Light induces ultrastructural changes in rod outer and inner segments, including autophagy, in a transgenic Xenopus laevis P23H rhodopsin model of retinitis pigmentosa

Investigative Ophthalmology and Visual Science

Volumn 56, Issue 13, 2015, Pages 7947-7955

  Bogéa, Tami H ^a   Wen, Runxia H ^a   Moritz, Orson L ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Autophagy; Cell death; P23H; Photoreceptor; Retinitis pigmentosa; Rhodopsin

Indexed keywords

CASPASE 9; MONOCLONAL ANTIBODY; RHODOPSIN; AP20187; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL VACUOLE; CONFOCAL LASER MICROSCOPY; ENDOPLASMIC RETICULUM MEMBRANE; FEMALE; GENE SILENCING; GENOTYPING TECHNIQUE; IMMUNOHISTOCHEMISTRY; LIGHT EXPOSURE; MALE; NONHUMAN; PHOTORECEPTOR INNER SEGMENT; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA DEGENERATION; RETINA ROD; RETINA ROD OUTER SEGMENT; RETINITIS PIGMENTOSA; TRANSMISSION ELECTRON MICROSCOPY; XENOPUS LAEVIS; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; EXPERIMENTAL RADIATION INJURY; LIGHT; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOTOPERIODICITY; RADIATION RESPONSE; RETINAL ROD OUTER SEGMENT; TRANSGENIC ANIMAL; ULTRASTRUCTURE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AUTOPHAGY; CASPASE 9; DISEASE MODELS, ANIMAL; LIGHT; PHOTOPERIOD; RADIATION INJURIES, EXPERIMENTAL; RETINAL PHOTORECEPTOR CELL INNER SEGMENT; RETINAL ROD PHOTORECEPTOR CELLS; RETINITIS PIGMENTOSA; RHODOPSIN; ROD CELL OUTER SEGMENT; TACROLIMUS; XENOPUS LAEVIS;

EID: 84950335519     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-16799     Document Type: Article

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