Nocodazole Induced Suicidal Death of Human Erythrocytes

Cellular Physiology and Biochemistry

Volumn 38, Issue 1, 2016, Pages 379-392

  Signoretto, Elena ^a,b   Honisch, Sabina ^a   Briglia, Marilena ^a,c   Faggio, Caterina ^c   Castagna, Michela ^b   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

Calcium; Cell volume; Eryptosis; Oxidative stress; Phosphatidylserine

Indexed keywords

ANTIBODY; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CALCIUM ION; CERAMIDE; DICHLORODIHYDROFLUORESCEIN DIACETATE; FLUO 3; LIPOCORTIN 5; NOCODAZOLE; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; REAGENT; TUBULIN; ANILINE DERIVATIVE; CALCIUM; TUBULIN MODULATOR; XANTHENE DERIVATIVE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL MEMBRANE; CELL SURFACE; CELL VOLUME; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DRUG EXPOSURE; ERYPTOSIS; ERYTHROCYTE; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ERYTHROCYTE MEMBRANE; HEMOLYSIS; METABOLISM;

ANILINE COMPOUNDS; APOPTOSIS; CALCIUM; CERAMIDES; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; HEMOLYSIS; HUMANS; MICROSCOPY, CONFOCAL; NOCODAZOLE; PHOSPHATIDYLSERINES; REACTIVE OXYGEN SPECIES; TUBULIN; TUBULIN MODULATORS; XANTHENES;

EID: 84969391798     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000438638     Document Type: Article

References (118)

1. Bereiter-Hahn J, Voth M, Mai S, Jendrach M: Structural implications of mitochondrial dynamics. Biotechnol J 2008;3:765-780.
2. Beswick RW, Ambrose HE, Wagner SD: Nocodazole, a microtubule de-polymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. Leuk Res 2006;30:427-436.
3. Calaghan SC, Le Guennec JY, White E: Cytoskeletal modulation of electrical and mechanical activity in cardiac myocytes. Prog Biophys Mol Biol 2004;84:29-59.
4. Choi HJ, Zhu BT: Role of cyclin B1/Cdc2 in mediating Bcl-XL phosphorylation and apoptotic cell death following nocodazole-induced mitotic arrest. Mol Carcinog 2014;53:125-137.
5. Frezzato F, Trimarco V, Martini V, Gattazzo C, Ave E, Visentin A, Cabrelle A, Olivieri V, Zambello R, Facco M, Zonta F, Cristiani A, Brunati AM, Moro S, Semenzato G, Trentin L: Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole. Br J Haematol 2014;165:659-672.
6. Gozes I: Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Curr Pharm Des 2011;17:3413-3417.
7. Ikegami R, Zhang J, Rivera-Bennetts AK, Yager TD: Activation of the metaphase checkpoint and an apoptosis programme in the early zebrafish embryo, by treatment with the spindle-destabilising agent nocodazole. Zygote 1997;5:329-350.
8. Kallas A, Pook M, Maimets M, Zimmermann K, Maimets T: Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells. PLoS One 2011;6:e19114.
9. Kirsch-Volders M, Vanhauwaert A, Eichenlaub-Ritter U, Decordier I: Indirect mechanisms of genotoxicity. Toxicol Lett 2003;140-141:63-74.
10. Kook S, Shim SR, Kim JI, Ahnn JH, Jung YK, Paik SG, Song WK: Degradation of focal adhesion proteins during nocodazole-induced apoptosis in rat-1 cells. Cell Biochem Funct 2000;18:1-7.
11. Modriansky M, Dvorak Z: Microtubule disruptors and their interaction with biotransformation enzymes. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005;149:213-215.
12. Rieder CL, Maiato H: Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint. Dev Cell 2004;7:637-651.
13. Verdoodt B, Decordier I, Geleyns K, Cunha M, Cundari E, Kirsch-Volders M: Induction of polyploidy and apoptosis after exposure to high concentrations of the spindle poison nocodazole. Mutagenesis 1999;14:513-520.
