Wild-type opsin does not aggregate with a misfolded opsin mutant

Biochimica et Biophysica Acta - Biomembranes

Volumn 1858, Issue 8, 2016, Pages 1850-1859

  Gragg, Megan ^a   Kim, Tae Gyun ^a   Howell, Scott ^a   Park, P S H ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Conformational disease; G protein coupled receptor; Protein aggregation; Protein misfolding; Retinal degeneration

Indexed keywords

ARGININE; GLYCINE; MUTANT PROTEIN; OLIGOMER; OPSIN; MEMBRANE PROTEIN; PHOTOPROTEIN; PROTEIN AGGREGATE; RHODOPSIN;

ARTICLE; AUTOSOMAL DOMINANT DISORDER; AUTOSOMAL DOMINANT INHERITANCE; BIOLOGICAL MONITORING; CELL MEMBRANE; CONTROLLED STUDY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; MOLECULAR PATHOLOGY; PHENOTYPE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; RETINITIS PIGMENTOSA; WILD TYPE; AMINO ACID SUBSTITUTION; CHEMISTRY; DEFICIENCY; DOMINANT GENE; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; MISSENSE MUTATION; POINT MUTATION; PROTEIN ANALYSIS; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; PROTEOSTASIS DEFICIENCY; RETINAL ROD OUTER SEGMENT;

AMINO ACID SUBSTITUTION; CELL MEMBRANE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENES, DOMINANT; HEK293 CELLS; HUMANS; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; MUTATION, MISSENSE; POINT MUTATION; PROTEIN AGGREGATES; PROTEIN FOLDING; PROTEIN INTERACTION MAPPING; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; PROTEOSTASIS DEFICIENCIES; RETINITIS PIGMENTOSA; RHODOPSIN; ROD CELL OUTER SEGMENT;

EID: 84969674394     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2016.04.013     Document Type: Article

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