Effects of Skeletonema costatum extracts on the central nervous system. Planta Med. 58: 398-404.
44. Wang, C. C. and Pong, S. S. 1982. Actions of avermectin B1a on GABA nerves. Prog. Clin. Biol. Res. 97: 373-395.
45. Williams, M. and Risley, E. A. 1984. Ivermectin interactions with benzodiazepine receptors in rat cortex and cerebellum in vitro. J. Neurochem. 42: 745-53.