14. Zacharaki P, Stephanou G, Demopoulos NA: Comparison of the aneugenic properties of nocodazole, paclitaxel and griseofulvin in vitro. Centrosome defects and alterations in protein expression profiles. J Appl Toxicol 2013;33:869-879.
15. Bhakta-Guha D, Saeed ME, Greten HJ, Efferth T: Dis-organizing centrosomal clusters: specific cancer therapy for a generic spread? Curr Med Chem 2015;22:685-694.
16. Decordier I, Cundari E, Kirsch-Volders M: Survival of aneuploid, micronucleated and/or polyploid cells: crosstalk between ploidy control and apoptosis. Mutat Res 2008;651:30-39.
17. Ho YS, Duh JS, Jeng JH, Wang YJ, Liang YC, Lin CH, Tseng CJ, Yu CF, Chen RJ, Lin JK: Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells. Int J Cancer 2001;91:393-401.
18. Hsu SL, Yu CT, Yin SC, Tang MJ, Tien AC, Wu YM, Huang CY: Caspase 3, periodically expressed and activated at G2/M transition, is required for nocodazole-induced mitotic checkpoint. Apoptosis 2006;11:765-771.
19. Scott RE, Gao S: P2P-R deficiency modifies nocodazole-induced mitotic arrest and UV-induced apoptosis. Anticancer Res 2002;22:3837-3842.
20. Katsaros C, Karyophyllis D, Galatis B: Cytoskeleton and morphogenesis in brown algae. Ann Bot 2006;97:679-693.
21. Agnese V, Bazan V, Fiorentino FP, Fanale D, Badalamenti G, Colucci G, Adamo V, Santini D, Russo A: The role of Aurora-A inhibitors in cancer therapy. Ann Oncol 2007;18 Suppl 6:vi47-52.
22. Kitagawa K, Niikura Y: Caspase-independent mitotic death (CIMD). Cell Cycle 2008;7:1001-1005.
23. Han CR, Jun do Y, Lee JY, Kim YH: Prometaphase arrest-dependent phosphorylation of Bcl-2 and Bim reduces the association of Bcl-2 with Bak or Bim, provoking Bak activation and mitochondrial apoptosis in nocodazole-treated Jurkat T cells. Apoptosis 2014;19:224-240.
24. Landsverk KS, Lyng H, Stokke T: The response of malignant B lymphocytes to ionizing radiation: cell cycle arrest, apoptosis and protection against the cytotoxic effects of the mitotic inhibitor nocodazole. Radiat Res 2004;162:405-415.
25. Li P, Zhou L, Dai Z, Jin X, Liu X, Matsumoto Y, Furusawa Y, Li Q: High LET radiation enhances nocodazole Induced cell death in HeLa cells through mitotic catastrophe and apoptosis. J Radiat Res 2011;52:481-489.
26. Song H, Kim SI, Ko MS, Kim HJ, Heo JC, Lee HJ, Lee HS, Han IS, Kwack K, Park JW: Overexpression of DRG2 increases G2/M phase cells and decreases sensitivity to nocodazole-induced apoptosis. J Biochem 2004;135:331-335.
27. Wang YJ, Jeng JH, Chen RJ, Tseng H, Chen LC, Liang YC, Lin CH, Chen CH, Chu JS, Ho WL, Ho YS: Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog 2002;34:199-210.
28. Zhang H, Shi X, Zhang QJ, Hampong M, Paddon H, Wahyuningsih D, Pelech S: Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem 2002;277:43648-43658.
29. Asnaghi L, Bruno P, Priulla M, Nicolin A: mTOR: A protein kinase switching between life and death. Pharmacol Res 2004;50:545-549.
30. Guo X, Zhang X, Li Y, Guo Y, Wang J, Li Y, Shen B, Sun D, Zhang J: Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-alpha. Mol Cell Biochem 2012;364:373-380.
