Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles

ACS Medicinal Chemistry Letters

Volumn 7, Issue 5, 2016, Pages 487-492

  Houck, Joseph D ^a   Dawson, Thomas K ^a   Kennedy, Andrew J ^a   Kharel, Yugesh ^b   Naimon, Niels D ^a   Field, Saundra D ^a   Lynch, Kevin R ^b   Macdonald, Timothy L ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

cancer; inhibitor; oxadiazoles; Sphingosine 1 phosphate; sphingosine kinase

Indexed keywords

AMIDINE; OXADIAZOLE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; ISOMER; METABOLIC STABILITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL;

EID: 84969506816     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.6b00002     Document Type: Article

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