31. Lang E, Qadri SM, Lang F: Killing me softly-suicidal erythrocyte death. Int J Biochem Cell Biol 2012;44:1236-1243.
32. Lang PA, Kaiser S, Myssina S, Wieder T, Lang F, Huber SM: Role of Ca2+-activated K+ channels in human erythrocyte apoptosis. Am J Physiol Cell Physiol 2003;285:C1553-C1560.
33. Abed M, Towhid ST, Mia S, Pakladok T, Alesutan I, Borst O, Gawaz M, Gulbins E, Lang F: Sphingomyelinaseinduced adhesion of eryptotic erythrocytes to endothelial cells. Am J Physiol Cell Physiol 2012;303:C991-999.
34. Lau IP, Chen H, Wang J, Ong HC, Leung KC, Ho HP, Kong SK: In vitro effect of CTAB-and PEG-coated gold nanorods on the induction of eryptosis/erythroptosis in human erythrocytes. Nanotoxicology 2012;6:847-856.
35. Maellaro E, Leoncini S, Moretti D, Del Bello B, Tanganelli I, De Felice C, Ciccoli L: Erythrocyte caspase-3 activation and oxidative imbalance in erythrocytes and in plasma of type 2 diabetic patients. Acta Diabetol 2013;50:489-495.
36. Lang E, Bissinger R, Fajol A, Salker MS, Singh Y, Zelenak C, Ghashghaeinia M, Gu S, Jilani K, Lupescu A, Reyskens KM, Ackermann TF, Foller M, Schleicher E, Sheffield WP, Arthur JS, Lang F, Qadri SM: Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen-and stressactivated kinase MSK1/2. Sci Rep 2015;5:17316.
37. Avantaggiati ML, Ogryzko V, Gardner K, Giordano A, Levine AS, Kelly K: Recruitment of p300/CBP in p53-dependent signal pathways. Cell 1997;89:1175-1184.
38. Abed M, Feger M, Alzoubi K, Pakladok T, Frauenfeld L, Geiger C, Towhid ST, Lang F: Sensitization of erythrocytes to suicidal erythrocyte death following water deprivation. Kidney Blood Press Res 2013;37:567-578.
39. Voelkl J, Alzoubi K, Mamar AK, Ahmed MS, Abed M, Lang F: Stimulation of suicidal erythrocyte death by increased extracellular phosphate concentrations. Kidney Blood Press Res 2013;38:42-51.
40. Abed M, Artunc F, Alzoubi K, Honisch S, Baumann D, Foller M, Lang F: Suicidal erythrocyte death in endstage renal disease. J Mol Med (Berl) 2014;92:871-879.
41. Ahmed MS, Langer H, Abed M, Voelkl J, Lang F: The uremic toxin acrolein promotes suicidal erythrocyte death. Kidney Blood Press Res 2013;37:158-167.
42. Polak-Jonkisz D, Purzyc L: Ca(2+) influx versus efflux during eryptosis in uremic erythrocytes. Blood Purif 2012;34:209-210; author reply 210.
43. Calderon-Salinas JV, Munoz-Reyes EG, Guerrero-Romero JF, Rodriguez-Moran M, Bracho-Riquelme RL, Carrera-Gracia MA, Quintanar-Escorza MA: Eryptosis and oxidative damage in type 2 diabetic mellitus patients with chronic kidney disease. Mol Cell Biochem 2011;357:171-179.
44. Lang PA, Beringer O, Nicolay JP, Amon O, Kempe DS, Hermle T, Attanasio P, Akel A, Schafer R, Friedrich B, Risler T, Baur M, Olbricht CJ, Zimmerhackl LB, Zipfel PF, Wieder T, Lang F: Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome. J Mol Med (Berl) 2006;84:378-388.
45. Nicolay JP, Schneider J, Niemoeller OM, Artunc F, Portero-Otin M, Haik G, Jr., Thornalley PJ, Schleicher E, Wieder T, Lang F: Stimulation of suicidal erythrocyte death by methylglyoxal. Cell Physiol Biochem 2006;18:223-232.
46. Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C, Orth HM, Klindt C, Schuier M, Keitel V, Reich M, Liu G, Schmidt S, Xu HC, Qadri SM, Herebian D, Pandyra AA, Mayatepek E, Gulbins E, Lang F, Haussinger D, Lang KS, Foller M, Lang PA: Conjugated bilirubin triggers anemia by inducing erythrocyte death. Hepatology 2015;61:275-284.
47. Attanasio P, Bissinger R, Haverkamp W, Pieske B, Wutzler A, Lang F: Enhanced suicidal erythrocyte death in acute cardiac failure. Eur J Clin Invest 2015;10.1111/eci.12555
48. Qadri SM, Mahmud H, Lang E, Gu S, Bobbala D, Zelenak C, Jilani K, Siegfried A, Foller M, Lang F: Enhanced suicidal erythrocyte death in mice carrying a loss-of-function mutation of the adenomatous polyposis coli gene. J Cell Mol Med 2012;16:1085-1093.
49. Kempe DS, Akel A, Lang PA, Hermle T, Biswas R, Muresanu J, Friedrich B, Dreischer P, Wolz C, Schumacher U, Peschel A, Gotz F, Doring G, Wieder T, Gulbins E, Lang F: Suicidal erythrocyte death in sepsis. J Mol Med (Berl) 2007;85:273-281.
50. Crisp RL, Vota DM, Donato H, Garcia E, Rapetti MC, Maltaneri RE, Vittori DC, Nesse AB: Eryptosis is induced by hyperthermia in hereditary spherocytosis red blood cells. Clin Chem Lab Med 2015;10.1515/cclm-2015-0618
51. Lang PA, Schenck M, Nicolay JP, Becker JU, Kempe DS, Lupescu A, Koka S, Eisele K, Klarl BA, Rubben H, Schmid KW, Mann K, Hildenbrand S, Hefter H, Huber SM, Wieder T, Erhardt A, Haussinger D, Gulbins E, Lang F: Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nat Med 2007;13:164-170.
52. Lupescu A, Bissinger R, Goebel T, Salker MS, Alzoubi K, Liu G, Chirigiu L, Mack AF, Qadri SM, Lang F: Enhanced suicidal erythrocyte death contributing to anemia in the elderly. Cell Physiol Biochem 2015;36:773-783.
53. Alzoubi K, Honisch S, Abed M, Lang F: Triggering of Suicidal Erythrocyte Death by Penta-O-galloyl-beta-dglucose. Toxins (Basel) 2014;6:54-65.
54. Arnold M, Lang E, Modicano P, Bissinger R, Faggio C, Abed M, Lang F: Effect of nitazoxanide on erythrocytes. Basic Clin Pharmacol Toxicol 2014;114:421-426.
55. Oswald G, Alzoubi K, Abed M, Lang F: Stimulation of suicidal erythrocyte death by ribavirin. Basic Clin Pharmacol Toxicol 2014;114:311-317.
56. Alzoubi K, Calabròa S, Bissinger R, Abed M, Faggio C, Lang F: Stimulation of Suicidal Erythrocyte Death by Artesunate. Cell Physiol Biochem 2014;34:2232-2244.
57. Arnold M, Bissinger R, Lang F: Mitoxantrone-induced suicidal erythrocyte death. Cell Physiol Biochem 2014;34:1756-1767.
58. Bissinger R, Fischer S, Jilani K, Lang F: Stimulation of Erythrocyte Death by Phloretin. Cell Physiol Biochem 2014;34:2256-2265.
59. Jacobi J, Lang E, Bissinger R, Frauenfeld L, Modicano P, Faggio C, Abed M, Lang F: Stimulation of erythrocyte cell membrane scrambling by mitotane. Cell Physiol Biochem 2014;33:1516-1526.
60. Jilani K, Qadri SM, Lang F: Geldanamycin-induced phosphatidylserine translocation in the erythrocyte membrane. Cell Physiol Biochem 2013;32:1600-1609.
61. Lupescu A, Bissinger R, Herrmann T, Oswald G, Jilani K, Lang F: Induction of suicidal erythrocyte death by novobiocin. Cell Physiol Biochem 2014;33:670-680.
62. Malik A, Bissinger R, Calabro S, Faggio C, Jilani K, Lang F: Aristolochic Acid Induced Suicidal Erythrocyte Death. Kidney Blood Press Res 2014;39:408-419.
63. Tesoriere L, Attanzio A, Allegra M, Cilla A, Gentile C, Livrea MA: Oxysterol mixture in hypercholesterolemiarelevant proportion causes oxidative stress-dependent eryptosis. Cell Physiol Biochem 2014;34:1075-1089.
64. Zhang R, Xiang Y, Ran Q, Deng X, Xiao Y, Xiang L, Li Z: Involvement of calcium, reactive oxygen species, and ATP in hexavalent chromium-induced damage in red blood cells. Cell Physiol Biochem 2014;34:1780-1791.
65. Aljanadi O, Alzoubi K, Bissinger R, Lang F: Stimulation of Suicidal Erythrocyte Death by Naphthazarin. Basic Clin Pharmacol Toxicol 2015;10.1111/bcpt.12420
66. Alzoubi K, Egler J, Abed M, Lang F: Enhanced Eryptosis Following Auranofin Exposure. Cell Physiol Biochem 2015;37:1018-1028.
67. Alzoubi K, Egler J, Briglia M, Fazio A, Faggio C, Lang F: Induction of Suicidal Erythrocyte Death by Cantharidin. Toxins (Basel) 2015;7:2822-2834.
68. Awasthi S, Gayathiri SK, Ramya R, Duraichelvan R, Dhason A, Saraswathi NT: Advanced Glycation-Modified Human Serum Albumin Evokes Alterations in Membrane and Eryptosis in Erythrocytes. Appl Biochem Biotechnol 2015;177:1013-1024.
69. Bissinger R, Barking S, Alzoubi K, Liu G, Liu G, Lang F: Stimulation of Suicidal Erythrocyte Death by the Antimalarial Drug Mefloquine. Cell Physiol Biochem 2015;36:1395-1405.
70. Bissinger R, Bouguerra G, Stockinger K, Abbes S, Lang F: Triggering of Suicidal Erythrocyte Death by Topotecan. Cell Physiol Biochem 2015;37:1607-1618.
71. Bissinger R, Malik A, Bouguerra G, Zhou Y, Singh Y, Abbes S, Lang F: Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol 2015;10.1111/bcpt.12503
72. Bissinger R, Waibel S, Bouguerra G, Al Mamun Bhuyan A, Abbes S, Lang F: Enhanced Eryptosis Following Exposure to Lopinavir. Cell Physiol Biochem 2015;37:2486-2495.
73. Bissinger R, Waibel S, Lang F: Induction of suicidal erythrocyte death by nelfinavir. Toxins (Basel) 2015;7:1616-1628.
74. Bouguerra G, Aljanadi O, Bissinger R, Abbes S, Lang F: Embelin-Induced Phosphatidylserine Translocation in the Erythrocyte Cell Membrane. Cell Physiol Biochem 2015;37:1629-1640.
75. Bouguerra G, Bissinger R, Abbes S, Lang F: Stimulation of Eryptosis by Narasin. Cell Physiol Biochem 2015;37:1807-1816.
76. Bouguerra G, Bissinger R, Abbes S, Lang F: Zopolrestat Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem 2015;37:1537-1546.
77. Briglia M, Calabro S, Signoretto E, Alzoubi K, Laufer S, Faggio C, Lang F: Fucoxanthin Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem 2015;37:2464-2475.
78. Briglia M, Fazio A, Faggio C, Lang F: Triggering of Suicidal Erythrocyte Death by Zosuquidar. Cell Physiol Biochem 2015;37:2355-2365.
79. Briglia M, Fazio A, Faggio C, Laufer S, Alzoubi K, Lang F: Triggering of Suicidal Erythrocyte Death by Ruxolitinib. Cell Physiol Biochem 2015;37:768-778.
80. Briglia M, Fazio A, Signoretto E, Faggio C, Lang F: Edelfosine Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem 2015;37:2221-2230.
81. Calabro S, Alzoubi K, Bissinger R, Faggio C, Lang F: Stimulation of suicidal erythrocyte death by ellipticine. Basic Clin Pharmacol Toxicol 2015;116:485-492.
82. Calabro S, Alzoubi K, Faggio C, Laufer S, Lang F: Triggering of Suicidal Erythrocyte Death Following Boswellic Acid Exposure. Cell Physiol Biochem 2015;37:131-142.
83. Cheung AK, Yang AK, Ngai BH, Yu SS, Gao M, Lau PM, Kong SK: Quantitative detection of eryptosis in human erythrocytes using tunable resistive pulse sensing and annexin-V-beads. Analyst 2015;140:1337-1348.
84. Egler J, Lang F: Licochalcone A Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem 2015;37:2060-2070.
85. Faggio C, Alzoubi K, Calabro S, Lang F: Stimulation of suicidal erythrocyte death by PRIMA-1. Cell Physiol Biochem 2015;35:529-540.
86. Fazio A, Briglia M, Faggio C, Alzoubi K, Lang F: Oxaliplatin Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem 2015;37:2393-2404.
87. Fazio A, Briglia M, Faggio C, Alzoubi K, Lang F: Stimulation of Suicidal Erythrocyte Death by Garcinol. Cell Physiol Biochem 2015;37:805-815.
88. Gao C, Ji S, Dong W, Qi Y, Song W, Cui D, Shi J: Indolic Uremic Solutes Enhance Procoagulant Activity of Red Blood Cells through Phosphatidylserine Exposure and Microparticle Release. Toxins (Basel) 2015;7:4390-4403.
89. Hoque M, Nanduri R, Gupta J, Mahajan S, Gupta P, Saleemuddin M: Oleic acid complex of bovine alphalactalbumin induces eryptosis in human and other erythrocytes by a Ca(2+)-independent mechanism. Biochim Biophys Acta 2015;1850:1729-1739.
90. Lang E, Jilani K, Bissinger R, Rexhepaj R, Zelenak C, Lupescu A, Lang F, Qadri SM: Vitamin D-Rich Diet in Mice Modulates Erythrocyte Survival. Kidney Blood Press Res 2015;40:403-412.
91. Lang E, Zelenak C, Eberhard M, Bissinger R, Rotte A, Ghashghaeinia M, Lupescu A, Lang F, Qadri SM: Impact of Cyclin-Dependent Kinase CDK4 Inhibition on Eryptosis. Cell Physiol Biochem 2015;37:1178-1186.
92. Malik A, Bissinger R, Liu G, Liu G, Lang F: Enhanced eryptosis following gramicidin exposure. Toxins (Basel) 2015;7:1396-1410.
93. Officioso A, Alzoubi K, Manna C, Lang F: Clofazimine Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem 2015;37:331-341.
94. Officioso A, Manna C, Alzoubi K, Lang F: Triggering of Erythrocyte Death by Triparanol. Toxins (Basel) 2015;7:3359-3371.
95. Pagano M, Faggio C: The use of erythrocyte fragility to assess xenobiotic cytotoxicity. Cell Biochem Funct 2015;33:351-355.
96. Peter T, Bissinger R, Enkel S, Alzoubi K, Oswald G, Lang F: Programmed erythrocyte death following in vitro Treosulfan treatment. Cell Physiol Biochem 2015;35:1372-1380.
97. Peter T, Bissinger R, Lang F: Erythrocyte Shrinkage and Cell Membrane Scrambling after Exposure to the Ionophore Nonactin. Basic Clin Pharmacol Toxicol 2015;10.1111/bcpt.12455
98. Ran Q, Xiang Y, Liu Y, Xiang L, Li F, Deng X, Xiao Y, Chen L, Chen L, Li Z: Eryptosis Indices as a Novel Predictive Parameter for Biocompatibility of Fe3O4 Magnetic Nanoparticles on Erythrocytes. Sci Rep 2015;5:16209.
99. Stockinger K, Bissinger R, Bouguerra G, Abbes S, Lang F: Enhanced Eryptosis Following Exposure to Carnosic Acid. Cell Physiol Biochem 2015;37:1779-1791.
100. Sun Y, Liu G, Li X, Shi Y, Guan G: L-Carnitine inhibits eryptosis induced by uremic serum and the related mechanisms. Ren Fail 2015;37:1050-1056.
101. Tesoriere L, Attanzio A, Allegra M, Livrea MA: Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers. Br J Nutr 2015;114:368-375.
102. Velasquez FC, Mate S, Bakas L, Herlax V: Induction of eryptosis by low concentrations of E. coli alphahemolysin. Biochim Biophys Acta 2015;1848:2779-2788.
103. Viskupicova J, Blaskovic D, Galiniak S, Soszynski M, Bartosz G, Horakova L, Sadowska-Bartosz I: Effect of high glucose concentrations on human erythrocytes in vitro. Redox Biol 2015;5:381-387.
104. Waibel S, Bissinger R, Bouguerra G, Abbes S, Lang F: Saquinavir Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem 2015;37:1973-1982.
105. Zierle J, Bissinger R, Egler J, Lang F: Lapatinib Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem 2015;37:2275-2287.
106. Calabro S, Alzoubi K, Bissinger R, Jilani K, Faggio C, Lang F: Enhanced eryptosis following juglone exposure. Basic Clin Pharmacol Toxicol 2015;116:460-467.
107. Gaffet P, Bettache N, Bienvenue A: Phosphatidylserine exposure on the platelet plasma membrane during A23187-induced activation is independent of cytoskeleton reorganization. Eur J Cell Biol 1995;67:336-345.
108. Lockshin RA, Zakeri Z: Apoptosis, autophagy, and more. Int J Biochem Cell Biol 2004;36:2405-2419.
109. Lockshin RA, Zakeri Z: Caspase-independent cell death? Oncogene 2004;23:2766-2773.
110. Naito M, Hashimoto C, Masui S, Tsuruo T: Caspase-independent necrotic cell death induced by a radiosensitizer, 8-nitrocaffeine. Cancer Sci 2004;95:361-366.
111. Borst O, Abed M, Alesutan I, Towhid ST, Qadri SM, Foller M, Gawaz M, Lang F: Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX. Am J Physiol Cell Physiol 2012;302:C644-C651.
112. Andrews DA, Low PS: Role of red blood cells in thrombosis. Curr Opin Hematol 1999;6:76-82.
113. Chung SM, Bae ON, Lim KM, Noh JY, Lee MY, Jung YS, Chung JH: Lysophosphatidic acid induces thrombogenic activity through phosphatidylserine exposure and procoagulant microvesicle generation in human erythrocytes. Arterioscler Thromb Vasc Biol 2007;27:414-421.
114. Zwaal RF, Comfurius P, Bevers EM: Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci 2005;62:971-988.
115. Closse C, Dachary-Prigent J, Boisseau MR: Phosphatidylserine-related adhesion of human erythrocytes to vascular endothelium. Br J Haematol 1999;107:300-302.
116. Gallagher PG, Chang SH, Rettig MP, Neely JE, Hillery CA, Smith BD, Low PS: Altered erythrocyte endothelial adherence and membrane phospholipid asymmetry in hereditary hydrocytosis. Blood 2003;101:4625-4627.
117. Pandolfi A, Di Pietro N, Sirolli V, Giardinelli A, Di Silvestre S, Amoroso L, Di Tomo P, Capani F, Consoli A, Bonomini M: Mechanisms of uremic erythrocyte-induced adhesion of human monocytes to cultured endothelial cells. J Cell Physiol 2007;213:699-709.
118. Wood BL, Gibson DF, Tait JF: Increased erythrocyte phosphatidylserine exposure in sickle cell disease: flowcytometric measurement and clinical associations. Blood 1996;88:1873-1880.